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Single‑cell RNA sequencing opens a new era for cotton genomic research and gene functional analysis

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Journal of Cotton Research 2024年第2期7卷 215-218页

作者： PAN Xiaoping PENG Renhai ZHANG Baohong Department of Biology East Carolina UniversityGreenvilleNC 27858USA College of Biology and Food Engineering Anyang Institute of TechnologyAnyangHenan 455000China

Single-cell RNA sequencing(scRNA-seq)is one of the most advanced sequencing technologies for studying transcriptome landscape at the single-cell *** provides numerous advantages over traditional *** it was first used to profile single-cell transcriptome in plants in 2019,it has been extensively employed to perform different research in ***,scRNA-seq was also quickly adopted by the cotton research community to solve lots of scientific questions which have been never *** this comment,we highlighted the significant progress in employing scRNA-seq to cotton genetic and genomic study and its future potential applications.

关键词： Cotton Single-cell RNA sequencing Transcriptome

Enhancing Cybersecurity through Cloud Computing Solutions in the United States

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Intelligent Information Management 2024年第4期16卷 176-193页

作者： Omolola F. Hassan Folorunsho O. Fatai Oluwadare Aderibigbe Abdullah Oladoyin Akinde Tolulope Onasanya Mariam Adetoun Sanusi Oduwunmi Odukoya Department of Computer Science Austin Peay State University Clarksville USA Department of Computer Science North Carolina Agricultural and Technical State University Greensboro USA Department of Cybersecurity University of Texas Dallas USA Department of Information Systems East Tennessee State University Johnson City USA

This study investigates how cybersecurity can be enhanced through cloud computing solutions in the United States. The motive for this study is due to the rampant loss of data, breaches, and unauthorized access of internet criminals in the United States. The study adopted a survey research design, collecting data from 890 cloud professionals with relevant knowledge of cybersecurity and cloud computing. A machine learning approach was adopted, specifically a random forest classifier, an ensemble, and a decision tree model. Out of the features in the data, ten important features were selected using random forest feature importance, which helps to achieve the objective of the study. The study’s purpose is to enable organizations to develop suitable techniques to prevent cybercrime using random forest predictions as they relate to cloud services in the United States. The effectiveness of the models used is evaluated by utilizing validation matrices that include recall values, accuracy, and precision, in addition to F1 scores and confusion matrices. Based on evaluation scores (accuracy, precision, recall, and F1 scores) of 81.9%, 82.6%, and 82.1%, the results demonstrated the effectiveness of the random forest model. It showed the importance of machine learning algorithms in preventing cybercrime and boosting security in the cloud environment. It recommends that other machine learning models be adopted to see how to improve cybersecurity through cloud computing.

关键词： Cybersecurity Cloud Computing Cloud Solutions Machine Learning Algorithm

Tacrolimus-induced posterior reversible encephalopathy syndrome following liver transplantation

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World Journal of Transplantation 2024年第2期14卷 1-7页

作者： Arthur Dilibe Lakshmi Subramanian Tracy-Ann Poyser Osejie Oriaifo Ryan Brady Sashwath Srikanth Olanrewaju Adabale Olayiwola Akeem Bolaji Hassam Ali Department of Medicine ECU Health Medical CenterGreenvilleNC 27834United States Department of Medicine Unity Health-White County Medical CenterSearcyAR 72143United States Department of Physical Medicine and Rehab ECU Health Medical CenterGreenvilleNC 27834United States Department of Medicine University of Maryland Capital Region HealthLargoMD 20774United States Division of Gastroenterology and Hepatology East Carolina University/Brody School of MedicineGreenvilleNC 27858United States

