检索结果-南通市图书馆

Chinese Chemical Letters 2022年第5期33卷 2537-2540页

作者： Chuanhao Liu Lin Zhou Lijuan Xie Ying Zheng Huizi Man Yi Xiao Engineering Research Center of Molecular Medicine of Ministry of Education Key Laboratory of Fujian Molecular MedicineSchool of MedicineHuaqiao UniversityQuanzhou 362021China State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116024China

To test the hypothesis that the microviscosity changes of Endoplasmic Reticulum(ER)can be a useful indicator of ferroptosis promoted by ER Stresses(ERS),a new ER targeting viscosity rotor,L-Vis-1 was developed and applied in the quantitation of viscosity by FLIM imaging in live cells.The FLIM imag-ing exhibited an excellent resolution almost as good as the corresponding confocal imaging,more sig-nificantly,during ferroptosis processes promoted by different types of ERS,the viscosity increases were clearly monitored by FLIM of L-Vis-1 within ER,which has not been demonstrated before.

关键词： Ferroptosis Viscosity FLIM ERS Rotor

Rhodium-catalyzed oxidative homologation of N-pyrimidyl indolines with alkynes via dual C—H activation: Facile synthesis of benzo[g] indolines

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2018年第6期29卷 907-910页

作者： Lianhui Wang Dan Xiong Lianghua Jie Chudan Yu Xiuling Cui engineering research center of molecular medicine Ministry of Education Key Laboratory of Fujian Molecular Medicine Key Laboratory of Xiamen Marine and Gene Drugs School of Biomedical Sciences Huaqiao University

We herein report a highly regioselective rhodium-catalyzed C6-and C7—H bond functionalization of indolines with alkynes by using 2-pyrimidine as a directing group. Moreover, NH-free benzo[g]indole unit could be obtai... 详细信息

关键词： Rhodium Indoline Alkyne Benzo[g]indoline C—H activation

Light-induced stepped thermal relaxation in a Hofmann-type metal-organic framework

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第6期67卷 1983-1989页

作者： Wen Cui Wei-Wei Wu Ze-Yu Ruan Yan-Cong Chen Guang-Jun Zeng Guan-Xi Chen Si-Guo Wu Zhao-Ping Ni Ming-Liang Tong Key Laboratory of Bioinorganic and Synthetic Chemistry of ministry of education School of ChemistryInstitute of Green Chemistry and Molecular EngineeringGuangdong Basic Research Center of Excellence for Functional Molecular EngineeringSun Yat-sen UniversityGuangzhou510275China

Spin-crossover(SCO)materials with light-induced multistability have potential applications in multi-addressable opto-magnetic memory devices and multiple switches.Here,we reported a three-dimensional Hofmann-type metal-organic framework(MOF)[Fe(bpy){Pt(CN)_(4)}]·coumarin(1·coumarin,bpy=4,4′-bipyridine),which exhibits an incomplete and hysteretic SCO behavior.Most importantly,the light-induced stepped thermal relaxation(LISTR)with obvious magnetic plateau for a hidden intermediate spin state is firstly realized.This hidden spin state is also observed for the first time in the thermal relaxation after light-assisted spin state annealing(LASSA).Meanwhile,an extremely rare bi-directional light-induced excited spin-state trapping(LIESST)with the highest reverse-LIESST temperature is observed.Therefore,five spin states can be captured in 1·coumarin and the tristability can be modulated below 102 K through the excitation-relaxation mechanism.Hence,the light-and temperatureinduced multistability provides a new strategy for developing multistable materials.

关键词： light magnetic multistability iron metal-organic framework spin-crossover

Specific Recognition of Breast Cancer Cells In Vitro Using Near Infrared-Emitting Long-Persistence Luminescent Zn_3Ga_2Ge_2O_(10):Cr^(3+)Nanoprobes

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2015年第2期7卷 138-145页

作者： Jinlei Li Junpeng Shi Jiangshan Shen Huizi Man Mingxi Wang Hongwu Zhang School of Biomedical Sciences Huaqiao University and Engineering Research Center of Molecular Medicine Ministry of Education Institute of Urban Environment Chinese Academy of Science

In this paper, near-infrared emitting long-persistence luminescent Zn3Ga2Ge2O10:Cr3?(ZGG) nanoparticles with diameters of 30–100 nm and bright luminescence were prepared by a sol–gel synthesis method. After the surface amination, the nanoparticles were further bioconjugated with breast cancer-specific monoclonal antibody(anti-Ep CAM) to form ZGG-Ep CAM nanoprobes which can specifically target breast cancer cell lines(MCF7) in vitro. The results of in vitro images show that the luminescence signals from the cells treated with ZGG-Ep CAM nanoprobes are stronger than those from cells treated with ZGG-unconjugated antibody, indicating that the prepared ZGG-Ep CAM nanoprobes possessed excellent specific recognition capability. Furthermore, due to their long afterglow properties, the imaging could persist more than 1 h. Therefore, these nanoprobes could not only provide a high specificity detection method for cancer cells but also realize the long-time monitoring. Developed near-infrared emitting long-persistence luminescent nanoprobes will be expected to find new perspectives for cell therapy research and diagnosis applications.

