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Prediction of the short-term efficacy of anti-VEGF therapy for neovascular age-related macular degeneration using optical coherence tomography angiography

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eye and Vision 2024年第3期10卷 21-30页

作者： Huixun Jia Bing Lu Zhi Zhao Yang Yu Fenghua Wang Minwen Zhou Xiaodong sun Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of Medicine100 Hai Ning RoadShanghai200080People’s Republic of China shanghai Key Laboratory of Ocular Fundus Diseases ShanghaiChina National Clinical Research Center for eye Diseases ShanghaiChina shanghai Engineering Center for Visual science and Photomedicine ShanghaiChina shanghai Engineering Center for Precise Diagnosis and Treatment of eye Diseases ShanghaiChina Clinical Research institute Shanghai Jiao Tong University School of MedicineShanghaiChina

Background To evaluate whether the specific choroidal neovascularization(CNV)characteristics measured using optical coherence tomography angiography(OCTA)can predict the 6-month prognosis of neovascular age-related macular degeneration(nAMD)after anti-vascular endothelial growth factor(anti-VEGF)*** Patients with type 1,type 2,or mixed-type neovascularization(NV)were prospectively *** underwent an initial loading phase of three consecutive monthly intravitreal injections of Conbercept(0.5 mg)and were switched to a pro re nata(PRN)treatment *** images were evaluated for eyes that underwent follow-up assessments for more than 6 *** lesions were manually segmented,and the CNV area,vessel area,greatest vascular caliber(GVC),and greatest linear dimension(GLD)were compared between responders and *** masked graders independently measured the above-mentioned parameters using OCTA,and consistency was assessed using the intraclass correlation coefficient(ICC)*** logistic regression analysis was performed to evaluate the effect of a 3-month change in the CNV area,GLD,and GVC on the 6-month response to anti-VEGF *** Among the 60 eyes of 60 patients with nAMD,39 were responders and 21 were *** proportion of CNV types was significantly different between responders and non-responders(P=0.009).Patients with type 2 or mixed NV seemed more likely to respond to the treatment(28.2%vs.0.0%,and 30.8%vs.23.8%,respectively).The change in GVC showed a significant difference between responders(−4.98±17.17μm)and non-responders(11.01±14.10μm)after three monthly intravitreal anti-VEGF *** logistic regression analysis showed that only the change in GVC remained significant after controlling for baseline GVC,injection number,and CNV type(adjusted OR=1.083;P=0.008).Conclusions Type 2 and mixed-type NV were significantly associated with a better response to anti-VEGF *** i

关键词： Age-related macular degeneration Choroidal neovascularization Optical coherence tomography angiography Anti-VEGF

Utility of real-time 3D visualization system in the early stage of phacoemulsification training

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 577-582页

作者： Zhe Xu Dan Chen Jing-Wei Xu Yi-Xuan Feng Ce shi Li Zhang Wen Xu eye Center the Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009Zhejiang ProvinceChina Zhejiang Provincial Key Laboratory of Ophthalmology Hangzhou 310009Zhejiang ProvinceChina Zhejiang Provincial Clinical Research Center for eye Diseases Hangzhou 310009Zhejiang ProvinceChina Zhejiang Provincial Engineering institute on eye Diseases Hangzhou 310009Zhejiang ProvinceChina

●AIM:To determine the teaching effects of a real-time three dimensional(3D)visualization system in the operating room for early-stage phacoemulsification training.●METHODs:A total of 10 ophthalmology residents of the first-year postgraduate were *** the residents were novices to cataract ***-time cataract surgical observations were performed using a custom-built 3D visualization *** training lasted 4wk(32h)in all.A modified International Council of Ophthalmology’s Ophthalmology surgical Competency Assessment Rubric(ICO-OsCAR)containing 4 specific steps of cataract surgery was *** self-assessment(self)and expert-assessment(expert)were performed through the microsurgical attempts in the wet lab for each participant.●REsULTs:Compared with pre-training assessments(self 3.2±0.8,expert 2.5±0.6),the overall mean scores of posttraining(self 5.2±0.4,expert 4.7±0.6)were significantly improved after real-time observation training of 3D visualization system(Pscores of 4 surgical items were significantly improved both self and expert assessment after training(PsION:The 3D observation training provides novice ophthalmic residents with a better understanding of intraocular microsurgical *** is a useful tool to improve teaching efficiency of surgical education.

