检索结果-南通市图书馆

Pollen analysis reveals the effects of uncovered interactions,pollen-carrying structures,and pollinator sex on the structure of wild bee-plant networks

引用

Insect Science 2024年第3期31卷 971-988页

作者： Clément Tourbez Carmelo Gómez-Martínez MiguelÁngel Gonzalez-Estévez Amparo Lazaro mediterranean Institute for Advanced Studies(UIB-CSIC) Global Change Research GroupEsporlesBalearic IslandsSpain Department of Biology Ecology AreaUniversity of the Balearic/slandsPalmaSpain

Pollination networks are increasingly used to model the complexity of interactions between pollinators and flowering plants in communities.Different methods exist to sample these interactions,with direct observations of plant-pollinator contacts in the field being by far the most common.Although the identification of pollen carried by pollinators allows uncovering interactions and increasing sample sizes,the methods used to build pollen-transport networks are variable and their effect on network structure remains unclear.To understand how interaction sampling influences the structure of networks,we analyzed the pollen found on wild bees from eight communities across Mallorca Island and investigated the differences in pollen loads between bee body parts(scopa vs.body)and sexes.We then assessed how these differences,as well as the uncovered interactions not detected in the field,influenced the structure of wild bee-plant networks.We identified a higher quantity and diversity of pollen in the scopa than in the rest of the female body,but these differences did not lead to differences in structure between plant-pollination(excluding scopa pollen)and bee-feeding interaction(including scopa pollen)networks.However,networks built with pollen data were richer in plant species and interactions and showed lower modularity and specialization(H2'),and higher nestedness than visitation networks based on field observations.Female interactions with plants were stronger compared to those of males,although not richer.Accordingly,females were more generalist(low d')and tended to be more central in interaction networks,indicating their more key role structuring pollination networks in comparison to males.Our study highlights the importance of palynological data to increase the resolution of networks,as well as to understand important ecological questions such as the differences between plant-pollination and bee-feeding interaction networks,and the role of sexes in pollination.

关键词： palynology pollen-transport networks pollination role of bee sexes sampling methodology visitation networks

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Approach to loss of response to advanced therapies in inflammatory bowel disease

引用

World Journal of Gastroenterology 2024年第22期30卷 2902-2919页

作者： Nikil Vootukuru Abhinav Vasudevan Department of Gastroenterology and Hepatology Eastern HealthVictoriaBox Hill 3128Australia eastern Health Clinical School Monash UniversityVictoriaBox Hill 3128Australia

BACKGROUND Remarkable progress over the last decade has equipped clinicians with many options in the treatment of inflammatory bowel disease.Clinicians now have the unique opportunity to provide individualized treatment that can achieve and sustain remission in many patients.However,issues of primary non-response(PNR)and secondary loss of response(SLOR)to non-tumour necrosis factor inhibitor(TNFi)therapies remains a common problem.Specific issues include the choice of optimization of therapy,identifying when dose optimization will recapture response,establishing optimal dose for escalation and when to switch therapy.AIM To explores the issues of PNR and SLOR to non-TNFi therapies.METHODS This review explores the current evidence and literature to elucidate management options in cases of PNR/SLOR.It will also explore potential predictors for response following SLOR/PNR to therapies including the role of therapeutic drug monitoring(TDM).RESULTS In the setting of PNR and loss of response to alpha-beta7-integrin inhibitors and interleukin(IL)-12 and IL-23 inhibitors dose optimization is a reasonable option to capture response.For Janus kinase inhibitors dose optimization can be utilized to recapture response with loss of response.CONCLUSION The role of TDM in the setting of advanced non-TNFi therapies to identify patients who require dose optimization and as a predictor for clinical remission is not yet established and this remains an area that should be addressed in the future.

