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TRP channels in prostate cancer： the good, the bad and the ugly？

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Asian Journal of Andrology 2011年第5期13卷 673-676页

作者： Dimitra Gkika Natalia Prevarskaya llnserm U1003 Equipe labellisee par la Ligue Nationale contre le cancer Villeneuve d＇Ascq France Universite des Sciences et Technologies de Lille （USTL） Villeneuve d＇Ascq France

During the last decade, transient receptor potential （TRP） channels emerge as key proteins in central mechanisms of the carcinogenesis such as cell proliferation, apoptosis and migration. Initial studies showed that expression profile of some TRP channels, notably TRP melastatin 8 （TRPM8）, TRP vanilloid 6 （TRPV6）,TRP canonical （TRPC6） and TRPV2, is changing during the development and the progression of prostate cancer towards the hormone-refractory stages. The link between the change in expression levels and the functional role of these channels in prostate cancer is step by step being elucidated. These recent advances are here described and discussed.

关键词： ion channel lysophospholipids migration neuroendocrine prostate cancer PSA transient receptor potential (TRP)channels TRP channels TRPM8 TRPV6 TRPV2

Fecal microbiota transplantation: can it circumvent resistance to PD-1 blockade in melanoma?

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1630-1631页

作者： Lisa Derosa laurence Zitvogel Gustave Roussy Comprehensive cancer Institute ClinicobiomeVillejuifFrance Faculty of Medicine Universite Paris SaclayLe Kremlin-BicetreFrance INSeRM U1015 VillejuifFrance equipe labellisee par la ligue contre le cancer VillejuifFrance Center of Clinical Investigations in Biotherapies of cancer(CICBT)BIOTHeRIS VillejuifFrance Suzhou Institute for Systems Medicine Chinese Academy of Medical SciencesSuzhouChina

In two recent articles,Baruch et al.1 and Davar et al.2 bring up the first proof-of-concept that fecal microbiota transplantation(FMT)transfer clinical benefit in metastatic melanoma patients primarily resistant to immune checkpoint blockade(ICB).FMT shifted the microbiota of recipients toward a donor-type taxonomic composition associated with immune activation,anti-inflammatory tonus,and changes in the host metabolism.

关键词： al. melanoma clinical

Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

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Frontiers of Chemical Science and engineering 2017年第4期11卷 663-675页

作者： Yu Cao Xiaoxuan Liu Ling Peng . Aix-Marseille Université CNRS Centre Interdisciplinaire de Nanoscience de Marseille UMR 7325 Equipe Labellisée Ligue Contre le Caner 13288 Marseille France.. State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases Center of Drug Discovery Center of Advanced Pharmaceuticals and Biomaterials China Pharmaceutical University Nanjing 210009 China

Small interfering RNA （siRNA） therapeutics hold great promise to treat a variety of diseases, as long as they can be delivered safely and effectively into cells. Dendrimers are appealing vectors for siRNA delivery by virtue of their well-defined molecular architecture and multivalent cooperativity. However, the clinical translation of RNA therapeutics mediated by dendrimer delivery is hampered by the lack of dendrimers that are of high quality to meet good manufacturing practice standard. In this context, we have developed small amphiphilic dendrimers that self-assemble into supramolecular structures, which mimic high-generation dendrimers synthesized with cova- lent construction, yet are easy to produce in large amount and superior quality. Indeed, the concept of supramolecular dendrimers has proved to be very promising, and has opened up a new avenue for dendrimer-mediated siRNA delivery. A series of self-assembling supramolecular dendrimers have consequently been established, some of them out-performing the currently available nonviral vectors in delivering siRNA to various cell types in vitro and in vivo, including human primary cells and stem cells. This short review presents a brief introduction to RNAi therapeutics, the obstacles to their delivery and the advantages of dendrimer delivery vectors as well as our bio-inspired struc^rally flexible dendrimers for siRNA delivery. We then highlight our efforts in creating self- assembling amphiphilic dendrimers to construct supramo- lecular dendrimer nanosystems for effective siRNA delivery as well as the related structural alterations to enhance delivery efficiency. The advent of self-assembling supramolecular dendrimer nanovectors holds great pro- mise and heralds a new era of dendrimer-mediated delivery of RNA therapeutics in biomedical applications.

