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Short-term efficacy of early percutaneous cholecystostomy for pancreatitis and factors associated with recurrence and mortality

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World Journal of Gastroenterology 2025年第6期31卷 20-33页

作者： Xin Yan Feng Xie Xiao-Dan Zhao Liang Li Jia-Xian Meng department of Nuclear Medicine The People’s Hospital of Liaoning ProvinceShenyang 110016Liaoning ProvinceChina department of Interventional Medicine Jin Qiu Hospital of Liaoning ProvinceShenyang 110016Liaoning ProvinceChina department of General Surgery The People’s Hospital of Liaoning ProvinceShenyang 110016Liaoning ProvinceChina department of Science and Education The People’s Hospital of Liaoning ProvinceShenyang 110016Liaoning ProvinceChina

BACKGROUND Percutaneous cholecystostomy(PC)can be used as a bridging therapy for moderately severe acute biliary pancreatitis(MSABP).Currently,there are only a limited number of reports of MSABP using *** To assess the short-term outcomes of early PC in MSABP and factors associated with recurrence and death in *** Patients who received conservative treatment or PC for acute biliary pancreatitis(ABP)in liaoning Provincial People’s Hospital from January 2017 to July 2022 were collected.A total of 54 patients with MSABP who received early-stage PC and 29 patients who received conservative *** short-term efficacy of PC was *** on whether there is a recurrence,compare the characteristics of the pre-PC and explore the factors of ***-PC features were compared and predictors were discussed,depending on the *** After 3 days of PC treatment,patients experienced a reduction in inflammatory markers compared to the conservative *** PC,patients were divided into non-recurrence(n=37)and recurrence(n=10)groups,and the results showed that age was an independent correlation affecting ABP recurrence[odds ratio(OR)=0.937,95%confidence interval(CI):0.878-0.999;P=0.0470.7).When the Youden index maximum was 0.565,the cut-off value was 5.5,the sensitivity was 71.4%,and the specificity was 85.1%.CONCLUSION PC is an important method in the early years(<72 hours)of *** is a protective factor against recurrence of *** pre-PC CCI is significantly associated with mortality.

关键词： Acute biliary pancreatitis Percutaneous cholecystostomy The revised Atlanta classification Charleson Comorbidity Index Yoden index

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Interleukin-6 in epilepsy and its neuropsychiatric comorbidities: How to bridge the gap

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World Journal of Psychiatry 2025年第1期15卷 1-6页

作者： Xiao-Man Chen Shuo Zhang Shi-Qi Gao Michael Xu department of Neurology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina department of Rehabilitation Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110004Liaoning ProvinceChina International Education School China Medical UniversityShenyang 110004Liaoning ProvinceChina

There is growing evidence that interleukin(IL)-6 plays an important role in neurological and psychiatric *** editorial comments on the study published in the recent issue of the World Journal of Psychiatry,which employed Mendelian randomization to identify a causal relationship between IL-6 receptor blockade and decreased epilepsy *** purpose of this editorial is to highlight the dual effects of IL-6 in epilepsy and its related neuropsychiatric ***-6 plays a critical role in the facilitation of epileptogenesis and maintenance of epileptic seizures and is implicated in neuroinflammatory proce-sses associated with ***,IL-6 significantly influences mood regulation and cognitive dysfunction in patients with epilepsy,highlighting its involvement in neuropsychiatric *** summary,IL-6 is not only a pivotal factor in the pathogenesis of epilepsy but also significantly contributes to the emergence of epilepsy-related neuropsychiatric *** resear-ch should prioritize elucidating the specific mechanisms by which IL-6 operates across different subtypes,stages and neuropsychiatric comorbidities of epilepsy,with the aim of developing more precise and effective ***,the potential of IL-6 as a biomarker for the early diagnosis and prognosis of epile-psy warrants further investigation.

