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Hepatectomy with primary closure of common bile duct for hepatolithiasis combined with choledocholithiasis

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World Journal of Gastroenterology 2015年第12期21卷 3564-3570页

作者： Chang-Ku Jia Jie Weng You-Ke Chen Qing-Zhuang Yang Yu Fu Qi-Fan Qin Wei-Ming Yu Department of Hepatobiliary Pancreatic Surgery The Affiliated Hospital of Hainan Medical College Department of General Surgery Lin’gao County Hospital Department of General Surgery Lin’an Municipal Hospital

AIM: To evaluate the feasibility of hepatectomy and primary closure of common bile duct for intrahepatic and extrahepatic calculi. METHODS: From January 2008 to May 2013, anatomic hepatectomy followed by biliary tract exploration without biliary drainage(non-drainage group) was performed in 43 patients with intrahepatic and extrahepatic calculi. After hepatectomy, flexible choledochoscopy was used to extract residual stones and observe the intrahepatic bile duct and common bile duct(CBD) for determination of biliary stricture and dilatation. Function of the sphincter of Oddi was determined by manometry of the CBD. Primary closure of the CBD without T-tube drainage or bilioenteric anastomosis was performed when there was no biliary stricture or sphincter of Oddi dysfunction. Dexamethasone and anisodamine were intravenously injected 2-3 d after surgery to prevent postoperative retrograde infection due to intraoperative bile duct irrigation, and to maintain relaxation of the sphincter of Oddi, respectively. During the same period, anatomic hepatectomy followed by biliary tract exploration with biliary drainage(drainage group) was performed in 48 patients as the control group. Postoperative complications and hospital stay were compared between the two ***: There was no operative mortality in either group of patients. Compared to intrahepatic and extrabiliary drainage, hepatectomy with primary closure of the CBD(non-drainage) did not increase the incidenceof complications, including residual stones, bile leakage, pancreatitis and cholangitis(P > 0.05). Postoperative hospital stay and costs were nevertheless significantly less in the non-drainage group than in the drainage group. The median postoperative hospital stay was shorter in the non-drainage group than in the drainage group(11.2 ± 2.8 d vs 15.4 ± 2.1 d, P = 0.000). The average postoperative cost of treatment was lower in the non-drainage group than in the drainage group(29325.6 ± 5668.2 yuan vs 32933.3

关键词： Hepatolithiasis Choledocholithiasis Primary closur

Effect of a fever in viral infections-the ‘Goldilocks’ phenomenon?

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World Journal of Clinical Cases 2021年第2期9卷 296-307页

作者： Lucas Belon Peter Skidmore Rohan Mehra Edward Walter Department of Intensive Care Medicine Royal Surrey County HospitalGuildford GU27XXSurreyUnited Kingdom Department of General Medicine Royal Surrey County HospitalGuildford GU27XXSurreyUnited Kingdom

Acute infections,including those due to Coronaviridae and other viruses,often stimulate a febrile response.A mild fever appears to improve outcome;it appears to diminish viral replication by several mechanisms,including virion entry into host cells and genome transcription,and improving host defence mechanisms against the ***,a fever may also damage host cellular and tissue function and increase metabolic *** temperatures at the lower end of the febrile range,the benefit of the fever appears to outweigh the detrimental ***,at higher temperatures,the outcome worsens,suggesting that the disadvantages of fever on the host predominate.A non-infective fever is associated with a worse outcome at lower temperatures,suggesting that hyperthermia carries less benefit in the absence of *** review discusses the risks and benefits of a fever on the host response,focusing on the effects of a fever on viral replication and host response,and the detrimental effect on the host.

关键词： Fever Virus Coronavirus Infection Body temperature regulation Hyperthermia

RESULTS ON IVOR-LEWIS ESOPHAGOGASTRECTOMY FOR 338 CASES OF CARCINOMA OF ESOPHAGUS

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Chinese Journal of Cancer Research 1997年第1期9卷 45-48页

作者：吴昌荣张振斌薛恒川朱宗海 Yangzhong People’s hospital Yangzhong County

Three hundred thirty-tight patients with carcinoma in the middle and lower thirds of the esophagus received Ivor-Lewis esophagogastrectomy (separate laparotomy and right thoracotomy incisions) from February 1986 to June 1992. The total resectability was 95.2%. Lymph node metastases were found in 136 cases (40.2%). Postoperative complications developed in 10.3% of the patients. No anastomotic leakage, nor postoperative (within 30 days) death and hospital death occurred. Major pulmonary complications occurred in 28.6% of the patients. The overall 1-, 3- and 5-year survival rate was 88.5% (231/261), 63.1% (125/198) and 48.4% (60/124), respectively. The 5-year survival rate was 64.1% (41/64) in patients with negative lymph nodes as compared to 31.7% (19/60) with positive nodes. The superiority of this technique was a significant improvement of the 5-year survival rate. This was due to better exposure of the operation field which made thorough dissection of lymph nodes possible, especially those along the right recurrent laryngeal nerve. Better operative exposure also provided chances for radical resection with less interference from the aortic arch. It made anastomosis easier to perform so that stenosis and leakage were less likely to occur. Ivor-Lewis esophagogastrectomy was a superior surgical procedure of choice for the treatment of cancer at the lower and middle thirds of the esophagus.

