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Cumulative effects of stress-sensitivity factors on depressive symptoms and suicide risk:A prospective study

World Journal of Psychiatry 2025年第2期15卷 173-185页

作者： Xue-Mei Qin Meng-Qi Xu Ya-Qi Qin Fang-Zhou Shao Mo-Han Ma Wen-Wen Ou Guan-Yi Lv Qian-QianZhang Wen-Tao Chen Xiao-Tian Zhao Ao-Qian Deng Jin-Tao Xiong Ling-Si Zeng Yi-Lin Peng Mei Huang Shu-Yin Xu Mei Liao Li Zhang Ling-Jiang Li Yu-Meng Ju Jin Liu Bang-Shan Liu Yan Zhang Department of Psychiatry National Clinical Research Center for Mental Disordersand National Center for Mental DisordersThe Second Xiangya Hospital of Central South UniversityChangsha 410011Hunan ProvinceChina

BACKGROUND Sensitivity to stress is essential in the onset,clinical symptoms,course,and prognosis of major depressive disorder(MDD).Meanwhile,it was unclear how variously classified but connected stress-sensitivity variables affect *** hypothesize that high-level trait-and state-related stress-sensitivity factors may have different cumulative effects on the clinical symptoms and follow-up outcomes of *** To investigate how stress-sensitivity factors added up and affected MDD clinical symptoms and follow-up *** In this prospective study,281 MDD patients were enrolled from a tertiary care ***-level stress-sensitivity factors were classified as trait anxiety,state anxiety,perceived stress,and neuroticism,with a total score in the top quartile of the research *** cumulative effects of stress-sensitivity factors on cognitive dysfunction,disability and functional impairment,suicide risk,and depressive and anxiety symptoms were examined using an analysis of variance with linear trend *** were investigated further using multiple regression *** Regarding high-level stress-sensitivity factors,53.40%of patients had at least one at baseline,and 29.61%had two or *** high-level stress-sensitivity components had significant cumulative impacts on MDD symptoms at baseline(all P<0.001).Perceived stress predicted the greatest effect sizes of state-related factors on depressive symptoms(partialη^(2)=0.153;standardizedβ=0.195;P<0.05).The follow-up outcomes were significantly impacted only by the high-level trait-related components,mainly when it came to depressive symptoms and suicide risk,which were predicted by trait anxiety and neuroticism,respectively(partialη^(2)=0.204 and 0.156;standardizedβ=0.247 and 0.392;P<0.05).CONCLUSION To enhance outcomes of MDD and lower the suicide risk,screening for stress-sensitivity factors and considering multifaceted measures,mainly focusing on trait-related ones,should be addres

关键词： Major depressive disorder Stress sensitivity Depressive symptoms Suicide risk Cumulative effect

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Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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Neural Regeneration research 2025年第10期20卷 2923-2937页

作者： Yan Li Peng Hao Hongmei Duan Fei Hao Wen Zhao Yudan Gao Zhaoyang Yang Kwok-Fai So Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

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Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

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Neural Regeneration research 2025年第8期20卷 2373-2381页

作者： Lifang Zhao Mingkai Zhang Qimeng Li Xuemin Wang Jie Lu Ying Han Yanning Cai Department of Clinical Biobank Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Geriatric Medical research center BeijingChina Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Radiology and Nuclear Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics BeijingChina Key Laboratory of Neurodegenerative diseases Ministry of EducationBeijingChina School of Biomedical engineering Hainan UniversityHaikouHainan ProvinceChina center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijingChina National Clinical research center for Geriatric Diseases BeijingChina Institute of Biomedical engineering Shenzhen Bay LaboratoryGaoke Innovation CenterShenzhenGuangdong ProvinceChina Department of Neurobiology Xuanwu HospitalCapital Medical UniversityBeijingChina

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative ***,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°*** aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large *** samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on cognitive Decline *** samples were stored at-80°C for up to 6 years before being used in this *** results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage ***,the level of total tau showed a negative correlation with sample storage ***,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage *** was not observed in individuals with cognitive ***,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage ***,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's ***,in cohort studies,it is important to consider the impact of storage time on the overall results.