关键词： gene therapy RNAi therapeutics dendrimer,nanovectors gene silencing

Peroxisome:the new player in ferroptosis

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Signal Transduction and Targeted Therapy 2020年第1期5卷 221-222页

作者： Daolin Tang Guido Kroemer Department of Surgery University of Texas Southwestern Medical CenterDallasTexas 75390USA Center for DAMP Biology University of Texas Southwestern Medical CenterDallasTexas 75390USA equipe labellisée par la ligue contre le cancer Universitéde ParisSorbonne UniversitéINSERM U1138Centre de Recherche des CordeliersParisFrance Metabolomics and Cell Biology Platforms Gustave Roussy Cancer Campus94800 VillejuifFrance Pôle de Biologie Hôpital Européen Georges PompidouAP-HP75015 ParisFrance

A recent paper published in Nature by Zou et *** that peroxisomes,membrane-bound oxidative organelles,contribute to ferroptosis through the biosynthesis of plasmalogens for lipid peroxidation(Fig.1).1 These observatio... 详细信息

关键词： peroxidation al death

Peripheral clonal selection shapes the human γδ T-cell repertoire

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Cellular & Molecular Immunology 2017年第9期14卷 733-735页

作者： Biagio Di Lorenzo Julie Déchanet-Merville Bruno Silva-Santos Instituto de Medicina Molecular Faculdade de MedicinaUniversidade de Lisboa1649-028 LisbonPortugal Instituto Superior Tecnico Universidade de Lisboa1649-028 LisbonPortugal ImmunoConcept CNRS UMR 5164Equipe Labelisée Ligue Contre le CancerUniversity of BordeauxF-33000 BordeauxFrance

γδT cells are often placed at the interface between innate and adaptive *** cells share T-cell receptor(TCR)rearrangements and memory functions1 in common with theirαβT-cell counterparts but differ in terms of the... 详细信息

关键词： Figure kinetics selection

A self-assembling prodrug nanosystem to enhance metabolic stability and anticancer activity of gemcitabine

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Chinese Chemical letters 2022年第5期33卷 2481-2485页

作者： Mei Cong Guangling Xu Shaoyou Yang Jing Zhang Wenzheng Zhang Dinesh Dhumal erik laurini Kaiyue Zhang Yi Xia Sabrina Pricl Ling Peng Weidong Zhao School of Pharmacy Xinxiang Medical UniversityXinxiang 453003China Henan Key laboratory of Immunology and Targeted Drugs School of Laboratory MedicineXinxiang Medical UniversityXinxiang 453003China Henan Collaborative Innovation Center of Molecular Diagnosis and laboratory Medicine School of Laboratory MedicineXinxiang Medical UniversityXinxiang 453003China Aix-Marseille Université CNRSCenter Interdisciplinaire de Nanoscience de MarseilleUMR 7325Equipe Labellisépar La LigueMarseille 13288France Chongqing Key laboratory of Natural Product Synthesis and Drug Research School of Pharmaceutical SciencesChongqing UniversityChongqing 401331China Molecular Biology and Nanotechnology laboratory Department of Engineering and ArchitectureUniversity of TriesteTrieste 34127Italy Department of General Biophysics Faculty of Biology and Environmental ProtectionUniversity of LodzLodz 90-236Poland

Self-assembly is a powerful approach in molecular engineering for biomedical applications,in particu-lar for creating self-assembling ***,we report a self-assembling prodrug of the anticancer drug gemcitabine(Gem)based on amphiphilic dendrimer *** prodrug reported in this study demonstrates high drug loading(40%)and robust ability to self-assemble into small nanomicelles,which increase the metabolic stability of Gem and enable entry into cells via endocytosis,hence bypassing transport-mediated *** addition,this prodrug nanosystem exhibited an effective pH-and enzyme-responsive release of Gem,resulting in enhanced anticancer activity and reduced *** ad-vantageous features of both prodrug-and nanotechnology-based drug delivery,this self-assembling Gem prodrug nanosystem constitutes a promising anticancer *** study also offers new perspectives of the amphiphilic dendrimer nanoplatforms for the development of self-assembling prodrugs.

