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Journal of Transportation Technologies 2013年第2期3卷 149-161页

作者： Christopher A. Bolin Stephen T. Smith AquAeTer Inc. Division of Sustainability Centennial USA AquAeTer Inc. Division of Sustainability Helena USA

Creosote-treated wooden railroad crossties have been used for more than a century to support steel rails and to transfer load from the rails to the underlying ballast while keeping the rails at the correct gauge. As transportation engineers look for improved service life and environmental performance in railway systems, alternatives to the creosote-treated wooden crosstie are being considered. This paper compares the cradle-to-grave environmental life cycle assessment (LCA) results of creosote-treated wooden railroad crossties with the primary alternative products: concrete and plastic composite (P/C) crossties. This LCA includes a life cycle inventory (LCI) to catalogue the input and output data from crosstie manufacture, service life, and disposition, and a life cycle impact assessment (LCIA) to evaluate greenhouse gas (GHG) emissions, fossil fuel and water use, and emissions with the potential to cause acidification, smog, ecotoxicity, and eutrophication. Comparisons of the products are made at a functional unit of 1.61 kilometers (1.0 mile) of rail-road track per year. This LCA finds that the manufacture, use, and disposition of creosote-treated wooden railroad crossties offers lower fossil fuel and water use and lesser environmental impacts than competing products manufactured of concrete and P/C.

关键词： Creosote Environmental Impact Railroad Crossties Life Cycle Assessment (LCA) Concrete Plastic Composite

TotalSeqTM, Standardized oligonucleotide barcode antibody conjugates for multiplex immunophenotyping by single cell sequencing

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Efficacy of nonsolvent flower pollen extracts in healthy women with urinary incontinence:A randomized,double-blind,placebo-controlled,parallel study

第十三届全国免疫学学术大会

作者： Chengrui Li Bertrand Yeung Kristopher Nazor Xinfang Zhao Xifeng Yang BioLegend Inc

The combination of next generation sequencing and protein expression profiling is a recent advance in single cell sequencing(scSeq) technologies. This advance will potentially transform how complex cell populations are studied, and accelerate precision medicine development. Published data, as well as our own studies, indicated that scSeq analysis on cell surface marker expression are comparable to multi-color flow cytometry, but provides superior capacity in multiplexing. To support these applications and enable reliable comparison of data across longitudinal or multi-site studies, we provide standardized oligonucleotide barcode-labeled antibodies. We assigned a unique oligo barcode to each monoclonal antibody, and prepared conjugates;we name it TotalSeq? product line. In addition, we attempted to assign/conjugate a series of oligonucleotide barcodes to select clones of antibodies specific to "universally" expressed cell surface molecules. These products, the Hashtags, can be used to label cells from different sources or experiments, in multiplex analysis. We will show data from our studies validating the application of these products.

关键词： TotalSeq? Single cell RNA sequencing immunophenotyping precision medicine

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Current Urology 2024年第3期18卷 203-211页

作者： Marc Moulin Erin D.Lewis David C.Crowley Colleen E.May Malkanthi Evans KGK Science inc. LondonOntarioCanada Graminex L.L.C.SaginawMIUSA

Background Urinary incontinence(UI)is a debilitating and common condition that adversely affects quality of *** and surgical approaches for managing UI symptoms may result in undesirable risks and *** randomized,double-blind,placebo-controlled,parallel study investigated the efficacy of 2 nonsolvent flower pollen extracts on UI in healthy *** and methods One-hundred and fourteen women aged 40–75 years who scored≥5 on the International Consultation on incontinence Questionnaire-Urinary incontinence Short Form(ICIQ-SF)were randomized to receive either Graminex®RCT Fem™UI,Graminex®PollenBerry®,or placebo for 24 *** primary outcome was the change in the ICIQ-SF score between the trial and placebo groups after 24 weeks of *** secondary outcomes included changes in the frequency of nocturia(recorded in 3-day void diaries)and 24-hour leakage volume(assessed via pad weight)after 6,12,18,and 24 weeks of supplementation and changes in stress-induced urinary leakage volume(after completion of a provocative maneuver challenge)after 24 weeks of *** All the groups demonstrated improvement in ICIQ-SF scores at week 24(pproducts demonstrated safe hematological and chemical *** RCT Fem™UI supplementation resulted in significant and clinically meaningful reductions in UI severity,with corresponding improvements in daily urinary leakage volume and frequency of ***®significantly improved stress-induced urinary leakage volume,suggesting that it may be eff