关键词： Alzheimer’s disease amyloid-β diagnostic ability glial fibrillary acidic protein neurodegeneration neurofilament light chain plasma biomarkers single molecule array storage time tau

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Mutations in GBA,SNCA,and VPS35 are not associated with Alzheimer's disease in a Chinese population:a case-control study

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Neural Regeneration research 2022年第3期17卷 682-689页

作者： Ya-Fei Wen Xue-Wen Xiao Lu Zhou Ya-Ling Jiang Yuan Zhu Li-Na Guo Xin Wang Hui Liu Ya-Fang Zhou Jun-Ling Wang Xin-Xin Liao Lu Shen Bin Jiao Department of Neurology Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Geriatrics Neurology Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical research center for Geriatric disorders Central South UniversityChangshaHunan ProvinceChina engineering research center of hunan province in cognitive impairment disorders Central South UniversityChangshaHunan ProvinceChina hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases ChangshaHunan ProvinceChina Key Laboratory of hunan province in Neurodegenerative disorders Central South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina

SNCA,GBA,and VPS35 are three common genes associated with Parkinson's *** studies have shown that these three genes may be associated with Alzheimer's disease(AD).However,it is unclear whether these genes increase the risk of AD in Chinese *** this study,we used a targeted gene sequencing panel to screen all the exon regions and the nearby sequences of GBA,SNCA,and VPS35 in a cohort including 721 AD patients and 365 healthy controls from *** results revealed that neither common variants nor rare variants of these three genes were associated with AD in a Chinese *** findings suggest that the mutations in GBA,SNCA,and VPS35 are not likely to play an important role in the genetic susceptibility to AD in Chinese *** study was approved by the Ethics Committee of Xiangya Hospital,Central South University,China on March 9,2016(approval No.201603198).

关键词： Alzheimer's disease Chinese population common variants GBA Parkinson's disease rare variants SNCA VPS35

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Parkinson’s disease and gut microbiota:from clinical to mechanistic and therapeutic studies

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Translational Neurodegeneration 2023年第1期12卷 1-30页

作者： Xuxiang Zhang Beisha Tang Jifeng Guo Department of Neurology Xiangya HospitalCentral South UniversityChangsha 410008China Key Laboratory of hunan province in Neurodegenerative disorders Central South UniversityChangsha 410008China hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases Changsha 410008China center for Medical Genetics and hunan Key Laboratory of Medical Genetics School of Life SciencesCentral South UniversityChangsha 410008China engineering research center of hunan province in cognitive impairment disorders Central South UniversityChangsha 410008China National Clinical research center for Geriatric disorders Xiangya HospitalCentral South UniversityChangsha 410008China

Parkinson’s disease(PD)is one of the most prevalent neurodegenerative *** typical symptomatology of PD includes motor symptoms;however,a range of nonmotor symptoms,such as intestinal issues,usually occur before the motor *** microorganisms inhabiting the gastrointestinal tract can profoundly influence the physiopathology of the central nervous system through neurological,endocrine,and immune system pathways involved in the microbiota-gut-brain *** addition,extensive evidence suggests that the gut microbiota is strongly associated with *** review summarizes the latest findings on microbial changes in PD and their clinical relevance,describes the underlying mechanisms through which intestinal bacteria may mediate PD,and discusses the correlations between gut microbes and anti-PD *** addition,this review outlines the status of research on microbial therapies for PD and the future directions of PD-gut microbiota research.

关键词： Gut microbiota Microbiota-gut-brain axis Mechanisms Alpha-synuclein Microbial therapy

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Clinical,mechanistic,biomarker,and therapeutic advances in GBA1-associated Parkinson’s disease

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Translational Neurodegeneration 2024年第1期13卷 356-376页

作者： Xuxiang Zhang Heng Wu Beisha Tang Jifeng Guo Department of Neurology Xiangya HospitalCentral South UniversityChangsha 410008China Department of Neurology Multi-Omics Research Center for Brain DisordersThe First Affiliated HospitalUniversity of South ChinaHengyang 421001China Clinical research center for Immune-Related Encephalopathy of hunan province Hengyang 421001China Key Laboratory of hunan province in Neurodegenerative disorders Central South UniversityChangsha 410008China hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases Changsha 410008China center for Medical Genetics and hunan Key Laboratory of Medical Genetics School of Life SciencesCentral South UniversityChangsha 410008China engineering research center of hunan province in cognitive impairment disorders Central South UniversityChangsha 410008China National Clinical research center for Geriatric disorders Xiangya HospitalCentral South UniversityChangsha 410008China

Parkinson’s disease(PD)is the second most common neurodegenerative *** development of PD is closely linked to genetic and environmental factors,with GBA1 variants being the most common genetic *** in the GBA1 gene lead to reduced activity of the coded enzyme,glucocerebrosidase,which mediates the development of PD by affecting lipid metabolism(especially sphingolipids),lysosomal autophagy,endoplasmic reticulum,as well as mitochondrial and other cellular ***,PD with GBA1 mutations(GBA1-PD)is characterized by particular features regarding the progression of symptom *** the therapeutic side,the discovery of the relationship between GBA1 variants and PD offers an opportunity for targeted therapeutic *** this review,we explore the genotypic and phenotypic correlations,etiologic mechanisms,biomarkers,and therapeutic approaches of GBA1-PD and summarize the current state of research and its challenges.

