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Proposals for the new maritime community in Japan

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Proposals for the new maritime community in Japan

Band structure of reconstructed Cu2O(-110)

Asia Navigation Conference 2005

作者： Yoshitaka Fukuo Kinzo Inoue Song Ninger Shinya Nakamura Japan Marine Science inc Faculty of Maritime SciencesKobe UniversityFaculty of Maritime SciencesKobe UniverstiyJapan Marine Science 2-3-6MinamiShinagawaShinagawa-kuTokyoJapan 5-1-1FukaeminamimachiHigashinada-kuKobeJapan Japan Marine Science inc Faculty of Maritime SciencesKobe UniversityFaculty of Maritime SciencesKobe UniverstiyJapan Marine Science 2-3-6MinamiShinagawaShinagawa-kuTokyoJapan 5-1-1FukaeminamimachiHigashinada-kuKobeJapan Japan Marine Science inc Faculty of Maritime SciencesKobe UniversityFaculty of Maritime SciencesKobe UniverstiyJapan Marine Science 2-3-6MinamiShinagawaShinagawa-kuTokyoJapan 5-1-1FukaeminamimachiHigashinada-kuKobeJapan Japan Marine Science inc Faculty of Maritime SciencesKobe UniversityFaculty of Maritime SciencesKobe UniverstiyJapan Marine Science 2-3-6MinamiShinagawaShinagawa-kuTokyoJapan 5-1-1FukaeminamimachiHigashinada-kuKobeJapan

＜正＞This research and study was a joint effort made by members of the Faculty of Maritime Sciences, Kobe University （former Kobe University of Mercantile Marine） and Japan Marine Science inc. The objective of the study was to make specific proposals for the structuring of a new maritime society from a national viewpoint. The study started with a questionnaire and interviews conducted with subjects from the maritime industry to get an idea of the current and near-futuristic pictures of marine technicians in our country. It revealed a growing need for human resources of management level with experience in sea service as officers/engineers. It also showed that the growth of such a job market is doomed to be restricted if the current system of life-time employment is maintained by shipping companies in our country. Then, research was conducted with its focus placed on European maritime communities. It uncovered initiatives undertaken in Europe to encourage seafarers to completely shift, earlier than before, to jobs ashore in order to cope with a shortage of marine technicians of management level. Following the results of the research, we have, as a conclusion of the study, proposed that: （1） Our country also promptly bring about a two-stage career system in which seafarers shift to shore-based work completely, after finishing sea service in the middle of their thirties;and （2） Initiatives be launched to structure some organizational and systematic arrangements in which each young marine technician can elect his own period of sea service as a career path because the current industrial landscape would be difficult to change if the two-stage career system is put in place under the life-time employment arrangement within the current framework in each group of shipping companies.

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Band structure of reconstructed Cu2O(-110)

Antiretroviral-Drug Resistant Mutations and Genetic Diversity in HIV-1 Infected Individuals in Nigeria

ICAM Workshop Physics of Novel Energy Materials

作者： N.Barrett M.Izquierdo J.Leroy F.Sirotti F.Bruneval L.Reining N.Vast DSM/IRAMIS/SPCSI Batiment 462 CEA Saclay 91191 Gif sur Yvette cedex Synchrotron Soleil L’Orme des MerisiersSt Aubin BP 48 91192 Gif sur Yvette DEN/DANS/DMN/SRMP Batiment 520 CEA Saclay 91191 Gif sur Yvette cedex Theory group LSI/Polytechnique Ecole Polytechnique 91128 Palaiseau Laboratoire des Solides Irradiés CEA/DSM-CNRS UMR7642-Ecole Polytechnique 91120 Palaiseau

Cu2O is a model oxide, with a direct band gap of 2.17 ev. This system has been of theoretical interest sinc. over more that 50 years due to its particular optical absorption spectrum (OAS). Recently, the interest has ...