In this editorial,we talk about a compelling case focusing on posterior reversible encephalopathy syndrome(PRES)as a complication in patients undergoing liver transplantation and treated with ***(FK 506),derived from Streptomyces tsukubaensis,is a potent immunosuppressive *** inhibits Tcell transcription by binding to FK-binding protein,and is able to amplify glucocorticoid and progesterone *** effectively prevents allograft rejection in transplant patients but has adverse effects such as Tacrolimus-related *** presents with various neurological symptoms alongside elevated blood pressure,and is primarily characterized by vasogenic edema on *** computed tomography detects initial lesions,magnetic resonance imaging,especially the Fluid-Attenuated Inversion Recovery sequence,is superior for diagnosing cortical and subcortical *** discussion centers on the incidence of PRES in solid organ transplant recipients,which ranges between 0.5 to 5+ACU-,with varying presentations,from seizures to visual *** case of a 66-year-old male status post liver transplantation highlights the diagnostic and management challenges associated with Tacrolimus-related *** evident in the parietal and occipital lobes,PRES underlines the need for heightened vigilance among healthcare *** editorial emphasizes the importance of early recognition,accurate diagnosis,and effective management of PRES to optimize outcomes in liver transplant *** case further explores the balance between the efficacy of immunosuppression with Tacrolimus and its potential neurological risks,underlining the necessity for careful monitoring and intervention strategies in this patient population.

关键词： Posterior reversible encephalopathy syndrome Liver transplantation Tacrolimus Immunocompromised patients Neurological complications Solid organ transplant

Coronary artery disease and heart failure:Late-breaking trials presented at American Heart Association scientific session 2023

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World Journal of Cardiology 2024年第7期16卷 389-396页

作者： Avilash Mondal Sashwath Srikanth Sanjana Aggarwal Naga R Alle Olufemi Odugbemi Ikechukwu Ogbu Rupak Desai Department of Internal Medicine Nazareth HospitalPhiladelphiaPA 19152United States Department of Internal Medicine East Carolina University GreenvilleGreenvilleNC 27834United States Department of Internal Medicine Hamdard Institute of Medical Sciences and ResearchNew Delhi 110062India Department of Medicine Narayana Medical CollegeNelloreAndhra Pradesh 524003India Department of Internal Medicine Lincoln Medical CenterBronxNY 10451United States Department of Internal Medicine Mountainview Hospital Sunrise GMELas VegasNV 89108United States Independent Researcher AtlantaGA 30079United States

The late-breaking science presented at the 2023 scientific session of the American Heart Association paves the way for future pragmatic trials and provides meaningful information to guide management strategies in coronary artery disease and heart failure(HF).The dapagliflozin in patient with acute myocardial infarction(DAPA-MI)trial showed that dapagliflozin use among patients with acute MI without a history of diabetes mellitus or chronic HF has better cardiometabolic outcomes compared with placebo,with no difference in cardiovascular *** MINT trial showed that in patients with acute MI and anemia(Hgb<10 g/dL),a liberal transfusion goal(Hgb≥10 g/dL)was not superior to a restrictive strategy(Hgb 7-8 g/dL)with respect to 30-day all-cause death and recurrent *** ORBITA-2 trial showed that among patients with stable angina and coronary stenoses causing ischemia on little or no antianginal therapy,percutaneous coronary intervention results in greater improvements in anginal frequency and exercise times compared with a sham *** ARIES-HM3 trial showed that in patients with advanced HF who received a HeartMate 3 levitated left ventricular assist device and were anticoagulated with a vitamin K antagonist,placebo was noninferior to daily aspirin with respect to the composite endpoint of bleeding and thrombotic events at 1 *** TEAMMATE trial showed that everolimus with low-dose tacrolimus is safe in children and young adults when given≥6 months after cardiac *** patients being treated for HF with reduced ejection fraction(HFrEF)with specific out-of-pocket(OOP)costs for multiple medication options at the time of the clinical encounter may reduce‘contingency planning’and increase the extent to which patients are taking the medications decided *** primary outcome,which was cost-informed decisionmaking,defined as the clinician or patient mentioning costs of HFrEF medication,occurred in 49%of encounters with the checklist only

关键词： Heart failure Coronary artery disease Clinical trials Myocardial infarction Cardiovascular outcome Percutaneous coronary intervention Blood transfusion Cardiac transplant

Impact of metabolic dysfunction-associated steatotic liver disease on COVID-19 hospitalizations:A propensity-matched analysis of the United States

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World Journal of Virology 2024年第1期13卷 51-60页

