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Langmuir-Schaefer Film Investigation and Density Functional Theory Band Gap Calculations of Calix[n]arene-Para-Aminobenzoic Acid for Drug Nanosensor Application

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Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1311-1318页

作者： WONG Yeong Yi F L Supian A Radzwan M Musa N F N Abd Karim department of Physics Sultan Idris Education UniversityTanjong Malim 35900Malaysia department of Chemistry Sultan Idris Education UniversityTanjong Malim 35900Malaysia

Calix[n]arenes was utilized to detect PABA,the primary sunscreen *** study investigates the interaction of calix[4]arene(C4),calix[6]arene(C6),and PABA using the Langmuir method and first-principle density functional theory(DFT).Using the Langmuir-Schaefer(LS)technique,an ultrathin film composed of calix[n]arenes and their complexes with PABA was deposited on various *** on the Langmuir study,the PABA molecule was bonded to the lower rims of both C4 and C6 with the host-guest ratio of 1:*** of the LS films formed were then characterized by ultravioletvisible spectroscopy(UV-Vis),Fourier-transform infrared spectroscopy(FTIR)and carbon,hydrogen,nitrogen,sulfur elemental analyzer(CHNS).The band gap reduction obtained in the DFT study denotes the charge transfer interaction with promising reactivity between the calix[n]arenes and *** sensing of PABA by C4 and C6 is successful based on the formation of bonding between them due to the hosts’effective trapping *** outcomes of this study could be applied to drug delivery systems for future pharmaceutical and medical applications.

关键词： calix[n]arenes band gap density functional theory Langmuir-Schaefer PABA sensor

Detection of 4p16.3 deletion and 11p15.5p15.4 gain in a boy by comparative genomic hybridization array:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1517-1522页

作者： Işın Kaya Medical Genetics Bakırçay UniversityÇiğli Education ve Training Hospitalİzmir 35620Turkey

BACKGROUND Nonallelic homologous recombination(NAHR)of segmental duplications or low copy repeats(LCRs)result in DNA gain/loss and play an important role in the origin of genomic *** SUMMARY A 3-year-old boy was referred for genetic *** genomic hybrid-ization array analysis revealed a loss of 3776 kb in the 4p16.3 chromosomal region and a gain of 3201 kb in the 11p15.5p15.4 chromosomal *** Genomic imbalances caused by NAHR in LCRs result in deletion and duplication syndromes.

关键词： Wolf-Hirschhorn syndrome Silver-Russell syndrome Recurrent rearrangements Case report

Neuroimaging in atypical normal tension glaucoma:debating routine implementation in the absence of classic neurological findings

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 509-517页

作者： Umay Güvenç Gülizar Demirok Güner Üney Selma Uzman Ophthalmology department Ankara Training and Research HospitalAnkara 06230Turkey

●AIM:To assess the necessity of neuroimaging in patients with neurological or atypical findings of normal tension glaucoma(NTG)who do not exhibit typical glaucoma manifestations.●METHODS:A retrospective analysis was conducted on 90 atypical NTG patients who underwent cranial magnetic resonance imaging(MRI)due to atypical *** demographic characteristics,clinical parameters,and radiological findings were recorded.●RESULTS:Among the patients,66.7%had abnormal radiology results,with the most common findings being gliosis(34.4%),sequelae of cerebrovascular events and vascular malformations(14.4%),and benign intracranial mass lesions(11%).Non-glaucomatous visual field defects were more frequently observed in patients with abnormal neuroimaging ***,there were no significant differences in intraocular pressure,optic disc parameters,retinal nerve fiber layer thickness,and visual field indices between patients with normal and abnormal radiological *** mean age of the patients was ***,there was a significant age difference,with the abnormal radiology group having a higher median age(P=0.021).●CONCLUSION:The study highlights the importance of cranial imaging in older NTG patients to detect underlying pathologies and prevent *** suggests that neuroimaging may be warranted in NTG patients with atypical visual field defects incompatible with ***,routine neuroimaging in all NTG patients without classic neurological signs may not be necessary.

