检索结果-南通市图书馆

Chinese Medical Journal 2008年第7期121卷 667-670页

作者： BI Yu-fang YE Lei CHEN Yu-hong NING Guang SUN Shou-yue JIANG Lei ZHU Na ZHOU Wei-wei WANG Wei-qing Department of endocrinology and Metabolism Shanghai ClinicalCenter for Endocrine and Metabolic Diseases Shanghai Instituteof Endocrine and Metabolic Diseases Ruijin Hospital ShanghaiJiao Tong University School of Medicine Shanghai 200025 China

Ectopic adrenocorticotropic hormone （ACTH） secretion rfrom a non-pituitary tumor is a main cause of Cushing＇s syndrome, which is associated with significant morbidity and mortality. Although early studies showed that the predominant cause of ectopic Cushing＇s syndrome is small cell carcinomas of the lungs, the incidence of carcinoid, including thymic carcinoid, has increased substantially in recent surveys） This evidence suggested that the clinical syndrome of ectopic ACTH production only occurs in tumors with high proopiomelanocortin （POMC, the precursor to ACTH） transcripts generated from the start of the pituitary transcription initiation site.2

关键词： ectopic A CTH syndrome Cushing's syndrome thymic tumor proopiomelanocortin

Role of nutritional ketosis in the improvement of metabolic parameters following bariatric surgery

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2022年第1期13卷 54-64页

作者： Fioralba Pindozzi Carlo Socci Massimiliano Bissolati Monica Marchi Elisabetta Devecchi Alessandro Saibene Caterina Conte Unitàdi Chirurgia Generale Provinciale Ospedale del DeltaLagosanto(FE)44023Italy Transplant and metabolic/Bariatric Surgery Unit IRCCS Ospedale San RaffaeleMilan 20132Italy Department of General Medicine Diabetes and EndocrinologyIRCCS Ospedale San RaffaeleMilan 20132Italy Department of Human Sciences and Promotion of the Quality of Life San Raffaele Open UniversityRome 00166Italy Department of endocrinology Nutrition and Metabolic DiseasesIRCCS MultiMedicaMilan 20099Italy

BACKGROUND Ketone bodies(KB)might act as potential metabolic modulators besides serving as energy *** metabolic surgery(BMS)offers a unique opportunity to study nutritional ketosis,as acute postoperative caloric restriction leads to increased lipolysis and circulating free fatty *** To characterize the relationship between KB production,weight loss(WL)and metabolic changes following *** For this retrospective study we enrolled male and female subjects aged 18-65 years who underwent BMS at a single *** on demographics,anthropometrics,body composition,laboratory values and urinary KB were *** Thirty-nine patients had data available for analyses[74.4%women,mean age 46.5±9.0 years,median body mass index 41.0(38.5;45.4)kg/m^(2),fat mass 45.2%±6.2%,23.1%had diabetes,43.6%arterial hypertension and 74.4%liver steatosis].At 46.0±13.6 d post-surgery,subjects had lost 12.0%±3.6%of pre-operative ***-nine percent developed *** with nutritional ketosis were significantly younger[42.9(37.6;50.7)years vs 51.9(48.3;59.9)years,P=0.018],and had significantly lower fasting glucose[89.5(82.5;96.3)mg/dL vs 96.0(91.0;105.3)mg/dL,P=0.025]and triglyceride levels[108.0(84.5;152.5)mg/dL vs 152.0(124.0;186.0)mg/dL,P=0.045]vs those with *** 6 mo,percent WL was greater in those with postoperative ketosis(-27.5%±5.1%vs 23.8%±4.3%,P=0.035).Urinary KBs correlated with percent WL at 6 and 12 *** metabolic changes were *** Our data support the hypothesis that subjects with worse metabolic status have reduced ketogenic capacity and,thereby,exhibit a lower WL following BMS.

