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The journey towards physiology and pathology: Tracing the path of neuregulin 4

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Genes & Diseases 2024年第2期11卷 687-700页

作者： Min Chen Jieying Zhu Hongyang Luo Wangjing Mu Liang Guo School of exercise and Health and Shanghai Frontiers science Research Base of exercise and Metabolic Health Shanghai University of SportShanghai 200438China

Neuregulin 4 (Nrg4),an epidermal growth factor (EGF) family member,can bind to and activate the ErbB4 receptor tyrosine ***4 has five different isoforms by alternative splicing and performs a wide variety of ***4 is involved in a spectrum of physiological processes including neurobiogenesis,lipid metabolism,glucose metabolism,thermogenesis,and *** pathological processes,Nrg4 inhibits inflammatory factor levels and suppresses apoptosis in inflammatory *** addition,Nrg4 could ameliorate obesity,insulin resistance,and cardiovascular ***,Nrg4 improves non-alcoholic fatty liver disease (NAFLD) by promoting autophagy,improving lipid metabolism,and inhibiting cell death of ***,Nrg4 is closely related to the development of cancer,hyperthyroidism,and some other ***,elucidation of the functional role and mechanisms of Nrg4 will provide a clearer view of the therapeutic potential and possible risks of Nrg4.

关键词： Angiogenesis Cardiovascular diseases Inflammation Insulin resistance Lipid and glucose metabolism NAFLD Neurobiogenesis Obesity

Acute effect of foot strike patterns on in vivo tibiotalar and subtalar joint kinematics during barefoot running

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Journal of Sport and Health science 2024年第1期13卷 108-117页

作者： Dongqiang Ye Lu Li Shen Zhang Songlin Xiao Xiaole Sun Shaobai Wang Weijie Fu Key Laboratory of exercise and Health sciences of Ministry of Education Shanghai University of SportShanghai 200438China Shanghai Frontiers science Research Base of exercise and Metabolic Health Shanghai University of SportShanghai 200438China

Background:Foot kinematics,such as excessive eversion and malalignment of the hindfoot,are believed to be associated with running-related *** maj ority of studies to date show that different foot strike patterns influence these specific foot and ankle ***,technical deficiencies in traditional motion capture approaches limit knowledge of in vivo joint kinematics with respect to rearfoot and forefoot strike patterns(RFS and FFS,respectively).This study uses a high-speed dual fluoroscopic imaging system(DFIS)to determine the effects of different foot strike patterns on 3D in vivo tibiotalar and subtalar joints ***:Fifteen healthy male recreational runners underwent foot computed tomography scanning for the construction of 3-dimensional models.A high-speed DFIS(100 Hz)was used to collect 6 degrees of freedom kinematics for participants’tibiotalar and subtalar joints when they adopted RFS and FFS in barefoot ***:Compared with RFS,FFS exhibited greater internal rotation at 0%-20%of the stance phase in the tibiotalar *** peak internal rotation angle of the tibiotalar joint under FFS was greater than under RFS(p<0.001,Cohen’s d=0.92).RFS showed more dorsiflexion at 0%-20%of the stance phase in the tibiotalar joint than *** also presented a larger anterior translation(p<0.001,Cohen’s d=1.28)in the subtalar joint at i nitial contact than ***:Running with acute barefoot FFS increases the internal rotation of the tibiotalar joint in the early *** use of high-speed DFIS to quantify the movement of the tibiotalar and subtalar joint was critical to revealing the effects of RF S and FFS during running.

关键词： Foot strike patterns High-speed dual fluoroscopic imaging system In vivo kinematics Running

Molecular insights of exercise therapy in disease prevention and treatment

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2564-2597页

作者： David Walzik Tiffany YWences Chirino Philipp Zimmer Niklas Joisten Division of Performance and Health(Sports Medicine) Institute for Sport and Sport ScienceTU Dortmund University44227 DortmundNorth Rhine-WestphaliaGermany Division of exercise and Movement science Institute for Sport ScienceUniversity of Göttingen37075 GöttingenLower SaxonyGermany

Despite substantial evidence emphasizing the pleiotropic benefits of exercise for the prevention and treatment of various diseases,the underlying biological mechanisms have not been fully *** exercise benefits have been attributed to signaling molecules that are released in response to exercise by different tissues such as skeletal muscle,cardiac muscle,adipose,and liver *** signaling molecules,which are collectively termed exerkines,form a heterogenous group of bioactive substances,mediating inter-organ crosstalk as well as structural and functional tissue *** scientific endeavors have focused on identifying and characterizing new biological mediators with such ***,some investigations have focused on the molecular targets of exerkines and the cellular signaling cascades that trigger adaption processes.A detailed understanding of the tissue-specific downstream effects of exerkines is crucial to harness the health-related benefits mediated by exercise and improve targeted exercise programs in health and ***,we review the current in vivo evidence on exerkine-induced signal transduction across multiple target tissues and highlight the preventive and therapeutic value of exerkine signaling in various *** emphasizing different aspects of exerkine research,we provide a comprehensive overview of(i)the molecular underpinnings of exerkine secretion,(ii)the receptor-dependent and receptor-independent signaling cascades mediating tissue adaption,and(iii)the clinical implications of these mechanisms in disease prevention and treatment.