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World Journal of AIDS 2014年第2期4卷 187-197页

作者： Olubunmi Ruth Negedu-Momoh Olayeni Stephen Olonitola Lillian Emiola Odama Helen Ineigo Inabo Henry Akwen Mbah Alex Nganga Kasembeli Seth Chekata Inzaule Edward Adekola Oladele Titilope Badru Simon Magaji Agwale Centre for Disease Control and Prevention HIV Research Laboratory Kisumu Kenya Department of Microbiology Ahmadu Bello University Zaria Nigeria Department of Microbiology Kogi State University Ayangba Nigeria Family Health International (FHI 360) Abuja Nigeria Innovative Biotech USA inc Frederick Innovative Technology Center Frederick USA

Introduction: Despite the success derived from antiretroviral therapy, drug resistance (DR) mutations are known to develop and are major impediments to treatment of HIV patients. Therefore, periodic assessment of HIVDR is needed to ensure continuous HAART efficacy. This study assessed the magnitude of drug resistance as well as HIV genetic variability in drug-naive and treated patients in Nigeria. Methodology: Genotypic analysis was performed by sequencing plasma specimens from 40 individuals in a cross sectional study involving 202 HIV infected patients from all the six geopolitical zones of Nigeria. Sequences were analyzed for presence of HIVDR mutation using the algorithm in Stanford HIVDR database and confirmed by IAS-USA 2009 mutation list. Phylogenetic and recombination analyses were done using PAUP V4.0 and REGA V2.0 respectively. Results: Major DR mutations were detected in the reverse transcriptase (RT) gene of 5 (33%) drug experienced and 2 (8%) na?ve patients. Most common mutations were M184V and K103N with no protease (PR) mutations detected. Thymidine analogue mutations (TAMs) and a complex multi resistance mutation Q151M were detected in 3 samples. Polymorphic substitutions were observed in both PR and RT gene. Phylogenetic analysis revealed group M isolates of G (20), J (1), circulating recombinant forms: CRF02_AG (14), CRF-18-cpx (1), CRF06_cpx (3) and a unique AD recombinant (1). Conclusion: Our findings corroborate previous studies on circulating DR viruses in Nigeria while genetic diversity is on the inc.ease. In view of ART scale-up, monitoring the resistance pattern and genetic diversity will aid in appropriate prevention strategies.

关键词： HIV Drug Resistance Mutation Nigeria

Bioengineered exosomal-membrane-camouflaged abiotic nanocarriers: neurodegenerative diseases, tissue engineering and regenerative medicine

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Military Medical Research 2023年第5期10卷 699-725页

作者： Daniela Lopes Joana Lopes Miguel Pereira-Silva Diana Peixoto Navid Rabiee Francisco Veiga Omid Moradi Zhan-Hu Guo Xiang-Dong Wang Joao Conde Pooyan Makvandi Ana Claudia Paiva-Santos Department of Pharmaceutical Technology Faculty of Pharmacy of the University of CoimbraUniversity of Coimbra3000-548 CoimbraPortugal REQUIMTE/LAQV Group of Pharmaceutical TechnologyFaculty of Pharmacy of the University of CoimbraUniversity of Coimbra3000-548 CoimbraPortugal School of Engineering Macquarie UniversitySydneyNsW 2109Australia Centre for Molecular Medicine and Innovative Therapeutics Murdoch UniversityPerthWA 6150Australia Department of Chemistry Shahr-e-Qods BranchIslamic Azad UniversityTehran 374-37515Iran lntegrated Composites Laboratory(iCL) Department of Mechanical and Construction EngineeringNorthumbria UniversityNewcastle Upon Tyne NE18STUK Department of Pulmonary and Critical Care Medicine Zhongshan HospitalFudan University Shanghai Medical CollegeShanghai 200032China Faculdade de Ciencias Medicas NOVA Medical SchoolUniversidade Nova de Lisboa1169-056 LisbonPortugal Centre for Toxicogenomics and Human Health GeneticsOncology and Human ToxicologyFaculdade de Ciencias MedicasNOVA Medical SchoolUniversidade Nova de Lisboa1169-056 LisbonPortugal school of Engineering Institute for Bioengineeringthe University of EdinburghEdinburgh EH93JLUK.

