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Association of Haplotypes in Exon 4 of KLK2 Gene with Raised Serum Prostate-Specific Antigen

American Journal of Molecular Biology 2023年第1期13卷 57-66页

作者： Innocent S. I. Ogbu Ogochukwu A. Nwankwo Chinemere C. Ogbu Emmanuel Nna Kingsley K. Anya Malachy O. Odoh David C. Obasi Department of Medical Laboratory Science Enugu Campus University of Nigeria Enugu Nigeria Department of Medical Laboratory Science Evangel University Akaeze Nigeria Safety Molecular Pathology Laboratory Enugu Nigeria Department of Medical Laboratory Science Ebonyi State University Abakaliki Nigeria Department of Biochemistry Evangel University Akaeze Nigeria

The standard diagnostic modalities for Prostate Cancer (PC) include serum Prostate-Specific Antigen (PSA) assay, Digital Rectal Examination (DRE), and histological examination of prostate biopsy. They are limited by low predictive potential and inability to predict which patients are at risk of developing metastatic disease. The aim of this study is to investigate the exon 4 of the KLK2 gene of subjects for changes in its nucleotide sequences (SNPs) and determine the correlation of these changes with serum PSA in an Igbo population of Nigeria. One hundred male subjects aged 40 years and above, who gave their consent, were used for the study. Their PSA determinations were done using ELISA technique while genetic studies were carried out using real-time PCR. tPSA, fPSA, and % fPSA of the subjects ranged between 0.8% - 18.30%, 0.10% - 1.60% and 0.0% - 0.7% respectively. Of the 100 subjects, 28 subjects had tPSA levels above 4.0 ng/ml with a mean of 7.10 (±3.30) ng/ml. Those with tPSA less than 4 ng/ml had a mean of 1.87 (±0.85) ng/m. 15 subjects showed SNPs with a mean tPSA of 6.87 (±4.82) ng/ml while the remaining 85 subjects without SNPs had a mean of 1.86 (±0.80) ng/ml. Results from direct DNA sequencing showed 11 SNPs. Ten subjects are curated in SNP database while one is uncurated. The Chi-square test showed significant association (p = 0.00) between tPSA levels and SNPs mutation (X2 = 17.35, p = 0.00). A Kruskal-Wallis test demonstrated that the positional arrangement of the SNP mutations had no effect on PSA-total or free-values (H (10) = 10.92, p = 0.28;H (10) = 10.07, p = 0.38 respectively). Two SNPs: rs6072 and rs74478031 were associated with elevated PSA levels (p < 0.05). Their presence, therefore, has the potential to serve, in conjunction with raised PSA, as biomarkers of prostate cancer in the study population.

关键词： Prostate Cancer Prostate-Specific Antigen Kallikrein 2 Gene Genetic Mutations Haplotypes Short Nucleotidepolymorphism

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Characteristics of Obstetric Fistula in Kaduna Metropolis

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Open Journal of Obstetrics and Gynecology 2017年第7期7卷 734-741页

作者： Sunday Jenner Lengmang Hannah Degge evangel Vesicovaginal Fistula Centre Bingham University Teaching Hospital Jos Nigeria Family Medicine Department Bingham University Jos Campus Jos Nigeria Department of Community Medicine Bingham University Jos Campus Jos Nigeria

Introduction: Obstetric fistula is prevalent in sub-Saharan Africa. In Nigeria, it is more prevalent in the North compared to the South;and mainly rural. Urbanization has had significant impact on global health. Rapid urbanization is predicted to intensify in developing countries where fistula is endemic, but the pattern of presentation of obstetric fistula in urban areas is yet to be described. Objective: The objective of the study was to find out if obstetric fistula exists in Kaduna metropolis, and if it does, to explore the pattern of presentation. Methodology: Women living with obstetric fistula were mobilized from Kaduna metropolis for free screening and repair. They were screened using direct dye and three swab tests. Consenting patients with confirmed obstetric fistula were included in the study. Their socio-demographic and clinical data were captured using Microsoft Access and analyzed with Statistical Package for Social Sciences (SPSS) version 17. Results: All twenty three consenting women confirmed to have obstetric fistula lived within Kaduna city and had phone contacts. A depreciating proportion of primiparous women presented with obstetric fistula in Kaduna metropolis as multiparous women were in majority. The women also appeared to have higher height and weight measures and majority of them had access to fistula repair. They married early and were mostly uneducated and illiterate. Conclusion: Obstetric fistula afflicts women living in Kaduna metropolis. Women living with fistula in Kaduna metropolis appear to present different socio-demographic features, suggesting an emerging trend related to urbanization.

