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中华放射学杂志 2023年第6期57卷 640-646页

作者：廖荟珽蔡子萌叶海琪陈骞蓝侯明佳蔡克家陈唯唯华中科技大学同济医学院附属同济医院放射科武汉430030 广东省医学科学院广东省人民医院放射科广州519041 浙江大学医学院附属杭州市第一人民医院放射科杭州310003 experimental and Clinical Research Centre Max Delbrück Centre for Molecular Medicine and Charité-Universitätsmedizin BerlinCorporate Member of Freie Universität BerlinHumboldt-Universität zu Berlinand Berlin Institute of HealthBerlin 13092 Department of Radiology University of Illinois Hospital&Health Science SystemChicago 60612

目的探讨质子交换速率(k_(ex))成像技术研究复发缓解型多发性硬化(RRMS)患者脑白质病灶(WML)及表观正常脑白质(NAWM)的氧化应激状态的价值。方法回顾性分析2018年11月至2021年11月在华中科技大学同济医学院附属同济医院就诊的RRMS患者(... 详细信息

目的探讨质子交换速率(k_(ex))成像技术研究复发缓解型多发性硬化(RRMS)患者脑白质病灶(WML)及表观正常脑白质(NAWM)的氧化应激状态的价值。方法回顾性分析2018年11月至2021年11月在华中科技大学同济医学院附属同济医院就诊的RRMS患者(病例组)37例的临床及影像资料,其中男11例、女26例,年龄18~41(29±7)岁。另招募同期年龄段相匹配的健康志愿者22名(对照组),其中男4名、女18名,年龄23~44岁,中位年龄25(24,28.25)岁。所有受检者均接受MR常规序列及化学交换饱和转移成像,并定性评估k_(ex) map上WML的位置和数量,WML的T1WI图像信号特征;定量分析病例组WML、NAWM和对照组正常脑白质(NWM)的k_(ex)值。采用成组t检验或独立样本t检验比较病例组WML与NAWM、病例组NAWM与对照组NWM以及T1WI呈低信号和等信号WML的k_(ex)值,采用Spearman秩相关分析WML的k_(ex)值与患者扩展残疾状态量表(EDSS)评分的相关性。结果病例组37例患者中共发现272个WML,其中25.4%(69/272)的WML在T1WI图像上呈明显低信号。病例组WML的k_(ex)值[(932±108)s-1]高于NAWM[(771±26)s-1],差异有统计学意义(t=8.95,Pex)值[(771±26)s-1]高于对照组NWM[(745±26)s-1],差异有统计学意义(t=3.96,Pex)值[(1039±110)s-1]高于呈等信号WML的k_(ex)值[(895±79)s-1],差异有统计学意义(t=9.78,Pex)值与EDSS评分呈正相关(r=0.54,Pex)值升高,反映氧化应激水平升高,且与组织损伤程度正相关,说明氧化应激不仅参与了RRMS脑白质病灶的形成还与全脑病变相关。

关键词：多发性硬化磁共振成像脑白质病灶表观正常脑白质质子交换率氧化应激

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Skin models of cutaneous toxicity,transdermal transport and wound repair

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Burns & Trauma 2023年第1期11卷 393-407页

作者： Inês Vilela de Sousa Miguel J.S.Ferreira Luís B.Bebiano Sandra Simões Ana Filipa Matos Rúben F.Pereira Pedro L.Granja i3S-Instituto de Investigação e Inovação em Saúde Universidade do PortoRua Dr.Manuel Pereira da Silva4200-393 PortoPortugal INEB-Instituto de Engenharia Biomédica Universidade do PortoRua do Campo Alegre8234150-180 PortoPortugal ICBAS-Instituto de Ciências Biomédicas Abel Salazar Universidade do PortoRua de Jorge Viterbo Ferreira 2284050-313 PortoPortugal FEUP-Faculdade de Engenharia da Universidade do Porto Rua Dr.Roberto Frias4200-465 PortoPortugal Department of Mechanical Aerospace and Civil EngineeringSchool of EngineeringFaculty of Science and Engineering&Henry Royce InstituteEngineering Building AThe University of ManchesterOxford RoadManchester M139PLUK ISEP-Instituto Superior de Engenharia do Porto Universidade do PortoRua Dr.António Bernardino de Almeida 4314200-072 PortoPortugal iMed.ULisboa Faculty of PharmacyUniversidade de LisboaAv.Prof.Gama Pinto1649-003 LisboaPortugal Faculty of Pharmacy Universidade de LisboaAv.Prof.Gama Pinto1649-003 LisboaPortugal

