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Omeprazole-based triple therapy with low-versus high-dose of clarithromycin plus amoxicillin for H pylori eradication in Iranian population

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World Journal of Gastroenterology 2007年第6期13卷 930-933页

作者： Ali Asghar Keshavarz Homayoon Bashiri Mahtab Rahbar Department of Gastroenterology and Hepatology Emam Reza Hospital Kermanshah University of Medical Sciences Kermanshah Iran Department of Internal Medicine emam Reza hospital Kermanshah Iran Department of Pathology Emam Reza Hospital Kermanshah Iran

AIM： To investigate the efficacy and tolerability of H pylori eradication in an omeprazole-based triple therapy with high and low dose of clarithromycin and amoxicillin. METHODS： One hundred and sixty H pylori positive patients were randomly assigned to two groups based on the following 2 wk investigation; （1） group A or low-dose regimen received omeprazole 20 mg b.i.d, clarithromycin 250 mg b.i.d and amoxicillin 500 mg b.i.d; and （2） group B or high-dose regimen received omeprazole 20 mg b.i.d, clarithromycin 500 mg b.i.d and amoxicillin 1000 mg b.i.d. During the study Hpylori status was assessed by histology and rapid urease test prior and by 13C-urea breath test 6 wk after the therapy. Standard questionnaires were administered to determine the compliance to treatment and possible adverse events of therapy. Data were subject to x^2 to compare the eradication rates in the two groups. The significant level of 95% （P ≤ 0.05） was considered statistically different. RESULTS： We found that the per-protocol eradication rate was 88% （68/77） in group A, and 89% （67/75） in group B. The intension-to-treat eradication rate was 85% （68/80） in group A and 83.75% （67180） in group B. Overall adverse events were 26% in group A and 31% in group B. The adverse events were generally mild in nature and tolerated well in both groups with a compliance of 98% in group A vs 96% in group B. CONCLUSION： The omeprazole-based low dose regimen of darithromycin and amoxicillin for two weeks in Hpylori eradication is as effective as high dose regimen in Iranian population.

关键词： Triple therapy Hpy/ori Amoxicillin Clarithromycin Low-dose regimen

Insight into small eyes: a practical description from phenotypes presentations to the management

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 380-391页

作者： Sana Niazi Sorcha NíDhubhghaill Farideh Doroodgar Zisis Gatzioufas Mohammad hossein Dehghan Translational Ophthalmology Research Center Tehran University of Medical SciencesTehran ***Iran Antwerp University hospital Edegem 2650Belgium Faculty of Health Sciences Antwerp UniversityAntwerpen 2000EdegemBelgium Negah Aref Ophthalmic Research Center Shahid Beheshti University of Medical SciencesTehran 16666Iran University Eye hospital Basel Basel 4031Switzerland

This narrative review aimed to have an algorithmic approach to microphthalmos by a systematic *** definition can be related to a number of special *** the more challenging cases of complex microphthalmos,relative anterior microphthalmos,and nanophthalmos,the surgeon can approach these cases more safely if they have a deep understanding of the anatomical variations and ideal formulae for intraocular lens computation and knows how to avoid intra-and post-operative *** this article,we review the criteria by which we recognize and describe pre-,intra-,and post-operative considerations,as well as discuss the ideal intraocular lenses for microphthalmos,given the intricate varieties of small eye phenotypes.

关键词： microphthalmos nanophthalmos lenses intraocular anterior chamber axial length eye cataract microcornea syndrome

Impact of coronary artery bypass grafting surgery on the chorioretinal biomicroscopic characteristics

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世界临床病例杂志 2023年第28期11卷 6754-6762页

作者： Mansoor Shahriari Homayoun Nikkhah Mohammad Parsa Mahjoob Nazanin Behnaz Shahriar Barkhordari Kasra Cheraqpour Department of Ophthalmology Imam Hossein Educational HospitalTehran ***Iran Department of Ophthalmology Torfe Medical CenterTehran ***Iran Cardiovascular Diseases Imam Hossein Educational HospitalTehran ***Iran Department of Ophthalmology Shahid Beheshti University of Medical SciencesTehran ***Iran Department of Ophthalmology Farabi Eye HospitalTehran ***Iran

