检索结果-南通市图书馆

Variations in terrestrial oxygen sources under climate change

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2022年第9期65卷 1810-1823页

作者： Lei DING Jianping HUANG Changyu LI Dongliang HAN Xiaoyue LIU Haiyun LI Yan BAI Jiping HUANG College of Atmospheric Sciences Lanzhou UniversityLanzhou 730000China Collaborative Innovation center for Western Ecological Safety Lanzhou UniversityLanzhou 730000China enlightening bioscience research center Mississauga L4X 2X7Canada

The terrestrial ecosystem is an important source of atmospheric oxygen, and its changes are closely related to variations in atmospheric oxygen level. However, few studies have focused on the characteristics and driving forces behind terrestrial ecosystem oxygen sources. In this study, based on observations and net carbon flux simulations from the Sixth Coupled Model Intercomparison Project, we investigated temporal and spatial variations in terrestrial oxygen sources. As the largest source of atmospheric oxygen, the terrestrial ecosystem can produce approximately 7.10±0.38 gigatons of oxygen per year, and the tropics are the main oxygen producing regions. Notably, there are many “non-oxygen-producing lands”, where the lands no longer provide oxygen to the atmosphere, located in the high latitudes and around the deserts of Central Asia. Long-term analysis reveals that anthropogenic activities and climate change are responsible for the variations in terrestrial oxygen sources owing to land-use changes and competing effects between net photosynthesis and heterotrophic respiration. By 2100, more oxygen will be produced from the low-middle latitudes, while the high latitudes will serve as a larger oxygen sink due to extreme land-use type changes and drastic increases in soil respiration. Through this study, we supplement the understanding of the modern oxygen cycle and help provide better estimates for future variations in atmospheric oxygen level.

关键词： Oxygen cycle Terrestrial ecosystem CMIP6 Anthropogenic forcing Climate change

The Variability of Air-sea O_(2)Flux in CMIP6:Implications for Estimating Terrestrial and Oceanic Carbon Sinks

在线全文

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2022年第8期39卷 1271-1284,I0024-I0026页

作者： Changyu LI Jianping HUANG Lei DING Yu REN Linli AN Xiaoyue LIU Jiping HUANG College of Atmospheric Sciences Lanzhou UniversityLanzhou 730000China Collaborative Innovation center for Western Ecological Safety Lanzhou UniversityLanzhou 730000China enlightening bioscience research center MississaugaL4X 2X7Canada

The measurement of atmospheric O_(2)concentrations and related oxygen budget have been used to estimate terrestrial and oceanic carbon ***,a discrepancy remains in assessments of O_(2)exchange between ocean and atmosphere(***-sea O_(2)flux),which is one of the major contributors to uncertainties in the O_(2)-based estimations of the carbon ***,we explore the variability of air-sea O_(2)flux with the use of outputs from Coupled Model Intercomparison Project phase 6(CMIP6).The simulated air-sea O_(2)flux exhibits an obvious warming-induced upward trend(~1.49 Tmol yr−2)since the mid-1980s,accompanied by a strong decadal variability dominated by oceanic climate *** subsequently revise the O_(2)-based carbon uptakes in response to this changing air-sea O_(2)*** results show that,for the 1990−2000 period,the averaged net ocean and land sinks are 2.10±0.43 and 1.14±0.52 GtC yr−1 respectively,overall consistent with estimates derived by the Global Carbon Project(GCP).An enhanced carbon uptake is found in both land and ocean after year 2000,reflecting the modification of carbon cycle under human *** derived from CMIP5 simulations also investigated in the study allow for comparisons from which we can see the vital importance of oxygen dataset on carbon uptake estimations.