关键词： normal tension glaucoma neuroimaging atypical visual field defects

Shifting the Paradigm:A Fresh Look at Physical Activity Frequency and Its Impact on Mental Health,Life Satisfaction,and Self-Rated Health in Adolescents

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International Journal of Mental Health Promotion 2024年第2期26卷 83-92页

作者： Wenjie Li Yucheng Gao Guoqing Liu Rongkai Hao Meijie Zhang Xiaotian Li Country School of Recreation and Community Sport Capital University of Physical Education and SportsBeijing100191China Institute of Physical education and training Capital University of Physical Education and SportsBeijing100191China

As adolescent mental health problems are becoming a more serious issue globally,this paper explores the relationship of physical activity in adolescents and its frequency on mental health as well as examines the mediating effects of life satisfaction and self-rated health in order to provide a reference for the promotion of mental health in adolescents.A sample of 3578 Chinese high school students completed questionnaires assessing their mental health,physical activity frequency,life satisfaction,and self-rated *** mean SCL-90 value for adolescents was found to be 1.629%,and 24.73%of adolescents had varying degrees of mental health *** physical activity frequency is positively associated with improved mental health(p<0.001).Additionally,life satisfaction and self-rated health were found to play significant mediating roles in the relationship between physical activity frequency and mental ***,low-frequency physical activity had the most pronounced mediating effect on mental health through life satisfaction,while high-frequency physical activity exerted the most significant mediating effect on mental health through self-rated *** findings underscore the importance of promoting physical activity among adolescents and highlight the distinct pathways through which physical activity frequency can influence mental health *** research is needed to explore these relationships in diverse populations and settings,as well as to develop targeted intervention.

关键词： Adolescents physical activity mental health life satisfaction self-rated health

Influencing factors and solution strategies of chimeric antigen receptor T-cell therapy(CAR–T)cell immunotherapy

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Oncology Research 2024年第9期32卷 1479-1516页

作者： ZHENGYI WANG LIANG ZHOU XIAOYING WU department of Institute of Laboratory Animal Sciences Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduChina Ministry of education and training Chengdu Second People’s HospitalChengduChina

Chimeric antigen receptor T-cesll therapy(CAR–T)has achieved groundbreaking advancements in clinical application,ushering in a new era for innovative cancer ***,the challenges associated with implementing this novel targeted cell therapy are increasingly *** in the clinical management of solid tumors,obstacles such as the immunosuppressive effects of the tumor microenvironment,limited local tumor infiltration capability of CAR–T cells,heterogeneity of tumor targeting antigens,uncertainties surrounding CAR–T quality,control,and clinical adverse reactions have contributed to increased drug resistance and decreased compliance in tumor *** factors have significantly impeded the widespread adoption and utilization of this therapeutic *** this paper,we comprehensively analyze recent preclinical and clinical reports on CAR–T therapy while summarizing crucial factors influencing its ***,we aim to identify existing solution strategies and explore their current research *** this review article,our objective is to broaden perspectives for further exploration into CAR–T therapy strategies and their clinical applications.

关键词： Chimeric antigen receptor T-cell therapy(CAR-T) Tumor targeting therapy Influencing factor Solution strategies

The Barrier of the Child and Parent Expected Models for Entering the School System-A Secondary Publication

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Journal of Contemporary educational Research 2024年第2期8卷 243-255页

作者： Xavier Conus department of education and training Sciences University of Fribourg1700 FribourgSwitzerland

The recognition of the positive value of student diversity and their right to full participation are key aspects of inclusion as a means of managing heterogeneity of the school population from an equality *** the school cannot welcome the diversity of children without including their families,the same logic needs to apply to the relationship between the school and parents,particularly in the current environment where the school-family partnership appears as a privileged institutional leverage in the fight against inequalities at *** on an ethnographical study exploring how the relationship between the school and the families builds up in a Swiss school located in a context of strong cultural diversity,this paper interrogates how the school norm can be the main limitation to the inclusion of students and parents who are unfamiliar with the *** from field observations and interviews,our results show how the teachers tend to approach their relationship with new students and their parents from the standpoint of narrowly defined expected models,leading them to engage in a vain attempt to conform the students and parents when they deviate from these *** possibility of entering the school system for students and parents unfamiliar with school is hindered by the exclusive and excluding normativity on which the models of the child and the parent expected by the teachers are *** on these observations,we discuss how an inclusive approach seems to us to require in the first place a necessary process of decentering from the school and teachers,as a condition for recognition of the actual child and parent.

