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Chinese Journal of Traumatology 2022年第5期25卷 272-276页

作者： Nils Muhlenfeld Philipp Stormann Ingo Marzi Felix Rosenow Adam Strzelczyk Rene D.Verboket Laurent M.Willems Department of Traurma Hand and Reconstructive SurgeryGoethe University FrankfurtFrankfurt Am MainGermany epilepsy center frankfurt rhine-main Department of NeurologyGoethe University FrankfurlFrankfurt Am MainGermany LOEWE center for Personalized Translational epilepsy Research(CePTER) Goethe-Universitat FrankfurtFrankfurt Am MainGermany Department of Neurology and epilepsy center Hessen Philipps-University MarburgMarburg(Lahn)Germany

Purpose: Epileptic seizures frequently result in distinct physical injuries, fractures, traumatic brain injuries and minor trauma. The aim of this study was to retrospectively determine the frequent injury patterns due to seizure episode and to analyze consecutive acute medical care. Methods: This retrospective mono-center study was conducted at frankfurt University Hospital, frankfurt am main, Germany between January 2007 and December 2017. epilepsy patients with seizure-related fractures admitted to the emergency department were identified via a retrospective systematic query in the hospital information system using the ICD-10 German modification codes G40.0—G40.9. Patients with an unclear diagnosis of epilepsy were excluded. Sociodemographic as well as disease specific aspects were analyzed. Descriptive and Kruskal—Wallis one-way analysis of variance were used for statistical analysis. Results: A total number of 62 epilepsy patients were included. The mean age was 58.1 years. Fractures concerned the upper extremity most frequently (43.5%,n= 20), and 70.0% (14/20) were humerus fractures. Admission to intensive care unit for acute trauma care was necessary in 29.0% patients (n = 18), and surgery in 45.2% patients (n = 28). Twenty-five patients (26.6%) showed clinical or radiological signs of traumatic brain injury. Provoking factors were identified in 20 patients (32.3%), i.e., acute withdrawal or excess of alcohol (n = 15), relevant sleep deprivation (n = 2), and intoxication or withdrawal of other illegal drugs or trivial infect (n = 1 for each) and non-compliance with anti-seizure drugs (n = 1). A decreased T-score (-1.04 ± 1.15) and Z-score (-0.84 ± 0.75) compared to healthy subjects were found. Conclusion: Fractures in upper extremities, trunk and craniocerebral trauma occur frequently as seizure-induced injuries. Alcohol excess and withdrawal are important provoking factors and should be targeted with preventive measurements to avoid seizure related injuries and accidents.

关键词： epilepsy Wounds and injuries Falls Quality of life

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Time's up:mutation rate and lifespan

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3166-3167页

作者： Anjali Cremer Wesley T.Abplanalp Michael A.Rieger Department of Medicine Hematology/OncologyGoethe University FrankfurtFrankfurt am MainGermany frankfurt Cancer Institute Frankfurt am MainGermany German Cancer Consortium(DKTK)and German Cancer Research center(DKTK) HeidelbergGermany Institute for Cardiovascular Regeneration Centre of Molecular MedicineGoethe University FrankfurtFrankfurt am MainGermany German center for Cardiovascular Research DZHK Partner site Frankfurt Rhine-MainBerlinGermany Cardiopulmonary Institute Goethe University FrankfurtFrankfurtGermany EnABLE Consortium Goethe University FrankfurtFrankfurtGermany

In a recent study published in Nature,Alex Cagan,Adrian Baez-Ortega and colleagues found that many mammalian species present a similar somatic mutational load at the end of life.The mutational burden is independent of lifetime and body mass,only varying by a relatively small fold change among species.1These data may suggest that mutational burden predicts mortality.

关键词： species. life lifetime

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Brain network correlates of epilepsy occurrence in multiple sclerosis and neuroinflammation

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Neural Regeneration Research 2023年第8期18卷 1717-1718页

作者： Dumitru Ciolac Gabriel Gonzalez-Escamilla Yaroslav Winter Vinzenz Fleischer Matthias Grothe Sergiu Groppa Department of Neurology Focus Program Translational NeuroscienceRhine Main Neuroscience Network(rmn2)University Medical Center of the Johannes Gutenberg University MainzMainzGermany State University of Medicine and Pharmacy“Nicolae Testemitanu” ChisinauRepublic of Moldova Department of Neurology Institute of Emergency MedicineChisinauRepublic of Moldova mainz Comprehensive epilepsy and Sleep Medicine center Department of NeurologyJohannes Gutenberg University MainzMainzGermany Department of Neurology Philipps-UniversityMarburgGermany Department of Neurology Heinrich Heine UniversityDüsseldorfGermany

Multiple sclerosis(MS),the most common inflammatory condition of the central nervous system in young adults,is characterized by immunemediated demyelination and neurodegeneration that translate into heterogeneous clin... 详细信息

关键词： epilepsy inflammation sclerosis

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