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Chinese Journal of Cancer Research 2018年第2期30卷 240-253页

作者： Hui Wang Yaqi Pan Chuanhai Guo Fenglei Li Ruiping Xu Mengfei Liu Zhen Liu Fangfang Liu Hong Cai Yang Ke Zhonghu He Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Laboratory of Genetics Peking University Cancer Hospital & Institute Beijing 100142 China Hua County People's hospital Anyang 456400 China Anyang Cancer hospital Anyang 455000 China

Objective： There have been few population-based studies evaluating health related quality of life（HRQOL） in rural populations in China, and this study aimed to assess the current status of and risk factors for HRQOL in a general rural population in high risk region of esophageal cancer in ***： From November 2015 to September 2016, 12,085 permanent residents aged 45–69 years from 257 villages in the Endoscopic Screening for Esophageal Cancer in China（ESECC） trial（Clinical ***：NCT01688908） randomly selected from Hua County, Henan Province, China were interviewed. The EQ-5 D-3 L,a generic measure of HRQOL, and a questionnaire were used to assess their HRQOL and potential risk ***： Among all the participants, 30.62% of the participants reported problems in at least one EQ-5 D dimension. Pain/discomfort（25.52%） was the most frequently reported problem followed by anxiety/depression（7.97%）, mobility（5.82%）, usual activities（2.61%） and self-care（1%）. These rural residents had a mean EQ-5 D index score of 0.948, and lower EQ-5 D index scores were associated with older age, female gender, lower levels of household annual per capita income, living alone, using shallow wells as main source of drinking water, exposure to family members smoking, testiness, unhealthy dietary habits, overweight or obesity, upper gastrointestinal cancer related symptoms and chronic ***： Rural residents in China have a relatively low quality of life. Health promotion programs in this population should focus on the elderly, especially elderly women and the elderly living alone. Improving basic living circumstances and primary medical care services should be priorities. Results of this study will also serve as the basis for the cost-utility evaluation in our ESECC screening trial.

关键词： HRQOL EQ-5D rural population China

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Safety and efficacy of Hansenula-derived PEGylated-interferon alpha-2a and ribavirin combination in chronic hepatitis C Egyptian children

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World Journal of Gastroenterology 2014年第16期20卷 4681-4691页

作者： Suzan El Naghi Tawhida Y Abdel-Ghaffar Hanaa El-Karaksy Elham F Abdel-Aty Mona S El-Raziky Aleef A Allam Heba Helmy Hanaa A El-Araby Behairy E Behairy Mohamed A El-Guindi Hatem El-Sebaie Aisha Y Abdel-Ghaffar Nermin A Ehsan Ahmed M El-Hennawy Mostafa M Sira Pediatric Department National Hepatology and Tropical Medicine Research Institute11441 CairoEgypt Yassin Abdel Ghaffar charity Center for Liver Disease and Research 2851 CairoEgypt Pediatric Department Ain Shams University11566 CairoEgypt Department of Pediatrics Cairo University Pediatric Hospital11562 CairoEgypt Pediatric Hepatology Department National Liver InstituteMenofiya UniversityShebin El-koom32511 MenofiyaEgypt Biochemistry Department National Liver Institute32511 MenofiyaEgypt Clinical Pathology Department Ain Shams University11566 CairoEgypt Pathology Department National Liver InstituteMenofiya UniversityShebin El-koom32511 MenofiyaEgypt Pathology Department Cairo UniversityFaculty of MedicineKasr El-Aini11562 CairoEgypt

AIM: To investigate the safety and efficacy of a Hansenula-derived PEGylated (polyethylene glycol) interferon (IFN)-alpha-2a (Reiferon Retard) plus ribavirin customized regimen in treatment-naïve and previously treate... 详细信息

关键词： Children Chronic hepatitis C Hansenula polymorpha PEGylated interferon Response rate Ribavirin Treatment

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Nanoparticles(NPs)-mediated lncBCMA silencing to promote eEF1A1 ubiquitination and suppress breast cancer growth and metastasis