关键词： Urinary incontinence Pollen extract Healthy women Dietary supplement ICIQ-SF Urinary leakage

Antitumor Effects and Acute Oral Toxicity Studies of a Plant Extract Mixture Containing <i>Rhus verniciflua</i>and Some Other Herbs

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Open Journal of Immunology 2015年第1期5卷 39-49页

作者： Wataru Hiruma Kohei Suruga Kazunari Kadokura Tsuyoshi Tomita Ayaka Miyata Yoshihiro Sekino Masahiko Kimura Nobuo Yamaguchi Yasuhiro Komatsu C. A. Tony Buffington Nobufumi Ono International Operation Department (FM Center for R & D) Kibun Foods Inc. Tokyo Japan Faculty of Pharmaceutical Sciences Fukuoka University Fukuoka Japan Ishikawa Natural Medicinal products Research Center Ishikawa Japan Department of Fundamental Research for CAM Kanazawa Medical University Ishikawa Japan Kitasato Institution for Life Science Kitasato University Tokyo Japan Sun R & D Institute for Natural Medicines Co. inc. Tokyo Japan Department of Veterinary Clinical Sciences The Ohio State University College of Veterinary Medicine Columbus USA

A novel antitumor agent was developed from six kinds of herbs containing Rhus verniciflua (Rv-PEM01). The components were traditionally established for each formula for traditional medicine. The formula was designed to affect antitumor effect as well as maintain host immune functions. First, we investigated the antiproliferative activities of Rv-PEM01 on human and canine tumor cell lines in vitro, and on antitumor effects using BALB/cAJcl-nu/nu mice in vivo. Acute oral toxicity of Rv-PEM01 was also investigated in vivo in ddY mice. Rv-PEM01 exhibited antiproliferative activities against PC-3 (IC50: 0.328 ± 0.081 mg/ml), A549 (IC50: 0.520 ± 0.070 mg/ml), D-17 (IC50: 0.124 ± 0.037 mg/ml) and MRC-5 (IC50: 0.505 ± 0.058 mg/ml) cells. Luteolin 7-β-D-glucopyranoside and apigenin 7-β-D-glucopyranoside were identified as the main active compounds in Rv-PEM01 by HPLC analysis. The single dose toxicity study of Rv-PEM01 did not result in any deaths or abnor-malities in daily behavior, body weight gain, or anatomical observations at necropsy. Thus, so we could not calculate the 50% lethal dose (LD50) in mice, but it would be higher than 5.0 g/kg. Treat- ment with Rv-PEM01 at a dose of 2.5 g/kg tended to show antitumor activities on mice bearing Colon26 tumors compared with the control group. It was concluded that the formula was a safe antitumor agent with no side effects on mouse physiological function as judged by survival and organ weight.

关键词： Rhus verniciflua Antitumor Antiproliferation Acute Toxicity

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北美钢铁工业结构调整和最优化

钢铁 1998年第11期33卷 73-77页

作者： John H Goodish (USX Engineers & Consultants,inc ) USX Engineers & Consultants inc

８０年代初，北美钢铁公司为了生存，关闭了许多设施，解雇了成千上万的职工，产品大纲也精简为只生产薄板、镀锡板、中厚板和管材。ＵＳＳｔｅｅｌ现年产１２Ｍｔ粗钢，雇员有１．９万人。新的预测预防性维修大纲起名为ＡＭＥＸ（所有... 详细信息

