检索结果-南通市图书馆

Association of Early-Life Famine Exposure with metabolic Dysfunction-Associated Fatty Liver Disease and Fibrosis in Adulthood

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2022年第6期35卷 558-562页

作者： WEI Ran QI Hong Yan LIN Lin ZHU Yuan Yue ZHANG Yi ZHANG Jie WU Xue Yan HU Chun Yan WANG Shuang Yuan LIN Hong XU Yu XU Min BI Yu Fang WANG Wei Qing LU Jie Li NING Guang CHEN Yu Hong Department of endocrine and metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China Shanghai National Clinical Research Center for metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR ChinaShanghai National Center for Translational MedicineRuijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China

Nonalcoholic fatty liver disease(NAFLD)is known for its insidious onset and chronic nature,which have jeopardized the health and life of 29.2%of adults in China[1].In 2020,metabolic dysfunctionassociated fatty liver disease(MAFLD),a more accurate nomenclature to replace NAFLD,was put forward in an international consensus of experts involving 22 countries[2].In China,at least 300 million people will suffer from MAFLD by 2030,which will be a heavy burden on national health[3].

关键词： NAFLD Liver metabolic

New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse wave velocity and albuminuria: a prospective cohort study

在线全文

学校读者我要写书评

暂无评论

Frontiers of Medicine 2022年第5期16卷 714-722页

作者： Jialu Wang Shanshan Liu Qiuyu Cao Shujing Wu Jingya Niu Ruizhi Zheng Lizhan Bie Zhuojun Xin Yuanyue Zhu Shuangyuan Wang Hong Lin Tiange Wang Min Xu Jieli Lu Yuhong Chen Yiping Xu Weiqing Wang Guang Ning Yu Xu Mian Li Yufang Bi Zhiyun Zhao Department of endocrine and metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai National Clinical Research Center for metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR ChinaShanghai Key Laboratory for Endocrine TumorState Key Laboratory of Medical GenomicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Clinical Trials Center Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

A new definition of metabolic dysfunction-associated fatty liver disease(MAFLD)has recently been *** aim to examine the associations of MAFLD,particularly its discordance from non-alcoholic fatty liver disease(NAFLD),with the progression of elevated brachial-ankle pulse wave velocity(baPWV)and albuminuria in a community-based study sample in Shanghai,*** 4.3 years of follow-up,778 participants developed elevated baPWV and 499 developed *** comparison with the non-MAFLD group,the multivariable adjusted odds ratio(OR)of MAFLD group for new-onset elevated baPWV was 1.25(95%confidence interval(CI)1.01–1.55)and 1.35(95%CI 1.07–1.70)for *** without NAFLD but diagnosed according to MAFLD definition were associated with higher risk of incident albuminuria(OR 1.77;95%CI 1.07–2.94).Patients with MAFLD with high value of hepamet fibrosis score or poor-controlled diabetes had higher risk of elevated baPWV or *** conclusion,MAFLD was associated with new-onset elevated baPWV and albuminuria independently of body mass index,waist circumference,and hip *** without NAFLD but diagnosed as MAFLD had high risk of albuminuria,supporting that MAFLD criteria would be practical for the evaluation of long-term risk of subclinical atherosclerosis among fatty liver patients.

关键词： metabolic dysfunction-associated fatty liver disease non-alcoholic fatty liver disease fibrosis score brachial-ankle pulse wave velocity albuminuria

Multifaceted superoxide dismutase 1 expression in amyotrophic lateral sclerosis patients:a rare occurrence?

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 130-138页

作者： Ilaria Martinelli Jessica Mandrioli Andrea Ghezzi Elisabetta Zucchi Giulia Gianferrari Cecilia Simonini Francesco Cavallieri Franco Valzania Department of Neurosciences Azienda Ospedaliero Universitaria di ModenaModenaItaly Clinical and Experimental Medicine Ph.D.Program University of Modena and Reggio EmiliaModenaItaly Department of Biomedical Metabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModenaItaly Neurology unit Neuromotor&Rehabilitation DepartmentAzienda USL-IRCCS di Reggio EmiliaReggio EmiliaItaly

