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Analysis of the Immune Response by Standardized Whole‑Blood Stimulation with Metabolism Modulation

Phenomics 2024年第1期4卷 81-89页

作者： Jialin Zhao Xuling Han Helian Li Yali Luo Yan Fang Yun Wang Jian Gao Yiran Zhao Jingxuan Han Feng Qian State Key Laboratory of Genetic engineering ShanghaiPublic Health Clinical CenterHuman PhenomeInstituteZhangjiang Fudan International InnovationCenter and School of Life SciencesFudan UniversityShanghai 200438China Ministry of Education Key Laboratory of ContemporaryAnthropology School of Life SciencesFudan UniversityShanghai 200438China Institute of Immunophenome International Human PhenomeInstitutes(Shanghai)Shanghai 200433China

The immune system defends the body from infection and plays a vital role in a wide range of health *** afects a series of physiological processes,including those linked to the function of human immune *** metabolism modulates immune cell activation and cytokine *** the relationship between metabolism and immune response has important implications for the development of immune-based ***,the deployment of large-scale functional assays to investigate the metabolic regulation of immune response has been limited by the lack of standardized ***,we present a protocol for the analysis of immune response using standardized whole-blood stimulation with metabolism *** immune stimuli including pattern recognition receptor(PRR)ligands and microbial stimuli were incubated with fresh human whole *** metabolic inhibitors were used to modulate metabolic status in the immune *** variable immune responses after metabolic interventions were *** described in detail the main steps involved in the whole-blood stimulation and cytokines quantifcation,namely,collection and treatment of whole blood,preparation of samples and controls,cytokines detection,and stimulation with metabolic *** metabolic inhibitors for anabolic pathways and catabolic pathways exert selective efects on the production of cytokines from immune *** addition to a robust and accurate assessment of immune response in cohort studies,the standardized whole-blood stimulation with metabolic regulation might provide new insights for modulating immunity.

关键词： Immune response Whole blood stimulation Cytokines Immunometabolism

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Experimental Study of Microalgae Cultivation under Selective Illumination by Ag/CoSO_(4)for Bioelectrode Materials preparation

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Journal of Renewable Materials 2023年第6期11卷 2849-2864页

作者： Kai Zhu Hao Chen Shuang Wang Chuan Yuan Bin Cao Jun Ni Lujiang Xu Anqing Zheng Arman Amani Babadi School of Energy and Power engineering Jiangsu UniversityZhenjiang212013China School of agricultural engineering Jiangsu UniversityZhenjiang212013China research center of Fluid Machinery engineering and Technology Jiangsu UniversityZhenjiang212013China Biomass Group College of EngineeringNanjing Agricultural UniversityNanjing210031China Guangzhou Institute of Energy Conversion Chinese Academy of SciencesGuangzhouChina

Microalgae biomass is an ideal precursor to prepare renewable carbon materials,which has broad *** bioaccumulation efficiency(lipids,proteins,carbohydrates)and biomass productivity of microalgae are influenced by spectroscopy during the culture *** this study,a bilayer plate-type photobioreactor was designed to cultivate Chlorella protothecoides with spectral selectivity by *** to culture without spectral selectivity,the spectral selectivity of Ag/CoSO_(4)nanofluids increased microalgae biomass by 5.76%,and the spectral selectivity of CoSO_(4)solution increased by 17.14%.In addition,the spectral selectivity of Ag/CoSO_(4)nanofluids was more conducive to the accumulation of nutrients(29.46%lipids,50.66%proteins,and 17.86%carbohydrates)in *** cultured chlorella was utilized to prepare bioelectrode materials,it was found that algal based biochar had a good pore structure(micro specific surface area:1627.5314 m^(2)/g,average pore size:0.21294 nm).As the current density was 1 A/g,the specific capacitance reached 230 F/g,appearing good electrochemical performance.

