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Clustering of voltage-gated ion channels as an evolutionary trigger of myelin formation

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Neural Regeneration Research 2024年第8期19卷 1631-1632页

作者： Henrike Ohm Simone Rey Christian Klambt institut fur Neuro-und Verhaltensbiologie MunsterGermany

Neurons carry apical dendrites that perceive information and a basal axon that transmits the computed information towards its to *** axon originates at the axon hillock which is followed by the axon initial ***,action potentials are initiated that are based on millisecond long openings of specific voltagegated sodium and potassium channels that are conserved in all parahoxozoa(Placozoa,Cnidaria,Bilateria)(Li et al.,2015).

关键词： initiated carry potassium

Synchronized off-harmonic probe laser with highly variable pulse duration for laser-plasma interaction experiments

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High Power Laser Science and Engineering 2024年第1期12卷 99-107页

作者： J.Hornung Y.Zobus H.Lorenté C.Brabetz B.Zielbauer V.Bagnoud GSI Helmholtzzentrum für Schwerionenforschung GmbH DarmstadtGermany institut d’Optique UniversitéParis-SaclayPalaiseauFrance institut für Angewandte Physik Technische Universität DarmstadtDarmstadtGermany

This paper presents the development and experimental utilization of a synchronized off-harmonic laser system designed as a probe for ultra-intense laser±plasma interaction experiments. The system exhibits a novel seed-generation design,allowing for a variable pulse duration spanning over more than three orders of magnitude, from 3.45 picoseconds to 10 nanoseconds. This makes it suitable for various plasma diagnostics and visualization techniques. In a side-view configuration, the laser was employed for interferometry and streaked shadowgraphy of a laser-induced plasma while successfully suppressing the self-emission background of the laser±plasma interaction, resulting in a signal-to-self-emission ratio of 110 for this setup. These properties enable the probe to yield valuable insights into the plasma dynamics and interactions at the PHELIX facility and to be deployed at various laser facilities due to its easy-to-implement design.

关键词： interferometry laser-plasma interaction off-harmonic probe laser streaked shadowgraphy

Experimental and numerical investigation on alternatives to sandy gravel

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Defence Technology（防务技术） 2024年第1期31卷 130-141页

作者： V.Denefeld H.Aurich Fraunhofer institute for High-Speed Dynamics Ernst-Mach-Institut(EMI)Ernst-Zermelo-Str.479104FreiburgGermany Fraunhofer institute for High-Speed Dynamics Ernst-Mach-Institut(EMI)Am Christianswuhr 279400KandernGermany

The NATO agreement STANAG 4569 defines the protection levels for the occupants of logistic and light armored *** Allied Engineering Publication,AEP-55,Volume 2 document outlines the test conditions for underbelly improvised explosive device(IEDs),which must be buried in water-saturated sandy *** use of sandy gravel has some drawbacks,for instance reproducibility,time consumption,and *** paper focuses on the investigation of four alternatives to sandy gravel,which could produce similar specific and cumulative impulses:a concrete pot filled with water,a concrete pot filled with quartz sand,a steel pot without filling and a concrete pot filled with glass spheres(diameter 200μm—300μm)and different water *** impulses are measured with a ring technology developed at the Fraunhofer EMI.A numerical soil model based on the work of Marrs,2014 and Fi serov a,2006 and considering the soil moisture was used to simulate the experiments with glass spheres at different water contents,showing much better agreement with the experiments than the classical Laine&Sandvik model,even for high saturation *** results can be used to create new test conditions at original scale that are more cost-effective,more reproducible and simpler to manage in comparison to the current tests carried out with STANAG sandy gravel.

