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Polyaspers A and B,the First Ergosterol-Polyether Adducts with Unprecedented 6/6/6/5/5/6/6/6/6 Nonacyclic Architecture from Aspergillus sp.TJ507

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chinese Journal of Chemistry 2024年第7期42卷 743-751页

作者： Hong Hu Lanqin Li Zhengyi Shi Xueqi Lan Yeting Zhang Xinye Huang Xincai Hao Qun Zhou Weiguang Sun Changxing Qi Yonghui Zhang Hubei Key Laboratory of Natural medicinal Chemistry and Resource Evaluation Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology Key Laboratory of Organ TransplantationMinistry of EducationNHC Key Laboratory of Organ TransplantationKey Laboratory of Organ TransplantationChinese Academy of Medical SciencesWuhanHubei 430030China Hubei Key Laboratory of Wudang Local chinese Medicine research Hubei Engineering Technology Center for Comprehensive Utilization of Medicinal PlantsCollege of PharmacyHubei University of MedicineShiyanHubei 442000China

Psoriasis is a chronic immune-mediated inflammatory skin disease and the TNF-αis an important therapeutic target of this disease.In our continuous study of bioactive natural products from fungi,the first ergosterol-polyether adducts,polyaspers A(1)and B(2),along with two known ergosterols,(36,5α,6α,22E)-5,6-epoxy-3-hydroxyergosta-8,22-dien-7-one(3)and calvasterol B(4),were iso-lated from Aspergillus sp.TJ507.Structure elucidation was accomplished by extensive spectroscopic analysis and single-crystal X-ray diffraction tests.Polyaspers A and B possessing an unequalled 6/6/6/5/5/6/6/6/6 nonacyclic system,and their biosynthetic path-ways were proposed to include intermolecular cyclization and Diels-Alder reactions.Activity screen of these isolates showed that 1-3 could improve the cell viability in an actinomycin D/TNF-αinduced L929 cells death model,with the EC50 values of 49.85,46.75 and 4.99μmol/L,respectively,and the activity of 3 was even comparable with that of the positive control SPD304.Further bioactive investigations discovered 3 could suppress the inflammatory response simulated with TNF-αin HaCaT cells.In an imiquimod-induced psoriasis murine model,3 significantly restrained the development of psoriasis symptoms and reduced the expression of IL-17 and IL-23,presenting an anti-psoriatic effect.As such,those ergosterol derivatives,might serve as lead compounds for the development of novel TNF-αinhibitory agents in the clinical treatment of psoriasis.

关键词： Psoriasis Aspergillus sp.TJ507 TNF-α Ergosterol-polyether adducts Inflammatory skin disease

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Isoforsythiaside confers neuroprotection against Alzheimer's disease by attenuating ferroptosis and neuroinflammation in vivo and in vitro

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Food Science and Human Wellness 2023年第5期12卷 1730-1742页

作者： Chunyue Wang Hongbo Jiang Honghan Liu Shanshan Chen Hangyu Guo Shuoshuo Ma Weiwei Han Yu Li Di Wang School of Life Sciences Jilin UniversityChangchun 130012China engineering research center of chinese ministry of education for edible and medicinal fungi Jilin Agricultural UniversityChangchun 130118China

Ferroptosis and neuroinflammation contribute to the development of Alzheimer's disease(AD). Isoforsythiaside(IFY)is a phenylethanoid glycoside isolated from the dried fruit of Forsythia suspensa(Thunb.)Vahl that has been confirmed to improve the memory and cognitive abilities of APP/PS1 mice in our previous study. The purpose of this study was to explore the anti-ferroptosis and anti-neuroinflammatory properties of IFY-mediated neuroprotection. In APP/PS1 mice, erastin-damaged HT22 cells, and LPS-exposed BV2 cells, the neuroprotective effects against ferroptosis and neuroinflammation were investigated using immunohistochemistry, label-free proteomics, western blot, ELISA, MTT, fluorescence, and TEM. IFY alleviated the expression levels of NO, IL-6, and IL-1β in LPS-exposed BV2 cells and improved the morphology of mitochondria in erastin-damaged HT22 cells. Additionally, IFY upregulated the expression levels of GPX4, FTH, FTL, p-GSK-3β, Nrf2, and NQO1, and downregulated the expression of TFR1, DMT1, p-Fyn, GFAP, p-IKKα+β, p-IκBα, p-NF-κB, and pro-inflammatory factors in the brains of APP/PS1 mice and erastin-damaged HT22 cells. In conclusion, IFY inhibits ferroptosis and neuroinflammation in erastin-damaged HT22 cells and APP/PS1 mice, at least partially by regulating the activation of Nrf2 and NF-κB signaling. IFY may prevent ferroptosis and neuroinflammation in AD and provide a new treatment strategy for AD.