Skin is widely used as a drug delivery route due to its easy access and the possibility of using relatively painless methods for the administration of bioactive ***,the barrier properties of the skin,along with its multilayer structure,impose severe restrictions on drug transport and ***,bioengineered models aimed at emulating the skin have been developed not only for optimizing the transdermal transport of different drugs and testing the safety and toxicity of substances but also for understanding the biological processes behind skin *** though in vivo research is often preferred to study biological processes involving the skin,in vitro and ex vivo strategies have been gaining increasing relevance in recent ***,there is a noticeably increasing adoption of in vitro and ex vivo methods by internationally accepted ***,microfluidic organ-on-a-chip devices are nowadays emerging as valuable tools for functional and behavioural skin *** in miniaturization,automation and reliability still need to be addressed in order to create skin models that can predict skin behaviour in a robust,high-throughput manner,while being compliant with regulatory issues,standards and *** this review,skin models for transdermal transport,wound repair and cutaneous toxicity will be discussed with a focus on high-throughput *** microfluidic strategies driven by advancements in microfabrication technologies will also be revised as a way to improve the efficiency of existing models,both in terms of complexity and throughput.

关键词： Skin In vitro models ex vivo models Transdermal transport assays Wound healing assays Toxicity assays Microfluidic chip Skin-on-a-chip

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Diagnosis of knee osteoarthritis by OCT and surface-enhanced Raman spectroscopy

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Journal of Innovative Optical Health sciences 2022年第5期15卷 13-27页

作者： Ran An Huaimin Gu Zhouyi Guo Huiqing Zhong Huajiang Wei Guoyong Wu Yonghong He Shusen Xie Hongqin Yang School of Semiconductor Science and Technology South China Normal University Guangzhou 510631P.R.China Publications Department Optica 2010 Massachusetts Avenue NWWashingtonDC 20036 MOE Key Laboratory of Laser Life Science&Institute of Laser Life ScienceCollege of Biophotonics South China Normal University Guangzhou 510631P.R.China The First Affliated Hospital of Sun Yat-Sen University Guangzhou 510080 P.R.China Tsinghua University Shenzhen 518055P.R.China Fujian Normal University Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education of China Fuzhou 350007 P.R.China

In this paper,optical coherence tomography(OCT)and surface-enhanced Raman spectroscopy(SERS)were used to characterize normal knee joint(NKJ)tissue and knee osteoarthritis(KOA)tissue ex *** images show that there is a clear hierarchical structure in NKJ tissue,including surface layer,transitional layer,radiation layer and cartilage matrix calcification layer tissue structure,while the hierarchical structure of KOA tissue is not clear and unevenly distributed,and the pathological tissues at different stages also show significant di®*** shows that NKJ tissue and mild osteoarthritic knee cartilage(MiKOA)tissue have strong characteristic Raman peaks at 964,1073(1086),1271,1305,1442,1660 and 1763 cm^(-1).Compared with the Raman spectrum of NKJ tissue,the Raman characteristic peaks of MiKOA tissue have some shifts,moving from 1073 cm^(-1)to 1086 cm^(-1)and from 1542 cm^(-1)to 1442 cm^(-1).There is a characteristic Raman peak of 1271 cm^(-1)in MiKOA tissue,but not in NKJ *** with NKJ tissue,severely degenerated cartilage(SdKOA)tissues show some new SERS peaks at 1008,1245,1285,1311 and 1321 cm^(-1),which are not seen in SERS spectra of NKJ *** component analysis(PCA)was used to analyze the Raman spectra of 1245–1345 cm^(-1)*** results show that PCA can distinguish NKJ,MiKOA and SdKOA tissues and the accuracy is about 90%.These results indicate that OCT can clearly distinguish NKJ,MiKOA,moderate osteoarthritic knee cartilage(MoKOA)and SdKOA tissue,while SERS can provide further judgment *** results also prove that the contents of protein and polysaccharide in knee tissue are changed during the pathological process of knee tissue,which is the cause of pain caused by poor friction in knee joint during movement.

关键词： Optical coherence tomography surface-enhanced Raman spectroscopy knee osteoarthritis.

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