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Association between Fish Consumption and Stroke Incidence Across Different Predicted Risk Populations:A Prospective Cohort Study from China

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Biomedical and Environmental Sciences 2025年第1期38卷 15-26页

作者： Hongyue Hu Fangchao Liu Keyong Huang Chong Shen Jian Liao Jianxin Li Chenxi Yuan Ying Li Xueli Yang Jichun Chen Jie Cao Shufeng Chen Dongsheng Hu Jianfeng Huang Xiangfeng Lu Dongfeng Gu Department of epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166JiangsuChina Department of epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Key Laboratory of Cardiovascular epidemiology Chinese Academy of Medical SciencesBeijing 100037China Research units of Cohort Study on Cardiovascular Diseases and Cancers Chinese Academy of Medical SciencesBeijing 100730China School of Public health and Emergency Management Southern University of Science and TechnologyShenzhen 518055GuangdongChina Department of Occupational and Environmental health School of Public HealthTianjin Medical UniversityTianjin 300070China Department of epidemiology and health Statistics College of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina Department of epidemiology and health Statistics School of Public HealthShenzhen University Health Science CenterShenzhen 518071GuangdongChina

Objective The relationship between fish consumption and stroke is inconsistent,and it is uncertain whether this association varies across predicted stroke *** A cohort study comprising 95,800 participants from the Prediction for Atherosclerotic Cardiovascular Disease Risk in China project was conducted.A standardized questionnaire was used to collect data on fish *** were stratified into low-and moderate-to-high-risk categories based on their 10-year stroke risk prediction *** ratios(HRs)and 95%confidence intervals(CIs)were estimated using Cox proportional hazard models and additive interaction by relative excess risk due to interaction(RERI),attributable proportion(AP),and synergy index(SI).Results During 703,869 person-years of follow-up,2,773 incident stroke events were *** fish consumption was associated with a lower risk of stroke,particularly among moderate-to-high-risk individuals(HR=0.53,95%CI:0.47-0.60)than among low-risk individuals(HR=0.64,95%CI:0.49-0.85).A significant additive interaction between fish consumption and predicted stroke risk was observed(RERI=4.08,95%CI:2.80-5.36;SI=1.64,95%CI:1.42-1.89;AP=0.36,95%CI:0.28-0.43).Conclusion Higher fish consumption was associated with a lower risk of stroke,and this beneficial association was more pronounced in individuals with moderate-to-high stroke risk.

关键词： Fish consumption Stroke Predicted stroke risk Cohort study Interaction

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Ozone exposure and cardiovascular disease: A narrative review of epidemiology evidence and underlying mechanisms

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Fundamental Research 2025年第1期5.0卷 249-263页

作者： Hua, Qiaoyi Meng, Xin Gong, Jicheng Qiu, Xinghua Shang, Jing Xue, Tao Zhu, Tong SKL-ESPC & SEPKL-AERM College of Environmental Sciences and Engineering and Center for Environment and Health Peking University Beijing 100871 China Institute of Reproductive and Child health/Ministry of health Key Laboratory of Reproductive health and Department of epidemiology and Biostatistics School of Public Health Peking University Health Science Center Beijing 100871 China

Ozone (O3) poses a significant global public health concern as it exerts adverse effects on human cardiovascular health. Nevertheless, there remains a lack of comprehensive understanding regarding the relationships between O3 exposure and the risk of cardiovascular diseases (CVD), as well as the underlying biological mechanisms. To address this knowledge gap, this narrative review meticulously summarizes the existing epidemiological evidence, susceptibility, and potential underlying biological mechanisms linking O3 exposure with CVD. An increasing body of epidemiological studies has demonstrated that O3 exposure heightens the incidence and mortality of CVD, including specific subtypes such as ischemic heart disease, hypertension, and heart failure. Certain populations display heightened vulnerability to these effects, particularly children, the elderly, obese individuals, and those with pre-existing conditions. Proposed biological mechanisms suggest that O3 exposure engenders respiratory and systemic inflammation, oxidative stress, disruption of autonomic nervous and neuroendocrine systems, as well as impairment of coagulation function, glucose, and lipid metabolism. Ultimately, these processes contribute to vascular dysfunction and the development of CVD. However, some studies have reported the absence of associations between O3 and CVD, or even potentially protective effects of O3. Inconsistencies among the literature may be attributed to inaccurate assessment of personal O3 exposure levels in epidemiologic studies, as well as confounding effects stemming from co-pollutants and temperature. Consequently, our findings underscore the imperative for further research, including the development of reliable methodologies for assessing personal O3 exposure, exploration of O3 exposure's impact on cardiovascular health, and elucidation of its biological mechanisms.