关键词： Epilepsy Interleukin-6 Neuropsychiatric comorbidities Depression Tocilizu-mab Neuroinflammation Interleukin-6 receptor blockade

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Systematic review of amyloid-beta clearance proteins from the brain to the periphery:implications for Alzheimer's disease diagnosis and therapeutic targets

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Neural Regeneration Research 2025年第12期20卷 3574-3590页

作者： Letian Huang Mingyue Liu Ze Li Bing Li Jiahe Wang Ke Zhang department of Oncology Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina department of Developmental Cell Biology Key Laboratory of Cell BiologyMinistry of Public HealthChina Medical UniversityShenyangLiaoning ProvinceChina department of Family Medicine Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

Amyloid-beta clearance plays a key role in the pathogenesis of Alzheimer's disease.H oweve r,the variation in functional proteins involved in amyloid-beta clearance and their correlation with amyloid-beta levels remain unclea *** this study,we conducted meta-analyses and a systematic review using studies from the PubMed,Embase,Web of Science,and Cochrane Library databases,including journal articles published from inception to J une 30,*** inclusion criteria included studies comparing the levels of functional proteins associated with amyloid-beta clearance in the blood,cere b rospinal fluid,and brain of healthy controls,patients with mild cognitive impairment,and patients with Alzheimer's ***,we analyzed the correlation between these functional proteins and amyloid-beta levels in patients with Alzheimer's *** methodological quality of the studies was assessed via the Newcastle-Ottawa *** to heterogeneity,we utilized either a fixed-effect or random-effect model to assess the 95%confidence interval(CI)of the standard mean difference(SMD)among healthy controls,patients with mild cognitive impairment,and patients with Alzheimer's *** findings revealed significant alterations in the levels of insulin-degrading enzymes,neprilysin,matrix metalloproteinase-9,cathepsin D,receptor for advanced glycation end products,and P-glycoprotein in the brains of patients with Alzheimer's disease,patients with mild cognitive impairment,and healthy *** cerebrospinal fluid,the levels of triggering receptor expressed on myeloid cells 2 and ubiquitin C-terminal hydrolase L1 are altered,whereas the levels of TREM2,CD40,CD40L,CD14,CD22,cathepsin D,cystatin C,andα2 M in peripheral blood ***,TREM2 and cathepsin D showed changes in both brain(SMD=0.31,95%CI:0.16-0.47,P<0.001,I^(2)=78.4%;SMD=1.24,95%CI:0.01-2.48,P=0.048,I^(2)=90.1%)and peripheral blood(SMD=1.01,95%CI:0.35-1.66,P=0.003,I^(2)=96.5%;SMD=7.55,95%CI:3.92-11.18,P<0.001,I^(

关键词： Alzheimer’s disease amyloid-β blood‒brain barrier cerebrospinal fluid diagnostic biomarker meta-analysis mild cognitive impairment peripheral blood systematic review therapeutic targets

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Research Progress of Chinese Medicine Monomers in Treatment of Cholangiocarcinoma

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Chinese Journal of Integrative Medicine 2025年第2期31卷 170-182页

作者： WANG Xiang WANG Xiao-qing LUO Kai BAI He QU Jia-lin ZHANG Gui-xin department of General Surgery the Second Hospital of Dalian Medical UniversityDalianLiaoning Province(116027)China Clinical Laboratory of Integrative Medicine First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning Province(116021)China Hepatobiliary Surgery department Shandong Provincial Third HospittalShandong UniversityJinan(250031)China Institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning Province(116044)China

Cholangiocarcinoma(CCA)is a malignant tumor originating from ***,it remains unclear about the pathogenesis of this carcinoma,which may be related to multiple ***,CCA is mainly treated by surgery,chemotherapy,and *** them,surgery is the only potentially curative option for ***,the high malignancy and asymptomatic nature of CCA may lead to poor treatment *** has been demonstrated that Chinese medicine(CM)plays a significant role in various antitumor ***,CM exhibits fewer side effects and high ***,the in vitro application of CM monomers has been explored in many domestic and foreign *** article mainly reviews the signaling pathways and molecular mechanisms of CM monomers in the treatment of CCA in recent *** findings are expected to provide new insights into the treatment of CCA.

关键词： cholangiocarcinoma Chinese medicine monomers antitumor signaling pathways molecular mechanisms review

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Protective effects of autologous bone marrow-derived mesenchymal stem cell transplantation on acute radioactive enteritis in Beagle dogs

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World Journal of Gastroenterology 2025年第7期31卷 98-109页

作者： Guang-Chen Sun Wen-Da Xu Hui Yao Jiang Chen Ruo-Nan Chai College of Medicine and Biological Information Engineering Northeastern UniversityShenyang 110000Liaoning ProvinceChina department of Respiratory Medicine General Hospital of Northern Theater CommandShenyang 110000Liaoning ProvinceChina department of Gastroenterology General Hospital of Northern Theater CommandShenyang 110000Liaoning ProvinceChina

