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Isodon suzhouensis extract interferes with miRNA expression profile for prevention and treatment of Chronic Obstructive Pneumonia Disease

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Food Science and Human Wellness 2024年

作者： Hong Duan Han Li Jun Feng Jing Zhou Ying Shi Li Wang Zeng Dong Kefeng Zhai Lili Li Zhaojun Wei School of Biological and Food engineering， engineering research center for Development and High Value Utilization of Genuine Medicinal Materials in North anhui province， suzhou university College of Biological and Food engineering， anhui Polytechnic university College of Pharmacy， Xinjiang Medical university General Clinical research center， anhui Wanbei coal-Electricity Group General Hospital School of Biological Science and engineering， North Minzu university

Chronic obstructive pulmonary disease (COPD) is a respiratory condition characterized by several symptoms. The pathogenesis of COPD is complex and involves multiple factors. A fantastic drug from traditional Chinese medicine (TCM)， Isodon suzhouensis (ISZ) is a perennial herb belonging to the labiaceae family. It has the functions of resolving phlegm， removing stasis， promoting blood circulation and eliminating qi stagnation. ISZ has been found to possess great potential against COPD. Present study is focused to identify microRNA (miRNA) biomarkers for COPD and to determine the role of ISZ leaves extract in regulating the disease through miRNA expression in serum exosomes. The sprague-dawley (SD) rats were randomly divided into control group， model group and drug groups. After the establishment of the model， the rats were sacrificed and the results were compared with control group. Then the total RNA， of rat serum was extracted and identified by nanoparticle tracker. Finally， high-throughput screening and sequencing were performed to screen miRNAs with significant differential expression. Then different databases were used to figure out the possible target genes and their functions were assessed by employing gene ontology (GO) as well as kyoto encyclopedia of genes and genomes (KEGG) analyses. The sequencing results were then further verified by qRT-PCR. The results pointed out that these 17 differentially expressed miRNAs may have the potential of diagnostic and prognostic biomarkers against COPD. Interestingly it was also found that ISZ leaves extract may regulate the occurrence of COPD by affecting the expression of miRNAs. This study identified the biomarkers of COPD and clarified the mechanism of the treatment of COPD by ISZ leaves extract， which is helpful to improve the level of early diagnosis and treatment of COPD.

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The potential mechanism of Isodon suzhouensis against COVID-19 via EGFR/TLR4 pathways

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Food Science and Human Wellness 2024年

作者： Hong Duan Wei Wang Shu Li Han Li Ghulam Jilany Khan Fawang Liu Kefeng Zhai Lili Li Zhaojun Wei General Clinical research center， anhui Wanbei coal-Electricity Group General Hospital Department of Pharmacology and Therapeutics， Faculty of Pharmacy， university of Central Punjab College of Biological and Food engineering， anhui Polytechnic university School of Biological and Food engineering， engineering research center for Development and High Value Utilization of Genuine Medicinal Materials in North anhui province， suzhou university School of Food and Biological engineering， Hefei university of Technology

Corona Virus Disease 2019 (COVID-19) has brought the new challenges to scientific research. Isodon suzhouensis has good anti-inflammatory and antioxidant stress effects， which is considered as a potential treatment for COVID-19. The possibility for the treatment of COVID-19 with suzhouensis and its potential mechanism of action were explored by employing molecular docking and network pharmacology. Network pharmacology and molecular docking were used to screen drug targets， and Lipopolysaccharide (LPS) induced RAW264.7 and NR8383 cells inflammation model was used for experimental verification. Collectively a total of 209 possible linkages against 18 chemical components from suzhouensis and 1194 COVID-19 related targets were selected. Among these， 164 common targets were obtained from the intersection of suzhouensis and COVID-19. GO and KEGG enriched 582 function targets and 87 target proteins pathways， respectively. The results from molecular docking studies revealed that rutin， vitexin， isoquercitrin and quercetin had significant binding ability with SARS-CoV-23CLpro and ACE2. In vitro studies showed that Isodon suzhouensis extract (ISE) may inhibit the activation of PI3K/Akt pathway and the expression level of downstream pro-inflammatory factors by inhibiting the activation of EGFR in RAW264.7 cells induced by LPS. In addition， ISE was able to inhibit the activation of TLR4/NF-κB signaling pathway in NR8383 cells exposed to LPS. Overall， the network pharmacology and in vitro studies conclude that active components from suzhouensis have strong therapeutic potential against COVID-19 through multi-target， multi-pathway dimensions and can be a promising candidate against COVID-19.