关键词： Esophageal tumor Esophagectomy

Should we continue breastfeeding after SARS-CoV-2 infection or mRNA vaccination?

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BIOCELL 2022年第6期46卷 1425-1433页

作者： FEI CHEN CHUN LUAN ZICHUN WEI DECHEN CAI ZHIWEN CUI YUYANG LI HAO WU XIAOXIA ZHANG XIAOLI WU Jining Medical University Jining272000China Dongping county People’s hospital Tai-an271500China

The coronavirus disease 2019(COVID-19),which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has posed a potential threat to infant *** World Health Organization recommended that the benefits of breastfeeding far outweigh the potential risk of transmission,but there is no denying that the current evidence is ***,although the COVID-19 mRNA vaccine has played an effective role in protection against infection,individuals have increasing concerns about the safety of breastfeeding after vaccination,and which have caused some breastfeeding women to postpone vaccination or stop breastfeeding ***,in this review,we provide an in-depth discussion of whether SARS-CoV-2 and the vaccine will affect babies through breast *** one hand,only a very small number of milk samples were identified positive for viral RNA and almost impossible to be live virus *** milk of most lactating women after vaccination did not contain vaccine-related mRNA and polyethylene *** the other hand,the antibodies and biologically active molecules like lactoferrin are abundant in the milk of lactating women who have been infected or vaccinated,which can provide potential protection against infants’respiratory and gastrointestinal ***,in terms of implications for clinical practice,the results of our study support that lactating women who have been infected or vaccinated should be encouraged to breastfeed their infants under the premise of taking appropriate sanitary measures.

关键词： COVID-19 Abs Breast milk mRNA vaccine Symptoms

Study on the influence of curcumin on chemosensitivity of nephroblastoma cells

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Asian Pacific Journal of Tropical Medicine 2016年第8期9卷 779-782页

作者： Xiao-Yong Li Yuan-Yuan Feng Wei Dan Deng Pan Guo-Feng Zhang Xian-Liang Wang Guang-Jun Hou Department of Pediatric Surgery Children's Hospital of Zhengzhou Department of Paediatrics Children's Hospital of Zhengzhou Department of Paediatrics Maternal and Child Health Hospital of Tonglu County

Objective:To study the influence of curcumin on chemosensitivity of nephroblastoma ***:Human nephroblastoma cells line SK-NEP-1 was transplanted to the nude mice subcutaneously to establish the implantation tumor model of human nephroblastoma cells.A total of 30 tumor-bearing mice were divided into three groups of ten *** routine chemotherapy group was given vincristine(0.05 mg/mL·0.2 mL/d) and actinomycin D(15 ng/mL·0.2 mL/d) combined chemotherapy *** curcumin chemotherapy group was given the same combined chemotherapy regimens and curcumin(30 mg/kg/d) by intraperitoneal *** control group was given normal saline(NS) of the same volume by intraperitoneal *** administration would be kept for 4 weeks and 3 days a *** volumetric changes of every group were *** serum of every group in different time was collected and the VEGF content was detected by *** mice were cercrificed and the tumor tissues were stripped and weighed after 4 weeks’ *** tumor inhibition rate was *** cell proliferation activity and apoptosis rate were detected by MTT and flow cytometry *** data were statistically analyzed by SPSS ***:The tumor volume,serum VEGF content,tumor inhibition rate,cell proliferation activity and apoptosis rate of routine chemotherapy group and curcumin chemotherapy group had significant differences comparing with the control group(P<0.05) after 4-week’s *** cancer growth of curcumin chemotherapy group was obviously decreased and even tended to shrink comparing with routine chemotherapy group(χ2=15.732,P=0.007).The cell proliferation activity was significantly reduced and the apoptosis rate was significantly higher,(χ~2=9.427,P=0.012)which showing the effect of chemotherapy was ***:The chemosensitivity of nephroblastoma cells could be improved by curcumin,then the effect of preoperative adjuvant chemotherapy scheme would be enhanced,the gro

关键词： Nephroblastoma Transplanted tumor model Curcumin Chemosensitivity Vincristine

SUSPENDED MOXIBUSTION OF IGNITED MOXA ROLL IN TREATING CORONARY HEART DISEASE:A CLINICAL OBSERVATION OF 138 CASES

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Journal of Traditional Chinese Medicine 1992年第2期12卷 95-99页

作者：张登部郑桂秋侯桂琴刘琴孙学全胡乃珂刘佩云韩友栋张静尹成娥孙红冰 Affiliated hospital of Shandong TCM College Ji'nan250011 Mengyin county TCM hospital Mengyin County 276200Shandong Province

Coronary heart disease is most com-monly seen in the middle-aged and *** 1986 and 1988 we adopted a therapyof suspended moxibustion with ignitedmoxa rolls in 138 patients with coronaryheart *** were a group of 45cases... 详细信息