关键词： Inflammatory bowel disease Ulcerative colitis Crohn Biologics Interleukin-12 and interleukin-23 inhibitors Alpha-beta7-integrin inhibitors Janus kinase inhibitors Sphingosine-1-phosphate receptor modulators

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of the concentration and nature of total dissolved solids in drinking water on feed intake, nutrient digestion, energy balance,methane emission, ruminal fermentation, and blood constituents in different breeds of young goats and hair sheep

引用

Animal Nutrition 2024年第1期16卷 84-95页

作者： Amlan Kumar Patra Luana Paula dos Santos Ribeiro Hirut Yirga Adekayode O.Sonibare Ahmed R.Askar Ali H.Hussein Ryszard Puchala Arthur Louis Goetsch American Institute for Goat Research Langston University Animal and Poultry Nutrition Department Desert Research Center Agriculture Food and Natural ResourcesEastern New Mexico University

Understanding how different livestock species and breeds respond to consumption of brackish water could improve usage of this resource.Therefore,Angora,Boer,and Spanish goat doelings and Dorper,Katahdin,and St.Croix ewe lambs (6 animals per animal type[AT];initial age=296±2.1 days)consuming water with varying concentrations of minerals of a natural brackish water source (BR) and sodium chloride (NaCl;SL) were used to determine effects on water and feed intake,nutrient digestion,heat energy,methane emission,ruminal fluid conditions,and blood constituent concentrations.There were 6 simultaneous 6 (water treatments[WT])×6 (AT) Latin squares with 3-wk periods.The WT were fresh (FR),BR alone (100-BR),a similar total dissolved solids (TDS) concentration as 100-BR via NaCl addition to FR (100-SL),BR with concentrations of all minerals increased by approximately 50%(150-BR),a similar TDS level as 150-BR by NaCl addition to FR (150-SL),and a similar 150 TDS level achieved by addition of a 1:1 mixture of BR minerals and NaCl to 100-BR (150-BR/SL).Concentrations (mg/kg) in BR were 4928 TDS,85.9 bicarbonate,224.9 calcium,1175 chloride,60.5 magnesium,4.59 potassium,1387sodium,1962 sulfate,and 8.3 boron,and TDS in other WT were 209,5684,7508,8309,and 7319 mg/kg for FR,100-SL,150-BR,150-SL,and 150-BR/SL,respectively.There were very few significant effects of WT or AT×WT interactions,although AT had numerous effects.Water intake was affected by AT (P=0.02)and WT (P=0.04),with greater water intake for 150-SL than for FR,100-BR,100-SL,and 150-BR.Dry matter intake among AT was lowest (P<0.05) for Angora.Digestion of organic matter and neutral detergent fiber and heat energy differed among AT (P<0.05),but nitrogen digestion and ruminal methane emission were similar among AT.Blood aldosterone concentration was higher (P<0.05) for FR than for other WT.In conclusion,all AT seemed resilient to these WT regardless of mineral source and concentrations,with TDS less than 8300 mg/kg,which did not influence nutrient utilization,ruminal ferme

关键词： Goats Hair sheep Nutrient utilization Ruminal fermentation Salinity Water quality

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

The functions of exosomes targeting astrocytes and astrocyte-derived exosomes targeting other cell types

引用

Neural Regeneration Research 2024年第9期19卷 1947-1953页

作者： Hongye Xu He Li Ping Zhang Yuan Gao Hongyu Ma Tianxiang Gao Hanchen Liu Weilong Hua Lei Zhang Xiaoxi Zhang Pengfei Yang Jianmin Liu Neurovascular Center Changhai HospitalNaval Medical UniversityShanghaiChina Department of Emergency Naval Hospital of Eastern TheaterZhoushanZhejiang ProvinceChina

Astrocytes are the most abundant glial cells in the central nervous system;they participate in crucial biological processes,maintain brain structure,and regulate nervous system function.Exosomes are cell-derived extracellular vesicles containing various bioactive molecules including proteins,peptides,nucleotides,and lipids secreted from their cellular sources.Increasing evidence shows that exosomes participate in a communication network in the nervous system,in which astrocyte-derived exosomes play important roles.In this review,we have summarized the effects of exosomes targeting astrocytes and the astrocyte-derived exosomes targeting other cell types in the central nervous system.We also discuss the potential research directions of the exosome-based communication network in the nervous system.The exosome-based intercellular communication focused on astrocytes is of great significance to the biological and/or pathological processes in different conditions in the brain.New strategies may be developed for the diagnosis and treatment of neurological disorders by focusing on astrocytes as the central cells and utilizing exosomes as communication mediators.