关键词： Fistula Metropolis Obstetric Rural Urban

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A Rare Case of Combined Vesico-Vaginal and Vesico-Cutaneous Fistulae Treated by One-Stage Surgical Repair

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Open Journal of Obstetrics and Gynecology 2017年第7期7卷 702-706页

作者： Sunday Jenner Lengmang Edwin Oseni-Momodu Paul Ushie George Anyuku Azubuike Chima evangel Vesico Vaginal Fistula Centre Bingham University Teaching Hospital Jos Nigeria Surgery Department Bingham University Jos Campus Jos Nigeria Family Medicine Department Bingham University Jos campus Jos Nigeria

Combined vesico-vaginal and vesico-cutaneous fistulae are exceptionally rare. We present a young woman who had combined vesico-vaginal fistula and vesico-cutaneous fistula following prolonged obstructed labour and caesarean section. The patient presented at three months of illness with total urine incontinence from the vagina and lower abdominal skin. One-stage surgical repair of both fistulae was done. The patient had a successful closure of the fistulae, regained full urinary continence, and remained continent at six months follow-up. We opine that one-stage repair of combined vesico-vaginal and vesico-cutaneous fistulae is feasible and preferred. Providers of pelvic surgery in low resource countries should be supervised and retrained accordingly, in order to prevent iatrogenic vesico-cutaneous fistula.

关键词： Vesico-Vaginal Vesico-Cutaneous Fistula Iatrogenic

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Effect of Planting Date, Spacing and Seeding Methods on Disease Development and Yield Components of Rice （Oryza sativa L.） in Southeastern Nigeria

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Journal of Agricultural Science and Technology(B) 2017年第2期7卷 100-113页

作者： Christian Chukwunenye Iwuagwu Charles Ikechukwu Umechuruba Andrew Chukwuma Nwogbaga Department of Crop Science and Horticulture Nnamdi Azikiwe University PMB 5025 Awka Anambra State Nigeria evangel university PMB 129 Abakaliki Ebonyi State Nigeria Department of Crop Production and Landscape Management Ebonyi State University PMB 053 Abakaliki Nigeria

To investigate the effect of planting date, spacing and seeding methods on disease development and yield components ofrice, a factorial experiment in randomized complete block design （RCBD） with four replications was conducted during 2011 plantingseason at Izzi Local Government Area （LGA） of Ebonyi State, Nigeria. This experiment was carried out with four levels of plantingdates （early June, late June, early July and late July）, three levels of spacing （15, 20 and 25 cm） and two levels of seeding method（direct seeding and seedling transplanting）. The studied traits included plant height （PH）, number of tillers （NT）, leaf area （LA）, rootlength （RL）, panicle length （PL）, 1,000 seed weight （SW）, disease incidence and severity. The result showed that all the factors hadsignificant effect on the parameters measured. Sowing in early July had the highest LA of 65.38 cm^2, PH of 122.00 cm, RL of 29.04cm and TN of 10.54, and the second largest PL of 25.08 cm and SW of 25.12 g. Also sowing in early July had the highest diseaseseverity of 3.21, followed by 3.14 which occurred in late July, while the least 2.17 occurred in early June. The direct seeding methodhad the highest disease incidence of 70.83%, followed by plant spacing of 15 cm × 15 cm which had the disease incidence of 69.72%,while sowing in early June had the least disease incidence of 57.50%. In conclusion, planting of rice in Southeastern Nigeria shouldbe done in early July, as the yield components were significantly better than in other dates though with the highest disease severity.

关键词： Disease development, planting dates, spacing, planting methods, rice, Southeastern Nigeria, yield components.

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Assessment of Seed-Borne Plant Pathogenic Fungi Associated with Rice Crop in South-Eastern Nigeria

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Journal of Agricultural Science and Technology(A) 2018年第2期8卷 68-75页

作者： Christian Chukwunenye, Iwuagwu Charles Ikechukwu, Umechuruba Charles Chimezie, Ononuju Andrew Chukwuma Nwogbaga Department of Crop Science and Horticulture Nnamdi Azikiwe University Awka Anambra State Nigeria evangel university Ikpoto Ebonyi State Nigeria Department of Plant Health Management Michael Okpara University of Agriculture Umudike Abia State Nigeria Department of Crop Production and Land Scape Management Ebonyi State University Ebonyi Nigeria

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