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Comparison of long-term results of trabeculectomy to treat pseudoexfoliative glaucoma and primary open angle glaucoma

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International Journal of Ophthalmology(English edition) 2018年第1期11卷 66-70页

作者： Vuslat Pelitli Gürlü Hande Gürlü Altan Ozal Omer Benian Levent Alimgil Department of Ophthalmology Trakya University Medical School Department of Ophthalmology Ekol Private Hospital Department of Ophthalmology Medicana Private Hospital

AIM： To compare the long term outcome of trabeculectomy in patients with pseudoexfoliative glaucoma（PEG） and primary open angle glaucoma（POAG） in terms of surgical success. METHODS： The success of the trabeculectomy was evaluated by three criteria. Criterion A： intraocular pressure（IOP） ≤21 mm Hg and decrease in IOP ≥20%; Criterion B： IOP ≤18 mm Hg and decrease in IOP ≥30%; Criterion C： IOP ≤15 mm Hg and decrease in IOP ≥50%. Patients that met these criteria without medical treatment were considered to be completely successful, while those that met these criteria with medical treatment were considered partially successful. Significance levels of differences between the POAG and PEG groups in the Kaplan-Meier survival curves were calculated with the log-rank test. RESULTS： Sixty-four eyes from 64 patients with PEG and 51 eyes from 51 patients with POAG were evaluated. No significant differences were detected between the PEG and POAG groups according to full or partial success relative to each of the three criteria（A： P=0.73, 0.32; B： P=0.73, 0.31; C：P=0.90, 0.27）. CONCLUSION： There is no difference in the long-term success of trabeculectomy between PEG and POAG patients whose clinical characteristics are otherwise the same.

关键词： primary open angle glaucoma pseudoexfoliative glaucoma trabeculectomy success

Case of takotsubo cardiomyopathy after surgical treatment of liver hydatid cyst: A case report

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World Journal of Clinical Cases 2023年第29期11卷 7187-7192页

作者： Yakup Altaş Ülfet Abdullayeva Department of Cardiology Private Melikgazi HospitalKayseri 38030Turkey Department of General Surgery Private Melikgazi HospitalKayseri 38030Turkey

BACKGROUND Takotsubo cardiomyopathy,also called apical ballooning syndrome,is a disease that is often triggered by stress factors in postmenopausal women and mimics acute coronary *** aim of this article is to draw attention to takotsubo cardiomyopathy after surgical treatment of liver hydatid *** SUMMARY A 50-year-old diabetic and hypertensive female patient was evaluated preoperatively before general surgery for liver hydatid cyst,and no cardiac problems were *** patient was discharged on the 3rd postoperative day without any postoperative *** postoperative day 5,the patient presented to the emergency department with fever,shortness of breath,chills,and shivering and was hospitalized with the diagnosis of *** troponin levels remained high during *** was performed on postoperative day 7,after which the patient was referred to a tertiary center with the diagnosis of non-ST-elevation myocardial infarction due to akinesia in the apical *** angiography performed at the tertiary center showed normal coronary anatomy,and the patient was diagnosed with takotsubo *** Takotsubo cardiomyopathy mimicking myocardial infarction without ST segment elevation may develop after surgical treatment of liver hydatid cyst.

关键词： Takotsubo cardiomyopathy Liver hydatid cyst Noncardiac surgery Coronary angiography Echocardiography Case report

Commercially available probiotic drinks containing Lactobacillus casei DN-114001 reduce antibiotic-associated diarrhea

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World Journal of Gastroenterology 2014年第42期20卷 15837-15844页

作者： Christoph G Dietrich Tanja Kottmann Manuela Alavi Department of Medicine Bethlehem Hospital Teaching Hospital of Aachen University RWTH private Institute of Medical Statistics

AIM: To investigate the effect of Lactobacillus-containing commercially available probiotic formulations in Germany during antibiotic treatment with an analysis of cost-efficiency.

关键词： Antibiotics-associated diarrhea Probiotics Lactobacillus casei

Stem cells:An eventual treatment option for heart diseases

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World Journal of Stem Cells 2015年第8期7卷 1118-1126页

作者： Joseph C Bilgimol Subbareddy Ragupathi Lakshmanan Vengadassalapathy Nathan S Senthil Kali-muthu Selvakumar M Ganesan Sadananda Rao Manjunath Micro Therapeutic Research Labs private Limited KMS Health Centre private Limited Chettinad hospital Thermo Fisher Scientific India private Limited

Stem cells are of global excitement for various diseases including heart diseases. It is worth to understand the mechanism or role of stem cells in the treatment of heart failure. Bone marrow derived stem cells are commonly practiced with an aim to improve the function of the heart. The majority of studies have been conducted with acute myocardial infarction and a few has been investigated with the use of stem cells for treating chronic or dilated cardiomyopathy. Heterogeneity in the treated group using stem cells has greatly emerged. Ever increasing demand for any alternative made is of at most priority for cardiomyopathy. Stem cells are of top priority with the current impact that has generated among physicians. However,meticulous selection of proper source is required since redundancy is clearly evident with the present survey. This review focuses on the methods adopted using stem cells for heart diseases and outcomes that are generated so far with an idea to determine the best therapeutic possibility in order to fulfill the present demand.