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Acta Pharmaceutica Sinica B 2023年第8期13卷 3489-3502页

作者： Ke Yang Lei Xu Ying Xu Qian Shen Tao Qin Yunfang Yu Yan Nie Herui Yao Xiaoding Xu Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Medical Research CenterSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Nanhai Translational Innovation Center of Precision Immunology Sun Yat-sen Memorial HospitalFoshan 528200China Department of Oncology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Clinical Pharmacology the Second Affiliated HospitalUniversity of South ChinaHengyang 421001China Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

Long non-coding RNAs(lncRNAs)play an important role in cancer *** metastasis-associated lncRNAs and developing effective strategy for targeted regulation of lncRNA function in vivo are of utmost importance for the treatment of metastatic cancer,which however remains a big ***,we identified a new functional lncRNA(denoted lncBCM A),which could stabilize the expression of eukaryotic translation elongation factor 1A1(eEF1A1)via antagonizing its ubiquitination to promote triple-negative breast cancer(TNBC)growth and *** on this regulatory mechanism,an endosomal pH-responsive nanoparticle(NP)platform was engineered for systemic lncBCMA siRNA(siBCMA)*** NPs-mediated siBCMA delivery could effectively silence lncBCMA expression and promote eEF1A1 ubiquitination,thereby leading to a significant inhibition of TNBC tumor growth and *** findings show that lncBCMA could be used as a potential biomarker to predict the prognosis of TNBC patients and NPs-mediated lncBCMA silencing could be an effective strategy for metastatic TNBC treatment.

关键词： Canermetastasis LncRNA Nanoparticles siRNA delivery Cancer therapy

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Lipid droplets as metabolic determinants for stemness and chemoresistance in cancer

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World Journal of Stem Cells 2021年第9期13卷 1307-1317页

作者： Alba Royo-Garcia Sarah Courtois Beatriz Parejo-Alonso Pilar Espiau-Romera Patricia Sancho hospital Universitario Miguel Servet IIS AragónZaragoza 50009Spain

Previously regarded as simple fat storage particles,new evidence suggests thatlipid droplets(LDs)are dynamic and functional organelles involved in keycellular processes such as membrane biosynthesis,lipid metabolism,cellsignalling and ***,an increased LD content is one of the mostapparent features resulting from lipid metabolism reprogramming necessary tosupport the basic functions of cancer *** have been associated to differentcellular processes involved in cancer progression and aggressiveness,such astumorigenicity,invasion and metastasis,as well as ***,all of these processes are controlled by a subpopulation of highly aggressivetumoral cells named cancer stem cells(CSCs),suggesting that LDs may befundamental elements for stemness in *** the key role of CSCs onchemoresistance and disease relapse,main factors of therapy failure,the design ofnovel therapeutic approaches targeting these cells may be the only chance forlong-term survival in cancer *** this sense,their biology and functionalproperties render LDs excellent candidates for target discovery and design ofcombined therapeutic *** this review,we summarise the currentknowledge identifying LDs and CSCs as main contributors to cancer aggressiveness,metastasis and chemoresistance.

关键词： Lipids Lipid droplets Lipid metabolism Stemness Cancer stem cells Chemoresistance

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Sinomenine promotes differentiation of induced pluripotent stem cells into immature dendritic cells with high induction of immune tolerance

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World Journal of Stem Cells 2022年第8期14卷 599-615页

作者： Xiao-Yan Huang Zhan-Kui Jin Meng Dou Bing-Xuan Zheng Xiang-Rong Zhao Qing Feng Yang-Meng Feng Xiang-Long Duan Pu-Xun Tian Cui-Xiang Xu Shaanxi Provincial Key Laboratory of Infection and Immune Diseases Shaanxi Provincial People’s HospitalXi'an 710068Shaanxi ProvinceChina Department of Orthopedics Shaanxi Provincial People’s HospitalXi'an 710068Shaanxi ProvinceChina Department of Kidney Transplantation The First Affiliated Hospital of Xi’an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Second Department of General Surgery Shaanxi Provincial People's HospitalXi'an 710068Shaanxi ProvinceChina