BACKGROUND Most patients with cardiovascular disorders suffer from coronary artery diseases,which can be treated successfully using coronary artery bypass grafting(CABG).One of the unpleasant events following CABG is postoperative vision loss(POVL).Vulnerability of retinal vessels to hemodynamic changes,an expectable event following CABG,may contribute to the development of POVL,which might be associated with the changes in the choroidal and retinal *** To investigate postoperative changes in chorioretinal and peripapillary nerve fiber layer(NFL)thickness,and progression of diabetic and hypertensive retinopathy after *** In this prospective,cross-sectional study,49 eyes in 25 candidates for CABG underwent both ophthalmic and cardiovascular examinations within 6 mo prior to and 9 mo after *** Among the study participants,56%were male with a mean age of 62.84 years±10.49 years(range 33–80 years).Diabetes mellitus was observed in eight participants(32%).None of the patients suffered from postoperative anterior or posterior ischemic optic neuropathy,central retinal artery occlusion,and cortical *** mean value of the preoperative best corrected visual acuity was 0.11±0.10 logMAR(range,0–0.4),which worsened to 0.15±0.08 logMAR(range,0–0.4)after CABG(P=0.031).No significant difference was observed between the preand postsurgical choroidal(P=0.853)and macular(P=0.507)thickness,NFL thickness in the subfoveal(P>0.999)and peripapillary areas(P=0.659),as well as the severity of diabetic and hypertensive *** CABG may reduce visual acuity without affecting ocular *** vision reduction might be attributable to molecular or cellular variations,changes in visual pathway function,or central nervous system.

关键词： Coronary artery bypass grafting Nerve fiber layer Diabetic retinopathy Hypertensive retinopathy

Engineering nanomedicines for immunogenic eradication of cancer cells:Recent trends and synergistic approaches

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2475-2504页

作者： Ahmed O.Elzoghby Omar Samir Hagar E.emam Ahmed Soliman Riham M.Abdelgalil Yomna M.Elmorshedy Kadria A.Elkhodairy Mahmoud L.Nasr Division of Engineering in Medicine and Division of Renal Medicine Department of MedicineBrigham and Women's HospitalHarvard Medical SchoolBoston 02115MAUSA Cancer Nanotechnology Research Laboratory(CNRL) Faculty of PharmacyAlexandria UniversityAlexandria 21521Egypt

Resistance to cancer immunotherapy is mainly attributed to poor tumor immunogenicity as well as the immunosuppressive tumor microenvironment(TME)leading to failure of immune *** therapeutic strategies including chemotherapy,radiotherapy,photodynamic,photothermal,magnetic,chemodynamic,sonodynamic and oncolytic therapy,have been developed to induce immunogenic cell death(ICD)of cancer cells and thereby elicit immunogenicity and boost the antitumor immune ***,many challenges hamper the clinical application of ICD inducers resulting in modest immunogenic ***,we outline the current state of using nanomedicines for boosting ICD of cancer ***,synergistic approaches used in combination with ICD inducing nanomedicines for remodeling the TME via targeting immune checkpoints,phagocytosis,macrophage polarization,tumor hypoxia,autophagy and stromal modulation to enhance immunogenicity of dying cancer cells were *** further highlight the emerging trends of using nanomaterials for triggering amplified ICD-mediated antitumor immune *** reticulum localized ICD,focused ultrasound hyperthermia,cell membrane camouflaged nanomedicines,amplified reactive oxygen species(ROS)generation,metallo-immunotherapy,ion modulators and engineered bacteria are among the most innovative *** challenges,merits and demerits of ICD inducer nanomedicines were also discussed with shedding light on the future role of this technology in improving the outcomes of cancer immunotherapy.

关键词： Immunogenic cell death Immunogenic eradication Nanomedicines Drug delivery Cancer immunotherapy Antitumor immunity T cells Tumor associated antigens Synergistic immune response

COVID-19 outbreak and surgical practice: The rationale for suspending non-urgent surgeries and role of testing modalities

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World Journal of Gastrointestinal Surgery 2020年第6期12卷 259-268页

作者： Andrew D Grubic Shahin Ayazi Javad Zebarjadi Hamed Tahmasbi Khosro Ayazi Blair A Jobe Esophageal and Lung Institute Department of SurgeryAllegheny Health NetworkPittsburghPA 15224United States Department of Surgery Imam Hossein HospitalShahid Beheshti University of Medical SciencesTehran ***Iran

