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Anti-Inflammatory and Neuroprotective Effect of Bilobalide on MPTP-Induced Parkinson's Disease Mice

神经药理学报 2019年第Z1期 111-112页

作者： SUI Ruo-xuan WANG Jing MIAO Qiang WANG Qing SONG Li-juan YU Jing-wen ZHONG Jie CHAI Zhi CAO Liang XIAO Wei XIAO Bao-guo MA Cun-gen The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine and Scientific and Technological Innovation Team of Integrated Chinese and Western Medicine for the Prevention and Treatment on Nervous System DiseasesShanxi University of Chinese Medicine Dept.of Neurology First Affiliated HospitalShanxi Medical University Institute of Brain Science Shanxi Key Laboratory of Inflammatory Neurodegenerative DiseasesShanxi Datong University Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process 5. Institute of Neurology Huashan HospitalInstitutes of Brain Science and State Key Laboratory of Medical NeurobiologyFudan University

Background:Parkinson’s disease(PD) is one of the most widespread neurodegenerative disorder,characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta(SNpc) of the brain. The precise pathogenesis of PD is still unclear. Currently,there are no effective drug that can prevente and improve the progression of PD. Bilobalide exhibites neuroprotective,anti-inflammatory and anti-apoptotic effects in various models of neurological diseases. However,the effect of Bilobalide(BB) on demyelinating lesion was not reported. Objective:To observe the therapeutic potential of Bilobalide in MPTP-induced PD model,and explore its possible mechanisms of action. material and Methods:Mice were randomly divided into three groups:healthy group,MPTP group and MPTP + BB group. PD model was induced by intraperitoneal injection of MPTP into male C57 BL/6 mice(the first day=15 mg·kg-1,the second day=20 mg·kg-1 and the third day=30 mg·kg-1 and for 5 consecutive days). Then,mice received intraperitoneal injection of BB(40 mg·kg-1·d-1) at the beginning of second week and for 7 consecutive days. The injection of saline was set up as control in a similar manner. DigiGait analysis was performed to evaluate motor symptoms. Flow cytometry was used to analyze the population of T cell subsets. Immunohistochemistry staining was used to detect microglia phenotype. Western blot technique was carried out to analyze the expression of protein. ELISA assay was used to measure the titer of antibody and the level of cytokines. Results:BB effectively relieved motor symptoms and declined the loss of Th+ neurons in the SNpc of the brain as compared MPTP-PD mice. Similarly,the expression of TH protein enhanced in the extract from brain of mice treated with BB. BB induced the transformation of inflammatory M1 into anti-inflammatory M2 microglia,revealing that BB attenuated microgliaassociated neuroinflammation. Besides,BB promoted the expression of neurotrophic factors BDNF and GDNF in GFAP

关键词： bilobalide Parkinson’s disease dopaminergic neuron nerve regeneration

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Nano-copper Oxide as Catalyst for Click Reactions

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Journal of Chemistry and Chemical Engineering 2016年第7期10卷 341-346页

作者： Reda Abdelhady Mustafa ElKhashab Abdelaziz Ahmed Nayl Elsayed Mohamed Badawy TamerAbdelmoemen El Malah Chemistry Department College of Science Aljouf University Sakaka Kingdom of Saudi Arabia National Center for Clinical and Environmental Toxicology Faculty of Medicine Cairo University Cairo Egypt Hot Laboratories Centre Atomic Energy Authority Cairo P.O. 13 759 Egypt Photochemistry Department National Research Centre 33 E1Buhouth Street PO 12622 Dokki Giza Egypt

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Diffraction-limited imaging with monolayer 2D material-based ultrathin flat lenses

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Light(Science & Applications) 2020年第1期9卷 696-706页

作者： Han Lin Zai-Quan Xu Guiyuan Cao Yupeng Zhang Jiadong Zhou Ziyu Wang Zhichen Wan Zheng Liu Kian Ping Loh Cheng-Wei Qiu Qiaoliang Bao Baohua Jia Centre for Translational Atomaterials Faculty of ScienceEngineering and TechnologySwinburne University of TechnologyP.O.Box 218HawthornVIC 3122Australia Department of materials Science and Engineering ARC Centre of Excellence in Future Low-Energy Electronics Technologies(FLEET)Monash UniversityWellington RoadClaytonVIC 3800Australia School of Mathematical and Physical Sciences Faculty of ScienceUniversity of Technology Sydney15 BroadwayUltimoNSW 2007Australia Institute of Microscale Optoelectronics Lab of Artificial Microstructure for OptoelectronicsShenzhen University518000 ShenzhenChina School of materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore Department of Chemistry National University of SingaporeSingapore 117543Singapore Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore The Australian Research Council(ARC)Industrial Transformation Training Centre in Surface Engineering for Advanced materials(SEAM) Swinburne University of TechnologyP.O.Box 218HawthornVIC 3122Australia

Ultrathin flat optics allow control of light at the subwavelength scale that is unmatched by traditional refractive *** approach the atomically thin limit,the use of 2D materials is an attractive possibility due to their high refractive ***,achievement of diffraction-limited focusing and imaging is challenged by their thickness-limited spatial resolution and focusing *** we report a universal method to transform 2D monolayers into ultrathin flat *** laser direct writing was applied to generate local scattering media inside a monolayer,which overcomes the longstanding challenge of obtaining sufficient phase or amplitude modulation in atomically thin 2D *** achieved highly efficient 3D focusing with subwavelength resolution and diffractionlimited *** high focusing performance even allows diffraction-limited imaging at different focal positions with varying *** work paves the way for downscaling of optical devices using 2D materials and reports an unprecedented approach for fabricating ultrathin imaging devices.