关键词： Ferroptosis Neuroinflammation Isoforsythiaside Alzheimer's disease

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Nostoc commune Vauch. Polysaccharide alleviates Pb-induced hepatorenal toxicity by changing gut bacteriome， mycobiome， and metabolome

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Food Science and Human Wellness 2023年

作者： Yue Liu Ping Ren Hailong Li Yingying Liu Yiting Yang Wanting Wang Jiaming Zhou Ling Su Lili Guan Hongxia Ma College of Life Sciences Jilin Agricultural University engineering research center of Bioreactor and Pharmaceutical Development ministry of education Jilin Agricultural University engineering research center of chinese ministry of education for edible and medicinal fungi Jilin Agricultural University

This study aimed to explore the protective effect and potential mechanism of Nostoc commune Vauch. polysaccharide (NCVP) on Pb-poisoning mice. NCVP improved Pb-induced hepatorenal toxicity and inflammatory responses and modulated key indicators of antioxidant capacity. Moreover， the down-regulation of critical proteins of the Nrf2 pathway induced by Pb could be reversed after NCVP intervention. In addition， NCVP maintained the diversity of gut bacteriobiota and restored the relative abundance of f＿Prevotellaceae， g＿Alloprevotella， and f＿Eubacterium＿coprostanoligenes＿group reduced by Pb. Also， NCVP regulated the diversity and abundance of gut mycobiota affected by Pb. Specifically， Pb decreased the proportion of pathogenic species (g＿Fusarium， p＿Basidiomycota， g＿Alternaria， g＿Aspergillus， and g＿Candida) while NCVP increased the abundance of probiotics species (g＿Kazachstania and p＿Ascomycota). Furthermore， the metabolomic analysis found that NCVP significantly altered a range of microbial metabolites， including porphobilinogen， cromakalim， salidroside， and trichostatin A， which has significant associations with specific gut bacteriobiota or mycobiota. These altered metabolites are involved in primary bile acid biosynthesis， metabolism of xenobiotics by cytochrome P450， lysine degradation， and other metabolic pathways. Overall， our findings indicate that NCVP might be an excellent natural product for eliminating Pb-induced hepatorenal toxicity， possibly by regulating gut bacteriome， mycobiome and metabolome.

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Determination of the available energy values and amino acid digestibility of Flammulina velutipes stem waste and its effects on carcass trait and meat quality fed to growing-finishing pigs

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Journal of Animal Science and Biotechnology 2020年第3期11卷 747-766页

作者： Xuzhou Liu Bo Zhang Hansuo Liu Gang Zhang Jinbiao Zhao Ling Liu Xiangshu Piao Hui Song Shuai Zhang Yu Li Institute of Mycology Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal FungiJilin Agricultural UniversityChangchun 130118China State Key Laboratory of Animal Nutrition Ministry of Agriculture Feed Industry CentreChina Agricultural UniversityBeijing 100193China