关键词： Bone marrow stem cells Mesenchymal stem cells Indu

Clinical variants of pityriasis rosea

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World Journal of Clinical Cases 2017年第6期5卷 203-211页

作者： Francisco Urbina Anupam Das Emilio Sudy Dermatologists in private Practice Dermatology KPC Medical College and Hospital

Pityriasis rosea(PR) is a common erythemato-squamous dermatosis which almost always, is easily diagnosed. Mostly the disease presents in its classical form. However, clinical dermatology is all about variations and PR is not an exception. Variants of the disease in some cases may be troublesome to diagnose and confuse clinicians. Prompt diagnosis and treatment of the condition becomes necessary to avoid unnecessary investigations. We hereby review and illustrate atypical presentations of the disease, including diverse forms of location and morphology of the lesions, the course of the eruption, and its differential diagnoses.

关键词： Pityriasis Pityriasis rosea Pityriasis rosea of Gibert Herald patch Papulo-squamous dermatosis

Surgical management of non-syndromic ectopia lentis

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International Journal of Ophthalmology(English edition) 2020年第7期13卷 1156-1160页

作者： Kirk AJ Stephenson Michael O’Keefe David J Keegan Retinal Research Group Mater Misericordiae University Hospital&Mater Private HospitalDublin 7Ireland

AIM:To compare whether aphakic contact lenses or secondary iris-claw intraocular lenses are superior in the refractive management post-pars plana vitreolensectomy in a pedigree with an FBN1 mutation causing non-syndromic ectopia lentis(NSEL)with retinal detachment(RD).METHODS:Eight affected individuals had pars plana vitreolensectomy for bilateral ectopia lentis(EL).Twelve eyes of 6 patients had secondary iris-claw intraocular lenses inserted and 4 eyes of 2 patients were managed with contact *** retinal detachment(RRD)was treated when ***-and post-operative assessment included visual acuity,endothelial cell count and dilated fundal ***:Macula-on RRD was present in all individuals>18 y,64%(7/11 eyes)presenting post-vitreolensectomy with 57%having bilateral non-synchronous *** aphakia was managed with iris-fixated intraocular lenses(IOL group,n=6),or contact lenses(CL group,n=2).Visual acuity≥0.3 log MAR(driving standard)was achieved in 75%of IOL group eyes and 25%of the CL group *** loss of corneal endothelial cell count in the IOL group was 4%at 2 y ***:In this cohort,refractive management with iris-claw IOLs provided superior outcomes to contact lenses and the authors recommend this as the optimal refractive correction in EL patients.

关键词： FBN1 isolated ectopia lentis retinal detachment iris-claw intraocular lenses

Regulation of the intestinal immune system by flavonoids and its utility in chronic inflammatory bowel disease

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World Journal of Gastroenterology 2018年第8期24卷 877-881页

作者： Harald Peter Hoensch Benno Weigmann private Practice Gastroenterology Marien hospital Department of Medicine 1 University Medical Center

Flavonoids are phytochemicals which can regulate the activity of the intestinal immune system. In patients with chronic inflammatory bowel disease(IBD) there is an overexpression and imbalance of the components of the inflammatory immune reactions which are chronically activated. Suppression of inflammation can be achieved by anti-inflammatory drugs which are used in clinical medicine but these can cause serious side effects. Flavonoids can have natural immunosuppressive properties and inhibit the activation of immune cells and its effectors(chemokines, TNF-, cytokines). Phytochemicals such as flavonoids bind to the nuclear Ah(aryl hydrocarbon)-receptor thereby stimulating protective enzyme activities. As shown by clinical evidence in patients and by experimental work some flavonoids(apigenin, epigallocatechin gallate) were effective in the inhibition of inflammation. Instead of or additionally to anti-inflammatory drugs flavonoids can be used in IBD patients to treat the over-reactive immunologic system. This is accomplished by upregulation of the Ah-receptor. Flavonoids interact with toll-like receptors expressing on the surface of immune cells, then they were internalized to the cytosol and transferred into the nucleus, where they were attached to the Ah-receptor. The Ah-receptor binds to the Ah-R nuclear translocator and via Ah response element beneficial protective enzymes and cytokines are induced, leading to upregulation of the anti-inflammatory system.