关键词： astrocytes communication exosomes neurological disorders targeting mechanism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High-performance portable grating-based surface plasmon resonance sensor using a tunable laser at normal incidence

引用

Photonics Research 2024年第5期12卷 947-958页

作者： Duc LE ANNI RANTA-LASSILA TEEMU SIPOLA MIKKO KARPPINEN JARNO PETAJA MINNA KEHUSMAA SANNA AIKIO TIAN-LONG GUO MATTHIEU ROUSSEY JUSSI HILTUNEN ALEXEY POPOV VTT Technical Research Centre of Finland 90570 OuluFinland Department of Physics and Mathematics University of Eastern FinlandFI-80101 JoensuuFinland

Surface plasmon resonance(SPR)sensors are among the most sensitive sensors.In such devices,a grating is a compelling alternative to a prism for the excitation of a surface plasmon,especially in the development of sensors for point-of-care applications due to their compactness and cost-effectiveness.Here,we demonstrate the use of a tunable laser in a grating-based SPR system for further miniaturization and integration.The tunable laser working at normal incidence replaces spectral and moving components,while also simplifying the optical setup.Normal incidence is conventionally avoided due to the complexity of the control of degenerated SPR modes.We investigate,both computationally and experimentally,the splitting of the SPR modes at small nonzero incidences,which is lacking in previously reported studies.By optimizing the grating configuration,we were able to diminish the SPR mode splitting phenomenon when the excitation was feasible with the normal incidence configuration.The fabricated sensor showed a high sensitivity of 1101.6 nm/RIU.Notably,the figure of merit of the sensor,defined as the ratio between the sensitivity and bandwidth of the SPR dip,was 229.5.The experimental results were consistent with the simulation results.We also demonstrate its capability for detecting low concentrations of glucose and creatinine with the limit of detection of 14.2 and 19.1 mmol/L,respectively.

关键词： tunable splitting excitation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Simple bone cysts of the proximal humerus presented with limb length discrepancy:A case report

引用

World Journal of Clinical Cases 2024年第6期12卷 1130-1137页

作者： Cing Syue Lin Shang Ming Lin Syang-Peng Rwei Chin-Wen Chen Tsung-Yu Lan Department of Orthopedic Surgery Far Eastern Memorial HospitalNew Taipei City 220Taiwan Department of Materials and Textiles Asia Eastern University of Science and TechnologyNew Taipei City 220Taiwan Institute of Organic and Polymeric Materials National Taipei University of TechnologyTaipei City 10608Taiwan

BACKGROUND Simple bone cysts(SBC)are benign tumor-like bone lesions typically identified in children.While SBC may lead to growth disturbances or growth arrest,such cases are uncommon.The mechanisms behind these observations remain unclear.Additionally,research on the etiology of SBC remains inconclusive,and there has been no consensus on the appropriate timing and methodology for treatment.CASE SUMMARY Here,we present our experience in the successful surgical management of a 10-year-old girl with SBC,who presented with a pathological fracture complicated by malunion of the displaced fracture,varus deformity,and limb length discrepancy.We hypothesized two possible etiologies for the patient’s growth arrest and subsequent humerus varus deformity:(1)Direct disruption of the physis by fluid from the cyst itself;and(2)damage to the epiphysis due to repetitive pathological fractures associated with SBC.In addressing this case,surgical intervention was undertaken to correct the proximal humerus varus deformity.This approach offered the advantages of simultaneously correcting angular abnormalities,achieving mild limb lengthening,providing definitive SBC treatment,and reducing the overall treatment duration.CONCLUSION As per current literature,acute correction of acute angular deformity in proximal humeral SBC is not well comprehended.However,in this specific case,acute correction was considered an optimal solution.

关键词： Bone cyst Solitary cysts Benign Humerus Growth arrest Limb length discrepancy Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Exploring the shadow of a rotating charged ModMax black hole

引用

Communications in Theoretical Physics 2024年第2期76卷 89-101页

作者： Khurshid Karshiboev Farruh Atamurotov Ahmadjon Abdujabbarov Ali Övgün Anvar Reyimberganov Institute of Theoretical Physics National University of UzbekistanTashkent 100174Uzbekistan New Uzbekistan university Movarounnahr Street 1Tashkent 100000Uzbekistan Central Asian university Milliy Bog'Street 264Tashkent 111221Uzbekistan university of Tashkent for Applied Sciences Str.Gavhar 1Tashkent 100149Uzbekistan Tashkent State Technical university Tashkent 100095Uzbekistan Ulugh Beg Astronomical Institute Astronomy Street 33Tashkent 100052Uzbekistan Institute of Fundamental and Applied Research National Research University TIIAMEKori Niyoziy 39Tashkent 100000Uzbekistan Physics Department Eastern Mediterranean UniversityFamagusta99628 North Cyprusvia Mersin 10Turkey Urgench State university Urgench 220100Uzbekistan