关键词： moxibustion acupuncture suspended elderly bilateral 化脓灸 sensation 新医药学杂志 minutes 针灸研究所

Effects of Helicobacter pylori eradication on the profiles of blood metabolites and their associations with the progression of gastric lesions: a prospective follow-up study

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Cancer Biology & Medicine 2022年第8期19卷 1259-1273页

作者： Wenhui Wu Zongchao Liu Zhexuan Li Weidong Liu Lanfu Zhang Yang Zhang Tong Zhou Weicheng You Kaifeng Pan Wenqing Li Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Cancer EpidemiologyPeking University Cancer Hospital and InstituteHaidian DistrictBeijing 100142China Linqu county Public Health Bureau Linqu 262600China Linqu county People’s hospital Linqu 262600China

Objective:This study aimed at examining the alterations in metabolomic profiles caused by treatment of *** infection,and the associations between key plasma metabolites and the risk of gastric lesion progression during follow-up after ***:An intervention trial was performed in 183 participants,117 of whom were *** positive participants receiving treatment for *** *** positive participants were prospectively followed for 182 to 1,289 *** metabolomics assays were conducted on plasma samples collected at baseline,6 months after treatment,and during continued ***:We identified 59 metabolites with differential posttreatment changes between participants with successful and failed *** eradication,17 metabolites significantly distinguished participants with successful *** *** metabolites[PC(18:1(11Z)/14:1(9Z))and(2S)-6-amino-2-formamidohexanamide]showed posttreatment changes positively associated with successful *** eradication,and were inversely associated with the risk of gastric lesion progression among participants with successful *** contrast,9-decenoic acid showed posttreatment changes inversely associated with successful eradication:its level was positively associated with the risk of gastric lesion progression among participants with successful *** the identified metabolites showed a temporary but significant decline after treatment,the trend generally reversed during continued follow-up,and pretreatment levels were ***:Treatment of *** infection significantly altered plasma metabolic profiles in the short term,and key metabolites were capable of distinguishing participants with successful *** eradication,but might not substantially affect metabolic regulation in the long *** plasma metabolites were differentially associated with the risk of gastric lesion progression among participants with successful or

关键词： Helicobacter pylori infection gastric cancer gastric lesion metabolomics eradication

Perforated gastric ulcer causing mediastinal emphysema: A case report

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World Journal of Clinical Cases 2024年第4期12卷 859-864页

作者： Zhi-Cheng Dai Xun-Wu Gui Feng-He Yang Hao-Yuan Zhang Wen-Feng Zhang Department of General Surgery Mengcheng County First People's HospitalMengcheng 233500Anhui ProvinceChina Department of Medical Imaging Mengcheng County First People's HospitalMengcheng 233500Anhui ProvinceChina

BACKGROUND Mediastinal emphysema is a condition in which air enters the mediastinum between the connective tissue spaces within the pleura for a variety of *** can be spontaneous or secondary to chest trauma,esophageal perforation,medi-cally induced factors,*** common symptoms are chest pain,tightness in the chest,and respiratory *** mediastinal emphysema patients have mild symptoms,but severe mediastinal emphysema can cause respiratory and circulatory failure,resulting in serious *** SUMMARY A 75-year-old man,living alone,presented with sudden onset of severe epigastric pain with chest tightness after drinking *** to the remoteness of his residence and lack of neighbors,the patient was found by his nephew and brought to the hospital the next morning after the disease *** tomography(CT)showed free gas in the abdominal cavity,mediastinal emph-ysema,and subcutaneous *** gastrointestinal angiography showed that the esophageal mucosa was intact and the gastric antrum was ***,we chose to perform open gastric perforation repair on the patient under thoracic epidural anesthesia combined with intravenous *** operative incision of the muscle layer of the patient's abdominal wall was made,and a large amount of subperitoneal gas was *** a continued incision of the peritoneum revealed the presence of a perforation of approx-imately 0.5 cm in the gastric antrum,which we repaired after pathological ***,the patient received high-flow oxygen and cough *** CT was performed on the first and sixth postoperative days,and the mediastinal and subcutaneous gas was gradually *** After gastric perforation,a large amount of free gas in the abdominal cavity can reach the mediastinum through the loose connective tissue at the esophageal hiatus of the diaphragm,and upper gastrointestinal angiography can clarify the site of *** pat

关键词： Gastric ulcer Perforated Mediastinal emphysema Case report

Acupuncture Treatment of Superficial Pain by Subcutaneous Needling

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Journal of Traditional Chinese Medicine 2002年第2期22卷 117-118页

作者：邬水兰朱剑文公维军毛树章 TCM hospital of Xingan county Jiangxi Province 331300 People's hospital of Daqing City Heiiongiiang Province 163317

　　Subcutaneous needling is an old art of the 'twelve needling methods' in TCM for treating arthralgia due to cold or disorders in the superficial tissues. Some cases are effectively treated as introduced below.……

关键词： Acupuncture Therapy Adult Humans Male Middle Aged Soft Tissue Injuries Tennis Elbow Tenosynovitis