Background:Flammulina velutipes stem waste(FVS)is the by-product of mushroom industry.The objectives of this study were to determine the available energy and amino acid digestibility of FVS fed to pigs,and to evaluate the effects of dietary FVS inclusion on growth performance,biochemical profile of serum,fecal short chain fatty acid(SCFA)concentration,carcass traits,meat quality,intestinal morphology and microflora of pigs.In Exp.1,twelve crossbred barrows with initial body weight(IBW)of 37.48±4.31 kg were randomly allotted to 2 dietary treatments,including a corn basal diet and an experimental diet containing 24.35%FVS.In Exp.2,twelve barrows fitted with an ileal T-cannula(IBW:32.56±1.67 kg)were randomly allotted to 2 dietary treatments,which included a N-free diet and an experimental diet containing 40.0%FVS.In Exp.3,ninety growing pigs(IBW:63.98±6.89 kg)were allotted to 1 of 3 treatment diets for 63 d,including a basal diet and 2 experimental diets with 2.5%and 5%FVS,respectively.Results:The digestible energy(DE)and metabolizable energy(ME)of FVS were 4.58 and 4.06 MJ/kg on dry matter basis,respectively,and the standardized ileal digestibility(SID)of indispensable AAs ranged from 17.50%to 59.47%.Pigs fed diets with 2.5%FVS showed no difference on average daily gain(ADG)and gain to feed ratio(G/F).Although dietary 5%FVS inclusion impaired apparent total tract digestibility(ATTD)of organic matter and gross energy,it elevated the SCFA concentration(P≤0.04)in gut and antioxidant capacity in serum.In addition,dietary FVS inclusion depressed the backfat thickness(P=0.03)in pigs.The longissimus dorsi muscle of pigs fed FVS revealed higher n-3 polyunsaturated fatty acid concentration and optimized fatty acid composition.Dietary 2.5%FVS inclusion also improved the intestinal development and health by increasing the villius height to crypt depth ratio(V/C)in jejunum(P<0.01),and promoting microbial diversity and beneficial microbiota proliferation.Conclusions:It is feasible to include moderate content of FVS as an unconv

关键词： Amino acid digestibility Available energy Fiber Flammulina velutipes stem waste Growing-finishing pigs Growth performance Meat quality

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Comparison of cultivation characteristics between a wild Sanghuangporus vaninii strain and domestic three Sanghuangporus species

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Mycosystema 2023年第4期42卷 896-906页

作者： Yang Y. Zhang Z. Liu J. Li C. Liu P. Li Y. engineering research center of chinese ministry of education for edible and medicinal fungi Jilin Agricultural University Jilin Changchun 130118 China Jilin Sanghuang Biotechnology Co. Ltd. Jilin Yanbian 133500 China

A wild strain of Sanghuangporus collected from Quanshuidong forest farm of Yanbian Korean Autonomous Prefecture in Jilin Province was identified as Sanghuangporus vaninii according to morphological and phylogenetic evidences. The effects of carbon and nitrogen source, pH value, and temperature on the mycelial growth of the wild strain were investigated by single factor test and optimized by orthogonal experiments. The results showed that the optimal carbon source and nitrogen source was sucrose and yeast extract powder respectively, the optimal pH was 5.0, and the optimal temperature was 29 °C. The domestic cultivation study of the wild strain was carried out, and the mycelial growth rate, primordium differentiation time, agronomic traits and yield of the strain were compared with those of domestically cultivated strains of S. vaninii, S. baumii and S. sanghuang. The comparison results showed that under the same culture conditions, the hyphae of the wild S. vaninii had the fastest growth rate and the best growth vigour; the primordia were rapidly differentiated. The agronomic traits showed excellent and high yielding. S. baumii showed the slowest in hyphal growth, and less in basidiomata yield. S. sanghuang comparatively grow fast but the yield of fruiting bodies was lowest. The wild strain of S. vaninii was named as SH14, and it might become a substitute for the current cultivars of S. vaninii. Copyright © 2023 Institute of Microbiology, CAS. All rights reserved.

关键词： biological characteristics cultivation domestication phylogeny Sanghuangporus

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Systematic arrangement within the family Clitocybaceae (Tricholomatineae, Agaricales): phylogenetic and phylogenomic evidence, morphological data and muscarine-producing innovation

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Fungal Diversity 2023年第6期123卷 1-47页

作者： Zheng-Mi He Zuo-Hong Chen Tolgor Bau Geng-Shen Wang Zhu L.Yang CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Yunnan Key Laboratory for Fungal Diversity and Green Development Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China College of Life Sciences Hunan Normal UniversityChangsha 410081China engineering research Centre of chinese ministry of education for edible and medicinal fungi Jilin Agricultural UniversityChangchun 130118China

