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Hydroxyl radicals induced by quartz particles in lung alveolar macrophages: the role of surface iron

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Progress in Natural Science:Materials International 2006年第10期16卷 1038-1044页

作者： LI Yi, ZHU Tong, GUO Xinbiao and SHANG Yu ( State Key Joint laboratory for environmental Simulation & Pollution Control, Peking University, Beijing 100871, China Occupational & environmental health Sciences, School of Public health, Peking University health Science Center, Beijing 100083, China) State Key Joint laboratory for environmental Simulation and Pollution Control Peking University Beijing 100871 China Occupational and environmental health Sciences School of Public Health Peking University Health Science Center Beijing 100083 China

Previous studies have shown that hydroxyl radical generation is a key step in the mechanism of pathogenic process caused by airborne particles to the lung. However, there is no direct evidence for dose-response relationship between airborne particles and hydroxyl radical generation. In this study, hydroxyl radicals generated in lung alveolar macrophages exposed to quartz particles were measured using a highly sensitive capillary electrophoresis-fluorescence detection method. The results demonstrated that quartz particles induced the generation of hydroxyl radical in a dose-dependent manner, and the amount of the hydroxyl radicals was 10-10 mol/10 cells. The viability of alveolar macrophages exposed to quartz particles decreased with the increase of quartz concentration, showing a clear dose-response relationship. Hydroxyl radical scavenger mannitol could increase the viability of quartz-treated cells, suggesting that hydroxyl radical contributed directly to cell death. In this study this contribution accounted for about 5%-20% of cell death. The hydroxyl radical generating potential was found to be related to surface iron content of the quartz particles.

关键词： inhalable quartz hydroxyl radical capillary electrophoresis dose-response relationship iron.

Advances and perspectives in environmental health research in China

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Frontiers of environmental Science & Engineering 2024年第6期18卷 105-113页

作者： Tong Zhu Yingjun Liu Shunqing Xu Guanghui Dong Cunrui Huang Nan Sang Yunhui Zhang Guanyong Su Jingwen Chen Jicheng Gong Guohua Qin Xinghua Qiu Jing Shang Haobo Wang Pengpeng Wang Mei Zheng SKL-ESPC&SEPKL-AERM Department of Environmental HealthCollege of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China Center for Environment and health Peking UniversityBeijing 100871China School of Life and health Sciences Huainan UniversityHaikou 570228China Joint International Research laboratory of Environment and health(Ministry of Education) Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk AssessmentDepartment of Occupational and Environmental HealthSchool of Public HealthSun Yat-sen UniversityGuangzhou 510080China Vanke School of Public health Tsinghua UniversityBeijing 100084China Research Center of Environment and health College of Environment and ResourceShanxi UniversityTaiyuan 030006China Department of environmental health School of Public HealthFudan UniversityShanghai 200032China School of environmental and Biological Engineering Nanjing University of Science and TechnologyNanjing 210094China Key laboratory of Industrial Ecology and environmental Engineering(Ministry of Education) Dalian Key Laboratory on Chemicals Risk Control and Pollution Prevention TechnologySchool of Environmental Science and TechnologyDalian University of TechnologyDalian 116024China Department of Occupational and environmental health College of Public HealthZhengzhou UniversityZhengzhou 450001China

environmental health research aims to identify environmental conditions suitable for the healthy living and reproduction of human *** the interdisciplinary research bridging environmental sciences and health/medical sciences,the impacts of physical,chemical,and biological environmental factors on human health are *** includes identifying environmental factors detrimental to human health,evaluating human exposure characteristics to environmental factors,clarifying causal relationships between environmental exposure and health effects,analyzing the underlying biochemical mechanisms,linking environmental factors to the onset and progression of diseases,establishing exposure-response relationships,and determining effect ***,the results of environmental health research can serve as a scientific basis for formulating environmental management strategies and guiding prevention and intervention measures at both the public and individual *** paper summarizes the recent advances and future perspectives of environmental health research in China,as reported by a group of Chinese scientists who recently attended a workshop in Hainan,*** it is not intended to provide a comprehensive review of this expansive field,it offers a glimpse into the significant progress made in understanding the health impacts of environmental factors over the past *** ahead,it is imperative not only to sustain efforts in studying the health effects of traditional environmental pollution,but also to prioritize research on the health impacts of emerging pollutants and climate change.