关键词： Gaucher’s disease Parkinson’s disease Glucocerebrosidase Mechanisms Biomarker Therapy

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Metformin promotes angiogenesis and functional recovery in aged mice after spinal cord injury by adenosine monophosphate-activated protein kinase/endothelial nitric oxide synthase pathway

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Neural Regeneration research 2023年第7期18卷 1553-1562页

作者： Jin-Yun Zhao Xiao-Long Sheng Cheng-Jun Li Tian Qin Run-Dong He Guo-Yu Dai Yong Cao Hong-Bin Lu Chun-Yue Duan Jian-Zhong Hu Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical research center for Geriatric disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina hunan engineering research center of Sports and Health ChangshaHunan ProvinceChina Department of Sports Medicine Research Centre of Sports MedicineXiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Treatment with metformin can lead to the recovery of pleiotropic biological activities after spinal cord ***,its effect on spinal cord injury in aged mice remains *** the essential role of angiogenesis during the regeneration process,we hypothesized that metformin activates the adenosine monophosphate-activated protein kinase/endothelial nitric oxide synthase pathway in endothelial cells,thereby promoting microvascular regeneration in aged mice after spinal cord *** this study,we established young and aged mouse models of contusive spinal cord injury using a modified Allen *** found that aging hindered the recovery of neurological function and the formation of blood vessels in the spinal *** with metformin promoted spinal cord microvascular endothelial cell migration and blood vessel formation in ***,intraperitoneal injection of metformin in an in vivo model promoted endothelial cell proliferation and increased the density of new blood vessels in the spinal cord,thereby improving neurological *** role of metformin was reversed by compound C,an adenosine monophosphate-activated protein kinase inhibitor,both in vivo and in vitro,suggesting that the adenosine monophosphate-activated protein kinase/endothelial nitric oxide synthase pathway likely regulates metformin-mediated angiogenesis after spinal cord *** findings suggest that metformin promotes vascular regeneration in the injured spinal cord by activating the adenosine monophosphate-activated protein kinase/endothelial nitric oxide synthase pathway,thereby improving the neurological function of aged mice after spinal cord injury.

关键词： adenosine monophosphate-activated protein kinase/endothelial nitric oxide synthase pathway angiogenesis aged mice compound C metformin spinal cord injury

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Mood symptoms,cognitive function,and changes of brain hemodynamics in patients with COVID-19:A functional near-infrared spectroscopy study

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World Journal of Psychiatry 2025年第3期15卷 193-215页

作者： Wen-Jin Ma Ruo-Chao Yuan Zi-Yu Peng Qian Wu Manal Al-Matary Hui-Shu Yang Peng Cheng Guang-Ju Zhao Chao-Chao Lu Yue-Xin Zhang Jia-Kun Hong Wei-Hui Li Department of Psychiatry National Clinical Research Center for Mental DisordersNational Center for Mental DisordersThe Second Xiangya Hospital of Central South UniversityChangsha 410011Hunan ProvinceChina research center of Educational Neuroscience School of Educational ScienceHuazhong University of Science and TechnologyWuhan 430074Hubei ProvinceChina Department of Education Hunan Normal UniversityChangsha 410081Hunan ProvinceChina Guigang Medical District of No.923 Hospital PLA Joint Logistics Support ForceGuigang 537000Guangxi Zhuang Autonomous RegionChina

BACKGROUND Many patients with coronavirus disease 2019(COVID-19)may experience emotional issues and cognitive ***,it remains unclear whether the brain mediates the impact of COVID-19 on the emergence of psychopathological *** remains unclear whether anxiety and depression are caused by stressors or viral *** To use functional near-infrared spectroscopy(fNIRS)to detect cortical hemodynamic changes in patients with COVID-19 and their relationship with mental symptoms(mainly depression and anxiety),to investigate whether COVID-19 causes these changes by affecting brain *** A total of 58 subjects,comprising 29 patients with first acute COVID-19 infection and 29 healthy controls without COVID-19 infection and without anxiety or depression were *** cortical activation during the performance of the verbal fluency test(VFT)and brain connectivity during the resting state(rs)were evaluated by 53-channel *** the COVID-19-infected group,Patient Health Questionnaire-9(PHQ-9)and General Anxiety Disorder-7(GAD-7)were used to assess the emotional state before fNIRS *** For the rs,compared to the uninfected group,the infected group exhibited lower rs functional connectivity(FC)in the dorsolateral prefrontal cortex(DLPFC),which was correlated with both the PHQ score and GAD *** the VFT,the infected group exhibited significantly lower cortical activation than the uninfected group in both Broca-left and ***,the integral value in the DLPFC-L showed a significant negative correlation with the PHQ-9 score during the VFT in the infected *** There were significant differences in the bilateral Broca area and DLPFC between the COVID-19-infected and uninfected groups,which may be the reason why COVID-19 infection impairs cognitive function and language function and leads to psychiatric *** addition,the rsFC in patients with COVID-19 was positively correlated with the severi