关键词： educational inclusion and exclusion Family and education Norms and regulations Primary and elementary education Switzerland

Trends and Age-Period-Cohort Effect on Incidence of Varicella Under Age 35—China,2005-2021

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China CDC weekly 2024年第18期6卷 390-395,I0005页

作者： Guijie Luan Hongyan Yao Dapeng Yin Jianjun Liu department of education and training Chinese center for Disease Control and PreventionBeijingChina Hainan Provincial Center for Disease Control and Prevention Haikou CityHainan ProvinceChina Chinese center for Disease Control and Prevention BeijingChina

Summary What is already known about this topic?Varicella is an acute respiratory infectious disease primarily affecting ***,recent studies have indicated an increasing susceptibility to varicella among older age *** is added by this report?The findings demonstrate a significant rise in the incidence rate among individuals aged *** under 20 years old were found to have a higher risk compared to females,whereas males had a lower risk compared to females aged 20-35 years.

关键词： acute respiratory Incidence

Evaluating the Effectiveness of Consultants’ Roles in Improving Value for Money in Public Infrastructure Projects in Ghana

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Journal of Building Construction and Planning Research 2024年第3期12卷 69-85页

作者： Sheitu Abu Nongiba Alkanam Kheni Adams Abudi department of Technical and Vocational education Mampong Technical College of Education Mampong Ghana department of Construction Akenten Appiah-Menka University of Skills Training and Entrepreneurial Development Kumasi Ghana department of Technical and Vocational education Bagabaga Training College Tamale Ghana

Ghanaian construction projects encounter a number of challenges, including low health, safety, and environmental requirements, poor performance, and time and cost overruns. To provide value for money (VFM) on government infrastructure projects in Ghana, this research assesses the roles of project consultants, specifically architects and quantity surveyors, and highlights important obstacles. A cross-sectional survey design involving architects and quantity surveyors yielded a 96% response rate after 100 questionnaires were distributed. Consultants’ responsibilities also include monitoring standards compliance, providing advice on delays, controlling budgets, and advising on project completion dates. Difficulties encompass a lack of promptness in decision-making, unethical conduct, political pressure, and inadequate focus on contract administration and construction audits. Project urgency, longevity, political clout, timely decision-making, and team experience are important variables that impact VFM. Policy makers and construction management practitioners should take note of the implications for Ghana’s public infrastructure projects.

关键词： Consultants Value for Money Physical Infrastructure Ghana

A Systematic Analysis of Systems Approach and Flood Risk Management Research:Trends,Gaps,and Opportunities

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International Journal of Disaster Risk Science 2024年第1期15卷 45-57页

作者： Lum Sonita Awah Johanes Amate Belle Yong Sebastian Nyam Israel Ropo Orimoloye Disaster Management training and education Centre for Africa University of the Free StateBloemfontein 9300South Africa School of Environment Geographyand SustainabilityWestern Michigan UniversityKalamazooMI 49008USA

Flooding is a global threat,necessitating a comprehensive management *** to the complexity of managing flood hazards and risks,researchers have advocated for holistic,comprehensive,and integrated *** study,employing a systems thinking perspective,assessed global flood risk management research trends,gaps,and opportunities using132 published documents in BibTeX format.A systematic review of downloaded documents from the Scopus and Web of Science databases revealed slow progress of approximately 11.61% annual growth in applying systems thinking and its concomitant approaches to understanding global flood risk management over the past two decades compared to other fields like water resource management and business management systems.A significant gap exists in the application of systems thinking methodologies to flood risk management research between developed and developing countries,particularly in Africa,highlighting the urgency of reoriented research and policy *** application gaps of the study methodology are linked to challenges outlined in existing literature,such as issues related to technical expertise and resource *** study advocates a shift from linear to holistic approaches in flood risk management,aligned with the Sendai Framework for Disaster Risk Reduction 2015-2023 and the Sustainable Development *** among researchers,institutions,and countries is essential to address this global challenge effectively.

关键词： Flood risk management research Gaps and opportunities Global trends in flood research Systematic review.Systems thinking