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Dip2a regulates stress susceptibility in the basolateral amygdala

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Neural Regeneration Research 2025年第6期20卷 1735-1748页

作者： Jing Li Zixuan He Weitai Chai Meng Tian Huali Yu Xiaoxiao He Xiaojuan Zhu Key Laboratory of Molecular Epigenetics Ministry of education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analysis stress susceptibility tryptophan

Motivational interviewing in postoperative rehabilitation and chronic disease management: Current findings and future research directions

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World Journal of Psychiatry 2025年第1期15卷 26-31页

作者： Bing-Ren Zhang Xiao Yang Affiliated Hospital(School of Clinical Medicine) Hangzhou Normal UniversityHangzhou 311121Zhejiang ProvinceChina Mental Health education and Counseling Center Hangzhou Normal UniversityHangzhou 311121Zhejiang ProvinceChina

This editorial highlights a recently published study examining the effectiveness of music therapy combined with motivational interviewing(MI)in addressing an-xiety and depression among young and middle-aged patients following percuta-neous coronary *** further explores existing evidence and potential future research directions for MI in postoperative rehabilitation and chronic disease *** aims to facilitate behavioral change and promote healthier lifestyles by fostering a trusting relationship with patients and enhan-cing intrinsic *** has demonstrated its effectiveness in posto-perative recovery for oncological surgery,stroke,organ transplants,and gastroin-testinal procedures,as well as in managing chronic conditions such as diabetes,obesity,and periodontal *** approach is patient-centered,adaptable,cost-effective,and easily replicable,though its limitations include reliance on the therapist’s expertise,variability in individual responses,and insufficient long-term follow-up *** research could focus on developing individualized and precise intervention models,exploring applications in digital health management,and confirming long-term outcomes to provide more compre-hensive support for patient rehabilitation.

关键词： Chronic disease management Motivational interviewing Patient-centered Postoperative rehabilitation Treatment adherence

Empirical Likelihood for Partially Linear Models Under Negatively Associated Errors

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Journal of Systems Science & Complexity 2016年第4期29卷 1145-1159页

作者： LEI Qingzhu QIN Yongsong department of Mathematics Guangxi Normal University

This paper proposes to use the blockwise empirical likelihood （EL） method to construct the confidence regions for the regression vector β in a partially linear model under negatively associated errors. It is shown that the blockwise EL ratio statistic for β is asymptotically χ^2 distributed. The result is used to obtain an EL-based confidence region for β. Results of a simulation study on the finite sample performance of the proposed confidence regions are reported.

关键词： Blockwise empirical likelihood confidence region negatively associated error partially linear model.

Joint Empirical Likelihood Confidence Regions for a Finite Number of Quantiles Under Negatively Associated Samples

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Journal of Systems Science & Complexity 2015年第6期28卷 1389-1398页

作者： QIN Yongsong LI Yinghua LEI Qingzhu department of Mathematics Guangxi Normal University

In this paper, the authors obtain the joint empirical likelihood confidence regions for a finite number of quantiles under negatively associated samples. As an application of this result, the empirical likelihood conf... 详细信息

关键词： Blockwise empirical likelihood confidence region negatively associated sample quantile

Lattice Boltzmann simulation for the energy and entropy of excitable systems

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Chinese Physics B 2011年第2期20卷 158-163页

作者：邓敏艺唐国宁孔令江刘慕仁 College of Physics and Technology Guangxi Normal University College of Physics and Electronic Engineering Guangxi Teachers Education University

The internal energy and the spatiotemporal entropy of excitable systems are investigated with the lattice Boltzmann method. The numerical results show that the breakup of spiral wave is attributed to the inadequate supply of energy, i.e., the internal energy of system is smaller than the energy of self-sustained spiral wave. It is observed that the average internal energy of a regular wave state reduces with its spatiotemporal entropy decreasing. Interestingly, although the energy difference between two regular wave states is very small, the different states can be distinguished obviously due to the large difference between their spatiotemporal entropies. In addition, when the unstable spiral wave converts into the spatiotemporal chaos, the internal energy of system decreases, while the spatiotemporal entropy increases, which behaves as the thermodynamic entropy in an isolated system.