A bio-inspired strategy has recently been developed for camouflaging nanocarriers with biomembranes,such as natural cell membranes or subcellular structure-derived *** strategy endows cloaked nanomaterials with improved interfacial properties,superior cell targeting,immune evasion potential,and prolonged duration of systemic ***,we summarize recent advances in the production and application of exosomal membrane-coated *** structure,properties,and manner in which exosomes communicate with cells are first *** is followed by a discussion of the types of exosomes and their fabrication *** then discuss the applications of biomimetic exosomes and membrane-cloaked nanocarriers in tissue engineering,regenerative medicine,imaging,and the treatment of neurodegenerative ***,we appraise the current challenges associated with the clinical translation of biomimetic exosomal membrane-surface-engineered nanovehicles and evaluate the future of this technology.

关键词： Biomimetic Cell membrane coating Exosome Exosomal-membrane-coated nanoparticle Extracellular vesicle(ev)

Local administration of porcine immunomodulatory,chemotactic and angiogenic extracellular vesicles using engineered cardiac scaffolds for myocardial infarction

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Bioactive Materials 2021年第10期6卷 3314-3327页

作者： Marta Monguió-Tortajada Cristina Prat-Vidal Miriam Moron-Font Marta Clos-Sansalvador Alexandra Calle Paloma Gastelurrutia Adriana Cserkoova Anna Morancho Miguel Angel Ramírez Anna Rosell Antoni Bayes-Genis Carolina Gàlvez-Montón Francesc E.Borràs Santiago Roura ICREC Research Program Health Science Research Institute Germans Trias i Pujol(IGTP)Can Ruti CampusBadalonaSpain REMAR-IVECAT group Health Science Research Institute Germans Trias i Pujol(IGTP)Can Ruti CampusBadalonaSpain Department of Cell Biology Physiology and ImmunologyUniversitat Autónoma de Barcelona(UAB)BellaterraSpain CIBERCV Instituto de Salud Carlos IIIMadridSpain Institut d’InvestigacióBiomèdica de Bellvitge-IDIBELL L’Hospitalet de LlobregatSpain Departamento de Reproducción Animal Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA)MadridSpain Neurovascular Research Laboratory Vall d’Hebron Research Institute(VHIR)UABBarcelonaSpain Cardiology Service Germans Trias i Pujol University HospitalBadalonaSpain Department of Medicine UABBarcelonaSpain Nephrology Service Germans Trias i Pujol University HospitalBadalonaSpain Faculty of Medicine University of Vic-Central University of Catalonia(UVic-UCC)VicBarcelona08500Spain

The administration of extracellular vesicles(ev)from mesenchymal stromal cells(MSC)is a promising cell-free nanotherapy for tissue repair after myocardial infarction(MI).However,the optimal ev delivery strategy remains ***,we designed a novel MSC-ev delivery,using 3D scaffolds engineered from decellularised cardiac tissue as a cell-free product for cardiac *** from porcine cardiac adipose tissue-derived MSC(cATMSC)were purified by size exclusion chromatography(SEC),functionally analysed and loaded to ***-ev markedly reduced polyclonal proliferation and pro-inflammatory cytokines production(IFNγ,TNFα,IL12p40)of allogeneic ***,cATMSC-ev recruited outgrowth endothelial cells(OEC)and allogeneic MSC,and promoted *** labelled cATMSC-ev were mixed with peptide hydrogel,and were successfully retained in decellularised ***,cATMSC-ev-embedded pericardial scaffolds were administered in vivo over the ischemic myocardium in a pig model of *** days from implantation,the engineered scaffold efficiently integrated into the post-infarcted ***-ev were detected within the construct and MI core,and promoted an inc.ease in vascular density and reduction in macrophage and T cell infiltration within the damaged *** confined administration of multifunctional MSC-ev within an engineered pericardial scaffold ensures local ev dosage and release,and generates a vascularised bioactive niche for cell recruitment,engraftment and modulation of short-term post-ischemic inflammation.

