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Cyclin-dependent kinase 7 inhibitor THZ1 in cancer therapy

Chronic Diseases and Translational Medicine 2019年第3期5卷 155-169页

作者： Bin-Bin Li Bo Wang Cheng-Ming Zhu Di Tang Jun Pang Jing Zhao Chun-Hui Sun Miao-Juan Qiu Zhi-Rong Qian School of Biological Sciences Nanyang Technological UniversitySingapore 639798Singapore Scientific Research Center The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdong 518107China equipe communication intercellulaire et infections microbiennes Centre de Recherche Interdisciplinaire en Biologie(CIRB)College de FranceParis 75005France

Current cancer therapies have encountered adverse response due to poor therapeutic efficiency,severe side effects and acquired resistance to multiple ***,there are urgent needs for finding new cancer-targeted pharmacological *** this review,we summarized the current understanding with THZ1,a covalent inhibitor of cyclin-dependent kinase 7(CDK7),which demonstrated promising anti-tumor activity against different cancer *** introducing the anti-tumor behaviors and the potential targets for different cancers,this review aims to provide more effective approaches to CDK7 inhibitor-based therapeutic agents and deeper insight into the diverse tumor proliferation mechanisms.

关键词： THZ1 Cyclin-dependent kinase 7 Cancer therapy Transcription Super-enhancer

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The role of Fusobacteriu mnucleatum in colorectal cancer:from carcinogenesis to clinical management

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Chronic Diseases and Translational Medicine 2019年第3期5卷 178-187页

作者： Chun-Hui Sun Bin-Bin Li Bo Wang Jing Zhao Xiao-Ying Zhang Ting-Ting Li Wen-Bing Li Di Tang Miao-Juan Qiu Xin-Cheng Wang Cheng-Ming Zhu Zhi-Rong Qian equipe communication intercellulaire et infections microbiennes Centre de Recherche Interdisciplinaire en Biologie(CIRB)College de FranceParis 75005France Research Center The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdong 518107China School of Biological Sciences Nanyang Technological UniversitySingapore 637551Singapore Department of Oncology The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdong 518107China Health Management Center The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdong 518107China Department of Gastroenterology The Second Medical Center of Chinese PLA General Hospital Beijing 100853China Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100021China Department of General Surgery The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdong 518107China

Colorectal cancer(CRC)is a common malignant tumor that affects people *** analyses have shown an enrichment of Fusobacterium nucleatum(***)in colorectal carcinoma tissue;many studies have indicated that *** is closely related to the colorectal *** this review,we provide the latest information to reveal the related molecular *** known virulence factors of *** promote adhesion to intestinal epithelial cells via FadA and ***,Fap2 also binds to immune cells causing ***,*** recruits tumor-infiltrating immune cells,thus yielding a pro-inflammatory microenvironment,which promotes colorectal neoplasia *** was also found to potentiate CRC development through toll-like receptor 2(TLR2)/toll-like receptor 4(TLR4)signaling and microRNA(miRNA)-21 *** addition,*** increases CRC recurrence along with chemoresistance by mediating a molecular network of miRNA-18a*,miRNA-4802,and autophagy ***,viable *** was detected in mouse xenografts of human primary colorectal adenocarcinomas through successive *** findings indicated that an increased number o f *** in the tissues is a biomarker for the diagnosis and prognosis of CRC,and the underlying molecular mechanism can probably provide a potential intervention treatment strategy for patients with ***-associaied CRC.

关键词： Fusobacterium nucleatum:Colorectal carcinoma Carcinogenesis Immune microenvironment Intervention therapy

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力敏感离子通道Piezo1分布与活性的力学调控及其与细胞转化态的关系

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医用生物力学 2021年第S1期36卷 88-88页

作者：姚明曦 Ajay Tijore Charles D Cox Anushya Hariharan Guy Tran Van Nhieu Boris Martinac Michael Sheetz 南方科技大学生物医学工程系深圳518055 Mechanobiology Institute National University of Singapore Victor Chang Cardiac Research Institute NSW 2010Australia equipe communication intercellulaire et infections microbiennes Centre de Recherche Interdisciplinaire en Biologie(CIRB)Collège de FranceFrance Department of Biological Sciences National University of Singapore Molecular MechanoMedicine Program Dept.of Biochemistry and Molecular BiologyUniversity of Texas Medical BranchUSA

目的近十年来新发现广泛表达于多种组织细胞中的力敏感钙离子通道Piezo1在触觉/听觉感受,血压控制,免疫激活等生理过程中起到关键的力学感知作用。经典模型认为,Piezo1在细胞膜上扩散分布并在细胞膜局部表面张力起伏的作用下被激活,但... 详细信息

目的近十年来新发现广泛表达于多种组织细胞中的力敏感钙离子通道Piezo1在触觉/听觉感受,血压控制,免疫激活等生理过程中起到关键的力学感知作用。经典模型认为,Piezo1在细胞膜上扩散分布并在细胞膜局部表面张力起伏的作用下被激活,但其在细胞复杂生理过程中的调控还有很多未知问题尚待回答。方法通过一系列显微成像方法研究了Piezo1的时空分布与活性在不同种类细胞中的力学调控。

关键词：钙离子通道细胞转化力学调控免疫激活血压控制组织细胞经典模型未知问题

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