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Dysfunction of synaptic endocytic trafficking in Parkinson's disease

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Neural Regeneration research 2024年第12期19卷 2649-2660页

作者： Xin Yi Ng Mian Cao programme in Neuroscience and Behavioural Disorders Duke-NUS Medical SchoolSingaporeSingapore Department of Physiology National University of SingaporeSingaporeSingapore

Parkinson's disease is characterized by the selective degeneration of dopamine neurons in the nigrostriatal pathway and dopamine deficiency in the *** precise reasons behind the specific degeneration of these dopamine neurons remain largely *** investigations have identified over 20 causative PARK genes and 90 genomic risk loci associated with both familial and sporadic Parkinson's ***,several of these genes are linked to the synaptic vesicle recycling process,particularly the clathrinmediated endocytosis *** suggests that impaired synaptic vesicle recycling might represent an early feature of Parkinson's disease,followed by axonal degeneration and the eventual loss of dopamine cell bodies in the midbrain via a"dying back"***,several new animal and cellular models with Parkinson's disease-linked mutations affecting the endocytic pathway have been created and extensively *** models faithfully recapitulate certain Parkinson's disease-like features at the animal,circuit,and cellular levels,and exhibit defects in synaptic membrane trafficking,further supporting the findings from human genetics and clinical *** this review,we will first summarize the cellular and molecular findings from the models of two Parkinson's disease-linked clathrin uncoating proteins:auxilin(DNAJC6/PARK19)and synaptojanin 1(SYNJ1/PARK20).The mouse models carrying these two PARK gene mutations phenocopy each other with specific dopamine terminal pathology and display a potent synergistic ***,we will delve into the involvement of several clathrin-mediated endocytosis-related proteins(GAK,endophilin A1,SAC2/INPP5 F,synaptotagmin-11),identified as Parkinson's disease risk factors through genome-wide association studies,in Parkinson's disease *** will also explore the direct or indirect roles of some common Parkinson's disease-linked proteins(alpha-synuclein(PARK1/4),Parkin(PARK2),and LRRK2(PARK

关键词： autophagy auxilin/PARK19 clathrin-mediated endocytosis dopamine neurons neurodegeneration nigrostriatal pathway Parkinson's disease synaptic vesicle recycling synaptojanin1/PARK20

Morphological and molecular analyses of a Philine kinglipini outbreak in summer of 2022 in Jiaozhou Bay,China

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Journal of Oceanology and Limnology 2024年第3期42卷 831-848页

作者： Zelin DUAN Yanan YU Jing WANG Junlong ZHANG Nansheng CHEN CAS Key Laboratory of Marine ecology and Environmental Sciences Institute of OceanologyChinese Academy of SciencesQingdao 266071China Laboratory of Marine ecology and Environmental Science Laoshan LaboratoryQingdao 266237China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China Laboratory of Marine Organism Taxonomy and Phylogeny Qingdao Key Laboratory of Marine Biodiversity and ConservationInstitute of OceanologyChinese Academy of SciencesQingdao 266071China Marine Biological Museum Chinese Academy of SciencesQingdao 266071China Department of Molecular Biology and Biochemistry Simon Fraser UniversityBurnabyBritish ColumbiaV5A 1S6Canada

A sudden and unprecedented outbreak of molluscan Philine kinglipini occurred in summer 2022 in Jiaozhou Bay,Shandong,China,causing substantial damage to local mariculture industry of the Manila clam Ruditapes *** *** has been found in many coastal regions of China,the molecular research of *** has not been extensively studied,making it difficult to accurately identify and track *** samples in field using molecular *** were collected during the outbreak and their morphological features and molecular sequences were *** show that the causative species of the outbreak was *** mitochondrial genome(mt DNA)of *** was constructed for the first time,based on which phylogenetic analysis of the mt DNAs of *** and related species in the order Cephalaspidea was carried *** revealed by metabarcoding analysis of 18S rDNA V4,the seasonal change of *** and closely related Philine species was striking with peaks between April and ***,metabarcoding analysis is applicable tool for monitoring the bloom development of *** and related *** study generated for the first time essential molecular marker sequences and mtDNA of ***,which provided a reference for future characterization and monitoring of its outbreaks and for phylogenetic analysis of Philine species.