BACKGROUND Immature dendritic cells(imDCs)play an important role in the induction of donor-specific transplant ***,these cells have limitations,such as rapid maturation and a short lifespan in *** previous studies,induced pluripotent stem cells(iPSCs)differentiated into imDCs,and sinomenine(SN)was used to inhibit the maturation of *** To study the capacity of SN to maintain iPSC-derived imDCs(SN-iPSCs-imDCs)in an immature state and the mechanism by which SN-iPSCs-imDCs induce *** In this study,mouse iPSCs were induced to differentiate into imDCs in culture medium without or with SN(iPSCs-imDCs and SN-iPSCs-imDCs).The imDCrelated surface markers,endocytotic capacity of fluorescein isothiocyanate Dextran and apoptosis were analyzed by flow *** effects of iPSCs-imDCs and SNiPSCs-imDCs on T-cell stimulatory function,and regulatory T(Treg)cell proliferative function in vitro were analyzed by mixed lymphocyte *** expression was detected by *** apoptosis-related proteins of iPSCs-DCs and SN-iPSCs-DCs were analyzed by western *** induced immunotolerance of SN-iPSCs-DCs was evaluated by treating recipient Balb/c skin graft *** evaluation of graft survival was performed using Kaplan–Meier *** Both iPSCs-imDCs and SN-iPSCs-imDCs were successfully obtained,and their biological characteristics and ability to induce immunotolerance were ***-iPSCs-imDCs exhibited higher CD11c levels and lower CD80 and CD86 levels compared with *** major histocompatibility complex II expression,worse T-cell stimulatory function,higher Treg cell proliferative function and stronger endocytotic capacity were observed with SN-iPSCs-imDCs(P<0.05).The levels of interleukin(IL)-2,IL-12,interferon-γin SN-iPSCs-imDCs were lower than those in iPSCs-imDCs,whereas IL-10 and transforming growth factor-βlevels were higher(P<0.05).The apoptosis rate of these cells was significan

关键词： Immature dendritic cells Induced pluripotent stem cells Sinomenine Immune tolerance Organ transplantation

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Evolving role of magnetic resonance techniques in primary sclerosing cholangitis

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World Journal of Gastroenterology 2019年第6期25卷 644-658页

作者： Emmanuel A Selvaraj Emma L Culver Helen Bungay Adam Bailey Roger W Chapman Michael Pavlides Oxford Centre for Clinical Magnetic Resonance Research Division of Cardiovascular Medicine Radcliffe Department of Medicine University of Oxford John Radcliffe Hospital Translational Gastroenterology Unit Nuffield Department of Medicine University of OxfordJohn Radcliffe Hospital Oxford NIHR Biomedical Research Centre Oxford University Hospitals NHS Foundation Trust and the University of Oxford Department of Radiology John Radcliffe Hospital

Development of non-invasive methods to risk-stratify patients and predict clinical endpoints have been identified as one of the key research priorities in primary sclerosing cholangitis(PSC). In addition to serum and histological biomarkers, there has been much recent interest in developing imaging biomarkers that can predict disease course and clinical outcomes in *** resonance imaging/magnetic resonance cholangiopancreatography(MRI/MRCP) continue to play a central role in the diagnosis and follow-up of PSC patients. Magnetic resonance(MR) techniques have undergone significant advancement over the last three decades both in MR data acquisition and interpretation. The progression from a qualitative to quantitative approach in MR acquisition techniques and data interpretation, offers the opportunity for the development of objective and reproducible imaging biomarkers that can potentially be incorporated as an additional endpoint in clinical trials. This review article will discuss how the role of MR techniques have evolved over the last three decades from emerging as an alternative diagnostic tool to endoscopic retrograde cholangiopancreatography, to being instrumental in the ongoing search for imaging biomarker of disease stage, progression and prognosis in PSC.