关键词： Nanoprobes Long afterglow Near-infrared luminescence Target imaging

Iridium-catalyzed direct ortho-C–H amidation of benzoic acids with sulfonylazides

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2015年第11期26卷 1336-1340页

作者： Ming-E Wei Lian-Hui Wang Yu-Dong Li Xiu-Ling Cui engineering research center of molecular medicine Ministry of Educationthe Key Laboratory of Xiamen Marine and Gene Drugs Institute of Molecular Medicine and School of Biomedical Sciences Huaqiao University

A mild and efficient iridium-catalyzed ortho-C-H amidation with sulfonyl azides by weakly coordinating carboxylic acid was demonstrated, which provided a novel approach to anthranilic acid derivatives.

关键词： lr-catalysisBenzoic acidSulfonyl azidesC-H bond amination

Iron-Catalyzed Intramolecular C-H Amidation of N-Benzoyloxyureas

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2021年第4期39卷 855-858页

作者： Dayou Zhong Lin-Yang Wu Xing-Zhen Wang Wen-Bo Liu Sauvage center for molecular Sciences Engineering Research Center of Organosilicon Compounds&Materials(Ministry of Education)College of Chemistry and Molecular SciencesWuhan UniversityWuhanHubei430072 China

Main observation and conclusion A redox-neutral Fe-catalyzed intramolecular C-H amidation of N-benzoyloxyureas is described.This methodology employs a simple iron complex in situ generated from Fe(OTf)2 and bipyridine as the catalyst and N-benzoyloxyureas as the nitrene precursors without using exogenous oxidants.An array of cyclic ureas were synthesized via aliphatic C(sp^(3))-H amidation in excellent yields.In addition,this catalytic system is also amenable to aryl C(sp^(2))-H nitrene insertion to provide benzimidazolones in moderate yields.

关键词： C-H activation Amination Cyclization Iron catalysis Nitrene insertion

Water-assisted and protein-initiated fast and controlled ring-opening polymerization of proline N-carboxyanhydride

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2022年第8期9卷 89-99页

作者： Yali Hu Zi-You Tian Wei Xiong Dedao Wang Ruichi Zhao Yan Xie Yu-Qin Song Jun Zhu Hua Lu Beijing National Laboratory for molecular Sciences Center for Soft Matter Science and EngineeringKey Laboratory of Polymer Chemistry and Physics of the Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking University Peking-Tsinghua center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking University Key Laboratory of Carcinogenesis and Translational research (ministry of education) Department of LymphomaPeking University Cancer Hospital and Institute

The production of polypeptides via the ring-opening polymerization(ROP) of N-carboxyanhydride(NCA) is usually conducted under stringent anhydrous conditions. The ROP of proline NCA(ProNCA)for the synthesis of poly-L-proline(PLP) is particularly challenging due to the premature product precipitation as polyproline type I helices, leading to slow reactions for up to one week, poor control of the molar mass and laborious workup. Here, we report the unexpected water-assisted controlled ROP of Pro NCA, which affords well-defined PLP as polyproline II helices in 2–5 minutes and almost-quantitative yields. Experimental and theoretical studies together suggest the as-yet-unreported role of water in facilitating proton shift, which significantly lowers the energy barrier of the chain propagation. The scope of initiators can be expanded from hydrophobic amines to encompass hydrophilic amines and thiol-bearing nucleophiles, including complex biomacromolecules such as proteins. Protein-mediated ROP of ProNCA conveniently affords various protein-PLP conjugates via a grafting-from approach. PLP modification not only preserves the biological activities of the native proteins, but also enhances their resistance to extreme conditions. Moreover, PLP modification extends the elimination half-life of asparaginase(ASNase) 18-fold and mitigates the immunogenicity of wt ASNase >250-fold(ASNase is a first-line anticancer drug for lymphoma treatment). This work provides a simple solution to a long-standing problem in PLP synthesis,and offers valuable guidance for the development of water-resistant ROP of other proline-like NCAs. The facile access to PLP can greatly boost the application potential of PLP-based functional materials for engineering industry enzymes and therapeutic proteins.