关键词： 3D visualization system phacoemulsification training wet lab

Amphipathic Phenylalanine-Induced Nucleophilic-Hydrophobic Interface Toward Highly Reversible Zn Anode

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Nano-Micro Letters 2024年第9期16卷 95-109页

作者： Anbin Zhou Huirong Wang Fengling Zhang Xin Hu Zhihang song Yi Chen Yongxin Huang Yanhua Cui Yixiu Cui Li Li Feng Wu Renjie Chen Beijing Key Laboratory of Environmental science and Engineering School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081People’s Republic of China Advanced Technology Research institute Beijing Institute of TechnologyJinan 250300People’s Republic of China Collaborative Innovation Center of Electric Vehicles in Beijing Beijing 100081People’s Republic of China institute of Electronic Engineering China Academy of Engineering PhysicsMianyang 621900People’s Republic of China

Aqueous Zn^(2+)-ion batteries(AZIBs),recognized for their high security,reliability,and cost efficiency,have garnered considerable ***,the prevalent issues of dendrite growth and parasitic reactions at the Zn electrode interface significantly impede their practical *** this study,we introduced a ubiquitous biomolecule of phenylalanine(Phe)into the electrolyte as a multifunctional additive to improve the reversibility of the Zn *** its exceptional nucleophilic characteristics,Phe molecules tend to coordinate with Zn^(2+)ions for optimizing the solvation ***,the distinctive lipophilicity of aromatic amino acids empowers Phe with a higher adsorption energy,enabling the construction of a multifunctional protective *** hydrophobic benzene ring ligands act as cleaners for repelling H_(2)O molecules,while the hydrophilic hydroxyl and carboxyl groups attract Zn^(2+)ions for homogenizing Zn^(2+)***,the preferential reduction of Phe molecules prior to H_(2)O facilitates the in situ formation of an organic-inorganic hybrid solid electrolyte interphase,enhancing the interfacial stability of the Zn ***,Zn||Zn cells display improved reversibility,achieving an extended cycle life of 5250 ***,Zn||LMO full cells exhibit enhanced cyclability of retaining 77.3%capacity after 300 cycles,demonstrating substantial potential in advancing the commercialization of AZIBs.

关键词： Zn anode Phenylalanine Adsorption energy solvation sheath

Functional Optical Fiber sensors Detecting Imperceptible Physical/Chemical Changes for smart Batteries

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Nano-Micro Letters 2024年第8期16卷 268-308页

作者： Yiding Li Li Wang Youzhi song Wenwei Wang Cheng Lin Xiangming He institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084People’s Republic of China National Engineering Research Center of Electric Vehicles Beijing Institute of Technology(BIT)Beijing 100081People’s Republic of China shenzhen Automotive Research institute of BIT(shenzhen Research institute of National Engineering Research Center of Electric Vehicles) Shenzhen 518118People’s Republic of China

The battery technology progress has been a contradictory process in which performance improvement and hidden risks *** the battery is still a“black box”,thus requiring a deep understanding of its internal *** battery should“sense its internal physical/chemical conditions”,which puts strict requirements on embedded sensing *** paper summarizes the application of advanced optical fiber sensors in lithium-ion batteries and energy storage technologies that may be mass deployed,focuses on the insights of advanced optical fiber sensors into the processes of one-dimensional nano-micro-level battery material structural phase transition,electrolyte degradation,electrode-electrolyte interface dynamics to three-dimensional macro-safety *** paper contributes to understanding how to use optical fiber sensors to achieve“real”and“embedded”*** the inherent advantages of the advanced optical fiber sensor,it helps clarify the battery internal state and reaction mechanism,aiding in the establishment of more detailed *** advancements can promote the development of smart batteries,with significant importance lying in essentially promoting the improvement of system ***,with the help of smart batteries in the future,the importance of consistency can be weakened or even *** application of advanced optical fiber sensors helps comprehensively improve the battery quality,reliability,and life.