关键词： Bioelectrode materials Ag/CoSO_(4)nanofluids spectral selectivity microalgae cultivation pore structure

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The effects of fermentation and adsorption using lactic acid bacteria culture broth on the feed quality of rice straw

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Journal of Integrative Agriculture 2015年第3期14卷 503-513页

作者： LIU Jing-jing LIU Xiao-ping REN Ji-wei ZHAO Hong-yan YUAN Xu-feng WANG Xiao-fen Abdelfattah Z M Salem CUI Zong-jun College of Agronomy and Biotechnology/center of Biomass engineering China Agricultural University Plants Protecting Station of agricultural Bureau Agronomy of Yanbian University Faculty of Veterinary Medicine and Animal Science Autonomous University of the State of Mexico

To improve the nutritional value and the palatability of air-dried rice straw, culture broth of the lactic acid bacteria community SFC-2 was used to examine the effects of two different treatments, fermentation and adsorption. Air-dried and chopped rice straw was treated with either fermentation for 30 d after adding 1.5 L nutrient solution（50 m L inocula L–1, 1.2×1012 CFU m L–1 inocula） kg–1 straw dry matter, or spraying a large amount of culture broth（1.5 L kg–1 straw dry matter, 1.5×1011 CFU m L–1 culture broth） on the straw and allowing it to adsorb for 30 min. The feed quality and aerobic stability of the resulting forage were examined. Both treatments improved the feed quality of rice straw, and adsorption was better than fermentation for preserving nutrients and improving digestibility, as evidenced by higher dry matter（DM） and crude protein（CP） concentrations, lower neutral detergent fiber（NDF）, acid detergent fiber（ADF） and NH3-N concentrations, as well as higher lactic acid production and in vitro digestibility of DM（IVDMD）. The aerobic stability of the adsorbed straw and the fermented straw was 392 and 480 h, respectively. After being exposed to air, chemical components and microbial community of the fermented straw were more stable than the adsorbed straw.

关键词： adsorption fermentation lactic acid bacteria culture broth rice straw

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QTL effects and epistatic interaction for flowering time and branch number in a soybean mapping population of Japanese×Chinese cultivars

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Journal of Integrative Agriculture 2017年第9期16卷 1900-1912页

作者： YANG Guang ZHAI Hong WU Hong-yan ZHANG Xing-zheng LüShi-xiang WANG Ya-ying LI Yu-qiu HU Bo WANG Lu WEN Zi-xiang WANG De-chun WANG Shao-dong Kyuya Harada XIA Zheng-jun XIE Fu-ti Soybean research Institute Shenyang Agricultural UniversityShenyang 110866P.R.China Key Laboratory of Soybean Molecular Design Breeding Northeast Institute of Geography and AgroecologyChinese Academy of SciencesHarbin 150081P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China Institute of Economic Crop of Liaoning Liaoyang 111000P.R.China Information center Heilongjiang Academy of Agricultural SciencesHarbin 150086P.R.China Department of Plant Soil and Microbial SciencesMichigan State University East LansingMichigan 48824USA National research center of Soybean engineering and Technology Northeast Agricultural UniversityHarbin 150028P.R.China Graduate School of engineering Osaka UniversitySuita 565-0871Japan

Flowering time and branching type are important agronomic traits related to the adaptability and yield of soybean. Molecular bases for major flowering time or maturity loci, E1 to E4, have been identified. However, more flowering time genes in cultivars with different genetic backgrounds are needed to be mapped and cloned for a better understanding of flowering time regulation in soybean. In this study, we developed a population of Japanese cultivar（Toyomusume）×Chinese cultivar（Suinong 10） to map novel quantitative trait locus（QTL） for flowering time and branch number. A genetic linkage map of a F_2 population was constructed using 1 306 polymorphic single nucleotide polymorphism（SNP） markers using Illumina Soy SNP8 ki Select Bead Chip containing 7 189（SNPs）. Two major QTLs at E1 and E9, and two minor QTLs at a novel locus, qFT2_1 and at E3 region were mapped. Using other sets of F_2 populations and their derived progenies, the existence of a novel QTL of qFT2_1 was verified. qBR6_1, the major QTL for branch number was mapped to the proximate to the E1 gene, inferring that E1 gene or neighboring genetic factor is significantly contributing to the branch number.