BACKGROUND Radiation enteritis is a common complication of radiation therapy in which the surrounding normal intestinal tissue is damaged by ionising radiation,and there is no standard pharmacological prophylaxis or treatment regimen *** stem cell transplantation can be used for radiation protection and the treatment of acute radiation injury,but its therapeutic mechanism of action remains *** To investigate the protective effects of autologous bone marrow-derived mesenchymal stem cell(ABMSC)transplantation on radiation-induced intestinal *** A model of acute radioactive enteritis was established in dogs by applying abdominal intensity-modulated radiation at a single X-ray dose of 12 *** were transplanted into the mesenteric artery with the technology of femoral artery puncture and DSA imaging two days after *** and histopathological changes of the experimental dogs were *** kinds of cytokines from intestinal samples were tested using Quantibody Canine Cytokine Array ***-linked immunosorbent assay(ELISA)was also used to evaluate the cytokines changes in *** The ABMSCs group showed significant improvements in survival status compared with the blank and saline treatment *** observations revealed that the former had lower histological scores than the later after treatment(P<0.05).Compared to the control groups,interleukin(IL)-10 and monocyte chemotactic protein(MCP)-1 from intestinal samples showed a remarkable increase and ELISA of serum samples proved higher secretion of the two target cytokines in the ABMSCs group(P<0.05).CONCLUSION Our data suggest that transplantation of ABMSCs promotes intestinal recovery after acute radioactive injury in Beagle *** cytokines of IL-10 and MCP-1 might play an important role in this process.

关键词： Mesenchymal stem cells Transplantation Acute radioactive enteritis Antibody array Interleukin 10 Monocyte chemotactic protein-1

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Tetrahydrocurcumin-induced apoptosis of hepatocellular carcinoma cells involves the TP53 signaling pathway,as determined by network pharmacology

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 221-236页

作者： Zhuo-Cong Bao Ye Zhang Zhao-Dong Liu Hui-Jun Dai Fu Ren Ning Li Shang-Yu Lv Yan Zhang Graduate School Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Guangxi Medical University Cancer Hospital Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Key Laboratory of Human Ethnic Specificity and Phenomics of Critical Illness in liaoning province Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Key Laboratory of Phenomics in Shenyang Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina department of Biochemistry School of Basic MedicineShenyang Medical CollegeShenyang 110034Liaoning ProvinceChina department of Clinical Medicine Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina International Education School International Exchange and Cooperation OfficeShenyang Medical CollegeShenyang 110034Liaoning ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is a malignant disease with high incidence and mortality *** study focuses on the TP53 target protein to investigate the potential therapeutic effect of tetrahydrocurcumin(THC)on HCC and its mechanism of *** research hypothesis is that THC can inhibit the proliferation,migration,and invasion of HCC cells,and promote their apoptosis by regulating the TP53 target *** To explore the mechanism by which THC inhibits HCC cell proliferation via the TP53 signaling *** Potential targets of THC and HCC were identified from multiple *** core targets were subjected to analyses using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases,and visualization processing,using the online platform Metascape to identify the key molecules and signaling pathways involved in the action of THC against *** molecular mechanisms of action of THC against TP53 in the inhibition of HCC cells were verified using cell counting kit-8,Transwell,apoptosis,and western blotting *** Molecular docking results showed that THC had a high score for the TP53 target *** vitro experiments indicated that THC effectively inhibited the proliferation and migration of HCC cells,and affected the expression levels of TP53,MDM2,cyclin B,Bax,Bcl-2,caspase-9,and *** THC induces the apoptosis of HCC cells through the TP53 signaling pathway,thereby inhibiting their proliferation and migration.

关键词： Hepatocellular carcinoma cells Tetrahydrocurcumin TP53 Network pharmacology Molecular docking

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Trends of alkaline phosphatase to prealbumin ratio in patients with hepatitis B linked to hepatocellular carcinoma development

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World Journal of Gastroenterology 2025年第2期31卷 42-51页

作者： Wen-Chong Zhen Jing Sun Xue-Ting Bai Qian Zhang Zi-Han Li Yi-Xin Zhang Rong-Xuan Xu Wei Wu Zhi-Han Yao Chun-Wen Pu Xiao-Feng Li School of Public Health Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Dalian Public Health Clinical Center Dalian Municipal Research Institute for Public HealthDalian 116001Liaoning ProvinceChina department of Epidemiology and Health Statistics Dalian Medical UniversityDalian 116044Liaoning ProvinceChina