关键词： marine species outbreaks metabarcoding analysis mitochondrial genome Philine kinglipini phylogenetics spatial-temporal dynamics

Cu single atoms embedded on hollow g-C_(3)N_(4)nanospheres with enhanced charge transfer and separation for efficient photocatalysis

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Chinese Chemical Letters 2024年第2期35卷 455-459页

作者： Linlin Zhang Jianjun Liao Yakun Li Wei Sun Chengjun Ge Key Laboratory of Agro-Forestry Environmental Processes and Ecological Regulation of Hainan Province School of Ecology and EnvironmentHainan UniversityHaikou 570228China Shandong Ocean Chemical Industry Scientific research Institute Weifang 262737China

Establishing an effective charge transfer mechanism in carbon nitride(g-C_(3)N_(4))to enhance its photocatalytic activity remains a limiting ***,the combination design of a single Cu atom with hollow g-C_(3)N_(4)nanospheres(Cu-N_(3)structure)has been proven to offer significant opportunities for this crucial ***,this structure endows two pathways for charge transfer in the reaction,namely,the N atoms in the three-dimensional planar structure are only bonded with a single Cu atom,and charge transfer occurs between the plane and the layered structure due to the bending of the interlayered g-C_(3)N_(4)hollow ***,Cu-N_(3)and hollow nanosphere structures have been certified to greatly enhance the efficiency of photogenerated carrier separation and transfer between the layers and planes by ultrafast spectral *** a result,this catalyst possesses unparalleled photocatalytic ***,the hydrogen production rate up to 2040μmol h^(−1) g^(−1),which is 51 times that of pure C_(3)N_(4)under visible light *** photocatalytic degradation performance of tetracycline and oxidation performance of benzene is also expressed,with a degradation rate of 100%,a conversion of 97.3%and a selectivity of 99.9%.This work focuses on the structure-activity relationship to provide the possibilities for the development of potential photocatalytic materials.

关键词： g-C_(3)N_(4) Cu single atom Hollow nanospheres Charge transfer pathways Photocatalytic hydrogen production

Near-surface wind field characteristics of the desert-oasis transition zone in Dunhuang,China

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Journal of Arid Land 2024年第5期16卷 654-667页

作者： PAN Jiapeng ZHANG Kecun AN Zhishan ZHANG Yu Key Laboratory of Desert and Desertification&Dunhuang Gobi and Desert ecology and Environment research Station Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China

The desert-oasis transition zone(DOTZ)serves as a buffer area between the desert and *** its wind field characteristics is of great significance for the prevention and control of aeolian disasters in the *** this study,we used meteorological data during 2013–2019 from the portable meteorological stations at five sites(site A on the edge of the oasis,sites B,C,and D in the DOTZ,and site O in the desert)in Dunhuang,China to analyze the near-surface wind field characteristics and their causes,as well as to reveal the key role of the DOTZ in oasis *** results showed that the mean wind speed,frequency of sand-driving wind,and directional variability of wind decreased from west to east within the DOTZ,and wind speed was significantly affected by air *** terrain influenced the prevailing winds in the region,mainly from northeast and *** some areas adjacent to the oasis were controlled by southeasterly *** indicated that the near-surface wind field characteristics of the DOTZ were caused by the combined effects of local terrain and surface hydrothermal *** site D,the annual drift potential(DP)was 24.95 vector units(VU),indicating a low wind energy environment,and the resultant drift direction(RDD)showed obvious seasonal ***,the DOTZ played an important buffering role between the desert and *** with the desert,the mean wind speed in the oasis decreased by 64.98%,and the prevailing wind direction was more *** results of this study will be useful in interpreting the aeolian activity of the DOTZ in Dunhuang.

关键词： desert-oasis transition zone near-surface wind field hydrothermal difference sand-driving wind aeolian environment Dunhuang

Identification and functional characterization of female antennae-biased odorant receptor 23 involved in acetophenone detection of the Indian meal moth Plodia interpunctella

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Insect Science 2024年第1期31卷 59-78页

作者： Qi Chen Xiaoyan Zhu Guoqing Kang Qiling Yu Qingxin Liu Lin Du Yi Yang Xinyu He Ying Zhao Junjie Zhang Ying Hu Bingzhong Ren Jilin Provincial Key Laboratory of Animal Resource Conservation and Utilization School of Life SciencesNortheast Normal UniversityChangchunChina Key Laboratory of Vegetation ecology Ministry of EducationNortheast Normal UniversityChangchunChina Jilin Provincial Engineering Laboratory of Avian ecology and Conservation Genetics Northeast Normal UniversityChangchunChina Engineering research Center of Natural Enemies Institute of Biological ControlJilin Agricultural UniversityChangchunChina

The Indian meal moth,Plodia interpunctella(Lepidoptera:Pyralidae),a globally distributed storage pest,relies on odors that are emitted from stored foods to select a suitable substrate for ***,the molecular mechanism underlying the chemical communication between *** and its host remains *** this study,130 chemosensory genes were identified from the transcriptomes of 7 *** tissues,and the quantitative expression levels of all 56 *** odorant receptor genes(PintORs)were validated using real-time quantitative polymerase chain *** functional characteristics of 5 PintORs with female antennae-biased expression were investigated using 2-electrode voltage clamp recordings in Xenopus laevis ***23 was found to be specifically tuned to *** could elicit a significant electrophysiological response and only attracted mated females when compared with males and virgin *** addition,molecular docking predicted that the hydrogen bonding sites,TRP-335 and ALA-167,might play key roles in the binding of PintOR23 to *** study provides valuable insights into the olfactory mechanism of oviposition substrate detection and localization in *** and points toward the possibility of developing eco-friendly odorant agents to control pests of stored products.