关键词： environmental pollution Emerging pollutants Climate change Exposure Mechanism

Association of Urinary Strontium Levels with Pregnancy-induced Hypertension

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Current Medical Science 2021年第3期41卷 535-541页

作者： Yi TANG Wei XIA Shun-qing XU Hong-xiu LIU Yuan-yuan LI Key laboratory of Environment and health(HUST) Ministry of Education&Ministry of Environmental Protectionand State Key Laboratory of Environmental Health(Incubation)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Pregnancy-induced hypertension(PIH),including gestational hypertension and preeclampsia,accounts for the majority of maternal and perinatal morbidity and ***(Sr)has been recently associated with preeclampsia in a small group of women;however,the role of Sr in PIH is not fully understood and warrants further *** this study,we examined the association between urinary Sr levels and PIH,and assessed the effect of maternal age on the *** Sr concentrations were measured in 5423 pregnant women before delivery by inductively coupled plasma mass spectrometry(ICP-MS).Logistic regression analysis adjusting for potential confounders was applied to explore the association between Sr and PIH,and to evaluate the Sr-PIH relationship stratified by maternal *** the participants,200(3.83%)women were diagnosed with *** with non-PIH women,women who developed PIH had lower urinary Sr concentrations(131.26 us.174.98μg/L creatinine,P<0.01).With the natural log-transformed urinary creatinine-standardized Sr concentrations increasing,the risk of PIH decreased significantly[adjusted OR=0.60(95%CI:0.51,0.72)].Furthermore,the significant association of Sr with PIH was found among women under 35 years(P<0.01).Our finding suggested that Sr may play a potential protective role in the pathogenesis of PIH,especially among young pregnant women under 35 years old.

关键词： strontium pregnancy hypertension maternal age trace elements

2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes migration ability of primary cultured rat astrocytes via aryl hydrocarbon receptor

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Journal of environmental Sciences 2019年第2期31卷 368-376页

作者： Yangsheng Chen Rui Sha Li Xu Yingjie Xia Yiyun Liu Xuejun Li Heidi Qunhui Xie Naijun Tang Bin Zhao State Key laboratory of environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of Sciences University of Chinese Academy of Sciences Department of Occupational and environmental health sTianjin Medical University

Emerging evidence showed that 2,3,7,8-Tetrachlorodibenzo-p-dioxin(TCDD) could induce expression of certain reactivation-associated genes in astrocytes, however, the consequent cellular effects and molecular mechanisms are still unclear. During the process of astrocyte reactivation, migration is a critical cellular event. In the present study, we employed woundhealing assay and Transwell? motility assay to explore the effects of TCDD on cell migration in primary cultured rat cortical astrocytes. We found that upon TCDD treatments at relative low concentrations(10^(-10) and/or 10^(-9) mol/L), the ability of primary astrocytes to migrate horizontally and vertically was promoted. In line with this cellular effect, the mR NA expression of two promigratory genes, including cell division cycle 42(CDC42) and matrix metalloproteinase 2(MMP2)was induced by TCDD treatment. Dioxin exerts its toxic effects mainly through aryl hydrocarbon receptor(AhR) pathway. So the role of AhR pathway in the pro-migratory effects of TCDD was examined using an AhR antagonist, CH223191. We found that application of CH223191 significantly reversed the pro-migratory effects of TCDD. Interestingly, the basal ability of horizontal migration as well as basal levels of CDC42 and MMP2 expression were dramatically reduced suggesting a possible physiological role of AhR in maintaining the endogenous migration ability of the primary astrocytes. These findings support the notion that dioxin promotes astrocyte reactivation at molecular and cellular levels.

关键词： 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Astrocyte Migration Gene expression Aryl hydrocarbon receptor (AhR) pathway

Brominated flame retardants in surface sediment from Western Guangdong,South China:Occurrence,distribution and toxicity in Caenorhabditis elegans

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Journal of environmental Sciences 2024年第11期145卷 97-106页

作者： Xiaoxia Chen Ping Ding Haibo Chen Tingzhen Li Min Zhang Yunjiang Yu Guocheng Hu State environmental Protection Key laboratory of environmental Pollution health Risk Assessment South China Institute of Environmental SciencesMinistry of Ecology and EnvironmentGuangzhou 510655China Institute for environmental pollution and health School of Environmental and Chemical EngineeringShanghai UniversityShanghai 200444China Chongqing Key laboratory of Water Environment Evolution and Pollution Control in Three Gorges Reservoir Chongqing Three Gorges UniversityChongqing 404000China