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Groundwater pollution and human health risk based on Monte Carlo simulation in a typical mining area in Northern anhui province,China

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International Journal of coal Science & Technology 2021年第5期8卷 1118-1129页

作者： Huili Qiu Herong Gui Pei Fang Guangping Li engineering research center of coal mine exploration of anhui province(suzhou university Suzhou 234000AnhuiChina School of Information engineering Suzhou UniversitySuzhou 234000AnhuiChina Qianyingzi coalmine of Wanbei coal-Electricity Group Co.Ltd. Suzhou 234000AnhuiChina

The main objective of this study was to evaluate eight kinds of trace element pollutants in groundwater from a typical coal mine area,and carry out a corresponding health risk assessment for the local *** do this,34 shallow groundwater(SG)samples and 18 mid-layer groundwater(MG)samples were collected from the Sulin mining *** minimize the uncertainties in the health risk assessment,this paper relied on Monte Carlo simulations and sensitivity *** results revealed that Sr and Mn contents exceeded their corresponding WHO(Guidelines for drinking water quality,4th ***,2011)guidelines and Chinese groundwater standards(GB/T14848-2017),while the other analyzed trace elements remain below those threshold *** calculated hazard quotient and hazard index values for adults from ingestion exposure to SG and MG were well below the threshold limit of *** simulations further show that the total cancer risk value above the limit of 1×10^(-6) is 0%for SG and 29.39%for *** analysis identified the Sr and Cr contents as the most relevant element variables affecting the probabilistic non-carcinogenic and carcinogenic risk values in the model,respectively.

关键词： Health risk assessment Trace elements Monte Carlo simulation Sensitivity analysis Mining area

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Hydrochemical characteristics and water quality evaluation of shallow groundwater in Suxian mining area,Huaibei coalfield,China

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International Journal of coal Science & Technology 2020年第4期7卷 825-835页

作者： Hao Yu Herong Gui Honghai Zhao Meichen Wang Jun Li Hongxia Fang Yaqi Jiang Yaru Zhang School of Earth and Environment Anhui University of Science and Technology.Huainan 232001AnhuiChina National engineering research center of coal mine Water Hazard Controlling(suzhou university) Suzhou 234000AnhuiChina 'anhui Provincial Bureau of coal Geology Hydrologic exploration Team Suzhou 234000 AnhuiChina School of Resources and Environmental engineering of Hefei university of Technology Hefei 232000.Anhui.China

The aim of this study is to evaluate the hydrogeochemical characteristics and water environmental quality of shallow groundwater in the Suxian mining area of Huaibei coalfield,*** natural formation process of shallow groundwater in Suxian is explored using Piper trilinear charts and Gibbs diagrams,and by examining the ratios between the major *** States Salinity Laboratory(USSL)charts,Wilcox diagrams,and the water quality index(WQI)are further employed to quantify the differences in water *** results reveal that the main hydrochemical facies of groundwater are HC03-Ca,and that silicate dissolution is the main factor controlling the ion content in shallow *** USSL charts and Wilcox diagrams show that most of the water samples would be acceptable for use in irrigation *** WQI results for each water sample are compared and analyzed,and the quality of groundwater samples around collapse ponds is found to be relatively poor.