关键词： acetophenone docking EAG odorant receptor Plodia interpunctella TEVC

Water quality and habitat drive phytoplankton taxonomic and functional group patterns in the Yangtze River

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Ecological Processes 2024年第1期13卷 144-158页

作者： Wenqi Gao Fangyuan Xiong Ying Lu Wei Xin Haihua Wang Gangpeng Feng Chiping Kong Lei Fang Xiaoping Gao Yushun Chen State Key Laboratory of Freshwater ecology and Biotechnology Institute of Hydrobiology Chinese Academy of Sciences University of Chinese Academy of Sciences Jiangxi Institute for Fisheries Sciences Poyang Lake Fisheries Research Centre of Jiangxi Province East China Sea Fisheries research Institute Chinese Academy of Fishery Sciences Jiujiang Institute of Agricultural Sciences

Background Although phytoplankton are important primary producers in food webs, they are relatively less studied in large rivers compared to other types of systems. To fill this research gap, we studied phytoplankton taxonomic and functional composition and their relationships with water quality, habitat, climate, and land use across 30 river sections in the middle and lower reaches of the Yangtze River during 2017–*** Major observed phytoplankton groups were cyanobacteria, bacillariophyta, and chlorophyta. Phytoplankton total abundance, total biomass, and species richness significantly decreased in the dry season compared to the wet season, with the species and functional composition differing significantly between seasons. Phytoplankton species differences between seasons were mainly contributed by Oscillatoria sp., Pseudanabaena sp., and Melosira granulata. The dfferences in phytoplankton functional groups between seasons were mainly contributed by P（including Closterium sp., Melosira sp.）, Lo（including Merismopedia sp., Peridinium sp., Ceratium sp., and Gymnodinium sp.）, and J（including Pediastrum sp., Tetraedron sp., Crucigenia sp., Scenedesmus sp., and Coelastrum sp.）. The variance partitioning showed that water quality（NO3-N, total suspended solids, turbidity） and habitat（water flow, river bank and river channel conditions） were critical factors in shaping phytoplankton patterns, followed by climate and land *** Results indicated that there was significant seasonal variation of phytoplankton in the Yangtze River, with water quality and habitat primarily driving phytoplankton patterns. Our study contributes to the understanding of natural and anthropogenic factors that drive seasonal successional processes of phytoplankton in the Yangtze River. These findings have important implications for environmental management as well as towards the ecological restoration of large rivers.

关键词： Yangtze River Phytoplankton Functional group Water quality Physical habitat

Odor cues rather than personality affect tadpole deposition in a neotropical poison frog

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Current Zoology 2024年第3期70卷 332-342页

作者： Melissa Peignier Max Ringler Eva Ringler Division of Behavioural ecology Institute of Ecology and EvolutionUniversity of BernCH-3032 HinterkappelenSwitzerland Messerli research Institute University of Veterinary Medicine Vienna1210 ViennaAustria Department of Behavioral and Cognitive Biology University of Vienna1030 ViennaAustria Departmento f Evolutionary Biology UniversityofVienna1030ViennaAustria lnstitute of Electronic Music and Acoustics University of Music and Performing Arts Graz8010 GrazAustria

Animals constantly need to evaluate available external and internal information to make appropriate ***,assessing,and acting on relevant cues in contexts such as mate choice,intra-sexual competition,and parental care is particularly important for optimizing individual reproductive *** factors can infuence decision-making,such as external environmental cues and the animal’s own internal state,yet,we have limited knowledge on how animals integrate available ***,we used an entire island population(57 males,53 females,and 1,109 tadpoles)of the neotropical brilliant-thighed poison frog Allobates femoralis to investigate how 2 factors(olfactory cues and personality traits)infuence the ability of males to fnd and use new resources for tadpole *** experimentally manipulated the location of tadpole deposition sites and their associated olfactory cues,and repeatedly measured exploration and boldness in adult *** further reconstructed tadpole deposition choices via inferred parent–offspring relationships of adult frogs and tadpoles deposited in our experimental pools using molecular parentage *** found that the discovery and use of new rearing sites were heavily infuenced by olfactory cues;however,we did not fnd an effect of the measured behavioral traits on resource discovery and *** conclude that in highly dynamic environments such as tropical rainforests,reliable external cues likely take priority over personality traits,helping individuals to discover and make use of reproductive resources.