关键词： Primary sclerosing cholangitis Magnetic resonance imaging Magnetic

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Mutational separation and clinical outcomes of TP53 and CDH1 in gastric cancer

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World Journal of Gastrointestinal Surgery 2023年第12期15卷 2855-2865页

作者： He-Li Liu Huan Peng Chang-Hao Huang Hai-Yan Zhou Jie Ge Department of Gastrointestinal Surgery Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Clinical Nursing Teaching and Research Section Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Teaching and Research Section of Clinical Nursing Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Department of Pathology Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina

BACKGROUND Gastric cancer(GC)is a deadly tumor with the fifth highest occurrence and highest global mortality *** to its heterogeneity,the underlying mechanism of GC remains unclear,and chemotherapy offers little benefit to *** To investigate the clinical outcomes of TP53 and CDH1 mutations in *** In this study,202 gastric adenocarcinoma tumor tissues and their corresponding normal tissues were collected.A total of 490 genes were identified using target *** t-test and Wilcoxon rank-sum test,somatic mutations,microsatellite instability,and clinical statistics,including overall survival,were detected,compared,and *** The mutation rates of 32 genes,including TP53,SPEN,FAT1,and CDH1 exceeded 10%.TP53 mutations had a slightly lower overall occurrence rate(33%).The TP53 mutation rate was significantly higher in advanced stages(stage Ⅲ/Ⅳ)than that in early stages(stage Ⅰ/Ⅱ)(P<0.05).In contrast,CDH1 mutations were significantly associated with diffuse ***53 is related to poor prognosis of advanced-stage tumors;nevertheless,CDH1 corresponds to a diffuse type of ***53 is exclusively mutated in CDH1 and is primarily affected by two distinct GC *** Different somatic mutation patterns in TP53 and CDH1 indicate two major mechanisms of GC.

关键词： Gastric cancer TP53 mutation CDH1 mutation Clinical outcome Somatic mutation Diffuse gastric cancer

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Advances in ATM,ATR,WEE1,and CHK1/2 inhibitors in the treatment of PARP inhibitor-resistant ovarian cancer

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Cancer Biology & Medicine 2023年第12期20卷 915-921页

作者： Qin Tang Xin Wang Haixia Wang Lin Zhong Dongling Zou Department of Gynecologic Oncology Chongqing University Cancer Hospital&Chongqing Cancer Institute&Chongqing Cancer HospitalChongqing 400030China Chongqing Specialized Medical Research Center of Ovarian Cancer Chongqing 400030China Organoid Transformational Research Center Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized TreatmentChongqing University Cancer HospitalChongqing 400030China

Ovarian cancer(OC)poses a significant challenge in modern gynecologic oncology,both diagnostically and *** to the American Cancer Society,an estimated 21,000 new cases of OC were reported in the United States alone in *** most prevalent subtype of OC87,highgrade serous(HGS),is characterized by heightened genomic instability and defects in DNA damage response(DDR)pathways,which contribute to disease development and ***,approximately 50%of HGS ovarian cancer(HGSOC)patients exhibit homologous recombination repair(HRR)defects(HRDs)3.

关键词： cancer treatment alone

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Machine learning applications for the prediction of extended length of stay in geriatric hip fracture patients

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World Journal of Orthopedics 2023年第10期14卷 741-754页

作者： Chu-Wei Tian Xiang-Xu Chen Liu Shi Huan-Yi Zhu Guang-Chun Dai Hui Chen Yun-Feng Rui Department of Orthopaedics Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009Jiangsu ProvinceChina Multidisciplinary Team for Geriatric Hip Fracture Comprehensive Management Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009Jiangsu ProvinceChina Trauma Center Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009Jiangsu ProvinceChina