关键词： air-sea O_(2)flux carbon budget land and ocean carbon sinks CMIP6

BCI induces apoptosis via generation of reactive oxygen species and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2018年第10期61卷 1243-1253页

作者： Jong-Woon Shin Sae-Bom Kwon Yesol Bak Sang-Ku Lee Do-Young Yoon Department of bioscience and Biotechnology Konkuk University Targeted Medicine research center Korea Research Institute of Bioscience and Biotechnology (KRIBB)

The compound(E)-2-benzylidene-3-(cyclohexylamino)-2,3-dihydro-1 H-inden-1-one(BCI) is known as an inhibitor of dual specific phosphatase 1/6 and mitogen-activated protein kinase. However, its precise anti-lung cancer mechanism remains unknown. In this study, the effects of BCI on the viability of non-small cell lung cancer cell lines NCI-H1299, A549, and NCI-H460 were evaluated. We confirmed that BCI significantly inhibited the viability of p53(-) NCI-H1299 cells as compared to NCI-H460 and A549 cells, which express wild-type p53. Furthermore, BCI treatment increased the level of cellular reactive oxygen species and pre-treatment of cells with N-acetylcysteine markedly attenuated BCI-mediated apoptosis of NCI-H1299 cells. BCI induced cellular morphological changes, inhibited viability, and produced reactive oxygen species in NCI-H1299 cells in a dose-dependent manner. BCI induced processing of caspase-9, caspase-3, and poly ADP-ribose polymerase as well as the release of cytochrome c from the mitochondria into the cytosol. In addition, BCI downregulated Bcl-2 expression and enhanced Bax expression in a dose-dependent manner in NCI-H1299 cells. However, BCI failed to modulate the expression of the death receptor and extrinsic factor caspase-8 and Bid, a linker between the intrinsic and extrinsic apoptotic pathways in NCI-H1299 cells. Thus, BCI induces apoptosis via generation of reactive oxygen species and activation of the intrinsic pathway in NCI-H1299 cells.

关键词： non-small cell lung cancer apoptosis BCI cytotoxicity anticancer ROS

Mitochondrial Ca^(2+) uptake in skeletal muscle health and disease

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2016年第8期59卷 770-776页

作者： Jingsong Zhou Kamal Dhakal Jianxun Yi Kansas City University of Medicine and bioscience Dybedal Research Center

Muscle uses Ca2＋ as a messenger to control contraction and relies on ATP to maintain the intracellular Ca2＋ homeostasis. Mi- tochondria are the major sub-cellular organelle of ATP production. With a negative inner membrane potential, mitochondria take up Ca2＋ from their surroundings, a process called mitochondrial Ca2＋ uptake. Under physiological conditions, Ca2＋ uptake into mitochondria promotes ATP production. Excessive uptake causes mitochondrial Ca2＋ overload, which activates down- stream adverse responses leading to cell dysfunction. Moreover, mitochondrial Ca2＋ uptake could shape spatio-temporal pat- terns of intracellular Ca〉 signaling. Malfunction of mitochondrial Ca2＋ uptake is implicated in muscle degeneration. Unlike non-excitable cells, mitochondria in muscle cells experience dramatic changes of intracellular Ca2＋ levels. Besides the sudden elevation of Ca2＋ level induced by action potentials, Ca2＋ transients in muscle cells can be as short as a few milliseconds during a single twitch or as long as minutes during tetanic contraction, which raises the question whether mitochondrial Ca2＋ uptake is fast and big enough to shape intracellular Ca2＋ signaling during excitation-contraction coupling and creates technical challeng- es for quantification of the dynamic changes of Ca2＋ inside mitochondria. This review focuses on characterization of mito- chondrial Ca2＋ uptake in skeletal muscle and its role in muscle physiology and diseases.

关键词： skeletal muscle mitochondria Ca2+

Estimation of Gridded Atmospheric Oxygen Consumption from 1975 to 2018

在线全文

学校读者我要写书评

暂无评论

Journal of Meteorological research 2020年第3期34卷 646-658页

作者： Xiaoyue LIU Jianping HUANG Jiping HUANG Changyu LI Lei DING Wenjun MENG Collaborative Innovation center for Western Ecological Safety Lanzhou UniversityLanzhou 730000China enlightening bioscience research center Mississauga L4X 2X7Canada Laboratory for Earth Surface Processes College of Urban and Environmental SciencesPeking UniversityBeijing 100871China