关键词： smart battery Advanced embedded optical fiber sensor Battery internal physical/chemical state Quality-reliability-life characteristic

Conceptual design of the tail research experiment at the space Plasma Environment Research Facility(sPERF-TREX)

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Plasma science and Technology 2024年第8期26卷 44-49页

作者：肖青梅毛傲华何向磊邹继同杨肖易孙萌萌李丰汤鹏飞周田春王晓钢 the sPERF Team Laboratory for space Environment and Physical sciences Harbin Institute of TechnologyHarbin 150001People’s Republic of China school of Physics Harbin Institute of TechnologyHarbin 150001People’s Republic of China Heilongjiang Provincial Key Laboratory of Plasma Physics and Application Technology Harbin Institute of TechnologyHarbin 150001People’s Republic of China

The space Plasma Environment Research Facility(sPERF)for ground simulation of the space plasma environment is a key component of the space Environment simulation Research Infrastructure(sEsRI),a major national science and technology infrastructure for fundamental *** is designed to investigate outstanding issues in the space plasma environment,such as energetic particle acceleration,transport,and interaction with electromagnetic waves,as well as magnetic reconnection processes,in magnetospheric *** Tail-Research EXperiment(TREX)is part of the sPERF for laboratory studies of space physics relevant to magnetic reconnection,dipolarization and hydromagnetic wave excitation in the *** is designed to carry out three types of experiments:the tail plasmoid for magnetic reconnection,dipolarization front formation,and magnetohydrodynamic waves excited by highspeed plasma *** this paper,the scientific goals and three scenarios of sPERF-TREX for typical processes in space plasmas are presented,and experimental plans for sPERF-TREX are also reviewed,together with the plasma sources applied to generate the plasma with the desired parameters and various magnetic configurations.

关键词： sPERF-TREX wave-particle interaction magnetic reconnection dipolarization

Preliminary study of the electrospray DPE peculiarities from the liquid surface in the presence of the CsWs

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Plasma science and Technology 2024年第5期26卷 110-120页

作者：贺伟国霍卫杰韩罗峰朱康武王锋王泽坤 school of Mechatronic Engineering and Automation Shanghai UniversityShanghai 200444People’s Republic of China shanghai Aerospace Electronic Technology institute Shanghai 201109People’s Republic of China shanghai Aerospace Control Technology institute Shanghai 201109People’s Republic of China

The Ultrasonic Electric Propulsion(UEP)system is a cutting-edge propulsion technology that is mostly used on platforms for small satellites(less than 10 kg).The characteristics of droplet partial emissions(DPEs)in the UEP system are investigated using a high-speed imaging technique(an ultra-high speed camera(NAC HX-6)and a long-distance microscope)in this *** experiments demonstrate that there are a few partial emission modes,including left-side emission,double-side emission,and right-side emission,that are present in the droplet emission process of the UEP *** modes are primarily caused by the partial formation of capillary standing waves(CsWs)on the emission surface of the ultrasonic *** emission rate for single-and double-sided emissions varies at different times,indicating that there are different CsWs engaged in droplet emission due to variations in the liquid film thickness and charge state of the liquid ***,as the droplets emit continuously,a raised area on the emission surface appears,with several droplets emitting there as a result of charge ***,photos of the CsWs with emitting droplets are obtained,which highlights the CsWs'distinctive wave morphology.

