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An adaptive physics-informed deep learning method for pore pressure prediction using seismic data

Petroleum Science 2024年第2期21卷 885-902页

作者： Xin Zhang Yun-Hu Lu Yan Jin Mian Chen Bo Zhou State Key laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China College of Petroleum Engineering China University of Petroleum(Beijing)Beijing102249China College of Artificial Intelligence China University of Petroleum(Beijing)Beijing102249China PetroChina Tarim Oilfield Company KorlaXinjiang841000China

Accurate prediction of formation pore pressure is essential to predict fluid flow and manage hydrocarbon production in petroleum *** deep learning technique has been receiving more interest due to the great potential to deal with pore pressure ***,most of the traditional deep learning models are less efficient to address generalization *** fill this technical gap,in this work,we developed a new adaptive physics-informed deep learning model with high generalization capability to predict pore pressure values directly from seismic ***,the new model,named CGP-NN,consists of a novel parametric features extraction approach(1DCPP),a stacked multilayer gated recurrent model(multilayer GRU),and an adaptive physics-informed loss *** machine training,the developed model can automatically select the optimal physical model to constrain the results for each pore pressure *** CGP-NN model has the best generalization when the physicsrelated metricλ=0.5.A hybrid approach combining eaton and Bowers methods is also proposed to build machine-learnable labels for solving the problem of few *** validate the developed model and methodology,a case study on a complex reservoir in Tarim Basin was further performed to demonstrate the high accuracy on the pore pressure prediction of new wells along with the strong generalization *** adaptive physics-informed deep learning approach presented here has potential application in the prediction of pore pressures coupled with multiple genesis mechanisms using seismic data.

关键词： Pore pressure prediction Seismic data 1D convolution pyramid pooling Adaptive physics-informed loss function High generalization capability

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Ultra-high speed holographic shape and displacement measurements in the hearing sciences

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Light(Advanced Manufacturing) 2022年第2期3卷 1-14页

作者： Haimi Tang Pavel Psota John J.Rosowski Cosme Furlong Jeffrey Tao Cheng Center for Holographic Studies and Laser micro-mechaTronics Worcester Polytechnic InstituteWorcesterMA USA01609 Mechanical Engineering Department Worcester Polytechnic InstituteWorcesterMA USA01609 Faculty of Mechatronics Informatics and Interdisciplinary StudiesTechnical University of LiberecLiberecCzech Republic46117 eaton-peabody laboratory Massachusetts Eye and EarBostonMA USA02114 Department of Otolaryngology-Head and Neck Surgery Harvard Medical SchoolBostonMAUSA02115

The auditory system of mammals enables the perception of sound from our surrounding *** some of the smallest bones in the body,the ear transduces complex acoustic signals with high-temporal sensitivity to complex mechanical vibrations with magnitudes as small as tens of *** of the shape and acoustically induced motions of different components of the ear are essential if we are to expand our understanding of hearing mechanisms,and also provide quantitative information for the development of numerical ear models that can be used to improve hearing protection,clinical diagnosis,and repair of damaged or diseased *** are developing digital holographic methods and instrumentation using an ultra-high speed camera to measure shape and acoustically-induced motions in the middle *** we study the eardrum,the first structure of the middle ear which initializes the acoustic-mechanical transduction of sound for *** measurement system is capable of performing holographic measurement at rates up to 2.1 M frames per *** shape measurement modalities had previously been implemented into our holographic systems:(1)a multi-wavelength method with a wavelength tunable laser;and(2)a multi-angle illumination method with a single wavelength *** this paper,we present a third method using a miniaturized fringe projection system with a microelectromechanical system(MEMS)***,we optimize the processing of large data sets of holographic displacement measurements using a vectorized Pearson's correlation *** validate and compare the shape and displacement measurements of our methodologies using a National Institute of Standards and Technology(NIST)traceable gauge and sound-activated latex membranes and human eardrums.

