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COVID-19 in Liver Transplant Recipients

Journal of Clinical and Translational Hepatology 2021年第4期9卷 545-550页

作者： Ravina Kullar Ankur Prakash Patel Sammy Saab expert stewardship Inc.Newport BeachCAUSA David Geffen School of Medicine at the University of California at Los Angeles Los AngelesCAUSA

Background and Aims:Coronavirus disease 2019(COVID-19)has infected over 93 million people worldwide as of January 14,*** studies have gathered data on liver transplant patients infected with ***,we discuss the presentation of COVID-19 in immunosuppressed patients with prior liver *** also evaluate patient outcomes after ***:We searched the PubMed database for all studies focused on liver transplant patients with ***:We identified eight studies that evaluated COVID-19 infection in liver transplant patients(n=494).Hypertension was the most prevalent comorbidity in our *** inhibitors were the most common immunosuppressant medications in the entire *** average time from liver transplant to COVID-19 infection in our cohort was 74.1 *** and cough,at 70%and 62%respectively,were the most common symptoms in our *** total,50%of the patients received hydroxychloroquine as treatment for *** next most prevalent treatment was azithromycin,given to 30%of patients in our *** total,80%of the patients were admitted to a hospital and 17%required intensive care unit-level care,with 21%having required mechanical *** mortality was 17%in our ***:Given the immunocompromised status of liver transplant patients,more intensive surveillance is necessary for severe cases of COVID-19 *** liver transplantations have been restricted during the COVID-19 pandemic,further investigation is warranted for studying the risk of COVID-19 infection in liver transplant patients.

关键词： COVID-19 Liver transplantation Immunosuppression

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