One-hundred years after the 1918-19 H1N1 flu pandemic and 10 years after the 2009 H1N1 flu pandemic, another respiratory virus has now inserted itself into the human population. Severe acute respiratory syndrome coronavirus has become a critical challenge to global health with immense economic and social disruption. In this article we review salient aspects of the coronavirus disease2019(COVID-19) outbreak that are relevant to surgical practice. The emphasis is on considerations during the pre-operative and post-operative periods as well as the utility and limitations of COVID-19 testing. The focus of the media during this pandemic is centered on predictive epidemiologic curves and models. While epidemiologists and infectious disease physicians are at the forefront in the fight against COVID-19, this pandemic is also a "stress test" to evaluate the capacity and resilience of our surgical community in dealing with the challenges imposed to our health system and society. As recently pointed out by Dr. Anthony Fauci,the virus decides the timelines in the models. However, the models can also change based on our decisions and behavior. It is our role as surgeons, to make every effort to bend the curves against the virus’ will.

关键词： COVID-19 SARS-CoV-2 Surgery Pandemic Predictive model Diagnosis

Novel technique of penetrating keratoplasty in high-risk grafts with significant corneal neovascularization

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International Journal of Ophthalmology(English edition) 2022年第9期15卷 1554-1556页

作者： Mohammad Soleimani Nader Mohammadi Mansoor Shahriari Morteza Karimi Ahmed Alshaheeb Atefeh Khalili Mohammad hossein Zamani Kasra Cheraqpour Eye Research Center Farabi Eye HospitalTehran University of Medical SciencesTehran ***Iran Imam hossein Medical Center Shahid Beheshti University of Medical SciencesTehran ***Iran

Dear Editor,We write to introduce a novel technique of penetrating keratoplasty(PK)with lower risk of graft rejection in high-risk *** transplantation may be required in a variety of conditions such as keratoconus,pse... 详细信息

关键词： such keratoplasty corneal

Prognostic Value of Promoter Hypermethylation of Retinoic Acid Receptor Beta (RARB) and CDKN2 (p16/MTS1) in Prostate Cancer

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Chinese Journal of Cancer Research 2011年第4期23卷 306-311页

作者： Ameri A Alidoosti A hosseini Y Parvin M Emranpour MH Taslimi F Salehi E Fadavi P Department of Radiation Oncology Imam Hossein Hospital Shahid Beheshti University of Medical Sciences Tehran Iran Department of Urology Shahid Modarres Hospital Shahid Beheshti University of Medical Sciences Tehran Iran Department of Pathology Shahid Labbafinezhad Hospital Shahid Beheshti University of Medical Sciences Tehran Iran Department of Immunology Faculty of Medicine Tehran University of Medical Sciences Tehran Iran Department of Radiation Oncology Tehran University of Medical Sciences Tehran Iran

Objective: The molecular mechanism of prostate cancer is poorly understood. The aim of the study was to investigate the prevalence and prognostic value of promoter hypermethylation of retinoic acid receptor beta (RARB) and p16 among benign prostatic hyperplasia (BPH) and prostate cancer patients. Methods: In this case-control study, 63 patients were included in three groups; 21 with BPH as the control group, 21 with prostate cancer and good prognostic factors (based on prostate-specific antigen, Gleason score and stage) as good prognosis group, and 21 with prostate cancer and poor prognostic features as poor prognosis group. The prostate biopsy specimen of each individual was examined for hypermethylation of RARB and p16 promoters by methylation specific PCR (MSPCR). Results: Seven (33.3%) patients with good prognosis and 15 (71.4%) patients with poor prognosis were positive for RARB methylation, which were significantly higher than controls (P <0.0001). p16 promoter methylation was shown in 19.0% and 47.6% patients with good and poor prognosis, respectively. The RARB and p16 promoter methylation in the poor prognosis group was significantly higher than that in the good prognosis group (P =0.02 for RARB and P<0.0001 for p16). Conclusion: Hypermethylation of RARB and p16 promoters may predict prognosis in prostate cancer.

关键词： Prostate cancer CpG island DNA methylation Retinoic acid receptor beta (RARB) CDKN2 (p16/MTS1) Methylation Specific PCR

Outbreak of methanol-induced optic neuropathy in early COVID-19 era;effectiveness of erythropoietin and methylprednisolone therapy

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World Journal of Clinical Cases 2023年第15期11卷 3502-3510页