作者： Abdullah Sohail Hassam Ali Pratik Patel Subanandhini Subramanium Dushyant Singh Dahiya Amir H Sohail Manesh Kumar Gangwani Sanjaya K Satapathy Department of Internal Medicine University of Iowa Roy J and Lucille A Carver College of MedicineIowaIA 52242United States Division of Gastroenterology and Hepatology East Carolina University/Brody School of MedicineGreenvilleNC 27858United States Department of Gastroenterology Mather Hospital/Hofstra University Zucker School of MedicineNY11777United States Department of Internal Medicine East Carolina University Brody School of MedicineGreenvilleNC 27834United States Division of Gastroenterology Hepatology&MotilityThe University of Kansas School of MedicineKansas CityKS 66160United States Department of Surgery University of New MexicoAlbuquerqueNM 87106United States Department of Internal Medicine The University of ToledoToledoOH 43606United States Section on Gastroenterology and Hepatology North Shore University Hospital and Long Island Jewish Medical CenterManhassetNY 11030United States

BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD),formally known as nonalcoholic fatty liver disease,is the most common chronic liver disease in the United *** with MASLD have been reported to be at a higher risk of developing severe coronavirus disease 2019(COVID-19)and ***,most studies are single-center studies,and nationwide data in the AIM To study the influence of MASLD on COVID-19 hospitalizations during the initial phase of the *** We retrospectively analyzed the 2020 National Inpatient Sample(NIS)database to identify primary COVID-19 hospitalizations based on an underlying diagnosis of MASLD.A matched comparison cohort of COVID-19 hospit-alizations without MASLD was identified from NIS after 1:N propensity score matching based on gender,race,and comorbidities,including hypertension,heart failure,diabetes,and *** primary outcomes included inpatient mortality,length of stay,and hospitalization *** outcomes included the prevalence of systemic *** A total of 2210 hospitalizations with MASLD were matched to 2210 hospitalizations without MASLD,with a good comorbidity ***,there was a higher prevalence of severe disease with more intensive care unit admissions(9.5%vs 7.2%,P=0.007),mechanical ventilation(7.2%vs 5.7%,P=0.03),and septic shock(5.2%vs 2.7%,P<0.001)in the MASLD cohort than in the non-MASLD ***,there was no difference in mortality(8.6%vs 10%,P=0.49),length of stay(5 d vs 5 d,P=0.25),and hospitalization costs(42081.5$vs 38614$,P=0.15)between the MASLD and non-MASLD *** The presence of MAFLD with or without liver cirrhosis was not associated with increased mortality in COVID-19 hospitalizations;however,there was an increased incidence of severe COVID-19 *** data(2020)predates the availability of COVID-19 vaccines,and many MASLD patients have since been *** will be interesting to see if these trends are

关键词： COVID-19 Metabolic dysfunction-associated steatotic liver disease Prevalence Hospital charges Inpatient resource utilization

Optomagnonic frequency combs

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Photonics Research 2022年第12期10卷 2786-2793页

作者： ZENG-XING LIU YONG-QING LI School of Electronic Engineering&Intelligentization Dongguan University of TechnologyDongguan 523808China Department of Physics East Carolina UniversityGreenvilleNorth Carolina 27858-4353USA

Optical frequency combs are fundamentally important in precision measurement physics,bringing unprecedented capabilities of measurements for time keeping,metrology,and *** this work,we investigate theoretically the formation of a form of frequency combs in cavity optomagnonics,in which a ferrimagnetic insulator sphere supports optical whispering gallery modes for both light photons and *** simulations of the optomagnonic dynamics show that a robust frequency comb can be obtained at low power under the bichromatic pumping drive,and the comb spacing is ***,the optomagnonic frequency comb structure has abundant non-perturbative features,suggesting that the magnon-induced Brillouin light scattering process in cavity optomagnonics may also exhibit phenomena similar to those in atomic–molecular *** addition to providing insight into optomagnonic nonlinearity,optomagnonic frequency combs may also provide the feasibility of implementing frequency combs based on spintronic platforms and may find applications for precision metrology based on magnonic devices.