关键词： soybean quantitative trait loci SNP flowering time branch number

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Effects of lead pollution on soil microbial community diversity and biomass and on invertase activity

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Soil Ecology Letters 2023年第1期5卷 118-127页

作者： Xin Sun Mingjie Sun Ying Chao Xiaoyang Shang Hui Wang Hong Pan Quangang Yang Yanhong Lou Yuping Zhuge National engineering research center for Efficient Utilization of Soil and Fertilizer Resources College of Resources and EnvironmentShandong Agricultural UniversityTai’an 271018China Tai’an Hi-Tech Industrial development Zone Tai’an 271000China Rizhao Municipal Bureau of agricultural and Rural Affairs Rizhao 276800China Key Laboratory of Technologies and Models for Cyclic Utilization from agricultural Resources Ministry of Agriculture and Rural AffairsBeiJing 100125China

Lead(Pb)pollution is one of the most widespread and harmful environmental problems *** of changes in soil properties and microbial functional diversity due to land use is needed to establish a basis for remediation of soil *** study aimed to investigate soils contaminated by Pb from different sources and to analyze the functional diversity and metabolism of soil microbial communities using Biolog *** pollution(>300 mg kg-1)significantly influenced the diversity and metabolic functions of soil microbial ***,Pb contamination significantly reduced soil microbial biomass carbon(C)and nitrogen(N)levels and catalase activity while increasing invertase ***,Biolog EcoPlate assays revealed that Pb pollution reduced the general activities of soil microorganisms,suppressing their ability to utilize C *** Pb-contaminated areas lacking vegetation cover,Shannon,Simpson,and McIntosh diversity indices of soil microorganisms were significantly *** microbial diversity and biomass C and N levels were affected by land use and soil properties,respectively,whereas soil enzyme activity was primarily affected by the interaction between land use and soil *** results provide a reference and a theoretical basis for developing soil quality evaluation and remediation strategies.

关键词： Lead pollution Biolog microbial functional diversity Soil enzyme activities Environment toxicity

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development of the straw biochar returning concept in China

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Biochar 2019年第2期1卷 139-149页

作者： Jun Meng Tianyi He Edmond Sanganyado Yu Lan Weiming Zhang Xiaori Han Wenfu Chen Biochar engineering and Technology research center Shenyang Agricultural UniversityShenyang 110866People’s Republic of China Marine Biology Institute Shantou UniversityShantouGuangdong 515063People’s Republic of China

Biochar produced from straw has been shown to improve soil physicochemical *** review introduces the fundamental concepts,the broad applications,and underlying theory of straw biochar *** developments in biochar industry and the production practices prevalent among enterprises in China are *** review analyzes current knowledge gaps,challenges,and opportunities in the industrial application of straw biochar *** standards,the quantitative and qualitative analysis methods for biochar,and high-value-added products that are based on biochar are critically examined with goal of providing recommendations for future *** propose production and modification of biochar that is application oriented to enhance its fitness for purpose as well as long-term and large-space-scale field study to better understand its impact on soil properties and ***,we make prospects for the future development of SBR,including constructing a standard system about straw biochar returning and promoting self-discipline of biochar industry and the establishment of a biochar-based agricultural production model.

关键词： Straw biochar returning(SBR) Biochar-based agricultural inputs Agriculture China

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Enrichment of beneficial cucumber rhizosphere microbes mediated by organic acid secretion

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Horticulture research 2020年第1期7卷 662-674页

作者： Tao Wen Jun Yuan Xiaoming He Yue Lin Qiwei Huang Qirong Shen Jiangsu Provincial Key Lab for Organic Solid Waste Utilization Key Laboratory of Plant ImmunityJiangsu Collaborative Innovation Center for Solid Organic WastesEducational Ministry Engineering Center of Resource-saving FertilizersNanjing Agricultural University210095 NanjingChina Vegetable research Institute Guangdong Academy of Agricultural SciencesGuangzhou510640 GuangdongChina