Amyotrophic lateral sclerosis(ALS)is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex,brainstem,and spinal *** the typical clinical phenotype of ALS involves both upper and lower motor neurons,human and animal studies over the years have highlighted the potential spread to other motor and non-motor regions,expanding the phenotype of *** superoxide dismutase 1(SOD1)mutations represent a minority of ALS cases,the SOD1 gene remains a milestone in ALS research as it represents the first genetic target for personalized *** numerous single case reports or case series exhibiting extramotor symptoms in patients with ALS mutations in SOD1(SOD1-ALS),no studies have comprehensively explored the full spectrum of extramotor neurological manifestations in this *** this narrative review,we analyze and discuss the available literature on extrapyramidal and non-motor features during *** multifaceted expression of SOD1 could deepen our understanding of the pathogenic mechanisms,pointing towards a multidisciplinary approach for affected patients in light of new therapeutic strategies for SOD1-ALS.

关键词： amyotrophic lateral sclerosis(ALS) autonomic extramotor genotype-phenotype multisystem involvement Parkinson’s disease sensory SOD1 superoxide dismutase 1 urinary vocal cord palsy

Association between Lipoprotein(a) Levels and metabolic Syndrome in a Middle-aged and Elderly Chinese Cohort

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2019年第7期32卷 477-485页

作者： WU Xue Yan LIN Lin Qi Hong Yan DU Rui HU Chun Yan MA Li Na PENG Kui LI Mian XU Yu XU Min CHEN Yu Hong LU Jie Li BI Yu Fang WANG Wei Qing NING Guang Rui-Jin Hospital Shanghai Jiao-Tong University School of Medicine Shanghai Institute of Endocrine and Metabolic Diseases Shanghai 200025 China Department of endocrine and metabolic Diseases Rui Jin Hospital North Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

Objective The association between lipoprotein(a)[Lp(a)] levels and metabolic syndrome(MetS) remains uncertain, especially in the Asian population. The purpose of this study was to demonstrate the association between Lp(a) levels and MetS in a middle-aged and elderly Chinese cohort. Methods A cross-sectional study of 10,336 Chinese adults aged 40 years or older was conducted in Jiading District, Shanghai, China. Logistic regression analysis was used to evaluate the association between serum Lp(a) levels and MetS. Results In the overall population, 37.5% of participants had MetS. Compared with individuals in the lowest quartile of serum Lp(a) levels, those in the highest quartile had a lower prevalence of MetS(30.9% vs. 46.9%, P for trend < 0.0001). Multivariate logistic regression analyses showed that compared with participants in the bottom quartile of serum Lp(a) levels, those in the top quartile had decreased odds ratio(OR) for prevalent MetS [multivariate-adjusted OR 0.45(95% confidence interval 0.39-0.51);P < 0.0001]. Additionally, Lp(a) level was conversely associated with the risk of central obesity, high fasting glucose, high triglycerides, and low HDL cholesterol, but not with hypertension. Stratified analyses suggested that increasing levels of Lp(a) was associated with decreased risk of MetS in all the subgroups. Conclusion Serum Lp(a) level was inversely associated with the risk of prevalent MetS in a middle-aged and elderly Chinese cohort.

关键词： Cardiovascular risk factor Lipoprotein(a) metabolic syndrome

Association of Visit-to-Visit Variabilities in metabolic Factors with Chronic Kidney Disease in Chinese Adults Living in Shanghai

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2021年第10期34卷 761-772页

作者： LI Ling WANG Fei XU Min LU Jie Li ZHAO Zhi Yun LI Mian WANG Tian Ge WANG Shuang Yuan BI Yu Fang XU Yu CAI Wei Min NING Guang Department of Clinical Pharmacy and Pharmaceutical Management School of PharmacyFudan UniversityShanghai 201203China Department of endocrine and metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai National Clinical Research Center for metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR ChinaShanghai National Center for Translational MedicineRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Objective This study aimed to examine the association of visit-to-visit variabilities in metabolic factors with chronic kidney disease(CKD)in Shanghai community *** We used data from a cohort study of community residents who participated in three examinations in 2008,2009,and 2013,*** plasma glucose(FPG)level,blood pressure(BP),and lipid levels were determined in 2,109 participants at all three visits,and CKD was evaluated between the second and the third ***-to-visit variabilities in metabolic factors were described by coefficients of variation(CV)at three visits.A variability score was calculated by adding the numbers of metabolic factors with a high variability defined as the highest quartile of *** was defined as the estimated glomerular filtration ratemetabolic factors were significantly associated with the risks of CKD in Shanghai community residents.

