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Clinical value of phenylephrine testing in the upper and lower eyelids of patients with aponeurotic and congenital eyelid ptosis

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International Journal of Ophthalmology(English edition) 2022年第9期15卷 1444-1452页

作者： Ozgun Melike Gedar Totuk Meltem Guzin Altinel Ayse Yagmur Kanra Umit Aykan Atakoy dunyagoz hospital BakirkoyIstanbul 34158Turkey Department of Ophthalmology Fatih Sultan Mehmet Training and Research HospitalAtasehirIstanbul 34752Turkey Department of Ophthalmology Sisli Hamidiye Etfal Training and Research HospitalSariyerIstanbul 34453Turkey etiler dunyagoz hospital BesiktasIstanbul 34337Turkey

·AIM:To characterize the phenylephrine test in aponeurotic and congenital eyelid ptosis,to determine the appropriate timing of the phenylephrine test,and to assess the responses of the upper and lower eyelids.·METHODS:This was a retrospective analysis of 140 eyes of 87 patients(mean age 52.29±16.45 y;22 males,65 females)with upper eyelid *** 88.6%had aponeurotic and 11.4%had congenital *** the evaluation of the responses of the upper and lower eyelids to topical 2.5%phenylephrine,the scleral show height,the marginal reflex distance(MRD)between the inferior margin of the upper eyelid and pupillary light reflex(MRD1),and between the central portion of the lower eyelid and pupillary light reflex(MRD2)were measured at the 2^(nd),5^(th),and15^(th)*** changes of MRD1 and MRD2 with time(ΔMRD1 andΔMRD2)were evaluated.·RESULTS:The mean MRD1,*** scleral show heights increased within 5 min after testing,remaining largely stable between the 5^(th)-15^(th)*** percentage of eyes with a greater response in MRD1 increased with increased severity of ptosis(P<0.05).Eyes with aponeurotic ptosis were more responsive to phenylephrine testing than congenital *** mild ptosis group had lower scleral show measurements and higherΔMRD2 ***ΔMRD1 andΔMRD2 values were poorly correlated in all measurement times.·CONCLUSION:Performing the phenylephrine test 5 min after instilling the reagent is adequate to assess the maximum response of the upper and lower *** upper and lower eyelid responses in phenylephrine testing are poorly ***,theΔMRD2 is related with baseline scleral show degree that may be a postoperative predictive *** studies are necessary to determine the relationship between the responses of the lower eyelids to phenylephrine testing.

关键词： eyelid ptosis phenylephrine testing scleral show aponeurotic ptosis congenital ptosis

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A new treatment option for the resistant spasm of accommodation:clear lens extraction and multifocal intraocular lens implantation

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International Journal of Ophthalmology(English edition) 2018年第1期11卷 172-174页

作者： Ozgun Melike Gedar Totuk Umit Aykan Department of Ophthalmology Faculty of MedicineBahcesehirUniversityIstanbu134734Turkey The European Board of Ophthalmology Dunyagoz HospitalIstanbul 34337Turkey

Dear Editor,We write you to present a 20-year-old man with resistant spasm of accommodation without any organic cause treated with clear lens extraction（CLE）with phacoemulsification and multifocal intraocular lens（... 详细信息

关键词： reatment option clear lens multifocal intraocular lens

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The effects of implantable collamer lens implantation on higher order aberrations

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International Journal of Ophthalmology(English edition) 2019年第12期12卷 1848-1852页

作者： Belma Kayhan Efekan Coskunseven Onurcan Sahin Ioannis Pallikaris dunyagoz hospital Group Istanbul 34337Turkey Department of Ophthalmology Sultan Abdulhamid Han Training and Research Hospitalthe University of Saglik BilimleriIstanbul 34668Turkey Institute of Vision and Optics University of CreteHeraklion 70013Greece