关键词： Obesity Ketone bodies Bariatric surgery Weight loss Glucose metabolism Lipid metabolism

Common and distinct regulation of human and mouse brown and beige adipose tissues： a promising therapeutic target for obesity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2017年第6期8卷 446-454页

作者： Xuejiao Liu Christopher Cervantes Feng Liu Department of Metabolism and endocrinology Metabolic Syndrome Research Center of Central South University The Second Xianqya Hospital Central South University Changsha 410011 China Department of Pharmacology University of Texas Health Science Center at San Antonio San Antonio TX 78229 USA

Obesity, which underlies various metabolic and cardio- vascular diseases, is a growing public health challenge for which established therapies are inadequate. Given the current obesity epidemic, there is a pressing need for more novel therapeutic strategies that will help adult individuals to manage their weight. One promising therapeutic intervention for reducing obesity is to enhance energy expenditure. Investigations into human brown fat and the recently discovered beige/brite fat have galvanized intense research efforts during the past decade because of their pivotal roles in energy dissi- pation. In this review, we summarize the evolution of human brown adipose tissue （hBAT） research and dis- cuss new in vivo methodologies for evaluating energy expenditure in patients. We highlight the differences between human and mouse BAT by integrating and comparing their cellular morphology, function, and gene expression profiles. Although great advances in hBAT biology have been achieved in the past decade, more cellular models are needed to acquire a better under- standing of adipose-specific processes and molecular mechanisms. Thus, this review also describes the development of a human brown fat cell line, which could provide promising mechanistic insights into hBAT function, signal transduction, and development. Finally, we focus on the therapeutic potential and current limi- tations of hBAT as an anti-glycemic, anti-lipidemic, and weight loss-inducing ＇metabolic panacea＇.

关键词： human brown adipose tissue energymetabolism obesity

3ehavioral Analysis of Chinese Adult Patients with Type 1 Diabetes on Self-monitoring of Blood Glucose

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2017年第1期130卷 39-44页

作者： Zhao-Yi Qin Jin-Hua Yan Dai-Zhi Yang Hong-Rong Deng Bin Yao Jian-Ping Weng Department of endocrinology and metabolic disease The Third Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong 510630 China Guangdong Diabetes Center Guangzhou Guangdong 510630 China Guangdong Provincial Key Laboratory of Diabetology Guangzhou Guangdong 510630 China

Background： The information-motivation-behavioral skills （IMB） model of health behavior is an effective tool to evaluate the behavior of diabetes self-management. The purpose of this study was to explore behavioral factors affecting the practice of self-monitoring of blood glucose （SMBG） within the frame of IMB model of health behavioral among adult patients with type 1 diabetes in a single diabetes clinic in China. Methods： A questionnaire with three subscales on SMBG information, motivation, and behavioral skills based on IMB model was developed. Validity and reliability of the measures were examined and guaranteed. Adult patients with type 1 diabetes visiting our diabetes clinic from January to March 2012 （n = 55） were consecutively interviewed. The self-completion questionnaires were administered and finished at face-to-face interviews among these patients. Both descriptive and correlational analyses were made. Results： Fifty-five patients finished the questionnaires, with the median duration of diabetes 4.5 years and the median of SMBG frequency 2.00. Specific SMBG information deficits, motivation obstacles, and behavioral skill limitations were identified in a substantial proportion of participants. Scores of SMBG motivation （r - 0.299, P = 0.026） and behavioral skills （r = 0.425, P = 0.001） were significantly correlated with SMBG frequency. The multiple correlation of SMBG information, SMBG motivation, and SMBG behavioral skills with SMBG frequency was R - 0.411 （R2 = 0.169, P = 0.023）. Conclusions： Adult patients with type 1 diabetes in our clinic had substantial SMBG information deficits, motivation obstacles, and skill limitations. This information provided potential-focused education targets for diabetes health-care providers.

关键词： Information-motivation-behavioral Skills Model Self-monitoring of Blood Glucose Type 1 Diabetes

The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2016年第9期59卷 930-939,938-939+932-937页

作者： Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang Department of endocrinology and Metabolism First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China Barbara Davis Center for Childhood Diabetes University of Colorado Denver Aurora Colorado 80045 USA Key Laboratory of Human Functional Genomics of Jiangsu Province Nanjing Medical University Nanjing 210000 China Department of Isotopic Laboratory of Nanjing Medical University Nanjing 210000 China HLA Laboratory of Jiangsu Province People's Hospital Nanjing 210029 China Department of endocrinology and Metabolism Nanjing General Hospital of Nanjing Military Command Nanjing 210002 China Department of endocrinology and Metabolism Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing 210008 China Department of endocrinology and Metabolism Zhongda Hospital Southeast University Nanjing 210009 China Department of endocrinology and Metabolism Nanjing First Hospital Nanjing 210000 China Department of endocrinology and Metabolism Nanjing Children's Hospital Nanfing 210008 China Department of endocrinology and Metabolism The Second Affiliated Hospital of Nanjing Medical University Nanjing 210011 China Department of endocrinology and Metabolism Nanjing Governmental Hospital Nanjing 210008 China Department of endocrinology and Metabolism Northern Jiangsu People's Hospital Yangzhou 225001 China Department of endocrinology and Metabolism Wuxi People's Hospital Wuxi 214023 China Department of endocrinology and Metabolism Jiangsu Jiangyin People's Hospital Wuxi 214400 China Department of endocrinology and Metabolism The Affiliated Hospital of Xuzhou Medical College Xuzhou 221006 China Department of endocrinology and Metabolism Xuzhou Central Hospital Xuzhou 221009 China Department of endocrinology and Metabolism The First Affiliated Hospital of Soochow University Suzhou 215006 China Department of endocrinology and Metabolism The Second Affiliated Hospital of Soochow University Suzhou 215004 China Department of Endocri

Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus.

关键词： autoantibodies heterogeneity islet failure type 1 diabetes

CETP as a Target in HDL-raising Therapy:lessons from APOE*3-Leiden. CETP Transgenic Mice

在线全文

学校读者我要写书评

暂无评论

中国动脉硬化杂志 2009年第7期17卷 574-575页

作者： Willeke de Haan Jitske de Vries-van der Weij Caroline C. van der Hoogt José W.A. van der Hoorn Johannes A. Romijn J. Wouter Jukema Louis M. Havekes Hans M.G. Princen Patrick C.N. Rensen Departments of General Internal Medicine Endocrinologyand Metabolic Diseases Departments of Human Genetics TNO-Biosciences Gaubius Laboratory Departments of Cardiology Leiden University Medical Center

Background Cardiovascular disease (CVD) is mainly caused by atherosclerosis,for which dyslipidemia (i.e. high (V)LDL-cholesterol (C),high triglycerides and low HDLC is a major risk factor. To reduce the risk to develo... 详细信息

关键词：心血管疾病动脉粥样硬化血脂胆固醇临床分析

Association between new onset type 1 diabetes and real-world antibiotics and neonicotinoids’exposure-related gut microbiota perturbation

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2022年第10期18卷 671-679页

作者： Zhen-Ran Xu Xiao-Xiao Yuan Rui-Min Chen Hai-Yan Wei Lin-Qi Chen Hong-Wei Du Gui-Mei Li Yu Yang Xiao-Juan Chen Xin Fang Fei-Hong Luo Department of Pediatric endocrinology and Inherited metabolic diseases National Children’s Medical CenterChildren’s Hospital of Fudan University399 Wan Yuan RoadShanghai201102China Fuzhou Children’s Hospitai of Fujian Medical University FuzhouChina Department of endocrinology and Inherited metabolic Children’s Hospital Affiliated to Zhengzhou UniversityHenan Children’s HospitalZhengzhou Children’s HospitalZhengzhouChina Children’s Hospital of Soochow University SuzhouChina The First Hospital of Jilin University ChangchunJilinChina Department of Pediatric endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanChina The Affiliated Children’s Hospital of Nanchang University NanchangChina Department of endocrinology Genetics and MetabolismThe Children’s Hospital of Shanxi ProvinceTaiyuanChina Fujian Medical University Union Hospital FuzhouChina

Background The real-world exposure levels of non-therapeutic antibiotics and neonicotinoids in type 1 diabetes(T1D)children and their associations as environmental triggers through gut microbiota shifts remained *** thus investigated the antibiotics and neonicotinoids’exposure levels and their associations with gut microbiota in pediatric *** Fifty-one newly onset T1D children along with 67 age-matched healthy controls were *** concentrations of 28 antibiotics and 12 neonicotinoids were measured by mass *** were grouped according to the kinds of antibiotics’and neonicotinoids’exposures,*** 16S rRNA of fecal gut microbiota was sequenced,and the correlation with urine antibiotics and neonicotinoids’concentrations was *** The overall detection rates of antibiotics were 72.5%and 61.2%among T1D and healthy children,whereas the neonicotinoids detection rates were 70.6%and 52.2%(P=0.044).Children exposed to one kind of antibiotic or two or more kinds of neonicotinoids had higher risk of T1D,with the odd ratios of 2.579 and ***,co-exposure to antibiotics and neonicotinoids was associated with T1D,with the odd ratio of *** or neonicotinoids exposure did not affect overall richness and diversity of gut ***,children who were exposed to neither antibiotics nor neonicotinoids had higher abundance of Lachnospiraceae than children who were exposed to antibiotics and neonicotinoids alone or *** High antibiotics and neonicotinoids exposures were found in T1D children,and they were associated with changes in gut microbiota featured with lower abundance of butyrate-producing genera,which might increase the risk of T1D.