８０年代初，北美钢铁公司为了生存，关闭了许多设施，解雇了成千上万的职工，产品大纲也精简为只生产薄板、镀锡板、中厚板和管材。ＵＳＳｔｅｅｌ现年产１２Ｍｔ粗钢，雇员有１．９万人。新的预测预防性维修大纲起名为ＡＭＥＸ（所有的维修最佳化）。并投资建立了新的设施，尤其是连铸机及满足环保法规要求的设施。实施ＡＰＥＸ（所有人员，所有过程，所有产品都达优秀）以提高品质。所有分厂都有ＩＳＯ９０００证书。降低成本大纲所采取的措施为改组、岗位组合、改变操作功能及合同服务。取得成功的最重要因素是其雇员的献身精神，努力实现能满足竞争性很强的市场所提出的要求的措施。在发展事业的同时，注视着在世界各地建立合资企业、战略伙伴关系及其它合作形式的机会，提高其在工业中的地位。

关键词：钢铁工业结构调整北美洲

SEGMENT SELECTION IN THE L＆H REALSPEAK LABORATORY TTS SYSTEM

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SEGMENT SELECTION IN THE L＆H REALSPEAK LABORATORY TTS SYSTE...

Preclinical study of a self-expanding pulmonary valve for the treatment of pulmonary valve disease

6～(th) International Conference on Spoken Language Processing

作者： GeertCoorman JustinFackrell PeterRutten BertVanCoile Lernout ＆ Hauspie Speech products NV Flanders Language Valley 50B-8900 leperBelgium geert.coorman justin. fackrell peter. rutten bert. vancoile Lernout ＆ Hauspie Speech products NV Flanders Language Valley 50B-8900 leperBelgium geert.coorman justin. fackrell peter. rutten bert. vancoile Lernout ＆ Hauspie Speech products NV Flanders Language Valley 50B-8900 leperBelgium geert.coorman justin. fackrell peter. rutten bert. vancoile Lernout ＆ Hauspie Speech products NV Flanders Language Valley 50B-8900 leperBelgium geert.coorman justin. fackrell peter. rutten bert. vancoile

＜正＞The L＆H RealSpeak Laboratory TFS （RSLab） system is a corpus based speech synthesis system comprising components that deal with linguistic processing, prosody prediction, segment selection, concatenation and modification. In this paper we focus on the segment selection process. During segment selection, the units in a large database of speech are scored with a cost according to their prosodic/phonetic mismatch with the target description of the utterance to be synthesized. This prosodic/phonetic cost is computed on the basis of a combination of symbolic and numeric features. The candidate units from the speech database are then evaluated for the ease with which they can be concatenated. A dynamic programming algorithm, using additive costs, is used to find the optimal path of candidates to represent the spoken utterance. Fhe chosen segments are then concatenated in the time domain to yield a smooth-sounding speech signal, with natural-sounding prosody. One of the keys to the success of the segment selection component is the context dependent choice of cost functions, and the method of combining the costs from the various features. The RSLab system makes use of a family of complex cost functions that allows linguistic and perceptual knowledge to be incorporated in the segment selection process.

关键词：

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Regenerative Biomaterials 2020年第6期7卷 609-618页

作者： Dajun Kuang Yang Lei Li Yang Yunbing Wang National Engineering Research Center for Biomaterials Sichuan UniversityNo 29 Wangjiang RoadChengdu 610064China Venus Medtech(Hangzhou)inc. 88 Jiangling RoadHangzhou 311053China