The research presented in this paper discusses the impact that the parameters of charge(Q)and screening factor(γ)have on properties of the horizon and silhouette of rotating charged Mod Max black holes which were reviewed in[Eur.Phys.J.C(2022)82:1155]recently,building upon previous findings in the field.Furthermore,the study explores the behavior of null geodesics,which can help us better understand the apparent shape of the black hole’s silhouette,as well as the distortion parameter and approximate radii of the silhouette that are influenced by the aforementioned parameters,and there are some values of parameter Q which corresponds to data from the Event Horizon Telescope(EHT).Notably,we explore the distortion parameter and approximate radii of the silhouette,revealing that while an increase inγleads to a growth in silhouette radius(Rs),it simultaneously reduces the distortion rate(δs).Conversely,heightened Q charge results in a reduction of Rsaccompanied by an increase inδs.Lastly,the paper analyzes the effects of the black hole’s parameters on the effective potential and energy emission:the peak value of the energy emission rate experiences a decrease as the screening factor(γ)increases,while it increases with higher values of the charge parameter(Q).

关键词： black hole ModMax gravity rotating black hole black hole shadow

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Heparin is an effective treatment for preventing liver failure after hepatectomy

引用

World Journal of Gastroenterology 2024年第22期30卷 2881-2892页

作者： Zhi-Ying Xu Min Peng Ming-Ming Fan Qi-Fei Zou Yi-Ran Li Dong Jiang Hepatic Surgery IV Shanghai Eastern Hepatobiliary Surgery HospitalThe Third Affiliated Hospital of Naval Medical UniversityShanghai 200433China Ultrasound Diagnosis PLA Naval Medical CenterShanghai 200437China Department of Ultrasound Eastern Hepatobiliary Surgery HospitalThe Third Affiliated Hospital of Naval Medical UniversityShanghai 200433China

BACKGROUND Posthepatectomy liver failure(PHLF)is one of the most important causes of death following liver resection.Heparin,an established anticoagulant,can protect liver function through a number of mechanisms,and thus,prevent liver failure.AIM To look at the safety and efficacy of heparin in preventing hepatic dysfunction after hepatectomy.METHODS The data was extracted from Multiparameter Intelligent Monitoring in Intensive Care III(MIMIC-III)v1.4 pinpointed patients who had undergone hepatectomy for liver cancer,subdividing them into two cohorts:Those who were injected with heparin and those who were not.The statistical evaluations used were unpaired ttests,Mann-Whitney U tests,chi-square tests,and Fisher’s exact tests to assess the effect of heparin administration on PHLF,duration of intensive care unit(ICU)stay,need for mechanical ventilation,use of continuous renal replacement therapy(CRRT),incidence of hypoxemia,development of acute kidney injury,and ICU mortality.Logistic regression was utilized to analyze the factors related to PHLF,with propensity score matching(PSM)aiming to balance the preoperative disparities between the two groups.RESULTS In this study,1388 patients who underwent liver cancer hepatectomy were analyzed.PSM yielded 213 matched pairs from the heparin-treated and control groups.Initial univariate analyses indicated that heparin potentially reduces the risk of PHLF in both matched and unmatched samples.Further analysis in the matched cohorts confirmed a significant association,with heparin reducing the risk of PHLF(odds ratio:0.518;95%confidence interval:0.295-0.910;P=0.022).Additionally,heparin treatment correlated with improved short-term postoperative outcomes such as reduced ICU stay durations,diminished requirements for respiratory support and CRRT,and lower incidences of hypoxemia and ICU mortality.CONCLUSION Liver failure is an important hazard following hepatic surgery.During ICU care heparin administration has been proved to decrease the occurrence of hepatectomy induced liver

关键词： Liver resection Posthepatectomy liver failure Prophylactic treatment Heparin Prognosis of hepatectomy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Treat to target in Crohn’s disease:A practical guide for clinicians