关键词： pumping scattering metrology

Acute venous thromboembolism in acute pancreatitis based on the severity:a retrospective cohort study

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Journal of Pancreatology 2022年第1期5卷 10-17页

作者： Hassam Ali Swethaa Manickam Rahul Pamarthy Muhamad Fahd Farooq William Leland Department of Internal Medicine East Carolina University/Vidant Medical CenterGreenvilleNC Department of Gastroenterology East Carolina University/Vidant Medical CenterGreenvilleNCUSA

Objective: Acute pancreatitis (AP) results in systemic inflammatory responses and activates coagulation pathways. We intend to investigate the risk and hospital outcomes of acute venous thromboembolisms (VTE) in patients with ***: We retrospectively analyzed patients with AP from 2016 to 2019 using the National Inpatient Sample database. Primary outcome was the effect of VTE on the length of stay, inpatient costs, and mortality. Hierarchical multivariate logistic regression models were built using univariate ***: The study included 909,354 weighted discharges with AP. 2.1% of cases had an acute VTE. The length of stay was 5.9 days longer in the hospital of AP patients with VTE compared to AP with no VTE (P <.001). Total hospital charge per patient was $71,914 in patients with VTE compared to AP with no VTE (P < .001). Mortality was higher in AP patients with VTE compared to AP with no VTE (adjusted odds ratio [AOR] 4.2, 95% confidence interval [CI]: 3.4-5.3,P <.001). AP was associated with an increased VTE risk during inpatient stay (AOR 1.06, 95% CI 1.04-1.1,P <.001) There was an increased association of lower and upper extremity deep venous thrombosis with AP without necrosis (AOR 6.9, 95% CI 6.4-7.4,P <.001) and AP with infected necrosis (AOR 12.2, 95% CI 10.6-14.1,P <.001) but not in AP without necrosis (AOR 0.77, 95% CI 0.74-0.81,P <.001).Conclusion: VTE in AP increases length of stay and inpatient costs. The prognosis is poor in such patients, with increased inpatient mortality compared to no VTE. AP with necrosis can increase chances of all VTE subtypes;however, AP without necrosis does not increase upper and lower extremity VTE risk.

关键词： Acute pancreatitis Deep venous thrombosis Necrosis Severity Venous thromboembolism

Cysteine carboxyethylation:a novel post-translational modification associated with autoimmune arthritis

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Signal Transduction and Targeted Therapy 2023年第8期8卷 3561-3562页

作者： Alessandro Didonna Department of Anatomy and Cell Biology Brody School of MedicineEast Carolina UniversityGreenvilleNC 27834USA

In a study recently published in Science,Zhai et *** that protein carboxyethylation results in the formation of neoantigens with the ability to trigger autoimmune arthritis in the context of ankylosing spondylitis(AS)pathology.1 This work defines a novel molecular mechanism underlying immune tolerance breakdown,which could serve as a target for innovative therapeutic strategies against AS and other autoimmune disorders.

关键词： autoimmune pathology

Disseminated herpes simplex infection induced hepatitis during pregnancy mimicking HELLP syndrome,a diagnostic challenge

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Infectious Medicine 2022年第1期1卷 67-72页

作者： Hassam Ali Shruthi Kumar Mary-Kate Kratzer Josef Kinderwater Department of Internal Medicine East Carolina University/Vidant Medical CenterGreenvilleNC

The disseminated herpes simplex virus 2(HSV-2)carries a high mortality rate in pregnant women if left *** often presents as unrelieved fever and *** is challenging due to vague symptoms and potential overlap with other *** is a risk factor as it conforms to a partially immunocompro-mised *** to the brain could be devastating,and the treatment requires intravenous antivirals like *** outcomes are variable based on previous case *** present a case of young female gravida 1 para 1 who presented with disseminated HSV infection mimicking HELLP(Hemolysis,Elevated Liver enzymes,and Low Platelets)*** responded well to intravenous acyclovir,and the fetus had a viable outcome at the 26th week of *** diagnosis can prevent progression to fulminant liver failure and the need for a liver transplant.

关键词： Disseminated herpes simplex virus 2 Pregnancy Infectious complications of pregnancy Hsv-2 infection Hepatitis in pregnancy