关键词： Shallow groundwater Hydrochemical characteristics Water-rock interaction Evaluation of water environment quality Suxian mining area

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Characteristics and geological significance of germanium in Taiyuan coal formation of Huainan coalfield,anhui,China

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International Journal of coal Science & Technology 2020年第4期7卷 662-675页

作者： Dun Wu Wenyong Zhang Guijian Liu Run Zhan Guangqing Hu School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026AnhuiChina exploration research Institute Anhui Provincial Bureau of Coal GeologyHefei 230088AnhuiChina anhui province Green mine engineering research center Hefei 230088AnhuiChina

HN-1#is the first fully working coring well of the Taiyuan Formation(Ty)in the Huinan coalfield and exploration studies are currently underway on the associated resources of the coal-bearing *** HN-1#well is located in the Fufeng thrust nappe structural belt in the south of the Huainan *** coal samples from the Ty were collected from HN-1#and inductively-coupled plasma mass spectrometry and inductively-coupled plasma atomic emission spectrometry were used to determine the Ge content of each *** on proximate and ultimate analyses,microscopy data,and analyses of the ash products,some important findings were *** Ty coal samples had a relatively high total sulfur(Sud)content(4.24%),thus the coal was considered to be a lower ranked coal(high volatility bituminous coal),which also had a low coal ash composition index(k,1.87).Collodetrinite was the main submaceral of the Ty *** amounts of pyrite particles were found in the coal seams of the Ty,while the contents of pyrite and algae in the top and bottom sections of the coal seam were relatively high,which meant that the swampy peat conditions which existed during the formation of the coal seams were affected by seawater;also the degree of mineralization of the coal seam was relatively high,which is consistent with reducing conditions in a coastal environment *** force microscopy(AFM)experiments showed that the modes of occurrence of Ge in the Ty coal were mainly those for organic-bound and adsorbed Ge *** organic carbon isotope values for the Ty coal ranged from-24.1‰to-23.8‰,with an average value of-24.0‰,which is equivalent to the value for terrestrial plants(average value-24.0‰).The Ge content of the Ty coal was 13.57 mg/*** Ge content was negatively correlated with volatile matter and the ash yield.

关键词： Germanium Modes of occurrence Chemical species ICP spectrometry Taiyuan coal formation Fufeng thrust nappe structural belt Huainan coalfield

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Characterization of a Lacustrine Shale Reservoir and the Evolution of its Nanopores: A Case Study of the Upper Cretaceous Qingshankou Formation in the Songliao Basin, Northeastern China

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Acta Geologica Sinica(English Edition) 2020年第2期94卷 337-351页

作者： ZHANG Xu LIU Chenglin LI Bing WU Linqiang GUI Herong WANG Ziling ZHANG Zhihui LIANG Dexiu State Key Laboratory of Petroleum Resource and Prospecting China University of PetroleumBeijing 102249China College of Geosciences China University of Petroleum.Beijing 102249China National engineering research center of coal mine Water Hazard Controlling(suzhou university) SuzhouAnhui234000China Geological exploration Technology Institute of anhui province Hefei 230031China Development and research center China Geological SurveyBeijing 100037China

The Songliao Basin is one of the most important petroliferous basins in northern China. With a recent gradual decline in conventional oil production in the basin, the exploration and development of unconventional resources are becoming increasingly urgent. The Qingshankou Formation consists of typical Upper Cretaceous continental strata, and represents a promising and practical replacement resource for shale oil in the Songliao Basin. Previous studies have shown that low-mature to mature Qingshankou shale mainly preserves type Ⅰ and type Ⅱ1 organic matter, with relatively high total organic carbon(TOC) content. It is estimated that there is a great potential to explore for shale oil resources in the Qingshankou Formation in this basin. However, not enough systematic research has been conducted on pore characteristics and their main controlling factors in this lacustrine shale reservoir. In this study, 19 Qingshankou shales from two wells drilled in the study area were tested and analyzed for mineral composition, pore distribution and feature evolution using Xray diffraction(XRD), scanning electron microscopy(SEM), low-pressure nitrogen gas adsorption(N2-GA), and thermal simulation experiments. The XRD results show that clay, quartz, and feldspar are the dominant mineral constituents of Qingshankou shale. The clay minerals are mostly illite/smectite mixed layers with a mean content of 83.5%, followed by illite, chlorite, and kaolinite. There are abundant deposits of clay-rich shale in the Qingshankou Formation in the study area, within which many mineral and organic matter pores were observed using SEM. mineral pores contribute the most to shale porosity;specifically, clay mineral pores and carbonate pores comprise most of the mineral pores in the shale. Among the three types of organic matter pores, type B is more dominant the other two. Pores with diameters greater than 10 nm supply the main pore volume;most are half-open slits and wedge-shaped pores. The total por