关键词： Cardiovascular disease Epidemiologic study Mechanism Ozone exposure Susceptibility

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Genetic variants and mRNA expression levels of KLF4 and KLF5 with hypertension:A combination of case-control study and cohort study

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Journal of Biomedical Research 2025年第1期39卷 103-113页

作者： Xu Han Wen Li Changying Chen Jiahui Liu Junxiang Sun Feifan Wang Chao Wang Jialing Mu Xincheng Gu Fangyuan Liu Hankun Xie Song Yang Chong Shen Department of epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Cardiology the Affiliated Yixing People's Hospital of Jiangsu UniversityPeople's Hospital of Yixing CityWuxiJiangsu 214200China Department of Environmental Genomics School of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China

Hypertension(HT)is a major risk factor for cardiovascular ***üppel-like factors(KLFs)are important transcription factors in *** have reported that KLF4 and KLF5 are correlated with several cardiovascular diseases,but population-based studies on associations between HT and KLF4 or KLF5 have rarely been ***,the current study investigated the associations of genetic variants and m RNA expression levels of KLF4 and KLF5 with HT,as well as the effects of antihypertensive drugs on the expression levels of these *** associations of one single-nucleotide polymorphism(SNP)in KLF4 and three SNPs in KLF5with HT were analyzed using a combination of case-control and cohort *** study populations were selected from a community-based cohort in four regions of Jiangsu *** risks of HT were estimated through logistic and Cox regression *** addition,m RNA expression levels of KLF4 and KLF5 were detected in 246 controls and 385 HT cases selected from the aforementioned *** the HT cases,263were not taking antihypertensive drugs[AHD(-)]and 122 were taking antihypertensive drugs[AHD(+)].In the case-control study,SNP rs9573096(C>T)in KLF5 was significantly associated with an increased risk of HT in the additive model(adjusted odds ratio[OR],1.106;95%confidence interval[CI],1.009 to 1.212).In the cohort study of the normotensive population,rs9573096 in KLF5 was also significantly associated with an increased risk of HT in the additive model(adjusted hazards ratio[HR],1.199;95%CI,1.070 to 1.344).KLF4 and KLF5m RNA expression levels were significantly higher in the AHD(-)group than in the control group(P<0.05),but lower in the AHD(+)group than in the AHD(-)group(P<0.05).The current study demonstrated the associations of KLF4 and KLF5 genetic variants with hypertension,as well as the association of the indicative variations in m RNA expression levels of KLF4 and KLF5 with the risk of hypertension and antihypertensive

关键词： hypertension KLF4 KLF5 single-nucleotide polymorphism mRNA expression antihypertensive drugs

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Arsenic exposure and oxidative damage to lipid,DNA,and protein among general Chinese adults:A repeated-measures cross-sectional and longitudinal study

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Journal of Environmental Sciences 2025年第1期147卷 382-391页

作者： Yongfang Zhang Min Zhou Dongming Wang Ruyi Liang Wei Liu Bin Wang Weihong Chen Department of Occupational and Environmental health School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Key Laboratory of Environment and health Ministry of Education and Ministry of Environmental Protectionand State Key Laboratory of Environmental Health(Incubating)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Arsenic-related oxidative stress and resultant diseases have attracted global concern,while longitudinal studies are *** assess the relationship between arsenic exposure and systemic oxidative damage,we performed two repeatedmeasures among 5236 observations(4067 participants)in theWuhan-Zhuhai cohort at the baseline and follow-up after 3 *** total arsenic,biomarkers of DNA oxidative damage(8-hydroxy-2-deoxyguanosine(8-OHdG)),lipid peroxidation(8-isoprostaglandin F2alpha(8-isoPGF2α)),and protein oxidative damage(protein carbonyls(PCO))were detected for all *** we used linearmixed models to estimate the cross-sectional and longitudinal associations between arsenic exposure and oxidative ***-response curves were constructed by utilizing the generalized additive mixed models with thin plate *** adjusting for potential confounders,arsenic level was significantly and positively related to the levels of global oxidative damage and their annual increased rates in dose-response *** cross-sectional analyses,each 1%increase in arsenic levelwas associated with a 0.406%(95%confidence interval(CI):0.379%to 0.433%),0.360%(0.301%to 0.420%),and 0.079%(0.055%to 0.103%)increase in 8-isoPGF2α,8-OHdG,and PCO,*** importantly,arsenic was further found to be associated with increased annual change rates of 8-isoPGF2α(β:0.147;95%CI:0.130 to 0.164),8-OHdG(0.155;0.118 to 0.192),and PCO(0.050;0.035 to 0.064)in the longitudinal *** study suggested that arsenic exposurewas not only positively related with global oxidative damage to lipid,DNA,and protein in cross-sectional analyses,but also associated with annual increased rates of these biomarkers in dose-dependent manners.