关键词： Chronic kidney disease Cohort metabolic factor Visit-to-visit variability

Serum Alanine Aminotransferase Is Associated with metabolic Syndrome and 10-year Risk of Cardiovascular Disease

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2019年第2期32卷 121-125页

作者： MA Li Na DU Rui CHENG Di LIN Lin WU Xue Yan HU Chun Yan DAI Meng XU Yu XU Min JIANG Lei LI Mian LU Jie Li BI Yu Fang WANG Wei Qing NING Guang Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai Institute of endocrine and metabolic Diseases

metabolic syndrome(MetS) is a cluster of metabolic disorders including obesity, hypertension, hyperglycemia, elevated triglyceride levels, and low high-density lipoprotein cholesterol(HDL-C) levels. In recent years, t... 详细信息

关键词： ALT HDL CVD LDL SBP BMI

Ideal Cardiovascular Health is Inversely Associated with Subclinical Atherosclerosis: A Prospective Analysis

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2019年第4期32卷 260-271页

作者： WANG Long NIU Jing Ya ZHAO Zhi Yun LI Mian XU Min LU Jie Li WANG Tian Ge CHEN Yu Hong WANG Shuang Yuan DAI Meng LI Lin LIU Shan Shan WANG Wei Qing XU Yu BI Yu Fang National Clinical Research Center for metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseasesand Department of Endocrine and Metabolic DiseasesRui-Jin HospitalShanghai Jiao Tong University School of Medicine

Objective Ideal cardiovascular health(CVH) could predict a lower risk of developing cardiovascular diseases. This study was conducted to investigate the association between ideal CVH and subclinical atherosclerosis in a population cohort of Chinese adults aged ≥ 40 years. Methods This study was designed as a cross-sectional analysis of 8,395 participants who had complete data at baseline and a prospective analysis of 4,879 participants who had complete data at 4.3 years of follow-up. Ideal CVH metrics were defined according to the American Heart Association. Subclinical atherosclerosis was evaluated by plaques in carotid arteries, carotid intima-media thickness(CIMT), brachial-ankle pulse wave velocity(baPWV), and urinary albumin-to-creatinine ratio(UACR). Results Both the prevalence and incidence of atherosclerosis measures were found to be decreased with increasing numbers of ideal CVH metrics at baseline(all P values for trend < 0.01). The levels of CIMT and UACR at follow-up showed an inverse and significant association with the numbers of ideal CVH metrics at baseline(both P values for trend < 0.05) but a borderline significant association with baPWV(P for trend = 0.0505). Taking participants with 0-1 ideal metric as reference, we found that participants with 5-6 ideal metrics had significantly lower risks of developing carotid plaques(odds ratio, OR = 0.46; 95% confidence interval, CI 0.27-0.79), increased CIMT(OR = 0.60; 95% CI 0.42-0.84), and increased baPWV(OR = 0.57; 95% CI 0.34-0.97) after full adjustments. A significant interactive effect of age and CVH was detected on CIMT and baPWV progression(both P values for interaction < 0.05). Conclusion The numbers of ideal CVH metrics showed a significant and inverse association with the risk of developing subclinical atherosclerosis in middle-aged and elderly Chinese adults, whereas its dose-response effect was attenuated in individuals aged ≥ 60 years and partially weakened in male participants.