关键词： prevention treatment collective

Diet restriction and exercise alleviate cognitive reduction of high fat diet(HFD)-induced obese mice by rescuing inflammation-mediated compromised insulin signaling pathway through activating AMPK/SIRT1 signal pathway and suppressing TLR4 signal pathway

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Food science and Human Wellness 2024年

作者： Hu Zhang Ye Zhang Jiling Liang Jiahang Li Miao He Xin Liu Jielun Huang Minghui Wang Jingjing Fan Ning Chen Tianjiu Research and Development Center for exercise Nutrition and Foods Hubei Key Laboratory of exercise Training and Monitoring College of Sports Medicine Wuhan Sports University Physical Education Institute Hubei University of science and Technology

Obesity， caused by excessive energy， leads to body weight gain and various diseases， including cognitive impairment. Current studies suggest that diet restriction such as optimal fasting and regular exercise are crucial for improving cognitive capacity. However， further exploration is needed to understand the specific mechanisms of high fat diet (HFD)-induced cognitive decline in obesity. In the present study， 4-month-old mice were subjected to HFD feeding for 18 weeks， followed by aerobic exercise and high-intensity intermittent exercise， regular diet feeding， and intermittent fasting for 8 weeks， and then used to evaluate cognitive capacity， inflammation， compromised insulin signaling pathway， oxidative stress， and apoptosis in hippocampal tissue， as well as AMPK/SIRT1 and TLR4 signal pathways. Obese mice revealed impaired cognitive capacity as compared with mice fed with regular diets. In contrast， aerobic exercise， high-intensity intermittent exercise， regular diet， and intermittent fasting could inhibit apoptosis caused by inflammation-mediated compromised insulin signaling pathway in hippocampal tissues through activating the AMPK/SIRT1 signal pathway and suppressing the TLR4 signal pathway， thereby rescuing the cognitive impairment of obese mice. Therefore， diet restriction and exercise interventions may play a positive role in reverting obesity-induced cognitive impairment.

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Foam rolling and stretching do not provide superior acute flexibility and stiffness improvements compared to any other warm-up intervention: A systematic review with meta-analysis

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Journal of Sport and Health science 2024年第4期13卷 509-520页

作者： Konstantin Warneke Gerit Plöschberger Lars H.Lohmann Eric Lichtenstein Daniel Jochum Stanislav D.Siegel Astrid Zech David G.Behm Institute of Sport science University of KlagenfurtKlagenfurt am Wörthersee 9020Austria Department of Human Motion science and exercise Physiology Friedrich Schiller UniversityJena 07749Germany Department Sport Exercise and HealthUniversity of BaselBasel 4052Switzerland Department of Health sciences and Technology ETH ZurichZurich 8092Switzerland School of Human Kinetics and Recreation Memorial University of NewfoundlandSt.JohnsNL A1C 5S7Canada

Background:Acute improvement in range of motion(ROM)is a widely reported effect of stretching and foam rolling,which is commonly explained by changes in pain threshold and/or musculotendinous ***,these effects were also reported in response to various other active and passive interventions that induce responses such as enhanced muscle ***,we hypothesized that acute ROM enhancements could be induced by a wide variety of interventions other than stretching or foam rolling that promote an increase in muscle ***:After a systematic search in PubMed,Web of science,and SPORTDiscus databases,38 studies comparing the effects of stretching and foam rolling with several other interventions on ROM and passive properties were *** studies had 1134 participants in total,and the data analysis resulted in 140 effect sizes(ESs).ES calculations were performed using robust variance estimation model with ***:Study quality of the included studies was classified as fair(PEDro score=4.58)with low to moderate certainty of *** showed no significant differences in ROM(ES=0.01,p=0.88),stiffness(ES=0.09,p=0.67),or passive peak torque(ES=-0.30,p=0.14)between stretching or foam rolling and the other identified *** plots revealed no publication ***:Based on current literature,our results challenge the established view on stretching and foam rolling as a recommended component of warm-up *** lack of significant difference between interventions suggests there is no need to emphasize stretching or foam rolling to induce acute ROM,passive peak torque increases,or stiffness reductions.