关键词： lattice Boltzmann method energy entropy spiral wave

A Temporal Knowledge Graph Embedding Model Based on Variable Translation

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Tsinghua Science and Technology 2024年第5期29卷 1554-1565页

作者： Yadan Han Guangquan Lu Shichao Zhang Liang Zhang Cuifang Zou Guoqiu Wen Key Lab of education Blockchain and Intelligent Technology Ministry of EducationGuangxi Normal UniversityGuilin 541004China and also with Guangxi Key Lab of Multi-Source Information Mining and SecurityGuangxi Normal UniversityGuilin 541004China

Knowledge representation learning(KRL)aims to encode entities and relationships in various knowledge graphs into low-dimensional continuous *** is popularly used in knowledge graph completion(or link prediction)***-based knowledge representation learning methods perform well in knowledge graph completion(KGC).However,the translation principles adopted by these methods are too strict and cannot model complex entities and relationships(i.e.,N-1,1-N,and N-N)***,these traditional translation principles are primarily used in static knowledge graphs and overlook the temporal properties of triplet ***,we propose a temporal knowledge graph embedding model based on variable translation(TKGE-VT).The model proposes a new variable translation principle,which enables flexible transformation between entities and relationship ***,this paper considers the temporal properties of both entities and relationships and applies the proposed principle of variable translation to temporal knowledge *** conduct link prediction and triplet classification experiments on four benchmark datasets:WN11,WN18,FB13,and *** model outperforms baseline models on multiple evaluation metrics according to the experimental results.

关键词： knowledge graph knowledge graph completion variable translation temporal properties link prediction triplet classification

Joint empirical likelihood confidence regions for a finite number of quantiles under strong mixing samples

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Applied Mathematics(A Journal of Chinese Universities) 2015年第1期30卷 44-54页

作者： LEI Qing-zhu QIN Yong-song department of Mathematics Guangxi Normal University

In this paper, we obtain the joint empirical likelihood confidence regions for a finite number of quantiles under strong mixing samples. As an application of this result, the empirical likelihood confidence intervals ... 详细信息

关键词： strong mixing sample quantile confidence region blockwise empirical likelihood.

On k-critical 2k-connected graphs

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Science China Mathematics 2003年第3期46卷 289-299页

作者：苏健基袁旭东赵巧凤 department of Mathematics Guangxi Normal University

A graph G is called an (n,k)-graph if κ(G-S)=n-|S| for any S ? V(G) with |S| ≤ k, where ?(G) denotes the connectivity of G. Mader conjectured that for k ≥ 3 the graph K2k+2?(1-factor) is the unique (2k, k)-graph. K... 详细信息

关键词： k-critical n-connected, fragment, second-end.

Cellular Chain Complex of Small Covers with Integer Coefficients and Its Application

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Acta Mathematica Sinica,English Series 2018年第11期34卷 1742-1754页

作者： Deng Pin LIU department of Mathematics Guangxi Normal University

Let Pn be a simple n-polytope with a Z2-characteristic function λ. And h is a Morse function over Pn. Then the small cover Mn（λ） corresponding to the pair （Pn, λ） has a cell structure given by h. From this cell structure we can derive a cellular chain complex of Mn（λ） with integer coefficients. In this paper, firstly, we discuss the highest dimensional boundary morphism ？n of this cellular chain complex and get that ？n=0 or 2 by a natural way. And then, from the well-known result that the submanifold corresponding to （F, λF） is naturally a small cover with dimension k, where F is any k-face of Pn and λF is the restriction of λ on F, we get that ？k=0 or ±2 for 0 ≤ k 〈 n. Finally, by using the definition of inherited characteristic function which is the restriction of λ on the faces of Pn, we get a way to calculate the homology groups of Mn（λ）. Applying our result to a 3-small cover we have that the homology groups of any 3-small cover is torsion-free or has only 2-torsion.

关键词： Small cover homology group orientation CW-complex