Sediment is the ultimate sink of environmental pollutants.A total of 128 surface sediment sampleswere collected from8 rivers and 3 reservoirs in Maoming City,Guangdong *** study assessed the content and distribution of brominated flame retardants in *** acute toxicity effects of tetrabromobisphenol A(TBBPA)and hexabromocyclododecane(HBCDs)in sediments were evaluated using Caenorhabditis elegans as model *** concentration of TBBPA in sediments ranged from not detected(ND)to 12.59μg/kg andwas mainly distributed in the central area,whichwas affected by the emission of TBBPA from residential and *** concentration of HBCDs ranged from ND to 6.31μg/kg,and the diastereoisomer distribution was consistent,showing a trend close to the South China *** composition pattern of HBCDs in the surface sediments from rivers were 41.73%-62.33%,7.89%-25.54%,and 18.76%-40.65%forα-,β-,andγ-HBCD,respectively,and in the sediments from reservoirs were 26.15%-45.52%,7.44%-19.23%,and 47.04%-61.89%forα-,β-,andγ-HBCD,*** the sum of concentrations of TBBPA and HBCD in sediments were above high levels,reactive oxygen species in nematodes significantly increased,resulting in an oxidative stress *** permeabilitywas also enhanced,causing intestinal *** addition,in terms of this study,TBBPA had a greater impact on biotoxicity compared to HBCDs,and more attention should be paid to the toxic effects of the river ecosystem organisms in Maoming City,Guangdong *** study can complement the pollution database in the study area and provide basic data for pollution control.

关键词： Tetrabromobisphenol A(TBBPA) Hexabromocyclododecane(HBCDs) Sediment Caenorhabditis elegans Biotoxicity

Highly stable and antifouling graphene oxide membranes prepared by bio-inspired modification for water purification

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Chinese Chemical Letters 2020年第10期31卷 2651-2656页

作者： Weiming Zhong Yuyu Zhang Ling Zhao Wanbin Li Guangdong Key laboratory of environmental Pollution and health School of EnvironmentJinan UniversityGuangzhou 511443China

Graphene oxide(GO)membranes show great potential in molecular separation for water ***,the inferior stability of GO membranes is a major bottleneck for practical *** this study,bio-inspired polydopamine(PDA)deposition is reported for enhancing the stability of GO *** simple and mild immersion,PDA is self-polymerized on GO *** blocking of PDA chains to membrane defects improves the rejections for various *** the inherently strong adhesion and crosslinking of PDA greatly strengthen the interactions of substrates to GO layers and the binding force of GO nanosheets,the prepared PDA-GO membranes exhibit impressive long-te rm stability in cross-flow filtration,and maintain good nanofiltration perfo rmance at various feed pressures,tangential velocities,and eve n after external ***,because the deposited PDA layers obstruct the direct contact between GO and contaminants,the antifouling property of the PDA-GO membranes increases substantially,with recovery ratio about 98%.

关键词： Graphene oxide Nanofiltration Polydopamine Stability Antifouling

Estrogenic activities of two synthetic pyrethroids and their metabolites

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Journal of environmental Sciences 2010年第2期22卷 290-296页

作者： Meiqing Jin Ling Li Chao Xu Yuezhong Wen Meirong Zhao MOE Key laboratory of environmental Remediation and Ecosystem health College of Environmental and Resource Sciences Zhejiang University Hangzhou 310027 China Research Center of environmental Science College of Biological and Environmental Engineering Zhejiang University of Technology Hangzhou 310032 China

Synthetic pyrethroids （SPs） are among the most common pesticides in current use, and so far, several SPs have been assessed for their potential estrogenicities by various methods. Previous studies have shown that the estrogenicities partly come from their metabolites. Although considerable information is available with respect to the metabolism and environmental degradation of SPs, little is known about the estrogenicities of the metabolites. In this study, permethrin （PM） and β-cypermethrin （CP）, as well as their metabolites （3-phenoxybenzoic alcohol （PBCOH）, 3-phenoxybenzaldehyde （PBCHO） and 3-phenoxybenzoic acid （PBCOOH） were evaluated for their estrogenic activities in the MCF-7 human breast carcinoma cell line. In the MCF-7 cell proliferation assay, PM and CP exhibited significant estrogenic activities at 10-7 mol/L, comparable to 17β-estradiol （E2） of 10-9 tool/L, with the relative proliferative effect ratios of 55.4% and 56.3%, respectively. The real-time quantitative polymerase chain reaction （qRT-PCR） results confirmed the estrogenicities of PM and CP with significant alteration of pS2 and ERα mRNA levels observed at 10-6 mol/L. For the three major metabolites, PBCOH and PBCOOH exhibited estrogenic activities in all assays, while no significant estrogenic responses was observed for PBCHO compared to the vehicle control. In particular, PBCOH had even slightly stronger estrogenic activity than its parent compounds, indicating that metabolism may be one of the reasons for the estrogenicities of the SPs. Given the widespread use of SPs, the toxicological effects of parent compounds and their metabolites should be taken into consideration in the risk assessment of SPs.