Resistant cultivars have played important roles in controlling Fusarium wilt disease,but the roles of rhizosphere interactions among different levels of resistant cultivars are still ***,two phenotypes of cucumber,one resistant and one with increased susceptibility to Fusarium oxysporum ***(Foc),were grown in the soil and hydroponically,and then 16S rRNA gene sequencing and nontargeted metabolomics techniques were used to investigate rhizosphere microflora and root exudate *** high microbial community evenness for the Foc-susceptible cultivar was detected,and the relative abundances of Comamonadaceae and Xanthomonadaceae were higher for the Foc-susceptible cultivar than for the other *** analysis revealed that specific functional traits,such as protein synthesis and secretion,bacterial chemotaxis,and small organic acid metabolism pathways,were significantly upregulated in the rhizobacterial community of the Foc-susceptible cultivar.A machinelearning approach in conjunction with FishTaco plus metabolic pathway analysis revealed that four organic acids(citric acid,pyruvate acid,succinic acid,and fumarate)were released at higher abundance by the Foc-susceptible cultivar compared with the resistant cultivar,which may be responsible for the recruitment of Comamonadaceae,a potential beneficial microbial *** validation demonstrated that Comamonadaceae can be“cultured”by these organic ***,compared with the resistant cultivar,the susceptible cucumber tends to assemble beneficial microbes by secreting more organic acids.

关键词： group susceptibility synthesis

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development of environmentally friendly biological algicide and biochemical analysis of inhibitory effect of diatom Skeletonema costatum

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Chinese Chemical Letters 2022年第3期33卷 1358-1364页

作者： Jie Yang Qingzheng Zhu Jinlong Chai Feng Xu Yunfei Ding Qiang Zhu Zhaoxin Lu Kuan Shiong Khoo Xiaoying Bian Shujun Wang Pau Loke Show Jiangsu Key Laboratory of Marine Bioresources and Environment/Jiangsu Key Laboratory of Marine Biotechnology Jiangsu Ocean UniversityLianyungang 222005China Jiangsu Marine Resources development research Institute Lianyungang 222005China Co-Innovation center of Jiangsu Marine Bio-industry Technology Jiangsu Ocean UniversityLianyungang 222005China Helmholtz Institute of Biotechnology State Key Laboratory of Microbial TechnologyShandong UniversityQingdao 266237China College of Food Science and Technology Nanjing Agricultural UniversityNanjing 210095China Department of Chemical and Environmental engineering Faculty of Science and EngineeringUniversity of Nottingham MalaysiaJalan Broga43500 SemenyihMalaysia

Skeletonema costatum is a diatom widely distributed in red tide microalgae blooms and as one of the main algae causing harmful algal blooms,because of their rapid reproduction and production of toxic and harmful substances,often play a negative role in aquatic ecosystems,and human health and *** D is a nonribosomal cyclic antifungal lipopeptide in the iturins *** this study,Bacillomycin D was tested for its ability to inhibit the growth of *** EC_(50 24h) of Bacillomycin D on *** was 24.70μg/*** chlorophyll fluorescence parameters F_(v)/F_(m),F_(v)/F_(o),and yield of the diatoms decreased significantly with increasing concentrations of Bacillomycin *** of the mechanism showed that Bacillomycin D induced cell death by changing cell membrane permeability,promoting the release of cellular *** this study,transcriptomic analysis showed Bacillomycin D significantly inhibited the photosynthesis and metabolism of *** findings investigated the inhibitory effect of Bacillomycin D on the growth of *** and provided a theoretical foundation for the development of new environmentally friendly biological algicide.