关键词： Ultra-high speed digital holography Microelectromechanical systems(MEMS) Miniaturized Fringe Projection Middle-ear mechanics Shape and displacement measurements.

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Current trends and applications in endoscopy for otology and neurotology

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2021年第2期7卷 101-108页

作者： Sarah E.Ridge Kunal R.Shetty Daniel J.Lee eaton-peabody Laboratories Massachusetts Eye and Ear InfirmaryBostonMAUSA Deportment of Otolorynsolosy Massachusetts Eye and Ear InfirmaryHarvard Medical SchoolBostonf MAf USA

There has been a rapid increase in endoscopic ear surgery for the management of middle ear and lateral skull base disease in children and adults over the last *** this review paper,we discuss the current trends and applications of the endoscope in the field of otology and *** of the endoscope include excellent ergonomics,compatibility with pediatric anatomy,and improved access to the middle ear through the external auditory *** endoscopic ear surgery has demonstrated comparable outcomes in the management of cholesteatoma,tympanic membrane perforations,and otosclerosis as compared to microscopic approaches,while utilizing less invasive surgical corridors and reducing the need for postauricular *** a postauricular approach is required,the endoscopic-assisted transmastoid approach can avoid a canal wall down mastoidectomy in cases of *** endoscope also has utility in treatment of superior canal dehiscence and various skull base lesions including glomus tumors,meningiomas,and vestibular *** of the operating room,the endoscope can be used during examination of the outer and middle ear and for debridement of complex mastoid *** these reasons,the endoscope is currently poised to transform the field of otology and neurotology.

关键词： Endoscopic ear surgery Transcanal endoscopic ear surgery Transmastoid endoscopic ear surgery Otoendoscopy Otology Neurotology

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Effects of the radial force on the static contact properties and sealing performance of a radial lip seal

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Science China(Technological Sciences) 2014年第6期57卷 1175-1182页

作者： JIA XiaoHong GUO Fei HUANG Le WANG LongKe GAO Zhi WANG YuMing State Key laboratory of Tribology Tsinghua University Guangzhou Mechanical Engineering Research Institute Co. Ltd. eaton Corporation

The radial force is a critical factor to determine the sealing performance of radial lip *** effects of radial force produced by garter spring and interference on the static contact properties and sealing performance of a radial lip seal are investigated by numerical simulations and ***-element analysis and mixed elastohydrodynamic lubrication simulation are *** force,contact width,temperature in the sealing zone,the reverse pumping rate and friction torque are measured.A critical value of interference for a cost-effectively designed radial lip seal is *** force is required to compensate the decrease of the radial force because of the interference and used as a possible way to obtain intelligent control of sealing *** quantitative results gotten in this study could provide guide for the seal design and improvement.

关键词：密封性能径向密封径向力静触头数值模拟密封设计有限元分析弹流润滑

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Reinnervation of hair cells by neural stem cell-derived neurons

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Chinese Medical Journal 2014年第16期127卷 2972-2976页

作者： Yuan Yasheng Wang Yang Chi Fanglu Department of ENT-Head & Neck Surgery Eye Ear Nose and Throat Hospital Shanghai 200031 China Shanghai Medical School FuDan University Shanghai 210029China Department of Anatomyl Shanghai Medical School FuDan University Shanghai 210029 China eaton-peabody laboratory Massachusetts Eye and Ear InfirmaryHarvard Medical School Boston MA 02114 USA

Background Replacement of spiral ganglion neurons would be one prioritized step in an attempt to restore sensory neuronal hearing ***,the possibility that transplanted neurons could regenerate new synaptic connections to hair cells has not been *** objective of this study was to test whether neural stem cell （NSC）-derived neurons can form synaptic connections with hair cells in *** NSCs were mechanically separated from the hippocampus in SD rat embryos （E12-E14） and cultured in a serum-free medium containing basic fibroblast growth factor and epidermal growth *** NSCs were co-cultured with explants of cochlea sensory epithelia obtained from postnatal Day 3 rats under transway filter *** At Day 3,the NSCs began to show chemotactic differentiation and grew toward cochlea sensory *** 9-day co-culture,neurites of NSC-derived neurons predominantly elongated toward hair *** analyses revealed the fibers overlapped with synapsin and hair cells,indicating the formation of new synaptic *** 14-day culture,triple staining revealed the fibers overlapped with PSD95 （postsynaptic density） which is juxtaposed with CtBP2 （presynaptic vesicle）,indicating the formation of new ribbon *** NSC-derived neurons can make synaptic connections with hair cells and provide a model for studying synaptic plasticity and *** the newly forming synapse is functional merits further electrophysiological study.