关键词： pyrethroids metabolites cell proliferation gene expression estrogenic activity

Ligand-mediated contaminant degradation by bare and carboxymethyl cellulose-coated bimetallic palladium-zero valent iron nanoparticles in high salinity environments

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Journal of environmental Sciences 2019年第3期31卷 303-311页

作者： Xiaoming Ma Di He Adele M.Jones T.David Waite Taicheng An Institute of environmental health and Pollution Control Guangdong University of Technology Guangzhou Key laboratory of environmental Catalysis and Pollution Control School of Environmental Science and Engineering Guangzhou University of Technology School of Civil and environmental Engineering University of New South Wales

The application of nanoscale zero-valent iron(nZVI) for the degradation of contaminants has been extensively investigated, however, few studies have focused on degradation in high salinity environments. In this study, the ability of bare and carboxymethyl cellulose(CMC)-coated bimetallic Pd-nZVI particles to degrade 33′44′-tetrachlorobiphenyl in high saline water(SW) is examined with particular attention given to the effects of ethylenediaminetetraacetic acid(EDTA) on the rate of degradation. EDTA enhances the reactivity of Pd-nZVI in SW, with evidence provided to link this to the removal of the passivating layer. Additionally, a conceptual model is proposed which provides a quantitative description of the removal of these iron oxide layers in the presence of EDTA. An optimum EDTA to bare Pd-nZVI molar ratio of 0.1 exists, with insufficient EDTA unable to remove the passivating layer whilst excess EDTA results in Fe loss and enhanced agglomeration due to magnetic attraction of the bare Fe(0) particles. In contrast, CMCcoating of Pd-nZVI assemblages actually impedes degradation, despite the coated particles displaying a smaller average size compared to uncoated particles, with even the presence of EDTA in this case not significantly improving degradation. The reduced reactivity in the presence of CMC is primarily attributed to the effect of CMC on the association of Pd with nZVI particles. In particular, the presence of CMC reduced the total amount of Pd incorporated with the stabilized particles compared to the non-stabilized ***, the presence of CMC results in less Pd present in its reactive zero-valent oxidation state.

关键词： Bimetallic zero valent iron ligand-mediated depassivation polychlorinated biphenyls high salinity water

Organophosphate esters in sediment from Taihu Lake,China:Bridging the gap between riverine sources and lake sinks

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Frontiers of environmental Science & Engineering 2022年第3期16卷 35-47页

作者： Wenping Zhang Changsheng Guo Jiapei Lv Xu Li Jian Xu State Key laboratory of environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China State environmental Protection Key laboratory of Ecological Effect and Risk Assessment of Chemicals Chinese Research Academy of Environmental SciencesBeijing 100012China Center for environmental health Risk Assessment and Research Chinese Research Academy of Environmental SciencesBeijing 100012China

Surface sediment samples from Taihu Lake in China and its inflow rivers,along with two lake sediment core samples,were collected and analyzed for organophosphate esters(OPEs).The concentrations of total OPEs varied from 28.60 ng/g to 158.72 ng/g(median:54.25 ng/g)in river surface sediment and from 62.57 ng/g to 326.84 ng/g(median:86.37 ng/g)in lake *** phosphate(TnBP)was the predominant compound in river surface sediment,and tris(2-butoxyethyl)phosphate was predominant in lake *** contamination occurred in the north-west region,which was related to the high level of urbanization and high usage of *** sediment–water partition coefficients of OPEs(log_(Koc))were calculated,showing a significant correlation with logKow(p<0.05).The concentration and composition of OPEs in two sediment cores varied due to the different sampling locations,with more OPE species found in the northern region than in the southern *** component analysis and positive matrix factorization indicated that sewage discharges,vehicle emissions,and atmospheric deposition were the possible sources of OPEs in Taihu Lake ***(1-chloro-2-propyl)phosphate,tris(2-chloroethyl)phosphate,and TnBP were the main OPEs causing ecological risks.

关键词： Organophosphate esters Partition Vertical distribution Composition profile Positive matrix factorization