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Combined hepatic resection with fenestration for highly symptomatic polycystic liver disease:A report on seven patients

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World Journal of Gastroenterology 2004年第17期10卷 2598-2601页

作者： Guang-ShunYang Qi-GenLi Jun-HuaLu NingYang Hai-BinZhang Xue-PingZhou easternhepatobiliaryhospital SecondMilitaryMedicalUniversityShanghai200438China

AIM: To evaluate the immediate and long-term results in a series of patients with highly symptomatic polycystic liver disease (PLD) treated by combined hepatic resection with cystic ***: We reviewed our recent experience with a combined hepatic resection-fenestration procedure in seven highly symptomatic patients with PLD. Clinical data, liver manifestation of computed tomography (CT), and morbidity were recorded pre- and post-operation. Follow-up was made by clinical and CT examinations in all ***: Symptomatic relief and reduction in abdominal girth were obtained in all patients during an average followup period of 20.4 mo. CT scans confirmed post-resection hypertrophy of the spared liver and lack of significant cyst progression. All patients had mild to severe ascites. Two patients were complicated with pleural ***: Some highly symptomatic patients with massive PLD may benefit from combined hepatic resection and fenestration at acceptable risk. To stitch the dissected hepatic ligaments could prevent the instable remnant liver from kinking and collapsing.

关键词：肝切除术手术治疗开窗手术多囊性肝脏疾病病例报告消化系统

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Transfection of ILL-2 and/or 1L-12 genes into spleen in treatment of rat liver cancer

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World Journal of Gastroenterology 2004年第15期10卷 2190-2194页

作者： Tian-GengYou Hong-ShunWang Jia-HeYang Qi-JunQian Rui-FangFan Meng-ChaoWu easternhepatobiliaryhospital SecondMlilitaryMedicalUniversity225ChanghaiRoadShanghai200433China

AIM:To test the efficacy of gene therapy in rat liver tumor, METHODS:A retroviral vector GCIL12EIL2PN encoding human IL-2(hIL-2)and mouse IL-12(mIL-12)fused gene and its packaging cell were *** packaging cell lines contained of IL-2 and/or IL-12 genes were injected intrasplenically to transfect splenocyte at different time. The therapeutic effect,immune function and toxic effect were evaluated. RESULTS:The average survival times of the 4 groups using IL genes at days 1,3,5 and 7 after tumor implantation were 53.3±3.7,493±4.2,31.0±2.1 and 24.3±1.4 d respectively in IL-2/IL-12 fused gene group,25.0±2.5,23.5±2.0, 18.3±2.4 and 12.0±1.8 d respectively in IL-2 gene treatment group,and 39.0±4.8,32.0±3.9,23.0±2.5 and 19.4±2.1 d respectively in IL-12 gene treatment group(P<0.01,n=10). In the IL-12/IL-2 fused gene treatment group,30% of rats treated at days 1 and 3 survived more than 60 d and serum mIL-12 and hIL-2 levels were still high at day 3 after *** with IL alone,NK cell activity was strongly stimulated by IL-2/IL-12 *** showed that livers were infiltrated by a number of lymphocytes. CONCLUSION:IL-2 and/or IL-12 genes injected directly into spleen increase serum IL-2 and IL-12 levels and enhance the NK cell activity,which may inhibit the liver tumor *** therapy of fused gene IL-2/IL-12 is of low toxicity and relatively high NK cell *** data suggest that IL-2/IL-12 fused gene may be a safe and efficient gene therapy for liver *** gene therapy should be administrated as early as possible.

关键词：基因转染 IL-2 IL-12 基因脾老鼠肝癌肿瘤

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