作者： Seyed Ali Tabatabaei Mohammad Amini Ali A Haydar Mohammad Soleimani Kasra Cheraqpour Mansoor Shahriari hossein Hassanian-Moghaddam Nasim Zamani Mohammad Reza AkbariDepartment of Ophthalmology Eye Research Center Farabi Eye hospital Tehran University of Medical SciencesTehran ***Iran Department of Ophthalmology Imam Hossein Medical CenterShahid Beheshti University of Medical SciencesTehran ***Iran Department of Clinical Toxicology Shohada-e-Tajrish HospitalShahid Beheshti University of Medical SciencesTehran ***Iran Department of Internal Medicine StreetAgnes Medical CenterFresnoCA 93720United States

BACKGROUND Methanol is a highly toxic,non-potable *** of methanol toxicity occur due to its fraudulent addition to alcoholic beverages as a cheaper substitute for ***,alongside the coronavirus disease 2019(COVID-19)pandemic,rumors circulated on social media that consuming alcohol can prevent or cure the virus,leading to a COVID-19 and methanol-induced optic neuropathy(MON)*** To investigate the impact of erythropoietin(EPO)on the outcomes of patients diagnosed with *** In this prospective study,105 patients presenting with acute bilateral visual loss secondary to methanol intoxication were enrolled from March to May 2020 at Farabi Eye hospital.A comprehensive ocular examination was conducted for all *** human EPO and methylprednisolone were administered intravenously to all patients for three consecutive *** The mean age of the participants was 39.9 years(±12.6).Ninety-four patients were male and eleven were *** mean pre-treatment best corrected visual acuity(BCVA)improved from 2.0±0.86 to 1.39±0.69 logarithm of the minimum angle of resolution post-treatment(P<0.001),with significant improvement observed in all age categories and genders(P<0.001).Visual acuity improvement was also significant regardless of whether the patient presented before or after 72 h(P<0.001),and the post-treatment BCVA remained significant at all monthly follow-up visits(P<0.001).CONCLUSION EPO and methylprednisolone therapy have been shown to be effective in improving visual outcomes in patients with MON when administrated within the first month of *** awareness efforts are necessary to prevent further outbreaks of methanol toxicity in the current COVID-19 era.

关键词： Alcohol Ethanol Methanol Optic neuropathy Erythropoietin COVID-19

Limb Lengthening and Reconstruction Society orthopedic surgeons in the United States:An analysis of geographical distribution,academic,leadership,and demographic characteristics

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World Journal of Orthopedics 2024年第2期15卷 147-155页

作者： Amir Human Hoveidaei Reza Niakan Seyed hossein hosseini-Asl Abijith Annasamudram Janet D Conway International Center for Limb Lengthening Rubin Institute for Advanced OrthopedicsSinai Hospital of BaltimoreBaltimoreMD 21215United States Student Research Committee Shiraz University of Medical SciencesShiraz 73Iran Students’Scientific Research Center Tehran University of Medical SciencesTehran ***Iran

BACKGROUND The Limb Lengthening and Reconstruction Society(LLRS)is a premier orthopedic specialty organization that promotes limb reconstruction for all *** membership characteristics,however,are poorly *** study delineates orthopedic surgeon LLRS members’demographic traits,academic achievement,leadership attainment,and geographical distribution across the United *** To inform aspiring orthopedic professionals,as well as to promote growth and diversity in both the LLRS organization and overarching *** This cross-sectional study examined United States LLRS members’academic,leadership,demographic,and geographical *** reviewing the 2023 LLRS member directory,Google search results were matched to the listings and appended to the compiled *** and ethnicity were evaluated visually utilizing retrieved *** Hirsch index(H-index)of academic activity,residency and fellowship training,other graduate degrees,leadership positions,practice type(academic or non-academic),and spoken languages were *** members per state and capita determined geographic *** Mann Whitney U test was applied to compare H-index between males and females,as well as to assess member differences pertaining to affiliation with academic vs non-academic practice *** The study included 101 orthopedic surgeons,78(77.23%)Caucasian and 23(22.77%)non-Caucasian,79(78.22%)male and 22(21.78%)*** with DO degrees comprised only 3.96%(4)of the cohort,while the vast majority held MDs[96.04%(97)].Mean H-index was 10.55,with male surgeons having a significantly higher score(P=0.002).Most orthopedic surgeons(88.12%,)practiced in academic *** those professionals who occupied leadership positions,14%were women,while 86%were ***,19(37.25%)United States regions and the District of Columbia lacked an LLRS-member orthopedic *** per capita rate across the United States was 0.30 LLRS orthopedic

关键词： Limb lengthening and reconstruction Orthopedic surgeon demographics Orthopedic surgeon societal membership Orthopedic fellowships