Atmospheric Oxygen(O2)is one of the dominating features that allow the earth to be a habitable planet with advanced civilization and diverse ***,since the late 1980 s,observational data have indicated a steady decline in O2 content on the scale of parts-per-million *** current scientific consensus is that the decline is caused by the fossil-fuel combustion;however,few works have been done to quantitatively evaluate the response of O2 cycle under the anthropogenic impact,at both the global and regional *** paper manages to quantify the land O2 flux and makes the initial step to quantificationally describe the anthropogenic impacts on the global O2 *** estimation reveals that the global O2 consumption has experienced an increase from 33.69±1.11 to47.63±0.80 Gt(gigaton,109 t)O2yr^-1 between 2000 and 2018,while the land production of O2(totaling 11.34±13.48 Gt O2yr^-1 averaged over the same period)increased only *** 2018,the combustion of fossil-fuel and industrial activities(38.45±0.61 Gt O2yr^-1)contributed the most to consumption,followed by wildfires(4.97±0.48 Gt O2yr^-1)as well as livestock and human respiration processes(2.48±0.16 and 1.73±0.13 Gt O2yr^-1,respectively).Burning of fossil-fuel that causes large O2 fluxes occurs in East Asia,India,North America,and Europe,while wildfires that cause large fluxes in comparable magnitude are mainly distributed in central Africa.

关键词： oxygen(O2)cycle climate change anthropogenic activities

Marine Metagenome as A Resource for Novel Enzymes

在线全文

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2015年第5期13卷 290-295页

作者： Amani D.Alma'abadi Takashi Gojobori Katsuhiko Mineta Computational bioscience research center (CBRC) King Abdullah University of Science and Technology (KAUST)

More than 99% of identified prokaryotes, including many from the marine environment, cannot be cultured in the laboratory. This lack of capability restricts our knowledge of microbial genetics and community ecology. Metagenomics, the culture-independent cloning of environmental DNAs that are isolated directly from an environmental sample, has already provided a wealth of information about the uncultured microbial world. It has also facilitated the discovery of novel bio- catalysts by allowing researchers to probe directly into a huge diversity of enzymes within natural microbial communities. Recent advances in these studies have led to a great interest in recruiting microbial enzymes for the development of environmentally-friendly industry. Although the metage- nomics approach has many limitations, it is expected to provide not only scientific insights but also economic benefits, especially in industry. This review highlights the importance of metagenomics in mining microbial lipases, as an example, by using high-throughput techniques. In addition, we dis- cuss challenges in the metagenomics as an important part of bioinformatics analysis in big data.

关键词： Microbial diversity Culture-independent studies Catalysis Lipase Biotechnology

HBx-induced reactive oxygen species activates hepatocellular carcinogenesis via dysregulation of PTEN/Akt pathway

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第39期16卷 4932-4937页

作者： Hye-Lin Ha Dae-Yeul Yu Disease Model research Laboratory Aging Research CenterKorea Research Institute of Bioscience and Biotechnology Department of Functional Genomics University of Science and Technology

AIM:To investigate the role of hepatitis B virus X-protein(HBx)-induced reactive oxygen species(ROS)on liver carcinogenesis in HBx transgenic mice and HepG2-HBx ***:Cell growth rate was analyzed,and through western blotting,mitogenic signaling was *** ROS from wild and HBx transgenic mice and HepG2-Mock and HBx cells were assayed by *** of oxidized and reduced phosphatase and tensin homolog(PTEN)was analyzed through N-ethylmaleimide alkylation,nonreducing ***:We observed that the cell-proliferation-related phosphoinositide 3-kinase/Akt pathway is activated by HBx in vivo and in *** ROS were detected by *** suppressor PTEN,via dephosphorylation of Akt,was oxidized and inactivated by increased *** oxidized PTEN activated the mitogenic pathway through over-activated ***,treatment with ROS scavenger N-acetyl cysteine can reverse PTEN to a reduced *** produced ROS also stimulated HBx ***:HBx induced ROS promoted Akt pathways via oxidized inactive *** and ROS maintained a positive regulatory loop,which aggravated carcinogenesis.