关键词： lacustrine shale pore structure pore evolution Upper Cretaceous Songliao Basin

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Method for evaluation of the cleanliness grade of coal resources in the Huainan coalfield,anhui,China:a case study

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International Journal of coal Science & Technology 2021年第4期8卷 534-546页

作者： Guangqing Hu Guijian Liu Dun Wu Wenyong Zhang Biao Fu School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026AnhuiChina Green Mining engineering Technology research center of anhui province Exploration Research InstituteAnhui Provincial Bureau of Coal GeologyHefei 230088AnhuiChina

Based on analysis of a large data set and supplementary sampling and analysis for hazardous trace elements in coal samples from the Huainan coalfield,a generalized contrast-weighted scale index method was used to establish a model to evaluate the grade of coal cleanliness and its regional distribution in the main coal seam(No.13-1)The results showed that:(1)The contents of Cr,Mn and Ni in the coal seam are relatively high and the average values are greater than 20μg/*** contents of Se and Hg are at a high level while most other trace elements are at normal levels.(2)The cleanliness grade of the coal seam is mainly grade III-IV,which corresponds to a relatively good-medium coal cleanliness ***,some parts of the seam are at grade V(relatively poor coal cleanliness).(3)coal of relatively good cleanliness grade(grade III)is distributed mainly in the regions corresponding to the Zhuji-Dingji-Gubei coal mines and in the eastern periphery of the Panji coal *** of medium cleanliness(grade IV)is distributed mainly in the regions of the Panji-Xiejiaji and Kouzidong *** poor grade coal(grade V)is distributed in the southwest regions of the coalfield and the contents of Cr,As and Hg in coal collected from the relatively poor coal cleanliness regions often exceed the regulatory standards for the maximum concentration limits.

关键词： coal cleanliness Hazardous trace elements Evaluation method Huainan coalfield

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THE EFFECTS OF GAS PRESSURE ON GAS INFILTRATION CHARACTERISTICS IN coal

THE EFFECTS OF GAS PRESSURE ON GAS INFILTRATION CHARACTERIST...

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第四届岩石力学与工程新进展国际学术会议（NDRM2012）

作者： JIAN-LOU LI JIA-PING YAN SHENG ZHANG SHUI-GEN HU suzhou university coal mine exploration engineering technology center of anhui province anhui university of Science and Technology

ISBN: (纸本)9781589490628

In order to study the characteristics of gas infiltration in coal body surrounded by rigid rock under the conditions of different gas pressure,a self-developed coal-gas sorption/desorption simulation device is used to establish a physical coal-gas infiltration *** this experiment,two types of gases(N2 & CO2) are used respectively to simulate gas penetrating through the tightly contained coal body,and gas pressure, total stress and infiltration velocity are *** results show that the relationship between gas infiltration velocity in gas-contained coal and gas pressure is fitted by second-order *** results also show that,under the conditions of same temperature and same pressure,the infiltration velocity of N2 is higher than that of *** experimental study is important for coal-gas hazard prevention and CBM exploration in coal mine.

关键词： gas pressure coal Infiltration rate Gases N2 Stage Finding nitrogen infiltration GALNS gene PAGR1 gene

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Coupling mechanism of THM fields and SLG phases during the gas extraction process and its application in numerical analysis of gas occurrence regularity and effective extraction radius

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Petroleum Science 2022年第3期19卷 990-1006页

作者： Hui-Huang Fang Chun-Shan Zheng Ning Qi Hong-Jie Xu Hui-Hu Liu Yan-Hui Huang Qiang Wei Xiao-Wei Hou Lei Li Shuai-Liang Song State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep coal mines Anhui University of Science and TechnologyHuainanAnhui 232001China Institute of Energy Hefei Comprehensive National Science CenterHefeiAnhui 230000China School of Earth and Environment Anhui University of Science and TechnologyHuainanAnhui 232001China Great Institute of Standardization China National Institute of Standardization's High Quality and Green Development Innovation R&D BaseJinanShandong 250101China State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China School of Resources and Civil engineering Suzhou UniversitySuzhouJiangsu 234000China School of Resources and Environmental engineering Hefei University of TechnologyHefeiAnhui 230009China The Third exploration Team of Shandong coalfield Geologic Bureau TaianShandong 250102China Shandong Provincial Lunan Geo-engineering exploration Instituts JiningShandong 272100China