关键词： neural stem cells hair cells reinnervation synapse

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Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing

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Signal Transduction and Targeted Therapy 2022年第4期7卷 1258-1270页

作者： Ziwen Zheng Guo Li Chong Cui Fang Wang Xiaohan Wang Zhijiao Xu Huiping Guo Yuxin Chen Honghai Tang Daqi Wang Mingqian Huang Zheng-Yi Chen Xingxu Huang Huawei Li Geng-Lin Li Xiaoxiang Hu Yilai Shu ENT Institute and Department of Otorhinolaryngology Eye&ENT HospitalState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceFudan UniversityShanghai 200031China Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China NHC Key laboratory of Hearing Medicine(Fudan University) Shanghai 200032China State Key laboratory of Agrobiotechnology China Agricultural UniversityBeijing 100193China College of Biological Sciences China Agricultural UniversityBeijing 100193China School of Life Science and Technology Southeast UniversityNanjing 210096China Department of Otolaryngology-Head and Neck Surgery Graduate Program in Speech and Hearing Bioscience and Technology and Program in NeuroscienceHarvard Medical SchoolBostonMA 02115USA eaton-peabody laboratory Massachusetts Eye and Ear InfirmaryBostonMA 02114USA School of Life Science and Technology ShanghaiTech UniversityShanghai 200031China CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Institutes of Brain Science and the Collaborative Innovation Center for Brain Science Fudan UniversityShanghai 200031China

CRISPR/RfxCas13d(CasRx)editing system can specifically and precisely cleave single-strand RNAs,which is a promising treatment for various disorders by downregulation of related gene ***,we tested this RNA-editing approach on Beethoven(Bth)mice,an animal model for human DFNA36 due to a point mutation in *** first screened 30 sgRNAs in cell cultures and found that CasRx with sgRNA3 reduced the Tmc1^(Bth)transcript by 90.8%,and the Tmc1 wild type transcript(Tmc1^(+))by 44.3%.We then injected a newly developed AAV vector(***)based CasRx into the inner ears of neonatal Bth mice,and we found that Tmc1^(Bth)was reduced by 70.2%in 2 weeks with few off-target effects in the whole ***,we found improved hair cell survival,rescued hair bundle degeneration,and reduced mechanoelectrical transduction ***,the hearing performance,measured in both ABR and DPOAE thresholds,was improved significantly in all ages over 8 ***,therefore,have validated the CRISPR/CasRx-based RNA editing strategy in treating autosomal-dominant hearing loss,paving way for its further application in many other hereditary diseases in hearing and beyond.

关键词： CRISPR/Cas editing hearing

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The Soft X-ray Imager(SXI)on the SMILE Mission

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Earth and Planetary Physics 2024年第1期8卷 5-14页