The Clitocybaceae is a recently established family.Currently,the infrafamilial divisions and relationships within the family are vague due to limited sampling and genes employed for phylogenetic analysis.Some mushrooms of the family contain the neurotoxic muscarine,which has caused many severe and even deadly poisonings worldwide.However,the taxonomic distribution and evolution of the toxin within the family is largely unknown.In this study,phylogenetic analyses based on nucleotide sequences of ITS and of six molecular loci(ITS,LSU,TEF1,RPB1,RPB2 and ATP6),plus a phylogenomic analysis based on 485 single-copy orthologous genes,were performed to reconstruct the framework of Clitocybaceae.BEAST analysis was used to estimate the divergence times within the family.Additionally,biochemical analysis for muscarine was conducted of 32 representative species.Based on these analyses,an updated classification of Clitocybaceae into six genera(Clitocybe,Collybia,Dendrocollybia,Lepista,Pseudolyophyllum,and Singerocybe)is proposed.The genus Collybia is emended to accommodate four subgenera(Collybia,Crassicybe,Leucocalocybe,and Macrosporocybe).Seventeen new chinese species and 15 new combinations are proposed.Keys to the genera of Clitocybaceae and the subgenera of Collybia,as well as to the known species of Clitocybe and Collybia subgen.Collybia in China,are presented.In addition,muscarine was detected in 18 species,and these muscarine-containing species formed a major monophyletic clade within Collybia subgen.Collybia.Finally,our phylogenetic,phylogenomic,chemotaxonomic and molecular dating results indicate that the Clitocybaceae is a natural group estimated to have arisen some 60 million years ago,and in this family,muscarine has evolved only once circa 20 million years ago without later losses.

关键词： Clitocybe Clitocyboid Collybia Muscarine Phylogenomic analysis Single-copy gene

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Anti-colon cancer activity of water-soluble polysaccharides extracted from Gloeostereum incarnatum via Wnt/β-catenin signaling pathway

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Food Science and Human Wellness 2021年第4期10卷 460-470页

作者： Jiawei He Anhui Yang Xuyu Zhao Yang Liu Shuyan Liu Di Wang engineering research center of chinese ministry of education for edible and medicinal fungi Jilin Agricultural UniversityChangchun 130118China School of Life Sciences Jilin UniversityChangchun 130012China

The incidence rate of colon cancer ranks the third among malignant tumors worldwide.Gloeostereum incarnatum(GI),a fungus with homology of medicine and food,has multiple pharmacological activities.It was investigated in this study that the anti-colon cancer effect of polysaccharides purifi ed from GI(GIPS)in ApcMinC/Gpt mice(an in situ colon cancer mouse model).Eight-week administration with GIPS at doses of 30 or 90 mg/kg strongly inhibited tumor growth including the reduction on numbers and the suppression of the size without infl uencing the animals’body weight and organ functions.According to the proteomics performing by antibody array,among 308 detected cytokines,GIPS significantly regulated 89 of them.Compared with vehicle-treated mice,GIPS effectively reduced the levels of interleukin(IL)-1β,IL-4,IL-6,IL-17,IL-22,tumor necrosis factor(TNF)-α,matrix metalloproteinase(MMP)-2,and enhanced the levels of IL-15 and IL-18 in serum and/or colon tissues,which suggested its anti-inflammation of GIPS.GIPS suppressed nuclear aggregation of β-catenin,affected the expression of WNT1 and related proteins,thereby regulated the activation of the Wnt signaling.Altogether,GIPS can inhibit the growth of colon cancer,at least partially,via inhibiting the Wnt/β-catenin signaling pathway.

关键词： Gloeostereum incarnatum Water-soluble polysaccharides Colon cancer Wnt/β-catenin

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Auricularia polytricha and Flammulina velutipes ameliorate inflammation and modulate the gut microbiota via regulation of NF-κB and Keap1/Nrf2 signaling pathways on DSS-induced inflammatory bowel disease

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Food Bioscience 2022年第3期47卷 356-370页

作者： Ivan Stève Nguepi Tsopmejio Miao Ding Jiali Wei Cong Zhao Yu Jiang Yuting Li Hui Song School of Life Science Jilin Agricultural UniversityJilinPR China Department of Animal Biology and Physiology University of Yaoundé ICameroon engineering research center of chinese ministry of education for edible and medicinal fungi ChangchunPR China