关键词： ultrathin scattering optics

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Improved Thermophysical Properties of Developed Ternary Nitrate-Based Phase Change material Incorporated with MXene as Novel Nanocomposites

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energy Engineering 2021年第5期118卷 1253-1265页

作者： I.Samylingam Navid Aslfattahi K.Kadirgama Mahendran Samykano L.Samylingam R.Saidur Faculty of Mechanical&Automotive Engineering Technology Universiti Malaysia PahangPekanPahang26600Malaysia Department of Mechanical Engineering Faculty of EngineeringUniversity of MalayaKuala Lumpur50603Malaysia College of Engineering Universiti Malaysia PahangGambangPahang26300Malaysia Research Centre for Nano-materials and energy Technology School of Engineering and TechnologySunway UniversityPetaling Jaya47500Malaysia Department of Engineering Lancaster UniversityLancasterLA14YWUK

In this study,nanocomposite of ternary nitrate molten salt induced with MXene is ***3-NaNO3-KNO3 with wt%of 35:12:53 and 35:10:55 are produced and doped with MXene in the wt%of 0.2,0.5,1.0,and *** result indicates the composites had no chemical reaction occurred during the ***-VIS analysis shows the absorption enhancement with respect to the concentration of *** analysis(TGA)was used to measure the thermal stability of the LiNO_(3)-NaNO_(3)-KNO_(3) induced with *** ternary molten salts were stable at temperature range of 600–700°*** stability increases with the addition of MXene.1.5 wt%of MXene doped with LiNO_(3)-NaNO_(3)-KNO_(3) with wt%35:10:55 and 35:12:53,increases the thermal stability from 652.13°C to 731.49°C and from 679.82°C to 684.57°C,*** thermophysically enhanced molten salt will increase the efficiency of CSP.

关键词： Molten salt MXene TES specific heat capacity PCM

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Chiral Dirac Fermion in a Collinear Antiferromagnet

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Chinese Physics Letters 2023年第12期40卷 84-91页

作者：张奥邓可盛洁明刘鹏飞 Shiv Kumar Kenya Shimada 江志诚刘正太沈大伟李嘉裕任俊王乐周良 Yoshihisa Ishikawa Takashi Ohhara Qiang Zhang Garry McIntyre Dehong Yu 刘恩克吴留锁陈朝宇刘奇航 Shenzhen Institute for Quantum Science and Technology and Department of Physics Southern University of Science and TechnologyShenzhen 518055China Academy for Advanced Interdisciplinary Studies Southern University of Science and TechnologyShenzhen 518055China Hiroshima Synchrotron Radiation Centre Hiroshima UniversityHigashi-HiroshimaHiroshima 739-0046Japan State Key Laboratory of Functional materials for Informatics and Center for Excellence in Superconducting Electronics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China Neutron Science and Technology Center Comprehensive Research Organization for Science and SocietyTokaiIbaraki 319-1106Japan Neutron Science Section J-PARC CenterJapan Atomic Energy AgencyIbaraki 319-1195Japan Neutron Science Division Oak Ridge National LaboratoryOak RidgeTennessee 37831USA Australian Nuclear Science and Technology Organisation Locked bag 2001Kirrawee DCNew South Wales 2232Australia State Key Laboratory for Magnetism Institute of PhysicsChinese Academy of SciencesBeijing 100190China

In a Dirac semimetal, the massless Dirac fermion has zero chirality, leading to surface states connected adiabatically to a topologically trivial surface state as well as vanishing anomalous Hall effect. Recently, it is predicted that in the nonrelativistic limit of certain collinear antiferromagnets, there exists a type of chiral“Dirac-like” fermion, whose dispersion manifests four-fold degenerate crossing points formed by spin-degenerate linear bands, with topologically protected Fermi arcs. Such an unconventional chiral fermion, protected by a hidden SU(2) symmetry in the hierarchy of an enhanced crystallographic group, namely spin space group, is not experimentally verified yet. Here, by angle-resolved photoemission spectroscopy measurements, we reveal the surface origin of the electron pocket at the Fermi surface in collinear antiferromagnet CoNb3S6. Combining with neutron diffraction and first-principles calculations, we suggest a multidomain collinear antiferromagnetic configuration, rendering the the existence of the Fermi-arc surface states induced by chiral Dirac-like *** work provides spectral evidence of the chiral Dirac-like fermion caused by particular spin symmetry in CoNb_(3)S_(6), paving an avenue for exploring new emergent phenomena in antiferromagnets with unconventional quasiparticle excitations.