关键词： ultrasonic electric propulsion system microsatellite high-speed imaging technique droplet partial emissions electric field

Two‑Dimensional Cr_(5)Te_(8)@Graphite Heterostructure for Efficient Electromagnetic Microwave Absorption

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Nano-Micro Letters 2024年第3期16卷 407-422页

作者： Liyuan Qin Ziyang Guo shuai Zhao Denan Kong Wei Jiang Ruibin Liu Xijuan Lv Jiadong Zhou Qinghai shu school of Materials science and Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China Centre for Quantum Physics Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement(MOE)School of PhysicsBeijing Institute of TechnologyBeijing 100081People’s Republic of China Advanced Research institute of Multidisciplinary science Beijing Institute of TechnologyBeijing 100081People’s Republic of China Tangshan Research institute Beijing Institute of TechnologyTangshan 063099People’s Republic of China

Two-dimensional(2D)transition metal chalcogenides(TMCs)hold great promise as novel microwave absorption materials owing to their interlayer interactions and unique magnetoelectric ***,overcoming the impedance mismatch at the low loading is still a challenge for TMCs due to the restricted loss pathways caused by their high-density ***,an interface engineering based on the heterostructure of 2D Cr_(5)Te_(8) and graphite is in situ constructed via a one-step chemical vapor deposit to modulate impedance matching and introduce multiple attenuation ***,the Cr_(5)Te_(8)@EG(ECT)heterostructure exhibits a minimum reflection loss of up to−57.6 dB at 15.4 GHz with a thin thickness of only 1.4 mm under a low filling rate of 10%.The density functional theory calculations confirm that the splendid performance of ECT heterostructure primarily derives from charge redistribution at the abundant intimate interfaces,thereby reinforcing interfacial polarization ***,the ECT coating displays a remarkable radar cross section reduction of 31.9 dB m^(2),demonstrating a great radar microwave scattering *** work sheds light on the interfacial coupled stimulus response mechanism of TMC-based heterogeneous structures and provides a feasible strategy to manipulate high-quality TMCs for excellent microwave absorbers.

关键词： Chemical vapor deposition Interface polarization engineering Cr_(5)Te_(8)-graphite heterojunctions Microwave absorption

Modification of streamer-to-leader transition model based on radial thermal expansion in the sphere-plane gap discharge at high altitude

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Plasma science and Technology 2024年第1期26卷 42-49页

作者：耿江海林果王平丁玉剑丁杨俞华 Department of Electric Power Engineering North China Electric Power UniversityBaoding 071003People’s Republic of China China Electric Power Research institute Beijing 100192People’s Republic of China Xinjiang Electric Power Company Research institute Urumchi 830000People’s Republic of China shanxi Electric Power Company Research institute Taiyuan 030001People’s Republic of China

Historically,streamer-to-leader transition studies mainly focused on the rod-plane gap and low altitude analysis,with limited attention paid to the sphere-plane gap at high altitude *** this work,sphere-plane gap discharge tests were carried out under the gap distance of 5 m at the Qinghai Ultra High Voltage(UHV)test base at an altitude of 2200 *** experiments measured the physical parameters such as the discharge current,electric field intensity and instantaneous optical *** duration of the dark period and the critical charge of streamer-toleader transition were obtained at high *** on radial thermal expansion of the streamer stem,we established a modified streamer-to-leader transition model of the sphere-plane gap discharge at high altitude,and calculated the stem temperature,stem radii and the duration of streamer-to-leader *** with the measured duration of sphere-plane electrode discharge at an altitude of 2200 m,the error rate of the modified model was 0.94%,while the classical model was 6.97%,demonstrating the effectiveness of the modified *** the comparisons and analysis,several suggestions are proposed to improve the numerical model for further quantitative investigations of the leader inception.

关键词： streamer-to-leader transition model high altitude streamer stem convective diffusion radial thermal expansion

Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia s.Rex David J.Calkins Vanderbilt eye institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National eye institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National science Foundation(NsF),the NEI,the Blue Ridge institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times