关键词： Arsenic Oxidative stress Oxidative damage 8-isoPGF2α 8-OHdG Protein carbonyls(PCO)

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Association between Per and Polyfluoroalkyl Substance and Abdominal Fat Distribution:A Trait Spectrum Exposure Pattern and Structure-Based Investigation

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Biomedical and Environmental Sciences 2025年第1期38卷 3-14页

作者： Zhi Li Shilin Shan Chenyang Song Chengzhe Tao Hong Qian Qin Yuan Yan Zhang Qiaoqiao Xu Yufeng Qin Yun Fan Chuncheng Lu State Key Laboratory of Reproductive Medicine Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166JiangsuChina Key Laboratory of Modern Toxicology of Ministry of Education School of Public HealthNanjing Medical UniversityNanjing 211166JiangsuChina Department of Public health Kangda College of Nanjing Medical UniversityLianyungang 222000JiangsuChina Department of Microbes and Infection School of Public HealthNanjing Medical UniversityNanjing 211166JiangsuChina

Objective To investigate the associations between eight serum per-and polyfluoroalkyl substances(PFASs)and regional fat depots,we analyzed the data from the National health and Nutrition Examination Survey(NHANES)2011-2018 *** Multiple linear regression models were developed to explore the associations between serum PFAS concentrations and six fat compositions along with a fat distribution score created by summing the concentrations of the six fat *** associations between structurally grouped PFASs and fat distribution were assessed,and a prediction model was developed to estimate the ability of PFAS exposure to predict obesity *** Among females aged 39-59 years,trunk fat mass was positively associated with perfluorooctane sulfonate(PFOS).Higher concentrations of PFOS,perfluorohexane sulfonate(PFHxS),perfluorodecanoate(PFDeA),perfluorononanoate(PFNA),and n-perfluorooctanoate(n-PFOA)were linked to greater visceral adipose tissue in this *** men,exposure to total perfluoroalkane sulfonates(PFSAs)and long-chain PFSAs was associated with reductions in abdominal fat,while higher abdominal fat in women aged 39-59 years was associated with short-chain *** prediction model demonstrated high accuracy,with an area under the curve(AUC)of 0.9925 for predicting obesity *** PFAS exposure is associated with regional fat distribution,with varying effects based on age,sex,and PFAS *** findings highlight the potential role of PFAS exposure in influencing fat depots and obesity risk,with significant implications for public *** prediction model provides a highly accurate tool for assessing obesity risk related to PFAS exposure.

关键词： Per-and polyfluoroalkyl substances Regional fat depots Obesity Structure-based NHANES

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Model-based frequency optimization for frequency-tunable superconducting processors

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Science China(Physics,Mechanics & Astronomy) 2025年第2期68卷 193-194页

作者： Qiujiang Guo ZJU-Hangzhou global Scientific and Technological Innovation Center School of PhysicsZhejiang UniversityHangzhou 311200China

Over the past twenty years,superconducting quantum computation has become one of the most promising candidates leading to fault-tolerant quantum *** is largely due to the huge experimental progress on improving coherence time,qubit number,and control accuracy on recent superconducting *** particular,frequency-tunable two-dimensional architecture and well-established device fabrication processes allow us to scale up the system size of superconducting processors while maintaining the quality of each qubit.