关键词： Fermi Dirac chiral

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Effects of Lizardite Addition on Technological Properties of Forsterite- monticellite Rich Ceramics Prepared from Natural Magnesite and Dolomite

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Journal of Construction Research 2020年第1期2卷 9-20页

作者： Ahmed Manni Achraf Harrati Abdelilah El Haddar Abdelwahed Chari Ali Sdiri Fahd Oudrhiri Hassani Abdeslam El Bouari Iz-Eddine El Amrani El Hassani Chaouki Sadik Laboratory of Physical Chemistry of Applied materials(LPCMA) Department of ChemistryFaculty of Sciences Ben MsikHassan II University of CasablancaMorocco Laboratory of Applied Geosciences Faculty of SciencesUniversity of Mohammed 1OujdaMorocco materials Sciences Energy and Nano-engineering DepartmentMohammed VI Polytechnic UniversityBen GuerirMorocco Department of Georessources and Environment National Engineering SchoolUniversity of SfaxP.Box 3052SfaxTunisia LMPEQ University of Cadi AyyadENSA of SAFIMorocco Geomaterials and Geo environment team/Geo-Biodiversity and Natural Patrimony Laboratory (GEOBIO)/GeophysicsNatural Patrimony and Green Chemistry Research Centre(GEOPAC)Scientific InstitutMohammed V University of RabatMorocco

Lizardite rich peridotite has never been used to prepare ceramic specimens,especially in *** this raison,potential use of naturally abundant lizarditic material from the Rif domain,as a supply for ceramic industry,has been *** effects of lizardite addition to magnesite and dolomite mixtures on the thermomechanical properties of the calcined ceramics were also *** achieve this target,natural lizardite,magnesite and dolomite samples were collected in ultrabasic Beni Bousra *** raw samples were used for the synthesis of a forsterite-monticellite rich *** raw and sintered samples were characterized by x-ray diffraction,scanning electron microscope and fourier transform *** obtained results showed that both magnesite and dolomite were mainly composed of MgCO_(3) and CaCO_(3).In contrast,lizardite sample showed high amounts of SiO_(2),MgO and Fe2O_(3).An increased amount of lizardite in the initial mixtures enhanced mechanical and dimensional properties of the prepared ceramic specimens,and subsequently,the production of ceramics with the required technological ***,the preparation of Moroccan lizardite-based ceramics is technically feasible,economically justifiable and socially desirable due to the contribution to the economic growth of the raw materials sector,especially ceramic industry.

关键词： Forsterite Monticellite Lizardite Basic ceramics Temperature

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具有超低热导率的一维铋硒卤族化合物

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Science China materials 2020年第9期63卷 1759-1768页

作者：王东洋黄志伟张杨郝丽杰王广涛邓司浩王洪亮陈洁何伦华肖宝徐亚东 Stephen J.Pennycook 武海军赵立东 School of materials Science and Engineering Beihang UniversityBeijing 100191China State Key Laboratory for Mechanical Behavior of materials Xi’an Jiaotong UniversityXi’an 710049China Instrumental Analysis Center of Xi’an Jiaotong University Xi’an Jiaotong UniversityXi’an 710049China Department of materials Science and Engineering National University of SingaporeSingapore 117575Singapore Department of Nuclear Physics Neutron Scattering LaboratoryChina Institute of Atomic EnergyBeijing 102413China School of Physics Henan Normal UniversityXinxiang 453007China Spallation Neutron Source Science Center Dongguan 523803China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Songshan Lake materials Laboratory Dongguan 523808China State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China

本征低热导率材料的研究具有重要的科学意义,已引起广泛关注.本工作报道了一类具有简单一维晶体结构的超低热导率材料:铋硒卤族化合物(BiSeX,X=Br,I).研究发现,BiSeI的热导率在573K仅为~0.27Wm^-1K^-1,达到了最低本征热导率的理论极限值... 详细信息

本征低热导率材料的研究具有重要的科学意义,已引起广泛关注.本工作报道了一类具有简单一维晶体结构的超低热导率材料:铋硒卤族化合物(BiSeX,X=Br,I).研究发现,BiSeI的热导率在573K仅为~0.27Wm^-1K^-1,达到了最低本征热导率的理论极限值.本研究采用第一性原理计算结合粉末中子衍射和变温球差扫描透射电子显微镜表征,深入探究了其超低热导率的机制.研究表明,BiSeX的一维结构赋予了材料低热导特性:弱的成键特性、低的声子速度、声学支和光学支的强非简谐性以及Bi和卤族元素较大的偏移效应,从而有效阻碍了声子输运,使得BiSeX具有超低的热导率.本研究提出了在具有一维结构的材料中寻找低传导特性的新思路,该研究思路在热电材料和热障涂层材料等低热传导需求领域中具有广阔的应用前景.

关键词： low thermal conductivity 1D bulk material bismuth selenohalides first-principles calculations

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