AIM: To evaluate the changes in higher order aberrations(HOAs) after implantable collamer lens(ICL;Staar Surgical, Nidau, Switzerland) implantation. METHODS: Totally 30 eyes of 18 patients with myopia were included in this study with an average age of 25.77y(min: 21, max: 40). Refraction, uncorrected distance visual acuity(UDVA), corrected distance visual acuity(CDVA), HOAs(entire, corneal and internal) were evaluated preoperatively and three months postoperatively. Ocular aberrations were measured by using iT race(Tracey Technology, Houston, Texas, USA). SPSS(IBM Corp. Released 2013. IBM SPSS Statistics for Windows, Version 22.0. Armonk, NY: IBM Corp) was used for the statistical analysis and the interpretation of the data. P values of less than 0.05 were considered statistically significant. RESULTS: The preoperative mean spherical power was -9.01 D(min:-5.00, max:-13.00) and the mean cylindrical error was -2.40 D(min:-0.50, max:-4.75). The postoperative mean residual spherical power was -0.73 D(min:-0.20, max:-1.75) and the mean cylindrical error was -0.89 D(min:-0.18, max:-2.09). Analyses were made on root mean square(RMS) values of total HOAs(tH OAs), spherical aberration, coma and trefoil as entire, corneal and internal components. The differences in entire t HOAs and in internal t HOAs were significant. There was no significant change found in spherical aberrations. The differences in entire coma and in internal coma were significant. There was no significant change found in corneal coma. With respect to trefoil, the only significant difference was in internal trefoil. CONCLUSION: The ICL implantation corrects the refractive error successfully and changes entire and internal HOAs of the eye.

关键词： implantable collamer lens myopia aberrations

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Meta-Herpetic Keratitis and Therapeutic Approach: Case Report

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Open Journal of Ophthalmology 2014年第3期4卷 75-78页

作者： Ozlem Sahin Department of Ophthalmology/Uveitis DunyaGoz Hospital Ltd. Ankara Turkey

The purpose of this study is to disclose the steps in the therapeutic approach for meta-herpetic corneal ulcer. Report of a case with anterior segment photography was used. The 6 months of follow-up results of the cas... 详细信息

关键词： Corneal Ulcer Corneal Neovascularization Herpes Simplex Virus-1 Meta-Herpetic Keratitis

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Ex-PRESS implantation for different types of glaucoma

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International Journal of Ophthalmology(English edition) 2019年第8期12卷 1290-1297页

作者： Meltem Guzin Altinel Ayse Yagmur Kanra Remzi Karadag Huseyin Bayramlar Department of Ophthalmology Fatih Sultan Mehmet Trainingand Research HospitalIcerenkoy Atasehir34752IstanbulTurkey dunyagoz hospitals Group Sultanbeyli34337IstanbulTurkey Department of Ophthalmology Istanbul Medeniyet UniversitySchool of MedicineGoztepe Research and Training HospitalGoztepe34000IstanbulTurkey

AIM: To evaluate the clinical results, efficacy and safety of Ex-PRESS P200 glaucoma shunt implant in different types of medically uncontrolled glaucoma. METHODS: The study included 31 eyes of 31 patients that were unresponsive to medical antiglaucomatous therapy in whom Ex-PRESS P200 glaucoma shunt implantation was performed. The demographic characteristics of the patients, type of glaucoma, complete ocular examination results, number of antiglaucomatous drugs before and after surgery, early and late complications of surgery, additional surgical and nonsurgical medical interventions, and success rates were investigated from the patients’ files, retrospectively. RESULTS: The mean postoperative follow-up time was 16.4±7.5 mo. The preoperative mean corrected intraocular pressure(IOP) was 28.7±10.3 mm Hg and postoperative mean corrected IOP was 15.3±5.2 mm Hg(P<0.05) at the last visit. The mean IOP reduction was 39.9% when the preoperative and postoperative values of the last visits were compared. The average number of antiglaucomatous drug use decreased from 3.9±0.3 to 1.7±1.7 postoperatively(P<0.05). The use of antiglaucomatous medications at the last visit was more than in other studies in the literature. The most common complication was conjunctival leakage, which was seen in 7 patients. Other early complications were iris touch, intravitreal hemorrhage, hyphema, choroidal effusion, early transient hypotonia and corneal edema. One of the late complications was endophthalmitiswhich was seen in one case 6 mo after the operation, and the other late complication was opacification of the cornea in one patient. Twelve additional surgical operations associated to Ex-PRESS surgery and 3 bleb needling have done. At the last visit, the complete success rate was 32.3% and the qualified success rate was 77.5% in all patients. CONCLUSION: Ex-PRESS P200 glaucoma shunt implantation may be an effective procedure for medically uncontrolled glaucoma with significantly lower use of a