BACKGROUND Chronic hepatitis B often progresses silently toward hepatocellular carcinoma(HCC),a leading cause of mortality *** detection of HCC is crucial,yet *** To investigate the role of dynamic changes in alkaline phosphatase to prealbumin ratio(APR)in hepatitis B progression to *** Data from 4843 patients with hepatitis B(January 2015 to January 2024)were *** incidence rates in males and females were compared using the log-rank *** were evaluated using Kaplan–Meier *** Linear Mixed-Effects Model was applied to track the fluctuation of APR levels over ***,Joint Modeling of Longitudinal and Survival data was employed to investigate the temporal relationship between APR and HCC *** The incidence of HCC was higher in *** ensure the model’s normality assumption,this study applied a logarithmic transformation to APR,yielding *** levels were higher in females(t=5.26,P<0.01).A 1-unit increase in ratio correlated with a 2.005-fold higher risk of HCC in males(95%CI:1.653-2.431)and a 2.273-fold higher risk in females(95%CI:1.620-3.190).CONCLUSION Males are more prone to HCC,while females have higher APR *** no baseline APR link,rising APR indicates a higher HCC risk.

关键词： Alkaline phosphatase to prealbumin ratio Chronic hepatitis B patients Hepatocellular carcinoma Retrospective cohort study Linear Mixed-Effect Mode Joint Modelling of Longitudinal and Survival data

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Metastatic lymph node distribution and pathology correlations in upper and lower gastric cancer patients:A multicenter retrospective study

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 56-66页

作者： Xian-Bei Yuan Gang Sun Jun Niu Lei Dong Yi Sui Yong-Zhu Lv department of General Surgery No.967 Hospital of the People's Liberation Army Joint Logistics Support ForceDalian 116000Liaoning ProvinceChina department of Trauma Surgery The No.967 Hospital of People's Liberation Army Joint Logistics Support ForceDalian 116000Liaoning ProvinceChina department of General Surgery The First Affiliated Hospital of Dalian Medical UniversityDalian 116000Liaoning ProvinceChina department of General Surgery The Fifth People's Hospital of ShenyangShenyang 110000Liaoning ProvinceChina department of General Surgery The Fifth People's Hospital of DalianDalian 116000Liaoning ProvinceChina

BACKGROUND Gastric cancer(GC)poses a significant threat to public ***,the clinicopathological features and tumor biological behaviors vary among the GC patients,leading to individual variations in lymph node ***,the stratification of lymph node dissection according to the specific type,particularly upper GC,has emerged as a prominent area of *** To investigate the distribution of metastatic lymph nodes in patients with upper and lower GC and to analyze the differences in related pathological elements and *** Differential analysis between upper and lower GC patients with various clinicopathological factors was performed using the chi-square test and rank-sum regression models were used to analyze risk factors affecting patient *** Kaplan-Meier method was used to construct survival curves associated with prognostic risk factors for *** Significant differences were observed between the two GC populations regarding tumor diameter,histological grade,pT stage,pN stage,tumor-node-metastasis(pTNM)stage,vascular invasion,and adjuvant chemotherapy usage(all P<0.05).Lymph node metastasis rates were highest for Siewert type II patients in groups Nos.1,3,2 and 7;for Siewert type III patients in groups Nos.3,1,2 and 7;and for other/unclassified patients in groups Nos.1,3,7,*** the lower GC samples,the sequences were Nos.3,6,7,*** type,pT stage,pTNM stage,and positive vascular invasion were independent risk factors for development of lymph node ***,pathological type,pT stage,pN stage,pTNM stage,vascular invasion,and absence of adjuvant chemotherapy were identified as independent prognostic *** Upper GC showed a significantly higher malignancy grade and different lymph node metastasis pattern than lower GC.