关键词： COVID-19 Depression Anxiety cognitive function Functional near-infrared spectroscopy Verbal fluency test

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engineering self-catabolic DNAzyme nanospheres for synergistic anticancer therapy

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Science China Chemistry 2024年第7期67卷 2412-2422页

作者： Yu Chen Yu Guo Jiaoli Wang Ruiting Liu Xiaohai Yang Kemin Wang Ying Pu Hui Shi Jin Huang Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringKey Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan ProvinceHunan UniversityChangsha 410082China National Clinical research center for Geriatric disorders Department of GeriatricsXiangya HospitalCentral South UniversityChangsha 410008China

DNAzyme-based gene therapy faces some challenges including cell penetration,activity limitation,and co-delivery ***-assembled DNA nanomedicine has attracted widespread attention due to its many *** is urgent to develop a universal DNA degradation strategy for precise programmable drug ***,we reported a self-catabolic DNAzyme nanospheres(SCNS),which could simultaneously achieve cell penetration,activity enhancement,and co-delivery *** SCNS were assembled through Y-DNA stepwise hybridization with each other,which were then loaded with aptamer(Apt),doxorubicin(Dox),and zinc oxide nanoparticles(ZnO NPs).The acid-triggered dissociation of ZnO NPs leads to the generation of Zn^(2+)ions cofactors for immediately self-catabolic DNAzyme *** the disassembly of the SCNS,three types of anticancer treatments would be activated,which include Zn^(2+)involved reactive oxygen species(ROS),Dox-induced chemotherapy,and DNAzyme-based gene *** experimental results show that the nanoplatform(Apt-SCNS-Dox-ZnO)has a good tumor-killing effect and minimal side *** a smart self-driven drug delivery nanoplatform,it is anticipated to displace extraordinary potential in biomedicine and bioengineering.

关键词： DNAzyme nanosphere ZnO NPs ROS Dox anticancer therapy

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Structural and functional connectivity of the whole brain and subnetworks in individuals with mild traumatic brain injury:predictors of patient prognosis

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Neural Regeneration research 2024年第7期19卷 1553-1558页

作者： Sihong Huang Jungong Han Hairong Zheng Mengjun Li Chuxin Huang Xiaoyan Kui Jun Liu Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Computer Science Aberystwyth UniversityAberystwythCeredigionUK Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhenGuangdong ProvinceChina School of Computer Science and engineering Central South UniversityChangshaHunan ProvinceChina Department of Radiology Quality Control Center of Hunan ProvinceChangshaHunan ProvinceChina Clinical research center for Medical Imaging of hunan province ChangshaHunan ProvinceChina

Patients with mild traumatic brain injury have a diverse clinical presentation,and the underlying pathophysiology remains poorly *** resonance imaging is a non-invasive technique that has been widely utilized to investigate neuro biological markers after mild traumatic brain *** approach has emerged as a promising tool for investigating the pathogenesis of mild traumatic brain injury.G raph theory is a quantitative method of analyzing complex networks that has been widely used to study changes in brain structure and ***,most previous mild traumatic brain injury studies using graph theory have focused on specific populations,with limited exploration of simultaneous abnormalities in structural and functional *** that mild traumatic brain injury is the most common type of traumatic brain injury encounte red in clinical practice,further investigation of the patient characteristics and evolution of structural and functional connectivity is *** the present study,we explored whether abnormal structural and functional connectivity in the acute phase could serve as indicators of longitudinal changes in imaging data and cognitive function in patients with mild traumatic brain *** this longitudinal study,we enrolled 46 patients with mild traumatic brain injury who were assessed within 2 wee ks of injury,as well as 36 healthy ***-state functional magnetic resonance imaging and diffusion-weighted imaging data were acquired for graph theoretical network *** the acute phase,patients with mild traumatic brain injury demonstrated reduced structural connectivity in the dorsal attention *** than 3 months of followup data revealed signs of recovery in structural and functional connectivity,as well as cognitive function,in 22 out of the 46 ***,better cognitive function was associated with more efficient ***,our data indicated that small-worldness in the acute sta

关键词： cognitive function cross-section follow-up functional connectivity graph theory longitudinal study mild traumatic brain injury prediction small-worldness structural connectivity subnetworks whole brain network

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