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Advancing environmental toxicology In Vitro:From Immortalized Cancer Cell Lines to 3D Models Derived from Stem Cells

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Environment & Health 2024年第6期2卷 332-349页

作者： Hanyue Li Nuoya Yin Renjun Yang Francesco Faiola State Key Laboratory of environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China

In recent years,rapid industrial development has resulted in the production and exposure of a substantial number of compounds to the human *** has created an urgent need in environmental toxicology for models that are efficient,accurate,and cost-effective in evaluating the health impacts of these compounds on *** the past seven decades,various cancer cell lines and immortalized cell lines have made significant contributions to the advancement of research on organ *** stem cell technology,especially toxicological models derived from pluripotent stem cells,presents modern environmental toxicologists with high-throughput,species-relevant,and predictive *** this comprehensive review,we assess the characteristics of representative human cancer cell lines and immortalized cell lines in environmental toxicology,as well as introduce two distinct human pluripotent stem cell types and their innovative toxicological *** explore their applications and prospects in the field of environmental toxicology,while also addressing the readiness of in vitro models to confront the emerging challenges of the future.

关键词： environmental toxicology Pluripotent stem cells Cancer cell lines Immortalized cell lines 3D cell-based models

Nanomaterials-assisted laser desorption/ionization-TOF MS-based metabolomics and imaging analysis in research of environmental toxicology

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Nanomaterials-assisted laser desorption/ionization-TOF MS-ba...

Direct and rapid detection of serum amino acid and monoamine neurotransmitters to assist the diagnosis of panic disorder

第五届全国原子光谱及相关技术学术会议

作者： Zongwei Cai State Key Laboratory of environmental and Biological analysis Department of ChemistryHong Kong Baptist University

＜正＞Matrix-assisted laser desorption ionization time-of-flight mass spectrometry（MALDI-TOF MS）provides a powerful tool in the analysis of diverse molecules because of its high sensitivity,high-throughput analysis and simplicity of *** improve the signal of small molecules（＜500 Da）due to the interference of the matrix ions,various matrices,such as porous silicon,nanomaterials,polymers and carbon materials have been ***,for example,is a

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Science China Chemistry 2025年第01期 377-384页

作者： Shiwen Liu Xuerui Wan Meng Zhao Jiaqi Wang Weilan Wu Linlin You Yonggui Yuan Qian Xu Rong Gao Key Laboratory of environmental Medicine Engineering Ministry of Education School of Public Health Southeast University Key Laboratory of Modern toxicology of Ministry of Education Department of Hygienic Analysis and Detection School of Public HealthNanjing Medical University Department of Psychosomatics and Psychiatry Zhongda Hospital School of Medicine Southeast University

The measurement of amino acid and monoamine neurotransmitters（NTs） in serum plays a central role in the identification and monitoring of clinical panic disorder（PD）. However, the strong polarity and chemical heterogeneity of NTs make direct extraction and rapid detection extremely challenging. Herein, we developed a strategy that integrated solid phase extraction based on magnetic Fe3O4coated with polydopamine（Fe3O4@PDA） and direct analysis of mass spectrometry in real time（DART-MS） for quantification of 10 NTs. We systematically investigated the optimal conditions of this strategy to achieve good accuracy and precision. Compared with existing magnetic solid phase extraction methods for NTs detection in biological samples, this strategy could adsorb more targets while having similar adsorption efficiencies, and the total process time was reduced by an average of 69.42%. We rapidly determined the metabolic abnormality of 6 types of NTs in the serum of PD patients and demonstrated their diagnostic accuracy. In addition, an outstanding feature of PD in which tryptophan was more metabolized by the KYN pathway and the 5-hydroxytryptamine pathway was inhibited could be elucidated by this strategy. Our results highlighted the potential ability of Fe3O4@PDA coupled with DART-MS to assist in the clinical diagnosis of PD.

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Bioaugmentation of DDT-contaminated soil by dissemination of the catabolic plasmid pDOD

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Journal of environmental Sciences 2015年第1期27卷 42-50页

作者： Chunming Gao Xiangxiang Jin Jingbei Ren Hua Fang Yunlong Yu Institute of Pesticide and environmental toxicology College of Agriculture and Biotechnology Zhejiang University

A plasmid transfer-mediated bioaugmentation method for the enhancement of dichlorodiphenyltrichloroethane（DDT） degradation in soil was developed using the catabolic plasmid pDOD from Sphingobacterium sp. D-6. The p DOD plasmid could be transferred to soil bacteria, such as members of Cellulomonas, to form DDT degraders and thus accelerate DDT degradation. The transfer efficiency of pDOD was affected by the donor, temperature,moisture, and soil type. Approximately 50.7% of the DDT in the contaminated field was removed 210 days after the application of Escherichia coli TG I（pDOD-gfp）. The results suggested that seeding p DOD into soil is an effective bioaugmentation method for enhancing the degradation of DDT.