关键词： superconducting quantum optimization

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Association between Organochlorine Exposures and Lung Functions Modified by Thyroid Hormones and Mediated by Inflammatory Factors among healthy Older Adults

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Biomedical and Environmental Sciences 2025年第2期38卷 144-153页

作者： Xiaojie Guo Huimin Ren Jiran Zhang Xiao Ma Shilu Tong Song Tang Chen Mao Xiaoming Shi School of Public health Southern Medical UniversityGuangzhou 510515GuangdongChina China CDC Key Laboratory of Environment and Population health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijing 100021China School of Public health China Medical UniversityShenyang 110122LiaoningChina School of Public health Shandong UniversityJinan 250100ShandongChina School of Public health and Social Work Queensland University of TechnologyBrisbane 4001Australia Center for global health School of Public HealthNanjing Medical UniversityNanjing 211166JiangsuChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijing 102206China

Objective To examine the mechanistic of organochlorine-associated changes in lung *** This study investigated 76 healthy older adults in Jinan,Shandong Province,over a fivemonth *** exposure to organochlorines was quantified using wearable passive samplers,while inflammatory factors and thyroid hormones were analyzed from blood ***’lung function was *** stratifying participants according to their thyroid hormone levels,we analyzed the differential effects of organochlorine exposure on lung function and inflammatory factors across the low and high thyroid hormone *** analysis was further conducted to elucidate the relationships among organochlorine exposures,inflammatory factors,and lung *** Bis(2-chloro-1-methylethyl)ether(BCIE),was negatively associated with forced vital capacity(FVC,–2.05%,95%CI:–3.11%to–0.97%),and associated with changes in inflammatory factors such as interleukin(IL)-2,IL-7,IL-8,and IL-13 in the low thyroid hormone *** mediation analysis indicated a mediating effect of IL-2(15.63%,95%CI:0.91%to 44.64%)and IL-13(13.94%,95%CI:0.52%to 41.07%)in the association between BCIE exposure and *** Lung function and inflammatory factors exhibited an increased sensitivity to organochlorine exposure at lower thyroid hormone levels,with inflammatory factors potentially mediating the adverse effects of organochlorines on lung function.

关键词： healthy older adults Inflammatory factors Lung function Organochlorines Thyroid hormones

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Isoproterenol mechanisms in inducing myocardial fibrosis and its application as an experimental model for the evaluation of therapeutic potential of phytochemicals and pharmaceuticals

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Animal Models and Experimental Medicine 2025年第1期8卷 67-91页

作者： Lujain Bader Eddin Mohamed Fizur Nagoor Meeran Niraj Kumar Jha Samer NGoyal Shreesh Ojha Department of Pharmacology and Therapeutics College of Medicine and Health SciencesUAE UniversityAl AinUnited Arab Emirates School of Bioengineering&Biosciences Lovely Professional UniversityPhagwaraIndia Centre for global health Research Saveetha Medical CollegeSaveetha Institute of Medical and Technical SciencesSaveetha UniversityChennaiIndia Shri Vile Parle Kelvani Mandal's Institute of Pharmacy DhuleMaharashtraIndia Zayed Bin Sultan Center for health Sciences United Arab Emirates UniversityAl AinUnited Arab Emirates

Cardiac injury initiates repair mechanisms and results in cardiac remodeling and fi-brosis,which appears to be a leading cause of cardiovascular *** fi-brosis is characterized by the accumulation of extracellular matrix proteins,mainly collagen in the cardiac *** experimental studies have demonstrated that fibrotic injury in the heart is reversible;therefore,it is vital to understand differ-ent molecular mechanisms that are involved in the initiation,progression,and resolu-tion of cardiac fibrosis to enable the development of antifibrotic *** the many experimental models,one of the recent models that has gained renewed interest is isoproterenol(ISP)-induced cardiac *** is a synthetic catecholamine,sympa-thomimetic,and nonselectiveβ-adrenergic receptor *** overstimulated and sustained activation ofβ-adrenergic receptors has been reported to induce biochemi-cal and physiological alterations and ultimately result in cardiac *** has been used for decades to induce acute myocardial ***,the use of low doses and chronic administration of ISP have been shown to induce cardiac fibrosis;this practice has increased in recent *** or subcutaneous ISP has been widely used in preclinical studies to induce cardiac remodeling manifested by fibrosis and *** induced oxidative stress with subsequent perturbations in cellular signaling cascades through triggering the release of free radicals is consid-ered the initiating mechanism of myocardial *** is consistently used to induce fibrosis in laboratory animals and in cardiomyocytes isolated from *** recent years,numerous phytochemicals and synthetic molecules have been evaluated in ISP-induced cardiac *** present review exclusively provides a comprehensive summary of the pathological biochemical,histological,and molecular mechanisms of ISP in inducing cardiac fibrosis and *** also summarizes the ap

关键词： cardiac fibrosis catecholamines experimental models isoproterenol myocardial fibrosis phytochemicals β-adrenergic receptors