Flammulina velutipes and Auricularia polytricha are two popular dietary mushrooms,especially in the Northeast of China.They have revealed many pharmacological effects due to their bioactive compounds,but their possible mechanism of action involved in inflammation remains poorly known.Therefore,Inflammatory bowel disease(IBD)which is a chronic disease and progressive inflammation in the gastrointestinal tract were used to evaluate their anti-inflammatory and modulatory properties on the intestinal microbiota via the signaling pathways involved by oral administration of F.velutipes(FVE)and A.polytricha(APE).Mice were daily received 3%DSS in the drinking water followed by the daily administration of FVE and APE.The food consumption,weight variation and DAI score were assessed during the experiment and inflammatory parameters,mRNA and protein expressions to determine the possible signaling pathways involved,and the gut microbiota from the cecum by high-throughput sequencing.Data showed that APE and FVE improved clinical symptoms,inflammatory cytokines and oxidative markers.They also attenuated the mRNA and proteins expressions in colon tissue.Moreover,APE and FVE regulated DSS-induced intestinal dysbiosis and stimulated the SCFAs production.Overall,APE and FVE could improve DSS-induced IBD in mice suggesting that they represent novels therapeutic drugs and could be used as prebiotic to modulate the gut microbiota and preserve intestinal integrity.

关键词： Flammulina velutipes Auricularia polytricha Inflammatory bowel disease Signaling pathways Intestinal microbiota

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Healthy function and high valued utilization of edible fungi

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Food Science and Human Wellness 2021年第4期10卷 408-420页

作者： Yanrong Zhang Dawei Wang Yuetong Chen Tingting Liu Shanshan Zhang Hongxiu Fan Hongcheng Liu Yu Li School of Food Science and engineering Jilin Agricultural UniversityChangchun 130118China Scientifi c research Base of edible Mushroom Processing Technology Integration of ministry of Agriculture and Rural Affairs Changchun 130118China engineering research center of Grain Deep-processing and High-effeciency Utilization of Jilin Province Changchun 130118China engineering research center of chinese ministry of education for edible and medicinal fungi Jilin Agricultural UniversityChangchun 130118China

edible fungi are large fungi with high added value that can be utilized as resources.They are rich in high-quality protein,carbohydrate,various vitamins,mineral elements and other nutrients,and are characterized by high protein,low sugar,low fat and low cholesterol.In addition,edible fungi contain a variety of bioactive substances,such as polysaccharides,dietary fiber,steroids,polyphenols,and most of these compounds have antioxidant,anti-tumor and other physiological functions.This review comprehensively discusses the bioactive components and functional characteristics of edible fungi(such as antioxidant,anti-aging,hypolipidemic activities,etc.).Then the recent developments and prospect in the high-valued utilization of edible fungi are discussed and summarized.The objective of this review is to improve the understanding of health-promoting properties of edible fungi,and provide reference for the industrial production of edible fungi-based health products.

关键词： edible fungi Functional components Processing and utilization High valued utilization

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Perilla frutescens:A traditional medicine and food homologous plant

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chinese Herbal Medicines 2023年第3期15卷 369-375页

作者： Xinling Wu Shuting Dong Hongyu Chen Miaoxian Guo Zhiying Sun Hongmei Luo College of Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China Key Lab of chinese Medicine Resources Conservation State Administration of Traditional Chinese Medicine of ChinaInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China engineering research center of chinese Medicine Resource Ministry of EducationBeijing 100193China

Perilla frutescens,an annual herb of the Labiatae family,has been cultivated in China for more than 2000 years.P.frutescens is the one of the first medicinal and edible plant published by the ministry of Health.Its leaves,stems and seeds can be used as medicine and edible food.Because of the abundant nutrients and bioactive components in this plant,P.frutescens has been studied extensively in medicine,food,health care and chemical fields with great prospects for development.This paper reviews the cultivation history,chemical compositions and pharmacological activities of P.frutescens,which provides a reference for the development and utilization of P.frutescens resources.

关键词： bioactive compounds medicine and food homology Perilla frutescens(L.)Britt pharmacological activities

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