关键词： Dichlorodiphenyltrichloroethane Bioaugmentation Plasmid transfer Soil Green fluorescent protein

Biochar: A review of its impact on pesticide behavior in soil environments and its potential applications

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Journal of environmental Sciences 2016年第6期28卷 269-279页

作者： Mahdi Safaei Khorram Qian Zhang Dunli Lin Yuan Zheng Hua Fang Yunlong Yu Institute of Pesticide and environmental toxicology College of Agriculture and Biotechnology Zhejiang University

Biochar is produced from the pyrolysis of carbon-rich plant- and animal-residues under low oxygen and high temperature conditions and has been increasingly used for its positive role in soil compartmentalization through activities such as carbon sequestration and improving soil quality. Biochar is also considered a unique adsorbent due to its high specific surface area and highly carbonaceous nature. Therefore, soil amendments with small amounts of biochar could result in higher adsorption and, consequently, decrease the bioavailability of contaminants to microbial communities, plants, earthworms, and other organisms in the soil. However, the mechanisms affecting the environmental fate and behavior of organic contaminants, especially pesticides in biochar-amended soil, are not well understood. The purpose of this work is to review the role of biochar in primary processes, such as adsorption–desorption and leaching of pesticides. Biochar has demonstrable effects on the fate and effects of pesticides and has been shown to affect the degradation and bioavailability of pesticides for living organisms. Moreover, some key aspects of agricultural and environmental applications of biochar are highlighted.

关键词： Adsorption–desorption Bioavailability Biochars Degradation Earthworm Leaching

Modern Issues in Food Safety - A Perspective

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Journal of Integrative Agriculture 2012年第1期11卷 9-13页

作者： James N Seiber Department of environmental toxicology University of California

There is much current interest worldwide in food safety. This results in large part from well publicized outbreaks due to foodborne pathogens, chemical food safety related to pesticides, and from persistent organic po... 详细信息

关键词： Modern Issues in Food Safety A Perspective

Hollow TiO_2 spheres with improved visible light photocatalytic activity synergistically enhanced by multi-stimulative: Morphology advantage,carbonate-doping and the induced Ti^(3+)

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Journal of environmental Sciences 2018年第10期30卷 153-165页

作者： Guoliang Li Chunyang Liao Guibin Jiang State Key Laboratory of environmental Chemistry and Eco-toxicology Research Center for Eco-Environmental SciencesChinese Academy of Sciences

Great efforts have been devoted to improve the photocatalytic activity of TiO2 in the visible light region. Rational design of the external structure and adjustment of intrinsic electronic status by impurity doping are two main effective ways to achieve this purpose. A facile onepot synthetic approach was developed to prepare C-doped hollow TiO2 spheres, which simultaneously realized these advantages. The synthesized TiO2 exhibits a mesoporous hollow spherical structure composed of fine nanocrystals, leading to high specific surface area（~180 m^2/g） and versatile porous texture. Carbonate-doping was achieved by a postthermal treatment at a relatively low temperature（200°C）, which makes the absorption edge red-shifted to the visible region of the solar spectrum. Concomitantly, Ti^（3＋） induced by C-doping also functions in improving the visible-light photocatalytic activity by reducing the band gap. There exists a synergistic effect from multiple stimulatives to enhance the photocatalytic effect of the prepared TiO2 catalyst. It is not out of expectation that the asprepared C-doped hollow TiO2 spheres exhibits an improved photocatalytic activity under visible light irradiation in organic pollutant degradation.

关键词： Hollow TiO2 sphere Carbonate Ti^3+ Visible light Photo-degradation Synergistic enhancement

Cadmium in soybeans and the relevance to human exposure

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Journal of environmental Sciences 2015年第11期27卷 157-162页

作者： Ashley M.Newbigging Xiaowen Yan X.Chris Le Division of Analytical and environmental toxicology Department of Laboratory Medicine and Pathology University of Alberta

Introduction Cadmium is considered a human carcinogen by the International Agency for Research on Cancer（IARC,1993）and the US National toxicology Program（NTP,1997）.Cadmium contamination of food crops is a persistent issue for both the agricultural industry as well as *** is an issue for agriculture because cadmium can be present in soils naturally or as a result of industrial processes and can contaminate foods that are consumed by ***

关键词： Cadmium Metals Food safety Dietary exposure Agricultural products Uptake of cadmium from soil

Consumption of rice and fish in an electronic waste recycling area contributes significantly to total daily intake of mercury

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Journal of environmental Sciences 2015年第12期27卷 83-86页

作者： Hanyong Peng Michael S.Reid X.Chris Le Division of Analytical and environmental toxicology Department of Laboratory Medicine and PathologyUniversity of Alberta

Mercury is a global pollutant due to its widespread use,emission,and long-range transport（Blum,2013;Pacyna et al.,2010）.It is considered a priority pollutant due to its neurological toxicity,persistence,and bioaccumulation（Pacyna et al.,2010;Sharma et al.,2015）.Mercury pollution can occur when products that contain mercury are improperly disposed of and mercury is released into the air,water,and soil（Zhang and Wong,2007）.An estimated 22%of the annual world usage of mercury is in electrical equipment such as batteries,thermometers,and discharge lamps,and electronic devices such as monitors and

关键词： Mercury Methyl mercury Electronic waste Biomonitoring Dietary intake Human exposure assessment environmental health