关键词： Bacillomycin D Skeletonema costatum Transcriptome Growth inhibition Photosynthesis

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Tea stain-inspired solar energy harvesting polyphenolic nanocoatings with tunable absorption spectra

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Nano research 2021年第4期14卷 969-975页

作者： Lu Yang Yuan Zou Wei Xia Haotian Li Xinyu He Yi Zhou Xianhu Liu Chaoqun Zhang Yiwen Li College of Polymer Science and engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China National engineering research center for Advanced Polymer Processing Technology Zhengzhou UniversityZhengzhou 450002China Key Laboratory for Biobased Materials and Energy of Ministry of Education College of Materials and EnergySouth China Agricultural University483 Wushan RoadGuangzhou 510642China Guangdong Laboratory for Lingnan Modem agricultural Science and Technology 483 Wushan RoadGuangzhou 510642China

Discovery and development of new sustainable photothermal materials with tunable light absorption spectra play a key role in solar energy harvesting and *** possible solution to this quest is to check nature as a source of matters or *** by the formation of tea stains,a unique class of dark stain materials generated by the interfacial reaction between tea polyphenols and metal substance,we reported the facile preparation and screening of a series of photothermal nanocoating layers via the metal ion(i.e.C u(ll)>Fe(lll),Ni(ll),Zn(ll))promoted in situ polymerization of typical phenolic moieties of tea polyphenols(i.e.,catechol and pyrogallol).It was found that those resulting metal-polyphenolic nanocoatings showed various promising features,such as high blackness and strong adhesion,excellent and tunable light absorption properties,good hydrophilicity and long-term *** further fabricated the photothermal composite devices by/n s/'fty formation of meta卜polyphenolic nanocoatings on pristine silks for solar desalination,which demonstrated promising durable evaporation behaviors with excellent evaporation rates and steam generation *** believe that this work could provide more opportunities towards new types of bio-inspired and sustainable photothermal nanomaterials for solar energy harvesting applications such as water desalination.

关键词： metal-polyphenolic nanocoating polymerization light absorption photothermal solar desalination

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Metabolic engineering of Bacillus amyloliquefaciens for efficient production ofα-glucosidase inhibitor1-deoxynojirimycin

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Synthetic and Systems Biotechnology 2023年第3期8卷 378-385页

作者： Xujie Li Meng Zhang Yu Lu Ningyang Wu Jian’gang Chen Zhixia Ji Yangyang Zhan Xin Ma Junyong Chen Dongbo Cai Shouwen Chen State Key Laboratory of Biocatalysis and Enzyme engineering Environmental Microbial Technology Center of Hubei ProvinceCollege of Life SciencesHubei UniversityWuhan430062China State Key Laboratory of agricultural Microbiology Huazhong Agricultural UniversityWuhan430070China Department of Urology Zhuhai People’s Hospital(Zhuhai Hospital Affiliated to Jinan University)Zhuhai519000China Wuhan Jun’an Biotechnology Co. Ltd.Wuhan430070China

Owing to the feature of strongα-glucosidase inhibitory activity,1-deoxynojirimycin(1-DNJ)has broad application prospects in areas of functional food,biomedicine,etc.,and this research wants to construct an efficient strain for 1-DNJ production,basing on Bacillus amyloliquefaciens ***,using the temperature-sensitive shuttle plasmid T2(2)-Ori,gene ptsG in phosphotransferase system(PTS)was weakened by homologous recombination,and non-PTS pathway was strengthened by deleting its repressor gene iolR,and 1-DNJ yield of resultant strain HZ-S2 was increased by 4.27-fold,reached 110.72 mg/***,to increase precursor fructose-6-phosphate(F-6-P)supply,phosphofructokinase was weaken,fructose phosphatase GlpX and 6-phosphate glucose isomerase Pgi were strengthened by promoter replacement,moreover,regulator gene nanR was deleted,1-DNJ yield was further increased to 267.37 mg/L by ***,promoter of 1-DNJ synthetase cluster was optimized,as well as 5′-UTRs of downstream genes in synthetase cluster,and 1-DNJ produced by the final strain reached 478.62 mg/*** but not the least,1-DNJ yield of 1632.50 mg/L was attained in 3 L fermenter,which was the highest yield of 1-DNJ reported to *** together,our results demonstrated that metabolic engineering was an effective strategy for 1-DNJ synthesis,this research laid a foundation for industrialization of functional food and drugs based on 1-DNJ.

关键词： 1-Deoxynojirimycin Bacillus amyloliquefaciens Metabolic engineering Glucose transport pathway Fructose 6-phosphate 1-DNJ synthetase Gene cluster

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