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Leveraging Artificial Intelligence to Achieve Sustainable Public healthcare Services in Saudi Arabia: A Systematic Literature Review of Critical Success Factors

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Computer Modeling in Engineering & Sciences 2025年第2期142卷 1289-1349页

作者： Rakesh Kumar Ajay Singh Ahmed Subahi Ahmed Kassar Mohammed Ismail Humaida Sudhanshu Joshi Manu Sharma Department of health Management College of Public Health and Health InformaticsUniversity of Ha’ilHa’il81451Saudi Arabia Department of Management&Information Systems College of Business AdministrationUniversity of Ha’ilHa’il81451Saudi Arabia Department of Public health College of Public Health and Health InformaticsUniversity of Ha’ilHa’il81451Saudi Arabia School of Management Doon UniversityDehradunUttarakhand248001India Department of Management Studies Graphic Era UniversityDehradunUttarakhand248002India

This review aims to analyze the development and impact of Artificial Intelligence(AI)in the context of Saudi Arabia’s public healthcare system to fulfill Vision 2030 *** is extensively devoted to AI technology deployment relevant to disease management,healthcare delivery,epidemiology,and ***,its AI is culturally sensitive and ethically grounded in *** on the PRISMA framework,an SLR evaluated primary academic literature,cases,and practices of Saudi Arabia’s AI implementation in the public healthcare ***,it categorizes prior research based on how AI can work,the issues it poses,and its implications for the Kingdom’s healthcare *** Saudi Arabian context analyses show that AI has increased the discreet prediction of diseases,resource management,and monitoring outbreaks during mass congregations such as ***,the study outlines critical areas for defining the potential for artificial intelligence and areas for enhancing digital development to support global healthcare *** key themes emerging from the review include Saudi Arabia:(i)the effectiveness of AI with human interaction for sustainable health services;(ii)conditions and quality control to enhance the quality of health care services using AI;(iii)environmental factors as influencing factors for public health care;(iv)Artificial Intelligence,and advanced decision-making technology for Middle Eastern health care *** policymakers,healthcare managers,and researchers who will engage with AI innovation,the review proclaims that AI applications should respect the country’s socio-cultural and ethical practices and pave the way for sustainable healthcare *** empirical research is needed on the implementation issues with AI,creating culturally appropriate models of AI,and finding new applications of AI to address the increasing demand for healthcare services in Saudi Arabia.

关键词： Artificial intelligence public health services sustainability healthcare Saudi Arabia PRISMA

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The Impacts of Climate Change on the Environment and Human health in China:A Call for more Ambitious Action

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Biomedical and Environmental Sciences 2025年第2期38卷 127-143页

作者： Shilu Tong Yu Wang Yonglong Lu Cunde Xiao Qiyong Liu Qi Zhao Cunrui Huang Jiayu Xu Ning Kang Tong Zhu Dahe Qin Ying Xu Buda Su Xiaoming Shi National Institute of Environmental health Chinese Center for Disease Control and PreventionBeijing 100021China School of Public health and Social Work Queensland University of TechnologyBrisbane 4001Australia State Key Laboratory of Marine Environmental Science and International Institute for Sustainability Science College of the Environment and EcologyXiamen UniversityXiamen 361102FujianChina State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal UniversityBeijing 100875China National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China School of Public health Shandong UniversityJinan 250012ShandongChina Vanke School of Public health Tsinghua UniversityBeijing 100084China Institute of Reproductive and Child health/National health Commission Key Laboratory of Reproductive health and Department of epidemiology and Biostatistics/Ministryof Education Key Laboratory of epidemiology of Major Diseases(PKU) School of Public HealthPeking University Health Science CentreBeijing 100191China SKL-ESPC&SEPKL-AERM Department of Environmental HealthCollege of Environmental Sciences and Engineering&Center for Environment and HealthPeking UniversityBeijing 100871China China Meteorological Administration Beijing 100081China National Climate Centre China Meteorological AdministrationBeijing 100081China Nanjing University of Information Science and Technology Nanjing 210044JiangsuChina Chinese Center for Disease Control and Prevention Beijing 102206China

As global greenhouse gases continue rising,the urgency of more ambitious action is clearer than ever *** is the world’s biggest emitter of greenhouse gases and one of the countries affected most by climate *** evidence about the impacts of climate change on the environment and human health may encourage China to take more decisive action to mitigate greenhouse gas emissions and adapt to climate impacts.

关键词： change. greenhouse climate

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