BACKGROUND Geriatric hip fractures are one of the most common fractures in elderly individuals,and prolonged hospital stays increase the risk of death and *** learning(ML)has become prevalent in clinical data processing and predictive *** study aims to develop ML models for predicting extended length of stay(eLOS)among geriatric patients with hip fractures and to identify the associated risk *** To develop ML models for predicting the eLOS among geriatric patients with hip fractures,identify associated risk factors,and compare the performance of each *** A retrospective study was conducted at a single orthopaedic trauma centre,enrolling all patients who underwent hip fracture surgery between January 2018 and December *** study collected various patient characteristics,encompassing demographic data,general health status,injury-related data,laboratory examinations,surgery-related data,and length of *** that exhibited significant differences in univariate analysis were integrated into the ML model establishment and subsequently *** study compared the performance of the ML models and determined the risk factors for *** The study included 763 patients,with 380 experiencing *** the models,the decision tree,random forest,and extreme Gradient Boosting models demonstrated the most robust ***,the artificial neural network model also exhibited impressive *** cross-validation,the support vector machine and logistic regression models demonstrated superior *** for eLOS included delayed surgery,D-dimer level,American Society of Anaesthesiologists(ASA)classification,type of surgery,and *** ML proved to be highly accurate in predicting the eLOS for geriatric patients with hip *** identified key risk factors were delayed surgery,D-dimer level,ASA classification,type of surgery,and *** valuable information can aid clinicians i

关键词： Machine learning Extended length of stay Hip fracture Enhanced recovery after surgery Risk factors

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Cohort study to assess geographical variation in cholangiocarcinoma treatment in England

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World Journal of Gastrointestinal Oncology 2023年第12期15卷 2077-2092页

作者： Sophie Jose Amy Zalin-Miller Craig Knott Lizz Paley Daniela Tataru Helen Morement Mireille B Toledano Shahid A Khan Health Data Analysis Health Data Insight CICCambridge CB215XEUnited Kingdom National Disease Registration Service National Health Service EnglandLondon SE18UGUnited Kingdom Department of Executive AMMF-The Cholangiocarcinoma CharityEssex CM241QWUnited Kingdom MRC Centre for Environment and Health Imperial College LondonLondon SW72BXUnited Kingdom Mohn Centre for Children's Health and Wellbeing Imperial College LondonLondon SW72BXUnited Kingdom Liver Unit Division of Digestive DiseasesImperial College LondonLondon SW72BXUnited Kingdom

BACKGROUND Outcomes for cholangiocarcinoma(CCA)are extremely poor owing to the complexities in diagnosing and managing a rare disease with heterogenous *** curative surgery,which is only an option for a minority of patients diagnosed at an early stage,few systemic therapy options are currently recommended to relieve symptoms and prolong *** insertion to manage disease complications requires highly specialised *** is lacking as to how CCA patients are managed in a real-world setting and whether there is any variation in treatments received by CCA *** To assess geographic variation in treatments received amongst CCA patients in *** Data used in this cohort study were drawn from the National Cancer Registration Dataset(NCRD),hospital Episode Statistics and the Systemic Anti-Cancer Therapy Dataset.A cohort of 8853 CCA patients diagnosed between 2014-2017 in the National Health Service in England was identified from the *** curative surgery for all patients and systemic therapy and stent insertion for 7751 individuals who did not receive surgery were identified as three end-points of *** probability models assessed variation in each of the three treatment modalities according to Cancer Alliance of residence at diagnosis,and for socio-demographic and clinical characteristics at *** Of 8853 CCA patients,1102(12.4%)received potentially curative *** mean[95%confidence interval(CI)]percentage-point difference from the population average ranged from-3.96(-6.34 to-1.59)%to 3.77(0.54 to 6.99)%across Cancer Alliances in England after adjustment for patient sociodemographic and clinical characteristics,showing statistically significant *** 7751 who did not receive surgery,1542(19.9%)received systemic therapy,with mean[95%CI]percentage-point difference from the population average between-3.84(-8.04 to 0.35)%to 9.28(1.76 to 16.80)%across Cancer Alliances after adjustm

关键词： Cholangiocarcinoma Biliary tract cancer Liver cancer Treatment Surgery Systemic therapy Chemotherapy Stent England

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