引用

World Journal of Gastroenterology 2024年第1期30卷 50-69页

作者： Ashish R Srinivasan Department of Gastroenterology Austin HealthVictoriaMelbourne 3083Australia Department of Gastroenterology Eastern HealthVictoriaMelbourne 3128Australia Department of Medicine University of MelbourneVictoriaMelbourne 3052Australia

A treat-to-target(T2T)approach applies the principles of early intervention and tight disease control to optimise long-term outcomes in Crohn's disease.The Selecting Therapeutic Targets in Inflammatory Bowel Disease(STRIDE)-II guidelines specify short,intermediate,and long-term treatment goals,documenting specific treatment targets to be achieved at each of these timepoints.Scheduled appraisal of Crohn’s disease activity against pre-defined treatment targets at these timepoints remains central to determining whether current therapy should be continued or modified.Consensus treatment targets in Crohn’s disease comprise combination clinical and patient-reported outcome remission,in conjunction with biomarker normalisation and endoscopic healing.Although the STRIDE-II guidelines endorse the pursuit of endoscopic healing,clinicians must consider that this may not always be appropriate,acceptable,or achievable in all patients.This underscores the need to engage patients at the outset in an effort to personalise care and individualise treatment targets.The use of non-invasive biomarkers such as faecal calprotectin in conjunction with cross-sectional imaging techniques,particularly intestinal ultrasound,holds great promise;as do emerging treatment targets such as transmural healing.Two randomised clinical trials,namely,CALM and STARDUST,have evaluated the efficacy of a T2T approach in achieving endoscopic endpoints in patients with Crohn’s disease.Findings from these studies reflect that patient subgroups and Crohn’s disease characteristics likely to benefit most from a T2T approach,remain to be clarified.Moreover,outside of clinical trials,data pertaining to the real-world effectiveness of a T2T approach remains scare,highlighting the need for pragmatic real-world studies.Despite the obvious promise of a T2T approach,a lack of guidance to support its integration into real-world clinical practice has the potential to limit its uptake.This highlights the need to describe strategies,processes,and models of care capable of

关键词： Treat to target Inflammatory bowel disease Crohn’s disease Treatment targets Endoscopic remission Transmural healing Time to response Intestinal ultrasound

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of small molecules on neurogenesis:Neuronal proliferation and differentiation

引用

Acta Pharmaceutica Sinica B 2024年第1期14卷 20-37页

作者： MichałK Jastrze˛bski Piotr Wo´jcik Piotr Ste˛pnicki Agnieszka A.Kaczor Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Laboratory Medical University of LublinFaculty of PharmacyLublin PL-20093Poland School of Pharmacy University of Eastern FinlandKuopio FI-70211Finland

Neurons are believed to be non-proliferating cells.However,neuronal stem cells are still present in certain areas of the adult brain,although their proliferation diminishes with age.Just as with other cells,their proliferation and differentiation are modulated by various mechanisms.These mechanisms are foundational to the strategies developed to induce neuronal proliferation and differentiation,with potential therapeutic applications for neurodegenerative diseases.The most common among these diseases are Parkinson's disease and Alzheimer's disease,associated with the formation ofβ-amyloid(Aβ)aggregates which cause a reduction in the number of neurons.Compounds such as LiCl,4-aminothiazoles,Pregnenolone,ACEA,harmine,D2AAK1,methyl 3,4-dihydroxybenzoate,and shikonin may induce neuronal proliferation/differentiation through the activation of pathways:MAPK ERK,PI3K/AKT,NFκB,Wnt,BDNF,and NPAS3.Moreover,combinations of these compounds can potentially transform somatic cells into neurons.This transformation process involves the activation of neuron-specific transcription factors such as NEUROD1,NGN2,ASCL1,and SOX2,which subsequently leads to the transcription of downstream genes,culminating in the transformation of somatic cells into neurons.Neurodegenerative diseases are not the only conditions where inducing neuronal proliferation could be beneficial.Consequently,the impact of pro-proliferative compounds on neurons has also been researched in mouse models of Alzheimer's disease.

关键词： Neurogenesis Proliferation Differentiation Maturation Small-molecules Drug coctail Alzheimer’s disease Parkinson’s disease

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：