关键词： Improvised explosive device(IED) Specific impulse Momentum transfer Sandy gravel Glass spheres Numerical model Soil moisture

Biomaterial engineering strategies for modeling the Bruch's membrane in age-related macular degeneration

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Neural Regeneration Research 2024年第12期19卷 2626-2636页

作者： Blanca Molins Andrea Rodríguez Víctor Llorenç Alfredo Adán Group of Ocular Inflammation:Clinical and Experimental Studies Institut d’Investigacions Biomèdiques AgustíPi I Sunyer(IDIBAPS)BarcelonaSpain institut Clínic d’Oftalmologia(ICOF) Hospital Clínic BarcelonaSpain

Age-related macular degeneration,a multifactorial inflammatory degenerative retinal disease,ranks as the leading cause of blindness in the ***,there is a scarcity of curative therapies,especially for the atrophic advanced form of age-related macular degeneration,likely due to the lack of models able to fully recapitulate the native structure of the outer blood retinal barrier,the prime to rget tissue of age-related macular *** in vitro systems rely on 2D monocultures unable to adequately reproduce the structure and function of the outer blood retinal barrier,integrated by the dynamic interaction of the retinal pigment epithelium,the Bruch's membrane,and the underlying *** Bruch's membrane provides structu ral and mechanical support and regulates the molecular trafficking in the outer blood retinal barrier,and therefo re adequate Bruch's membrane-mimics are key for the development of physiologically relevant models of the outer blood retinal barrie *** the last years,advances in the field of biomaterial engineering have provided novel approaches to mimic the Bruch's membrane from a variety of *** review provides a discussion of the integrated properties and function of outer blood retinal barrier components in healt hy and age-related macular degeneration status to understand the requirements to adequately fabricate Bruch's membrane biomimetic ***,we discuss novel materials and techniques to fabricate Bruch's membrane-like scaffolds for age-related macular degeneration in vitro modeling,discussing their advantages and challenges with a special focus on the potential of Bruch's membrane-like mimics based on decellularized tissue.

关键词： age-related macular degeneration Bruch's membrane decellularization retinal pigment epithelium scaffold

Microplastics and microbiota:Unraveling the hidden environmental challenge

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World Journal of Gastroenterology 2024年第16期30卷 2191-2194页

作者： Jean Demarquoy Universitéde Bourgogne Institut Agro-DijonDijon 21000France

This editorial explores the intricate relationship between microplastics(MPs)and gut microbiota,emphasizing the complexity and environmental health *** gut microbiota,a crucial component of gastrointestinal health,is examined in the context of potential microbial degradation of ***,dysbiosis induced by MPs emerges as a consensus,disrupting the balance of gut microbiota and decreasing *** mechanisms triggering dysbiosis,including physical interactions and chemical composition,are under *** research addresses the consequences of MPs on immune function,nutrient metabolism,and overall host *** bidirectional relationship between MPs and gut microbiota has significant implications for environmental and human *** uncertainties,MPs negatively impact gut microbiota and *** research is essential to unravel the complex interactions and assess the long-term consequences of MPs on both environmental and human well-being.

关键词： Microplastics Microbiota Gut Dysbiosis

Energy enhancement of laser-driven ions by radiation reaction and Breit-Wheeler pair production in the ultra-relativistic transparency regime

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High Power Laser Science and Engineering 2024年第1期12卷 60-73页

作者： Shikha Bhadoria Mattias Marklund Christoph H.Keitel Max-Planck-institut für Kernphysik HeidelbergGermany Department of Physics University of GothenburgGöteborgSweden

The impact of radiation reaction and Breit±Wheeler pair production on the acceleration of fully ionized carbon ions driven by an intense linearly polarized laser pulse has been investigated in the ultra-relativistic transparency *** initial expectations, the radiation reaction and pair production at ultra-high laser intensities are found to enhance the energy gained by the ions. The electrons lose most of their transverse momentum, and the additionally produced pair plasma of Breit±Wheeler electrons and positrons co-streams in the forward direction as opposed to the existing electrons streaming at an angle above zero degree. We discuss how these observations could be explained by the changes in the phase velocity of the Buneman instability, which is known to aid ion acceleration in the breakout afterburner regime, by tapping the free energy in the relative electron and ion streams. We present evidence that these non-classical effects can further improve the highest carbon ion energies in this transparency regime.