关键词： animal personality Anura decision-making parental care tadpole transport.

The neglect of nonnative orthopterans as potential invaders:A call for awareness

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Insect Science 2024年第4期31卷 994-1000页

作者： Anna K.Kulessa Paride Balzani Ismael Soto Antonín Kouba David Renault Ali Serhan Tarkan Phillip J.Haubrock Ruhr University Bochum Faculty of Biology and BiotechnologyBochumGermany Faculty of Biology University of Duisburg-EssenUniversitätsstraße 5EssenGermany Faculty of Fisheries and Protection of Waters South Bohemian Research Center of Aquaculture and Biodiversity of HydrocenosesUniversity of South Bohemia in CˇeskéBudeˇjoviceVodnˇanyCzech Republic University of Rennes CNRSECOBIO(EcosystèmesBiodiversitéEvolution)UMRRennesFrance Faculty of Fisheries Department of Basic SciencesMu˘gla SıtkıKoçman UniversityMu˘glaTurkey Department of Life and Environmental Sciences Bournemouth UniversityPooleDorsetUK Faculty of Biology and Environmental Protection Department of Ecology and Vertebrate ZoologyUniversity ofŁodzŁodzPoland Department of River ecology and Conservation Senckenberg Research Institute and Natural History Museum FrankfurtGelnhausenGermany Center for Applied Mathematics and Bioinformatics Gulf University for Science and TechnologyMubarak Al-AbdullahKuwait

Despite the potential ecological and economic impacts of invasive species,there is a dearth of data on the presence,impacts,and management implications of potentially invasive Orthoptera *** lack of research and inconsistent data,including risk screenings and impact assessments,is especially evident in ***,assessing the status,distribution,and potential threats of nonnative Orthoptera in Europe remains challenging,impeding the development of effective management *** address this gap,we call for increased efforts to collect and curate data on non-native and possibly invasive Orthoptera in *** efforts will improve our understanding of this order’s invasion dynamics,facilitate the identification of priority areas for conservation,and support the development of effective management policies and preventive measures.

关键词： costs cricket damages grasshopper impact research

Simultaneous removal of Cd(Ⅱ)and As(Ⅴ)by ferrihydrite-biochar composite:Enhanced effects of As(Ⅴ)on Cd(Ⅱ)adsorption

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Journal of Environmental Sciences 2024年第5期139卷 267-280页

作者： Wenjun Zeng Yang Lu Jingyan Zhou Jie Zhang Yuanxiao Duan Changxun Dong Wencheng Wu College of Sciences Nanjing Agricultural UniversityNanjing 210095China South China Institute of Environmental Sciences Ministry of Ecology and EnvironmentGuangzhou 510655China Guangdong Engineering&Technology research Center for System Control of Livestock and Poultry breeding Pollution Guangzhou 510655China

The coexistence of cadmium(Cd(Ⅱ))and arsenate(As(Ⅴ))pollution has long been an environmental ***,a porous carbonaceous material with tunable functionality,has been used for the remediation of contaminated ***,it is still challenging for the dynamic quantification and mechanistic understanding of the simultaneous sequestration of multi-metals in biochar-engineered environment,especially in the presence of *** this study,ferrihydrite was coprecipitated with biochar to investigate how ferrihydritebiochar composite affects the fate of heavy metals,especially in the coexistence of Cd(Ⅱ)and As(Ⅴ).In the solution system containing both Cd(Ⅱ)and As(Ⅴ),the maximum adsorption capacities of ferrihydrite-biochar composite for Cd(Ⅱ)and As(Ⅴ)reached 82.03μmol/g and 531.53μmol/g,respectively,much higher than those of the pure biochar(26.90μmol/g for Cd(Ⅱ),and 40.24μmol/g for As(Ⅴ))and ferrihydrite(42.26μmol/g for Cd(Ⅱ),and 248.25μmol/g for As(Ⅴ)).Cd(Ⅱ)adsorption increased in the presence of As(Ⅴ),possibly due to the changes in composite surface charge in the presence of As(Ⅴ),and the increased dispersion of ferrihydrite by *** microscopic and mechanistic results showed that Cd(Ⅱ)complexed with both biochar and ferrihydrite,while As(Ⅴ)was mainly complexed by ferrihydrite in the Cd(Ⅱ)and As(Ⅴ)coexistence *** posed vital importance for the co-adsorption of Cd(Ⅱ)and As(Ⅴ).The different distribution patterns revealed by this study help to a deeper understanding of the behaviors of cations and anions in the natural environment.

关键词： Ferrihydrite Biochar Cadmium Arsenate Simultaneous sequestration Binding mechanisms