关键词： Antibiotics Gut microbiota Neonicotinoids Type 1 diabetes mellitus

Effectiveness of quality of care for patients with type 2 diabetes in China:findings from the Shanghai Integration Model(SIM)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Medicine 2022年第1期16卷 126-138页

作者： Chun Cai Yuexing Liu Yanyun Li Yan Shi Haidong Zou Yuqian Bao Yun Shen Xin Cui Chen Fu Weiping Jia the SIM Study Group Shanghai Diabetes Institute Shanghai Jiao Tong University Affiliated Sixth People’s HospitalNational Office for Primary Diabetes CareShanghai Technical Center for Diabetes Prevention and Clinical CareShanghai Key Laboratory of Diabetes MellitusDepartment of Endocrinology and MetabolismShanghai Clinical Center for DiabetesShanghai Key Clinical Center for Metabolic DiseaseShanghai 200233China Shanghai Municipal Center for disease Control&Prevention Shanghai 200336China Shanghai Eye disease Prevention and Treatment Center/Shanghai Eye Hospital Shanghai Key Laboratory of Ocular Fundus DiseasesShanghai General HospitalShanghai Engineering Center for Visual Science and PhotomedicineShanghai 200040China Shanghai Municipal Health Commission Information Center Shanghai 200040China 不详

This cross-sectional study aimed to investigate the quality of care of diabetes in Shanghai,China.A total of 173235 patients with type 2 diabetes in 2017 were included in the *** of risk factors and intermediate outcomes were *** patients had a mean age of 66.43±8.12(standard deviation(SD))years and a mean diabetes duration of 7.95±5.53(SD)*** percentage of patients who achieved the target level for HbA_(1c)(<7.0%)was 48.6%.Patients who achieved the target levels for blood pressure(BP)<130/80 mmHg and low-density lipoprotein-cholesterol(LDL-c)<2.6 mmol/L reached 17.5%and 34.0%,respectively.A total of 3.8%achieved all three target levels,and the value increased to 6.8%with an adaptation of the BP target level(<140/90 mmHg)for those over 65 *** analysis identified the factors associated with a great likelihood of achieving all three target levels:male,young age,short diabetes duration,low body mass index,macrovascular complications,no microvascular complications,prescribed with lipid-lowering medication,and no prescription of antihypertensive *** conclusion,nearly 50%and one-third of the patients with diabetes met the target levels for HbA_(1c)and LDL-c,respectively,with a low percentage achieving the BP target *** percentage of patients who achieved all three target levels needs significant improvement.

关键词： type 2 diabetes quality of care macrovascular complication microvascular complication treatment pattern epidemiology

Combination therapy with saxagliptin and vitamin D for the preservation ofβ-cell function in adult-onset type 1 diabetes:a multi-center,randomized,controlled trial

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2023年第5期8卷 2354-2362页

作者： Xiang Yan Xia Li Bingwen Liu Jiaqi Huang Yufei Xiang Yuhang Hu Xiaohan Tang Ziwei Zhang Gan Huang Zhiguo Xie Houde Zhou Zhenqi Liu Xiangbing Wang Richard David Leslie Zhiguang Zhou National Clinical Research Center for metabolic diseases Key Laboratory of Diabetes Immunology(Central South University)Ministry of Educationand Department of Metabolism and EndocrinologyThe Second Xiangya Hospital of Central South UniversityChangshaHunanChina Division of endocrinology and Metabolism Department of MedicineUniversity of Virginia Health SystemCharlottesvilleVAUSA Division of endocrinology Metabolism and NutritionRutgers University-Robert Wood Johnson Medical SchoolNew BrunswickNJUSA Centre for Immunobiology Blizard InstituteQueen Mary University of LondonLondonUK