关键词： ion acceleration quantum electrodynamic effects

Small molecules to target tau amyloid aggregation

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Neural Regeneration Research 2024年第3期19卷 509-511页

作者： Zoe Manglano-Artuñedo Samuel Peña-Díaz Salvador Ventura institut de Biotecnologia i Biomedicina Universitat Autònoma de BarcelonaBellaterraSpain

Protein aggregation has been linked with many neurodegenerative diseases,such as Alzheimer’s disease(AD)or Parkinson’s *** belongs to a group of heterogeneous and incurable neurodegenerative disorders collectively known as *** comprise frontotemporal dementia,Pick’s disease,or corticobasal degeneration,among *** symptomatology varies with the specific tau protein variant involved and the affected brain region or cell ***,they share a common neuropathological hallmark-the formation of proteinaceous deposits named neurofibrillary *** tangles,primarily composed of aggregated tau(Zhang et al.,2022),disrupt normal neuronal functions,leading to cell death and cognitive decline.

关键词： tau degeneration aggregation

Unscented Kalman filter for a low-cost GNSS/IMU-based mobile mapping application under demanding conditions

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Geodesy and Geodynamics 2024年第2期15卷 166-176页

作者： Mokhamad Nur Cahyadi Tahiyatul Asfihani Hendy Fitrian Suhandri Risa Erfianti Department of Geomatics Engineering Institut Teknologi Sepuluh NopemberSurabaya 6011Indonesia Research Center of Marine and Earth Science Technology Directorate of Research and Community ServiceInstitut Teknologi Sepuluh NopemberSurabaya 60111Indonesia Department of Mathematics Institut Teknologi Sepuluh NopemberSurabaya 60111Indonesia Centre of Studies for Surveying Science&Geomatics Universiti Teknologi Mara(UiTM)Shah Alam 40450Malaysia

For the last two decades,low-cost Global Navigation Satellite System(GNSS)receivers have been used in various *** receivers are mini-size,less expensive than geodetic-grade receivers,and in high *** of these outstanding features,low-cost GNSS receivers are potentially poorer hardwares with internal signal processing,resulting in lower *** typically come with low-cost GNSS antenna that has lower performance than their counterparts,particularly for multipath ***,this research evaluated the low-cost GNSS device performance using a high-rate kinematic *** this purpose,these receivers were assembled with an Inertial Measurement Unit(IMU)sensor,which actively transmited data on acceleration and orientation rate during the *** position and navigation parameter data were obtained from the IMU readings,even without GNSS signals via the U-blox F9R GNSS/IMU device mounted on a *** research was conducted in an area with demanding conditions,such as an open sky area,an urban environment,and a shopping mall basement,to examine the device’s *** data were processed by two approaches:the Single Point Positioning-IMU(SPP/IMU)and the Differential GNSS-IMU(DGNSS/IMU).The Unscented Kalman Filter(UKF)was selected as a filtering algorithm due to its excellent performance in handling nonlinear system *** result showed that integrating GNSS/IMU in SPP processing mode could increase the accuracy in eastward and northward components up to 68.28%and 66.64%.Integration of DGNSS/IMU increased the accuracy in eastward and northward components to 93.02%and 93.03%compared to the positioning of standalone *** addition,the positioning accuracy can be improved by reducing the IMU noise using low-pass and high-pass *** application could still not gain the expected position accuracy under signal outage conditions.

关键词： LoW-cost GNSS GNSS/IMU Single Point Positioning-IMU(SPP/IMU) Differential GNSS-IMU(DGNSS/IMU) Unscented Kalman Filter(UKF) Outageconditions

In vivo astrocyte reprogramming following spinal cord injury

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Neural Regeneration Research 2024年第3期19卷 487-488页

作者： Yannick N.Gerber Florence E.Perrin MMDN University of MontpellierEPHEINSERMMontpellierFrance institut Universitaire de France(IUF) ParisFrance

Harmful and helpful roles of astrocytes in spinal cord injury(SCI):SCI induce gradable sensory,motor and autonomic impairments that correlate with the lesion severity and the rostro-caudal location of the injury *** absence of spontaneous axonal regeneration after injury results from neuron-intrinsic and neuron-extrinsic ***,not only adult neurons display limited capability to regrow axons but also the injury environment contains inhibitors to axonal regeneration and a lack of growth-promoting *** other cell populations that respond to the lesion,reactive astrocytes were first considered as only detrimental to spontaneous axonal ***,astrocytes.

关键词： injury impairment programming