作者： S.Sembay A.L.Alme D.Agnolon T.Arnold A.Beardmore A.Belén Balado Margeli C.Bicknell C.Bouldin G.Branduardi-Raymont T.Crawford J.P.Breuer T.Buggey G.Butcher R.Canchal J.A.Carter A.Cheney Y.Collado-Vega H.Connor T.Crawford N.eaton C.Feldman C.Forsyth T.Frantzen G.Galgóczi J.Garcia G.Y.Genov C.Gordillo H-P.Gröbelbauer M.Guedel Y.Guo M.Hailey D.Hall R.Hampson J.Hasiba O.Hetherington A.Holland S-Y.Hsieh M.W.J.Hubbard H.Jeszenszky M.Jones T.Kennedy K.Koch-Mehrin S.Kögl S.Krucker K.D.Kuntz C.Lakin G.Laky O.Lylund A.Martindale J.Miguel Mas Hesse R.Nakamura K.Oksavik N.Østgaard H.Ottacher R.Ottensamer C.Pagani S.Parsons P.Patel J.Pearson G.Peikert F.S.Porter T.Pouliantis B.H.Qureshi W.Raab G.Randal A.M.Read N.M.M.Roque M.E.Rostad C.Runciman S.Sachdev A.Samsonov M.Soman D.Sibeck S.Smit J.Søndergaard R.Speight S.Stavland M.Steller TianRan Sun J.Thornhill W.Thomas K.Ullaland B.Walsh D.Walton C.Wang S.Yang School of Physics and Astronomy University of LeicesterLeicesterLE17RHUK Space Park Leicester University of LeicesterLeicesterLE17RHUK Mullard Space Science laboratory University College LondonDorkingRH56NTUK Centre for Electronic Imaging Open UniversityMilton KeynesMK76 AAUK Birkeland Centre for Space Science Department of Physics and TechnologyUniv.of BergenN-5007 BergenNorway University of Vienna A-1010 ViennaAustria Space Research Institute Austrian Academy of SciencesA-8042 GrazAustria National Institute of Aerospace Technology MadridSpain ESTEC European Space Agency2201 AZ NoordwijkNetherlands State Key laboratory of Space Weather National Space Science CentreBeijing 100190China University of Applied Sciences and Arts Northwestern Switzerland CH-5210 WindischSwitzerland Koegl Space GmbH CH-8157 DielsdorfSwitzerland Space Acoustics GmbH CH-8157 DielsdorfSwitzerland Zurich University of Applied Sciences 8400 WinterhurSwitzerland Genov Solutions N-5172 LoddefjordNorway STM Engineering N-5165 LaksevagNorway John Hopkins University Applied Physics laboratory MD 20723USA NASA/Goddard Space Flight Centre MD 20771USA Center for Space Physics Boston UniversityBostonMA 02215USA Department of Theoretical Physics and Astrophysics Masaryk University60177 BrnoCzech Republic Institute of Physics E¨otvo¨s Lor´and University1053 BudapestHungary Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100045China Centro de Astrobiologia(CAB) CSIC-INTAMadridSpain

The Soft X-ray Imager(SXI)is part of the scientific payload of the Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)*** is a joint science mission between the European Space Agency(ESA)and the Chinese Academy of Sciences(CAS)and is due for launch in *** is a compact X-ray telescope with a wide field-of-view(FOV)capable of encompassing large portions of Earth’s magnetosphere from the vantage point of the SMILE *** is sensitive to the soft X-rays produced by the Solar Wind Charge eXchange(SWCX)process produced when heavy ions of solar wind origin interact with neutral particles in Earth’s *** provides a mechanism for boundary detection within the magnetosphere,such as the position of Earth’s magnetopause,because the solar wind heavy ions have a very low density in regions of closed magnetic field *** sensitivity of the SXI is such that it can potentially track movements of the magnetopause on timescales of a few minutes and the orbit of SMILE will enable such movements to be tracked for segments lasting many *** is led by the University of Leicester in the United Kingdom(UK)with collaborating organisations on hardware,software and science support within the UK,Europe,China and the United States.