disease modifying therapies aiming to preserveβ-cell function in patients with adult-onset autoimmune type 1 diabetes are ***,we conducted a multi-centre,randomized,controlled trial to assess theβ-cell preservation effects of saxagliptin alone and saxagliptin combined with vitamin D as adjunctive therapies in adult-onset autoimmune type 1 *** this 3-arm trial,301 participants were randomly assigned to a 24-month course of the conventional therapy(metformin with or without insulin)or adjunctive saxagliptin or adjunctive saxagliptin plus vitamin D to the conventional *** primary endpoint was the change from baseline to 24 months in the fasting *** secondary endpoints included the area under the concentration-time curve(AUC)for C-peptide level in a 2-h mixed-meal tolerance test,glycemic control,total daily insulin use and safety,*** primary endpoint was not achieved in saxagliptin plus vitamin D group(P=0.18)and saxagliptin group(P=0.26).However,compared with the conventional therapy,2-h C-peptide AUC from 24 months to baseline decreased less with saxagliptin plus vitamin D(-276 pmol/L vs.-419 pmol/L;P=0.01),and not to the same degree with saxagliptin alone(-314 pmol/L;P=0.14).Notably,for participants with higher glutamic acid decarboxylase antibody(GADA)levels,the decline ofβ-cell function was much lower in saxagliptin plus vitamin D group than in the conventional therapy group(P=0.001).Insulin dose was significantly reduced in both active treatment groups than in the conventional therapy group despite all groups having similar glycemic *** conclusion,the combination of saxagliptin and vitamin D preserves pancreaticβ-cell function in adult-onset autoimmune type 1 diabetes,an effect especially efficacious in individuals with higher GADA *** results provide evidence for a novel adjunct to insulin and metformin as potential initial treatment for adult-onset type 1 diabetes.(*** identifier:NCT024

关键词： vitamin alone treatment

Retinal microvascular and microstructural alterations in the diagnosis of meibomian gland dysfunction in severely obese population:a new approach

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2023年第12期16卷 1977-1985页

作者： Hai Huang Xiao-Yu Wang Hong Wei Min Kang Jie Zou Qian Ling San-Hua Xu Hui Huang Xu Chen Yi-Xin Wang Yi Shao Yao Yu Nanchang Aier Eye Hospital Nanchang 330006Jiangxi ProvinceChina Department of endocrinology and Metabolism the First Affiliated Hospital of Nanchang UniversityJiangxi Clinical Research Center for Endocrine and Metabolic DiseaseJiangxi Branch of National Clinical Research Center for Metabolic DiseaseNanchang 330006Jiangxi ProvinceChina The First Clinical Medical College Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Ophthalmology Eye&ENT Hospital of Fudan UniversityShanghai 200433China Department of Ophthalmology the First Affiliated Hospital of Nanchang UniversityJiangxi Branch of National Clinical Research Center for Ocular DiseaseNanchang 330006Jiangxi ProvinceChina Department of Ophthalmology and Visual Sciences Maastricht UniversityMaastricht 6200MALimburg ProvinceNetherlands School of Optometry and Vision Sciences Cardiff UniversityCardiff CF244HQUnited Kingdom

AIM:To study retinal microvascular and microstructural alterations in meibomian gland dysfunction(MGD)in severely obese population using optical coherence tomography angiography(OCTA).METHODS:Twelve MGD patients with severely obese population(PAT group;24 eyes)and 12 healthy controls(HC group;24 eyes)were *** images were segmented into five[superior(S),nasal(N),inferior(I),temporal(T),and central foveal(C)]or nine[inner superior(IS),outer superior(OS),inner nasal(IN),outer nasal(ON),inner inferior(II),outer inferior(OI),inner temporal(IT),outer temporal(OT),and C]*** superficial vessel density(SVD),retinal thickness(RT),foveal avascular zone(FAZ)parameters,and retinal volume were ***:Visual acuity was significantly different between two groups(0.8±0.17 in PAT group vs 0.2±0.06 in HC group).SVD was significantly lower in PATs in N,T,OS,IN,OT,and *** area under the receiver operating characteristic curve(AUC)for T was 0.961[95% confidence interval(CI):0.908 to 1.000],for OS was 0.962(95%CI:0.915 to 1.000).RT was significantly lower in PATs in IS,OS,OI,OT,ON,IT,IN,and *** for OT was 0.935(95%CI:0.870 to 0.999),for IS was 0.915(95%CI:0.838 to 0.992).Angiography results showed significantly lower area and perimeter of FAZ,SVD of the inner retina and both retinal volume and the average volume thickness in the PAT ***:Vision may be affected in patients with MGD due to changes in retinal microvessels and *** changes detected by OCTA may be a potential marker for diagnosing MGD in severe obesity.

关键词： superficial vessel density retinal thickness severely obesity meibomian gland dysfunction optical coherence tomography angiography