关键词： glaucoma Ex-PRESS implant glaucoma surgery

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Natural products,PGC-1α,and Duchenne muscular dystrophy

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Acta Pharmaceutica Sinica B 2020年第5期10卷 734-745页

作者： Ipek Suntar[ Antoni Sureda Tarun Belwal Ana Sanches Silva Rosa Anna Vacca Devesh Tewari Eduardo Sobarzo-Sánchez Seyed Fazel Nabavi Samira Shirooie Ahmad Reza Dehpour Suowen Xu Bahman Yousefi Maryam Majidinia Maria Daglia Giuseppe D’Antona Seyed Mohammad Nabavi Department of Pharmacognosy Faculty of PharmacyGazi UniversityEtilerAnkara 06330Turkey Research Group in Community Nutrition and Oxidative Stress Health Research Institute of the Balearic Islands(IdISBa)and CIBEROBN(Physiopathology of Obesity and Nutrition)University of Balearic IslandsPalmaBalearic Islands E-07122Spain G.B.Pant National Institute of Himalayan Environment and Sustainable Development AlmoraUttarakhand 263643India National Institute for Agricultural and Veterinary Research(INIAV) VairaoVila do CondePortugal Center for Study in Animal Science(CECA) ICETAUniversity of PortoPortoPortugal Institute of Biomembranes Bioenergetics and Molecular BiotechnologiesNational Council of ResearchBari 70126Italy Department of Pharmacognosy School of Pharmaceutical SciencesLovely Professional UniversityPhagwaraPunjab 144411India Laboratory of Pharmaceutical Chemistry Faculty of PharmacyUniversity of Santiago de CompostelaSantiagode Compostela 15782Spain Department of Organic Chemistry Faculty of PharmacyUniversity of Santiago de CompostelaSantiago de Compostela 15782Spain Applied Biotechnology Research Center Baqiyatallah University of Medical SciencesTehran ***Iran Pharmaceutical Sciences Research Center Health InstituteKermanshah University of Medical SciencesKermanshah ***Iran Department of Pharmacology Faculty of MedicineTehran University of Medical SciencesTehran ***Iran Experimental Medicine Research Center Tehran University of Medical SciencesTehran ***Iran The First Affiliated hospital of USTC Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Molecular Medicine Research Center Tabriz University of Medical SciencesTabriz 516615731Iran Drug Applied Research Center Tabriz University of Medical SciencesTabriz 516615731Iran Solid Tumor Research Center Urmia University of Medical SciencesUrmia 571478334Iran Department of Pharmacy University of Naples FedericoⅡNaples 80138Italy International Research Center for Foo

Peroxisome proliferator-activated receptorγ(PPARγ)is a transcriptional coactivator that binds to a diverse range of transcription ***γcoactivator 1(PGC-1)coactivators possess an extensive range of biological effects in different tissues,and play a key part in the regulation of the oxidative metabolism,consequently modulating the production of reactive oxygen species,autophagy,and mitochondrial *** to these findings,a large body of studies,aiming to establish the role of PGC-1 in the neuromuscular system,has shown that PGC-1 could be a promising target for therapies targeting neuromuscular *** these,some evidence has shown that various signaling pathways linked to PGC-1αare deregulated in muscular dystrophy,leading to a reduced capacity for mitochondrial oxidative phosphorylation and increased reactive oxygen species(ROS)*** the light of these results,any intervention aimed at activating PGC-1 could contribute towards ameliorating the progression of muscular ***-1αis influenced by different patho-physiological/pharmacological *** products have been reported to display modulatory effects on PPARγactivation with fewer side effects in comparison to synthetic *** together,this review summarizes the current knowledge on Duchenne muscular dystrophy,focusing on the potential effects of natural compounds,acting as regulators of PGC-1α.

关键词： Muscular dystrophy Natural product Peroxisome proliferator-activated receptor Y coactivator la PPARγactivation Reactive oxygen species Mitochondrial oxidative phosphorylation

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