关键词： Upper gastric cancer Lower gastric cancer Metastatic lymph nodes Prognosis Retrospective study

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Nomogram based on a novel nutritional immune-inflammatory status score to predict postoperative outcomes in esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2025年第4期31卷 42-58页

作者： Qing-Wen Liu Lin Liu Jun-Xi Hu Jia-Qi Hou Wen-Bo He Yu-Sheng Shu Xiao-Lin Wang department of Graduate School Dalian Medical UniversityDalian 116000Liaoning ProvinceChina department of Thoracic Surgery The Affiliated Wuxi People's Hospital of Nanjing Medical UniversityWuxi People's HospitalWuxi Medical CenterNanjing Medical UniversityWuxi 214000Jiangsu ProvinceChina Clinical Medical College Yangzhou UniversityYangzhou 225000Jiangsu ProvinceChina department of Thoracic Surgery Northern Jiangsu People's HospitalYangzhou 225000Jiangsu ProvinceChina

BACKGROUND The relationship between patient nutritional,immune,and inflammatory status is linked to tumor progression and ***,there are limited studies on the prognosis of esophageal squamous cell carcinoma(ESCC)after surgery based on the comprehensive indicators of these *** To develop and validate a novel nomogram based on a nutritional immuneinflammatory status(NIIS)score for predicting postoperative outcomes in *** This retrospective study examined 829 patients with ESCC who underwent radical surgery between June 2016 and June 2020,with 568 patients in the training cohort and 261 patients in the validation *** incorporated comprehensive indicators related to nutrition,immunity,and inflammation to develop the NIIS score, using LASSO regression. Subsequently, a nomogram combining the NIIS score and other clinicopathologicalparameters was developed and validated using calibration curves, time-dependent area under curves, and decisioncurve *** identified eight indicators that constitute the NIIS score. High-risk scores emerged as an independent riskfactor for overall survival [training set HR 2.497 (1.802, 3.458), P < 0.001]. A NIIS nomogram for personalizedprognostic prediction was developed by integrating the NIIS score with clinicopathological variables, yieldingenhanced predictive value relative to individual indicators and the UICC/TNM staging *** NIIS score provides strong predictive value for postoperative outcomes in ESCC, thus offering a valuable toolfor clinical decision-making.

关键词： Esophageal squamous cell carcinoma Nutrition Immunity Inflammation Overall survival

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Clinical study on the effect of jejunoileal side-to-side anastomosis on metabolic parameters in patients with type 2 diabetes

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World Journal of Diabetes 2025年第1期16卷 58-64页

作者： Ji-Kui Wang Di Zhang Jin-Feng Wang Wan-Lin Lu Jing-Yuan Wang Shi-Feng Liang Ran Liu Jing-Xin Jiang Hong-Tao Li Xuan Yang department of General Thoracic Surgery Liaoning Electric Power Center HospitalShenyang 110000Liaoning ProvinceChina department of Health Management Center Liaoning Electric Power Center HospitalShenyang 110000Liaoning ProvinceChina

BACKGROUND At present,the existing internal medicine drug treatment can alleviate the high glucose toxicity of patients to a certain extent,to explore the efficacy of laparoscopic jejunoileal side to side anastomosis in the treatment of type 2 diabetes,the report is as *** To investigate the effect of jejunoileal side-to-side anastomosis on metabolic parameters in patients with type 2 diabetes mellitus(T2DM).METHODS We retrospectively analyzed the clinical data of 78 patients with T2DM who were treated via jejunoileal lateral *** indicators were collected preoperatively,as well as at 3 and 6 months *** metabolic indicators analyzed included body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP),fasting blood glucose(FBG),2-hour blood glucose(PBG),glycated hemoglobin(HbA1c),fasting C-peptide,2-hour C-peptide(PCP),fasting insulin(Fins),2-hour insulin(Pins),insulin resistance index(HOMA-IR),βCellular function index(HOMA-β),alanine aminotransferase,aspartate aminotransferase,serum total cholesterol(TC),low-density lipoprotein cholesterol(L DL-C),triglycerides(TG),high-density lipoprotein,and uric acid(UA)*** SBP,DBP,PBG,HbA1c,LDL-C,and TG were all significantly lower 3 months postoperative vs preoperative values;body weight,BMI,SBP,DBP,FBG,PBG,HbA1c,TC,TG,UA,and HOMA-IR values were all significantly lower 6 months postoperative vs at 3 months;and PCP,Fins,Pins,and HOMA-βwere all significantly higher 6 months postoperative vs at 3 months(all P<0.05).CONCLUSION Side-to-side anastomosis of the jejunum and ileum can effectively treat T2DM and improve the metabolic index levels associated with it.

关键词： Metabolic diseases Type 2 diabetes Jejunoileal side-to-side anastomosis Glycolipid metabolism Islet function

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