关键词： proline PPII helix ring-opening polymerization N-carboxyanhydride protein-polymer conjugates

Investigation on insulation properties of HFO-1336mzz(E)and N_(2)/CO_(2)mixtures as SF_(6) substitutes in gas-insulated electrical applications

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

High Voltage 2023年第1期8卷 48-58页

作者： Zhanyang Gao Yunbai Luo Ruichao Peng Xiaoxiao Wang Ping Yu Wenjun Zhou engineering research center of Organosilicon Compounds&Materials Ministry of EducationCollege of Chemistry and Molecular SciencesWuhan UniversityWuhanChina School of Electrical engineering and Automation Wuhan UniversityWuhanChina

The emissions of SF6 have been restricted owing to 3400 years of atmospheric lifetime and high global warming potential(GWP)as an insulating gas in gas-insulated electrical equipment.In this study,HFO-1336mzz(E)and N_(2)/CO_(2)mixtures are proposed as SF6 substitutes for their short atmospheric lifetime,low GWP and superior insulation performance.The GWP of HFO-1336mzz(E)is only 18 and its atmospheric lifetime is days to weeks.The breakdown voltage of 25%HFO-1336mzz(E)and N_(2)/CO_(2)mixtures is about 85%that of pure SF6 under alternating current.The self-recovery ability of HFO-1336mzz(E)and CO_(2)mixtures is superior to that of HFO-1336mzz(E)and N_(2)mixtures.The decomposition characteristic of HFO-1336mzz(E)shows that a tiny amount of its gas might initiate a carbonisation reaction to form carbon after multiple breakdown tests,which is verified by observations using energy dispersive X-rays spectroscopy and scanning electron microscope.The acute toxicity test of HFO-1336mzz(E)indicates that the gas is non-toxic.The results show that HFO-1336mzz(E)and N_(2)/CO_(2)mixtures are potential substitutes for SF6 in electrical applications.

关键词： SF6 electrical insulation

Targeted thrombolysis strategies for neuroprotective effect

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration research 2014年第13期9卷 1316-1322页

作者： Junping Zhang Guoxing Ma Zhimin Lv Yu Zhou Chunguang Wen Yaqing Wu Ruian Xu School of Biomedical Sciences Huaqiao University & Engineering Research Center of Molicular Medicine Ministry of Education

Stroke is usually treated by systemic thrombolytic therapy if the patient presents within an appropriate time window. There is also widespread interest in the development of thrombolytic agents that can be used in cases of delayed presentation. Current agents that can be used in cases of delayed presentation of nerve damage by thrombus. Current systemic thrombolytic therapy is associated with adverse effects such as fibrinogenolysis and bleeding. In an attempt to increase the efficacy, safety, and specificity of thrombolytic therapy, a number of targeted thrombolytic agents have been studied in recent years. This review focuses on the concepts underlying targeted thrombolytic therapy and describes recent drug developments in this field.

关键词： nerve regeneration review thrombolytic agent fibrinolytic system stroke cerebrovasculardisease neuroprotective drug fibrinolytic mechanism fbrin targeting platelet targeting red bloodcell targeting cerebral hemorrhage NSFC grant neural regeneration

Divergent synthesis of chiral amines via Ni-catalyzed chemo-and enantioselective hydrogenation of alkynone imines

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2023年第11期66卷 3186-3192页

作者： Yuchuan Ma Kai Liu Lin He Hui Lv Key Laboratory for Green Processing of Chemical engineering of Xinjiang Bingtuan School of Chemistry and Chemical EngineeringShihezi UniversityShihezi 832000China Hubei Key Lab on Organic and Polymeric Optoelectronic Materials Engineering Research Center of Organosilicon Compounds&MaterialsMinistry of EducationSauvage Center for Molecular SciencesKey Laboratory of Biomedical Polymers of Ministry of Education&College of Chemistry and Molecular SciencesWuhan UniversityWuhan 430072China

Ligand-mediated nickel-catalyzed asymmetric hydrogenation of alkynone imines has been achieved. By using Ni(OAc)_2·4H_2O/(S,S)-Ph-BPE complex as a catalyst, the chemo-and enantioselective hydrogenation of alkynone imines occurred efficiently to afford chiral propargyl amines with high yields and excellent enantioselectivities(up to 99% yield, >99% ee), leaving the readily reducible alkynyl group intact. Both the C=N and C≡C bonds of alkynone imines were hydrogenated efficiently in the presence of Ni(OAc)_2·4H_2O and Josiphos SL-J011-1, furnishing unfunctionalized chiral imines efficiently(up to 99% yield, >99% ee).The(Z)-allylamines and(E)-allylamines were also efficiently prepared from alkynone imines by the combination of the different catalytic systems. The preliminary mechanism study revealed that the reduction of alkynone imines was a stepwise process and the C=N bonds were preferably hydrogenated in the complete reduction of alkynone imines. The synthetic utility of this method was demonstrated by its application in the late-stage modification of the antiviral drug Zidovudine and the concise synthesis of chiral dibenzoazepine.

关键词： alkynone imine asymmetric hydrogenation propargyl amine enantioselectivity chiral amine