关键词： Self-assembling prodrug Gemcitabine Amphiphilic dendrimer Anticancer candidate Nanomicelles

exercise sustains the hallmarks of health

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Journal of Sport and Health Science 2023年第1期12卷 8-35页

作者： Yan Qiu Benjamin Fernández-García H.Immo lehmann Guoping Li Guido Kroemer Carlos López-Otín Junjie Xiao Institute of Geriatrics(Shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)School of MedicineShanghai UniversityNantong 226011China Cardiac Regeneration and Ageing lab Institute of Cardiovascular SciencesShanghai Engineering Research Center of Organ RepairSchool of Life ScienceShanghai UniversityShanghai 200444China Health Research Institute of the Principality of Asturias(ISPA) Oviedo 33011Spain Department of Morphology and Cell Biology AnatomyUniversity of OviedoOviedo 33006Spain Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School BostonMA 02114USA Centre de Recherche des Cordeliers Equipe labellisee par la Ligue contre le cancerUniversite de Paris CiteSorbonne UniversiteInserm U1138Institut Universitaire de FranceParis 75231France Metabolomics and Cell Biology Platforms Institut Gustave RoussyVillejuif 94805France Institut du cancer paris CARPeM Department of BiologyHopital Europeen Georges PompidouAP-HPParis 75015France Departamento de Bioquımica y Biologıa Molecular Facultad de MedicinaInstituto Universitario de OncologıaUniversidad de OviedoOviedo 33006Spain Centro de Investigacion Biomedica en Red enfermedades cancer(CIBeRONC) Oviedo 33006Spain

exercise has long been known for its active role in improving physical fitness and sustaining *** moderate-intensity exercise improves all aspects of human health and is widely accepted as a preventative and therapeutic strategy for various *** is well-documented that exercise maintains and restores homeostasis at the organismal,tissue,cellular,and molecular levels to stimulate positive physiological adaptations that consequently protect against various pathological *** we mainly summarize how moderate-intensity exercise affects the major hallmarks of health,including the integrity of barriers,containment of local perturbations,recycling and turnover,integration of circuitries,rhythmic oscillations,homeostatic resilience,hormetic regulation,as well as repair and ***,we summarize the current understanding of the mechanisms responsible for beneficial adaptations in response to *** review aimed at providing a comprehensive summary of the vital biological mechanisms through which moderate-intensity exercise maintains health and opens a window for its application in other health *** hope that continuing investigation in this field will further increase our understanding of the processes involved in the positive role of moderate-intensity exercise and thus get us closer to the identification of new therapeutics that improve quality of life.

关键词： Beneficial effects of exercise exercise-related physiological adaptations Hallmarks of health Moderate-intensity exercise Therapeutic exercise

High-throughput multiplexed fluorescence-activated droplet sorting

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Microsystems & Nanoengineering 2018年第1期4卷 95-104页

作者： Ouriel Caen Simon Schütz M.S.Suryateja Jammalamadaka Jérémy Vrignon Philippe Nizard Tobias M.Schneider Jean-Christophe Baret Valérie Taly INSeRM UMR-S1147 CNRS SNC5014Paris Descartes UniversityEquipe labellisée Ligue Nationale contre le cancerParisFrance emergent Complexity in Physical Systems laboratory(eCPS) Ecole Polytechnique Fédérale de Lausanne1015 LausanneSwitzerland CNRS University BordeauxCRPPUMR 5031115 Avenue Schweitzer33600 PessacFrance

Fluorescence-activated droplet sorting(FADS)is one of the most important features provided by droplet-based ***,to date,it does not allow to compete with the high-throughput multiplexed sorting capabilities offered by flow ***,we demonstrate the use of a dielectrophoretic-based FADS,allowing to sort up to five different droplet populations *** system provides means to select droplets of different phenotypes in a single experimental run to separate initially heterogeneous *** experimental results are rationalized with the help of a numerical model of the actuation of droplets in electric fields providing guidelines for the prediction of sorting designs for upscaled or downscaled microsystems.

关键词： rational initially sorting

A dual targeting dendrimer-mediated siRNA delivery platform

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A dual targeting dendrimer-mediated siRNA delivery platform