The analysis of the coupling mechanism of thermal-hydraulic-mechanical(THM)fields,and solid-liquidgas(SLG)phases during gas extraction process is of profound significance to explore its numerical application in the gas occurrence regularity and its effective extraction *** this study,the Hudi coal mine in Qinshui basin is taken as the research area,the influencing factors of gas occurrence were analyzed,the differences in overburden load for gas pressure distribution and the factors influencing the effective extraction radius were further discussed by using the COMSOL *** results show that the derivation of mathematical model in gas extraction shows that the process is a process the THM fields restrict each other,and the SLG phases influence each *** longer the extraction time,the larger the influencing range of borehole,and the better the extraction *** larger the diameter of borehole,the larger the effective extraction radius,and the influence on gas extraction effect is smaller in the early stage and larger in the late *** borehole arrangement should be flexibly arranged according to the actual extraction *** higher the porosity,the higher the permeability,the better the gas extraction *** larger the overburden load of reservoir,the stronger the effective stress,which will result in the more severe the strain,and the closure of pore and fracture,which in turn will lead to the decrease of permeability and slow down the gas *** relationship among extraction time,borehole diameter,negative pressure of gas extraction,permeability with effective extraction radius is *** study has important theoretical and practical significance for clarifying and summarizing the gas occurrence regularity and its engineering practice.

关键词： Gas occurrence regularity Effective extraction radius THM fields and SLG phases Numerical simulation COMSOL Multiphysics Hudi coal mine

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3D reconstruction of coal pore network and its application in CO_(2)-ECBM process simulation at laboratory scale

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Frontiers of Earth Science 2022年第2期16卷 523-539页

作者： Huihuang FANG Hongjie XU Shuxun SANG Shiqi Liu Shuailiang SONG Huihu LIU State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep coal mines Anhui University of Science and TechnologyHuainan 232001China School of Earth and Environment Anhui University of Science and TechnologyHuainan 232001China Institute of Energy Hefei Comprehensive National Science CenterHefei 230000China Jiangsu Key Laboratory of coal-based Greenhouse Gas Control and Utilization China University of Mining and TechnologyXuzhou 221008China Low Carbon Energy Institute China University of Mining and TechnologyXuzhou 221008China Shandong Provincial Lunan Geo-engineering exploration Institute Jining 272100China

Three-dimensional(3D)reconstruction of the equivalent pore network model(PNM)using X-ray computed tomography(CT)data are of significance for studying the CO_(2)-enhanced coalbed methane recovery(CO_(2)-ECBM).The docking among X-ray CT technology,MATLAB,with COMSOL software not only can realize the 3D reconstruction of PNM,but also the CO_(2)-ECBM process *** results show that the Median filtering algorithm enabled the de-noising of the original 2D CT slices,the image segmentation of all slices was realized based on the selected threshold,and the PNM can be constructed based on the Maximum Sphere *** mathematical model of CO_(2)-ECBM process fully coupled the expanded Langmuir *** the same time for CO_(2)injection,CH_(4)pressure tends to decrease with the increase of CO_(2)pressure,but its difference is not *** CH_(4)pressure in the slice center changed a lot,while at the edge it changed a little under different CO_(2)*** injected CO_(2)was transported to matrix along the macro and micro-fractures with continuous *** injected CO_(2)first replaced the adsorbed CH_(4)by covering the inner surface of macro-pores and meso-pores to form the single molecular layer adsorption of CO_(2).Then they migrated to micro-pores by Fick’s diffusion,sliding flow,and surface ***,the CO_(2)replaced CH_(4)adsorbed by volumetric filling in micro-pores,and formed the multi-molecular layer adsorption of CO_(2).The gas pressure and migration path between CO_(2)and CH_(4)are *** study can provide a theoretical basis for studying digital rock physics technology and enrich the development of CO_(2)-ECBM technology.

关键词： CO_(2)-ECBM 3D reconstruction numerical simulation X-ray CT COMSOL Qinshui Basin

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