关键词： Flavonoids Inflammatory bowel disease Ah-receptor

Comparison of a modified Mogen clamp and classic dorsal slit circumcision under local anesthesia:A clinical study

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Current Urology 2022年第3期16卷 175-179页

作者： Yavuz Güler Department of Urology Private Safa HospitalIstanbul34000Turkey

Background:Currently,although various methods are used,there is no gold standard method for ***,we developed a modified circumcision clamp inspired by the Mogen clamp suitable for circumcisions performed under local anesthesia in our *** evaluate its success and complications,we compared our modified Mogen clamp with a dorsal slit *** and methods:From 2013 to 2017,we retrospectively evaluated 1309 patients who had undergone circumcision;of these,832 used the modified Mogen clamp method(Group 1)and 477 used the dorsal slit method(Group 2).The patients'age,surgery duration,minor hemorrhage(not requiring suture or repeated surgical exploration after circumcision but with buffer or clotting solution used),major hemorrhage(hemorrhage requiring suture or exploration),redundant prepuce skin remnants,revision numbers,and family satisfaction values were evaluated and compared between the 2 ***:Patients were assessed at least 3 times:1 day,1 week,and 1 month after *** mean ages in Groups 1 and 2 were 16.5±22.8 versus 15.5±18.8 months,*** surgical procedure durations were 9.2±1.7 and 15.4±2.5 minutes in Groups 1 and 2,respectively(p<0.001).Complications were found in 164(19.7%)versus 81 patients(17.0%)(p=0.522),including redundant skin in 42(5.4%)versus 15 patients(3.14%)(p=0.105)and major hemorrhage in 20(2.4%)versus 15 patients(3.3%)(p=0.230)in Groups 1 and 2,***:Under local anesthesia,the circumcision procedure with the modified Mogen clamp can be performed more rapidly than with the dorsal slit,and the cosmetic results are better as the incision line is more *** postoperative complications were similar,with problems related to redundant skin occurring more frequently with clamp circumcision.

关键词： Circumcision Mogen clamp Dorsal slit

Navigating the intersection of psychiatry and ophthalmology:A comprehensive review of depression and anxiety management in glaucoma patients

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World Journal of Psychiatry 2024年第3期14卷 362-369页

作者： Prasanna Venkatesh Ramesh Arvind Kumar Morya Ashik Azad Pavithra Pannerselvam Aji Kunnath Devadas Sai Thaejesvi Gopalakrishnan Shruthy Vaishali Ramesh Ajanya K Aradhya Department of Glaucoma and Research Mahathma Eye Hospital Private LimitedTrichy 620017Tamil NaduIndia Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Optometry and Visual Science Mahathma Eye Hospital Private LimitedTrichy 620017Tamil NaduIndia Junior Resident Mahathma Eye Hospital Private LimitedTrichy 620017Tamil NaduIndia Department of Cataract and Refractive Surgery Mahathma Eye Hospital Private LimitedTrichy 620017Tamil NaduIndia

Glaucoma,a prevalent and debilitating eye disease,has long been associated with vision impairment and ***,recent research has shed light on the often-underestimated psychological dimensions of this *** and depression,two pervasive psychiatric comorbidities,have been increasingly recognized among glaucoma *** comprehensive review aims to explore the intricate relationship between psychiatry and ophthalmology,in the context of managing depression and anxiety in glaucoma *** meticulously examining peer-reviewed literature,we synthesize current knowledge on the prevalence,risk factors,and underlying mechanisms of anxiety and depression in *** evidence reveals that glaucoma patients face an elevated risk of experiencing these mood *** such as progressive vision loss,complex medication regimens,and the fear of further visual deterioration contribute to their ***,we delve into the bidirectional relationship between glaucoma and mood disorders,shedding light on the complex interplay between ocular and emotional *** review investigates the implications of anxiety and depression on glaucoma management,including their potential impact on treatment adherence,disease progression,and overall quality of *** also explore the neurobiological pathways linking glaucoma and mood disorders,providing a foundation for future research and potential therapeutic *** conclusion,recognizing the psychological burden carried by glaucoma patients is essential for holistic and patient-centered *** review underscores the pressing need for integrated approaches that bring together ophthalmological and psychiatric expertise to optimize the well-being of individuals facing the challenges of *** addressing anxiety and depression in glaucoma care,healthcare providers can enhance the overall quality of life for these patients,ultimately leading to improved outcomes and a brighter

关键词： Glaucoma Psychiatry Depression Anxiety Risk factors Bidirectional relationship