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世界核心医学期刊文摘（皮肤病学分册） 2006年第6期2卷 17-17页

作者： Gedicke M.M. Traupe H. Fischer B. H.C. Hennies 王琼 Division of Dermatogenetics Cologne Centre for Genomics University of Cologne Zülpicher Str. 47 50674 Cologne Germany

loricrin keratoderma is an autosomal dominant palmoplantar keratoderma heterogeneous in clinical appearance. We report a family with diffuse ichthyosis and honeycomb palmoplantar keratoderma but no occurrence of pseudoainhums or autoamputations. All patients were born as collodion babies and displayed prominent knuckle pads. We identified the previously reported mutation 730insG in lor, which elongates loricrin by 22 amino acids because of delayed termination. As pseudoainhums are missing in all patients of the family reported, we propose two compulsory features of loricrin keratoderma: (i) honeycomb palmoplantar keratoderma and (ii) diffuse ichthyosiform dermatosis. Therefore we suggest that the condition should be described clinically as ‘honeycom bpalmoplantar keratoderma with ichthyosis’. Furthermore, we have assessed the amounts of transcript of lor using pyrosequencing. This revealed an equal expression of mutant and wild-type alleles of lor in an affected individual. These findings further underline the gain-of-function theory for mutant lor in loricrin keratoderma.

关键词：掌跖角化病家系分析 G突变获得性文献回顾蛋白功能常染色体显性遗传性野生型等位基因作者分析皮肤角化病

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The Effect of Weather and Agronomic Practice on Deoxynivalenol Mycotoxin in Durum Wheat

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Journal of Life Sciences 2012年第5期6卷 513-517页

作者： Isabel Giménez Jacqueline Escobar Elena Ferruz Susana lorán Marta Herrera Teresa Juan Antonio Herrera Agustin Arino Department of Animal Production and Food Scienee University of Zaragoza Zaragoza 50013 Spain Fundaci6n Parque Cientifico Tecnol6gico Aula Dei (PCTAD) Zaragoza 50059 Spain Agri-Food Research and Technology Center (CITA) Zaragoza 50059 Spain

Deoxynivalenol (DON) produced by Fusarium graminearum and F. culmorum in durum wheat (Triticum turgidum L. var. durum) is an important food safety issue for the cereal chain. A number of agronomic practices are known to affect the infection and mycotoxin production by these Fusarium species in cereal grains. A field study was conducted to compare the natural occurrence of DON in durum wheat grown under conventional (n = 67 samples) and organic (n = 50) farming conditions during two consecutive crop years. DON mean levels were 95 and 194 μg/kg in conventional and organic durum wheat, respectively. The incidence and levels of DON were higher in the second crop year due to higher rainfall (> 100 mm) during flowering. Overall, organically managed farming system may provide some reduction in DON levels in durum wheat, which could be attributable to the lower intensity of cultivation in addition to the different system of cropping rotation. However, favourable weather conditions are likely to be more important for DON contamination than crop system.

关键词：脱氧雪腐镰刀菌烯醇硬粒小麦霉菌毒素农艺措施天气条件食品安全问题农业生产条件农业系统

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