关键词： Exosomes Mesenchymal stem/stromal cells Migration Infiltration Cardiac tissue engineering

Hydroxyprogesterone caproate for preterm birth:A situational analysis from the Indian perspective

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Gynecology and Obstetrics Clinical Medicine 2021年第3期1卷 144-147页

作者： Pugazhenthan Thangaraju Shoban Babu Varthya Prakash Srinivasan Timiri Shanmugam T.Y.Sree Sudha Chaitanya Mittal Department of Pharmacology All India Institute of Medical SciencesRaipurChhattisgarhIndia Department of Pharmacology All India Institute of Medical SciencesJodhpurRajasthanIndia Global Product Safety&Toxicology Avanos Medical IncAlpharettaGAUSA Forensic Toxicology All India Institute of Medical SciencesJodhpurRajasthanIndia

Background:Preterm birth can cause morbidity and mortality in addition to trauma or loss to the mother,and present a major financial burden to the *** risk may be minimized by timely ***:To understand the safety and efficacy of hydroxyprogesterone in decreasing the inc.dence of preterm birth,neonatal complications,and maternal mortality,based on evidence obtained from the Indian scientific ***:Relevant articles were searched for and retrieved from the databases PubMed,medrXiv,Embase,Cochrane,biorXiv,and ***:A total of 62 relevant articles were assessed,and of these,59 articles did not meet the eligibility *** total,3 articles which satisfied the criteria and 2 articles sourced from cross references were inc.uded in the *** these 5 articles,a total of 536 patients received hydroxyprogesterone caproate or placebo for preterm ***:In all five articles,recurrence rate of preterm birth was reduced in the treated group compared to control *** safety profile of progesterone tends to be better than that of the *** findings of our analysis of individual patient data(IPD)summarizes various clinical trial data,which can assure clinicians that vaginal progesterone administration is effective and well tolerated.

关键词： Preterm birth Hydroxyprogesterone India

重组sCR1对大鼠急性脊髓损伤组织免疫炎症反应的影响

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中华创伤骨科杂志 2005年第6期7卷 548-551,555页

作者：李良满朱悦范广宇 Henry Marsh 中国医科大学附属第一医院骨科 02494 USA Needham MAAVANT Im-munotherapeutics Inc

目的探讨重组可溶性补体受体Ⅰ型(sCR1)对大鼠急性脊髓损伤组织免疫炎症反应的影响及对脊髓损伤的保护作用。方法采用改良Allen重物打击法制成SD大鼠脊髓急性损伤模型,观察伤后12h、1d、3d、7d、14d时间点sCR1组与生理盐水(NS)组脊髓损... 详细信息

目的探讨重组可溶性补体受体Ⅰ型(sCR1)对大鼠急性脊髓损伤组织免疫炎症反应的影响及对脊髓损伤的保护作用。方法采用改良Allen重物打击法制成SD大鼠脊髓急性损伤模型,观察伤后12h、1d、3d、7d、14d时间点sCR1组与生理盐水(NS)组脊髓损伤组织中性粒细胞浸润程度及C3c的阳性表达,测定髓过氧化物酶(MPO)活性,并采用BBB评分法评定大鼠后肢运动功能。结果sCR1组在伤后各时间点C3c阳性表达均明显少于NS组,差异有极显著性意义(P<0.01);sCR1组在伤后各时间点损伤组织髓过氧化物酶(MPO)活性弱于NS组,差异有极显著性意义(P<0.01);sCR1组在伤后7、14d时间点大鼠后肢BBB评分明显优于NS组(P<0.05、P<0.01)。结论重组sCR1可通过抑制补体系统激活机制显著减轻急性脊髓损伤组织的免疫炎症反应,减轻继发性脊髓损伤。

关键词：脊髓损伤补体髓过氧化物酶可溶性补体受体Ⅰ型

Co-,Fe-,Ni-doped and co-doped rutile GeO_(2):insights from ab-initio calculations

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Communications in Theoretical Physics 2022年第4期74卷 113-126页