关键词： Hepatitis B virus X protein Hepatocellular carcinoma Akt Reactive oxygen species Phosphatase and tensin homolog

KoNA:Korean Nucleotide Archive as A New Data Repository for Nucleotide Sequence Data

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2024年第1期22卷 161-167页

作者： Gunhwan Ko Jae Ho Lee Young Mi Sim Wangho Song Byung-Ha Yoon Iksu Byeon Bang Hyuck Lee Sang-Ok Kim Jinhyuk Choi Insoo Jang Hyerin Kim Jin Ok Yang Kiwon Jang Sora Kim Jong-Hwan Kim Jongbum Jeon Jaeeun Jung Seungwoo Hwang Ji-Hwan Park Pan-Gyu Kim Seon-Young Kim Byungwook Lee Korea Bioinformation center Korea Research Institute of Bioscience&BiotechnologyDaejeon 34141Republic of Korea

During the last decade,the generation and accumulation of petabase-scale high-throughput sequencing data have resulted in great challenges,including access to human data,as well as transfer,storage,and sharing of enormous amounts of *** promote data-driven biological research,the Korean government announced that all biological data generated from government-funded research projects should be deposited at the Korea BioData Station(K-BDS),which consists of multiple databases for individual data ***,we introduce the Korean Nucleotide Archive(KoNA),a repository of nucleotide sequence *** of July 2022,the Korean Read Archive in KoNA has collected over 477 TB of raw next-generation sequencing data from national genome *** ensure data quality and prepare for international alignment,a standard operating procedure was adopted,which is similar to that of the International Nucleotide Sequence Database *** standard operating procedure includes quality control processes for submitted data and metadata using an automated pipeline,followed by manual *** ensure fast and stable data transfer,a high-speed transmission system called GBox is used in ***,the data uploaded to or downloaded from KoNA through GBox can be readily processed using a cloud computing service called *** seamless coupling of KoNA,GBox,and Bio-Express enhances the data experience,including submission,access,and analysis of raw nucleotide *** not only satisfies the unmet needs for a national sequence repository in Korea but also provides datasets to researchers globally and contributes to advances in *** KoNA is available at https://***/kona/.

关键词： Korea BioData Station Nucleotide sequence Next-generation sequencing repository Genomics Deposition and access of big data

SMALL ORGAN SIZE 1 and SMALL ORGAN SIZE 2/DWARF AND LOW-TILLERING Form aComplex to Integrate Auxin and Brassinosteroid Signaling in Rice

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2017年第4期10卷 590-604页

作者： Ko Hirano Hideki Yoshida Koichiro Aya Mayuko Kawamura Makoto Hayashi Tokunori Hobo Karma Sato-lzawa Hidemi Kitano Miyako Ueguchi-Tanaka Makoto Matsuoka bioscience and Biotechnology center Nagoya University Nagoya 464-8601 Japan

Although auxin and brassinosteroid （BR） synergistically control various plant responses, the molecular mechanism underlying the auxin-BR crosstalk is not wen understood. We previously identified SMOS1, an auxin-regulated APETALA2-type transcription factor, as the causal gene of the small organ size 1 （smosl） mutant that is characterized by a decreased final size of various organs in rice. In this study, we identified another smos mutant, smos2, which shows the phenotype indistinguishable from smosl. SMOS2 was identical to the previously reported DWARF AND LOWoTILLERING （DLT）, which encodes a GRAS protein involved in BR signaling. SMOS1 and SMOS2/DLT physically interact to cooperatively enhance transcriptional transactivation activity in yeast and in rice nuclei. Consistently, the expression of OsPHI-1, a direct target of SMOS1, is upregulated only when SMOS1 and SMOS2/DLT proteins are both present in rice ceils. Taken together, our results suggest that SMOS1 and SMOS2/DLT form a keystone complex on auxin-BR signaling crosstalk in rice.

关键词： auxin brassinosteroid crosstalk rice transcription factor