关键词： Cardiovascular health Subclinical atherosclerosis Cohort

The association between the baseline bone resorption marker CTX and incident dysglycemia after 4 years

在线全文

学校读者我要写书评

暂无评论

Bone Research 2017年第3期5卷 235-241页

作者： Ting-ting Liu Dong-mei Liu Yan Xuan Lin Zhao Li-hao Sun Dian-dian Zhao Xiao-feng Wang Yang He Xing-Zhi Guo Rui Du Ji-qiu Wang Jian-min Liu Hong-yan Zhao Bei Tao Department of endocrine and metabolic Diseases Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai Institute of endocrine and metabolic Diseases Shanghai Clinical Center for Endocrine and Metabolic Diseases Department of Geriatrics Ruijin Hospital North Shanghai Jiao Tong University School of Medicine Department of endocrine and metabolic Diseases Zhong Shan Hospital Fudan University

Bone is an endocrine organ involved in modulating glucose homeostasis. The role of the bone formation marker osteocalcin （OCN） in predicting diabetes was reported, but with conflicting results. No study has explored the association between baseline bone resorption activity and incident diabetes or prediabetes during follow-up. Our objective was to examine the relationship between the baseline bone resorption marker crosslinked C-telopeptide of type I collagen （CTX） and glycemic dysregulation after 4 years. This longitudinal study was conducted in a university teaching hospital. A total of 195 normal glucose tolerant （NGT） women at baseline were invited for follow-up. The incidence of diabetes and prediabetes （collectively defined as dysglycemia） was recorded. A total of 128 individuals completed the 4-year study. The overall conversion rate from NGT to dysglycemia was 31.3%. The incidence of dysglycemia was lowest in the middle tertile [16.3% （95% confidence interval （CI）, 6.8%-30.70/0）] compared with the lower [31.0% （95% CI, 17.2%-46.1%）] and upper [46.5% （95% CI, 31.2%-62.6%）] tertiles of CTX, with a significant difference seen between the middle and upper tertiles （P = 0.002 5）. After adjusting for multiple confounding variables, the upper tertile of baseline CTX was associated with an increased risk of incident dysglycemia, with an odds ratio of 7.09 （95% CI, 1.73-28.99） when the middle tertile was the reference. Osteoclasts actively regulate glucose homeostasis in a biphasic model that moderately enhanced bone resorption marker CTX at baseline provides protective effects against the deterioration of glucose metabolism, whereas an overactive osteoclastic function contributes to an increased risk of subsequent dysglycemia.

关键词： CTX The association between the baseline bone resorption marker CTX and incident dysglycemia after 4 years

Association between Coronary Atherosclerotic Plaque Composition and Cardiovascular Disease Risk

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2019年第2期32卷 75-86页

作者： LI Lin WANG Long LIU Shan Shan ZHAO Zhi Yun LI Mian WANG Tian Ge XU Min LU Jie Li CHEN Yu Hong WANG Shuang Yuan DAI Meng HOU Ya Nan WU Xue Yan MA Li Na WANG Wei Qing XU Yu BI Yu Fang National Clinical Research Center for metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases and Department of Endocrine and Metabolic Diseases Rui-Jin Hospital Shanghai Jiao-Tong University School of Medicine

Objective The objective of this study is to determine whether coronary atherosclerotic plaque composition is associated with cardiovascular disease(CVD) risk in Chinese adults. Methods We performed a cross-sectional analysis in 549 subjects without previous diagnosis or clinical symptoms of CVD in a community cohort of middle-aged Chinese adults. The participants underwent coronary computed tomography(CT) angiography for the evaluation of the presence and composition of coronary plaques. CVD risk was evaluated by the Framingham risk score(FRS) and the 10-year atherosclerotic cardiovascular disease(ASCVD) risk score. Results Among the 549 participants, 267(48.6%) had no coronary plaques, 201(36.6%) had noncalcified coronary plaques, and 81(14.8%) had calcified or mixed coronary plaques. The measures of CVD risk including FRS and ASCVD risk score and the likelihood of having elevated FRS significantly increased across the groups of participants without coronary plaques, with noncalcified coronary plaques, and with calcified or mixed coronary plaques. However, only calcified or mixed coronary plaques were significantly associated with an elevated ASCVD risk score [odds ratio(OR) 2.41; 95% confidence interval(CI) 1.09-5.32] compared with no coronary plaques, whereas no significant association was found for noncalcified coronary plaques and elevated ASCVD risk score(OR 1.25; 95% CI 0.71-2.21) after multivariable adjustment. Conclusion Calcified or mixed coronary plaques might be more associated with an elevated likelihood of having CVD than noncalcified coronary plaques.

关键词： Coronary plaque composition Framingham risk score 10-year atherosclerotic cardiovascular disease risk score