作者： R Essajai E Salmani M Bghour A Labrag F Goumrhar M Fahoume H Ez-Zahraouy Materials and Subatomic Physics Laboratory Faculty of SciencesIbn Tofail UniversityKenitraMorocco group of Semiconductors and Environmental Sensor Technologies-Energy Research Center Faculty of ScienceMohammed V UniversityB.P.1014RabatMorocco Laboratory of Condensed Matter and Interdisciplinary Sciences Department of PhysicsFaculty of SciencesMohammed V UniversityP.O.Box 1014RabatMorocco Equipe des Matériaux Supraconducteursàhaute température critique Department of PhysicsIbn Zohr UniversityFaculty of SciencesBP:8106AgadirMorocco Faculty of Applied Sciences Route Nationale N°10 citéAzrouAit MelloulIbn Zohr UniversityAit MelloulIbn Zohr UniversityMorocco Higher School of Education and Training of El Jadida(ESEF) Chouaib Doukkali UniversityEl Jadida 24000Morocco Laboratory of Physics of High Energy Modeling&Simulations(LPHE-MS)Faculty of SciencesMohammed V University of RabatIbn BatoutaB.P.1014 RabatMorocco Laboratoire des Sciences de l’Ingénieur pour l’Energie Ecole Nationale des Sciences Appliquées d’El Jadida(ENSA-J)BP 1166EL Jadida Plateau24002Morocco

Rutile germanium oxide(rutile GeO_(2)),a semiconductor,can act as a half-metallic compound and is a promising material for spintronic and optoelectronic *** were performed using the Korringa–Kohn–Rostoker(KKR)approach and the coherent potential approximation(CPA),which were further combined with two approximations,the local density approximation(LDA)and the self-interaction corrected LDA approximation(LDA-SIC),to study the electronic structure of bulk rutile GeO_(2) doped and co-doped with three transition-metal impurities:Fe,Co,and *** doping value was set to 10%,while the co-doping level was set to 5%for each *** main findings of this work are:(1)a direct ultrawide bandgap of4.80 ev is observed and the rutile GeO_(2) exhibits an N-type semiconducting property.(2)Doped and co-doped GeO_(2) acquire a magnetic behavior and exhibit half-metallicity.(3)The mechanism responsible for these properties is also studied.(4)The critical temperature can reach 334 K when GeO_(2) is doped with Fe,while it rises to 398 K when it is co-doped with Fe and Co.(5)The spin polarization can be improved by *** can be inferred that rutile GeO_(2) doped or codoped with(Co,Fe)transition metals can be considered to be potential candidates for spintronic and optoelectronic applications.

关键词： LDA approximation spintronic Curie temperature spin polarization LDA-SIC approximation rutile germanium oxide

A novel acquired EGFR-SEPT14 fusion confers differential drug resistance to EGFR inhibitors in lung adenocarcinoma

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Genes & Diseases 2023年第6期10卷 2241-2244页

作者： Weidong Wang Wang Lv Hui Wang Yang Xu Junrong Yan Han-Ming Shen Liqun Shan Jian Hu Department of Thoracic Surgery The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiang 310003China Department of Thoracic Surgery The First People's Hospital of WenlingWenlingZhejiang 317599China Medical Department Nanjing Geneseeq Technology IncNanjingJiangsu 210000China Department of Physiology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 119077Singapore Faculty of Health Sciences University of MacaoMacao SAR 519000China Department of Thoracic Surgery Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510060China

Around 10%-30%of non-small cell lung cancer(NSCLC)patients harbored epidermal growth factor receptor(EGFR)mutations,with L858R and exon-19 deletions(19-Del)accounting for 90%of *** tyrosine kinase inhibitors(TKls)showed significant efficacy against common EGFR ***,the therapeutic relevance of uncommon EGFR mutations remained insufficiently *** fusions are extremely rare(0.05%-0.13%)in NSCLC,and Konduri group reported only 5 EGFR fusions from 10,097 patients.i2Additional EGFR'fusions were reported in NSCLC,3,4 all of which were oncogenic drivers and sensitive to EGFR ***,we reported an NSCLC patient with leptomeningeal metastasis(LM)who acquired a novel EGFR-SEPT14 fusion during TKI resistance and showed promising responses to certain EGFR TKls and intrathecal pemetrexed(IP).

关键词： lung acquired adenocarcinoma