关键词： Soft X-ray Imaging micropore optics large area CCD

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Frontiers in auditory bioscience and technology: a special feature on recent advances in hearing research

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2019年第2期20卷 109-110页

作者： Yen-Fu CHENG Department of Otology and Laryngology Harvard Medical School eaton-peabody laboratory Massachusetts Eye and Ear Infirmary Department of Medical Research Taipei Veterans General Hospital Department of Otolaryngology-Head and Neck Surgery Taipei Veterans General Hospital School of Medicine Yang-Ming University Department of Speech Language Pathology and Audiology Taipei University of Nursing and Health Science

IwasgreatlyhonoredtobeaskedbyHelen ZHANG,Former Managing Editor,to serve as a guest editorofthisspecialfeatureofJournalofZhejiang University-SCIENCEB(Biomedicine&Biotechnology)on'FrontiersinAuditoryBioscienceand Techn... 详细信息

关键词： auditory bioscience and technology a special feature

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Mid-Cretaceous Hothouse Climate and the Expansion of Early Angiosperms

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Acta Geologica Sinica(English Edition) 2018年第5期92卷 2004-2025页

作者： ZHANG Mingzhen DAI Shuang DU Baoxia JI Liming HU Shusheng Key laboratory of Petroleum Resources Gansu Province/ Key Laboratory of Petroleum Resources Research Northwest Institute of Eco-Environment and Resources Chinese Academy of Sciences Key laboratory of Mineral Resources in Western China (Gansu Province) and School of Earth Science Lanzhou University Division of Paleobotany Peabody Museum of Natural History Yale University

The remarkable transition of early angiosperms from a small to a dominant group characterized the terrestrial ecosystem of the Cretaceous. This transition was instigated and promoted by environmental changes. Mid-Cretaceous is characterized by major geological events that affected the global environment. δ^18O, palaeothermometer TEX86, and other climatic indices from marine sediments suggest rapid temperature increase during mid-Cretaceous despite occasional short cooling events. Simultaneously, terrestrial deposits in East Asia changed from coal-bearing to shale, then to red beds and evaporites. Plant assemblages and other paleoclimate indicators point to rapid aridification for midCretaceous terrestrial environments. In addition, the wildfires were frequently spread all over the earth by the numerous charcoal evidence during the Mid-Cretaceous. Thus, we speculate that the seasonally dry and hot conditions of mid-Cretaceous created a fiery hothouse world. Early angiosperms increased in abundance and diversity and evolved from a few aquatic species to terrestrial herbaceous and then to the diversified flora of today. Angiosperms showed rapid physiological evolution in vein density and leaf area that improved photosynthesis and water absorption. These ecophysiological changes made early angiosperms well adapted to the hot and dry environment in mid-Cretaceous. Moreover, these physiological changes facilitated the fire–angiosperm cycles in mid-Cretaceous that likely further stimulated the early angiosperm evolution.

关键词： Mid-Cretaceous hothouse wildfire early angiosperm diversification

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Clinical and scientific innovations in auditory brainstem implants

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2021年第2期7卷 109-115页

作者： Kunal R.Shetty Sarah E.Ridge Vivek Kanumuri Angela Zhu M.Christian Brown Daniel J.Lee Department of Otorhinolaryngology Head and Neck Surgery McGovern Medical School at the University of Texas Health Science Center at HoustonHoustonTXUSA eaton-peabody Laboratories Massachusetts Eye and Ear InfirmaryHarvard Medical SchoolBostonMAf USA

The auditory brainstem implant(ABI)was originally developed to provide rehabilitation of retrocochlear deafness caused by neurofibromatosis type 2(NF2).Recent studies of the ABI have investigated outcomes in non-NF2 cohorts,such as patients with cochlear nerve aplasia or cochlear ossification and more recently,intractable *** technologies that improve the ABI-neural tissue interface are being explored as means to improve performance and decrease side *** discoveries in optogenetics and bioengineering present opportunities to continually evolve this technology into the future,enhancing spatial selectivity of neuronal activation in the cochlear nucleus and preventing side effects through reduction in activation of non-target neuronal *** advances will improve surgical planning and ultimately improve patients1 audiological *** research has rapidly increased in the 21st century and applications of this technology are likely to continually ***,we aim to characterize ongoing clinical,basic science,and bioengineering advances in ABIs and discuss future directions of this technology.

关键词： Auditory brainstem implant Cochlear nucleus Neurofibromatosis type 2 Optogenetics ABI Conformable electrode array Otology Neurotology

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