关键词： Range of motion Passive properties Muscletendon unit Muscle tissue

Commentary on "Association of daily sitting time and leisure-time physical activity with body fat among ***"

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Journal of Sport and Health science 2024年第2期13卷 127-129页

作者： Barbara E.Ainsworth School of exercise and Health Shanghai University of SportShanghai 200438China

In their study,association of daily sitting time and leisure-time physical activity (LTPA) with body fat among ***,Liao et al.^(1) analyzed data from the 2011-2018 National Health and Examination Survey to examine associations between h/day sitting,meeting (or not meeting) the *** Activity Guidelines of≥150 min/week of moderate-and vigorous-intensity LTPA,and combinations of sitting time and LTPA on totaland trunk percent body fat (BF%).

关键词： U.S. adult among

Commentary on"Alexa,let's train now!A systematic review and classification approach to digital and home-based physical training interventions aiming to support healthy cognitive aging"

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Journal of Sport and Health science 2024年第5期13卷 672-673页

作者： Barbara E.Ainsworth Zeyun Feng School of exercise and Health Shanghai University of SportShanghai 200438China

In Volume 13,Issue 1,of the Journal of Sport and Health science,Herold et al.1 present a systematic review and classification of digital and home-based physical training interventions aiming to support healthy cognitive *** interventions were reviewed:digital databases(i.e.,YouTube videos and apps),online classes,and technology-based exercise devices(e.g.,exergames).

关键词： cognitive games aging

Resveratrol combats chronic diseases through enhancing mitochondrial quality

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Food science and Human Wellness 2024年第2期13卷 597-610页

作者： Weichu Tao Hu Zhang Xia Jiang Ning Chen Tianjiu Research and Development Center for exercise Nutrition and Foods Hubei Key Laboratory of Exercise Training and MonitoringCollege of Sports MedicineWuhan Sports UniversityWuhan 430079China The University Hospital of Wuhan Sports University Wuhan 430079China

Resveratrol(RSV),as a functional food component extracted from natural plants,has been widely studied and recognized in preventing and treating various diseases,with major mechanisms including executing anti-inflammation and anti-oxidation functions,and improving mitochondrial *** diseases as non-communicable diseases are mainly caused by multiple factors,such as physiological decline and dysfunction in the body,and have become a significant challenge on public health *** is worth noting that chronic diseases such as Alzheimer's disease(AD),Parkinson's disease(PD),muscle atrophy,cardiovascular disease,obesity,and cancer are accompanied by abnormal mitochondrial ***,targeted regulation of mitochondria may be a meaningful way to prevent and treat chronic *** evidence has confirmed that RSV is actively involved in regulating mitochondria,and it has become an essential consideration to prevent and treat chronic diseases through targeting mitochondria and improving corresponding *** this article,current studies on RSV to optimize mitochondrial quality for preventing and alleviating chronic disease are systematically summarized,which can provide a theoretical reference for the development of functional foods or drugs to combat chronic diseases.

关键词： Resveratrol Functional food Mitochondrial quality Chronic disease Anti-inflammation Anti-oxidation

The current practice and future promise of integration of exercise science and medicine in China

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Global Health Journal 2018年第3期2卷 31-35页

作者： Jianjun Guo Xiaomin Sun Jing Wu Qing Chang Mitsuru Higuchi Weimin Li Sirui Zhou Youfa Wang Integration of Sport and Medicine Innovation Research Center China Institute of Sport ScienceBeijing 100763China Global Health Institute Xi’an Jiaotong UniversityXi’an 710061China School of Public Health Xi’an Jiaotong University Health Science CenterXi’an 710061China National Center for Chronic and Noncommunicable Diseases Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China College of Sports Medicine Chongqing Medical UniversityChongqing 400016China Faculty of Sport sciences Waseda UniversityTokorozawaSaitama 359-1192Japan Department of Clinical Nutrition First Affi liated Hospital of Xi’an Jiaotong UniversityXi’an 710061China

With an increasing proportion of sedentary lifestyle related chronic diseases,an efficient way to help fight the growing world epidemic of non-communicable diseases(NCDs)and promote public health in a fast-changing world is urgently *** and medicine science have played an important role in prevention and control of ***,the current status and future development directions regarding the integration of exercise science and medicine(IESM)in China have not been well *** 2017 Belt and Road Initiative Global Health International Congress&2017 Chinese Preventive Medicine Association-Chinese Society on Global Health Annual Meeting,Xi’an Jiaotong University Global Health Institute,and the Integration of Sport and Medicine Innovation Research Center,China Institute of Sport science organized the IESM Forum on September *** leaders and experts from China and abroad presented excellent research reports in the IESM Forum from several *** reached a consensus at the end of their discussions that,in the near future,the IESM will be a key part of a sustainable health care system and as such should contribute to prosperity in China and around the ***,compared with European,American and Japanese universities,the development of the IESM in China is in its early stages with huge development potential.

关键词： integration of exercise science and medicine healthy lifestyle talent training weight management