In the past decade,balloon-expandable percutaneous pulmonary valves have been developed and applied in clinical ***,all the existing products of pulmonary artery interventional valves in the market have a straight structure design,and they require a preset support frame and balloon *** shape design of the valve limits the application *** addition,the age of the population with pulmonary artery disease is generally low,and the existing products cannot meet the needs of anti-calcification properties and valve material *** this study,through optimization of the support frame and leaflet design,a self-expanding pulmonary valve product with a double bell-shaped frame was designed to improve the match of the valve and the implantation site.A loading and deployment study showed that the biomaterial of the valve was not damaged after being *** flow and fatigue in vitro tests showed that the fabricated pulmonary valve met the hydrodynamic requirements after 2108 accelerated fatigue *** safety and efficacy of the pulmonary valve product were demonstrated in studies of pulmonary valve implantation in 11 *** and echocardiography showed that the pulmonary valves were implanted in a good position,and they had normal closure and acceptable valvular *** 180 days’implantation results showed that the calcium content was 0.31-1.39 mg/g in the anti-calcification treatment group,which was significantly lower than that in the control valve without anti-calcification treatment(16.69 mg/g).Our new interventional pulmonary valve product was ready for clinical trials and product registration.

关键词： pulmonary valve self-expanding double bell-shaped anti-calcification preclinical

大型粉末冶金/热等静压(PM HIP)产品:一个增长有望的产业

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粉末冶金技术 2015年第1期33卷 64-71页

作者： Stephen J Mashl Z-Met Inc. USA Dr

用热等静压能生产出用任何其他工艺无法生产的大型粉末冶金产品,大型的HIP(热等静压)装置能制造非常大的零件。大型粉末冶金/热等静压产品(以下简称PM HIP)装置为产业带来了新的机会。ZMet inc的Dr Stephen J Mashl在为Powder Metallurg... 详细信息

用热等静压能生产出用任何其他工艺无法生产的大型粉末冶金产品,大型的HIP(热等静压)装置能制造非常大的零件。大型粉末冶金/热等静压产品(以下简称PM HIP)装置为产业带来了新的机会。ZMet inc的Dr Stephen J Mashl在为Powder Metallurgy Review撰写的这篇独家报告中,概述了HIP装置的发展,并估计了大型粉末冶金产品的生产潜力。

关键词：大型粉末冶金产品热等静压 PM HIP 粉末冶金/热等静压

Practical Considerations for Implementing Adaptive Acoustic Noise Cancellation in Commercial Earbuds

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Journal of Electronic & Information Systems 2023年第2期5卷 25-34页

作者： Agustinus Oey VizWave inc. Seongnam13595Korea

Active noise cancellation has become a prominent feature in contemporary in-ear personal audio ***,due to constraints related to component arrangement,power consumption,and manufacturing costs,most commercial products utilize fixed-type controller systems as the basis for their active noise control *** systems offer robust performance and a straightforward structure,which is achievable with cost-effective digital signal ***,a major drawback of fixed-type controllers is their inability to adapt to changes in acoustic transfer paths,such as variations in earpiece fitting ***,adaptive-type active noise control systems that employ adaptive digital filters are considered as the *** address the increasing system complexity,design concepts and implementation strategies are discussed with respect to actual hardware *** illustrate these considerations,a case study showcasing the implementation of a filtered-x least mean square-based active noise control algorithm is presented.A commercial evaluation board accommodating a low-cost,fixed-point digital signal processor is used to simplify operation and provide programming *** earbuds are obtained from a commercial product designed for noise *** study underscores the importance of addressing hardware constraints when implementing adaptive active noise cancellation,providing valuable insights for real-world applications.

关键词： Active noise cancellation Adaptive filter DSP implementation

Processing, Recovery and Analysis of Precious Metals Using Molecular Recogntion Technology

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贵金属 2012年第A01期33卷 88-95页

作者： IZATT Steven R. BRUENING Ronald L. IZATT Nell E. IBC Advanced Technologies Inc.856 East Utah Valley DriveAmerican ForkUT 84003USA

IBC Advanced Technologies' Molecular Recognition Technology(MRT) products,trade named SuperLig,selectively and rapidly bind with target metal ions to remove them from *** MRT process can produce a high purity separation product of maximum added value at low *** this paper,applications of MRT in the precious metals industry,including selective commercial separations involving Au,Pd,Pt,Rh,and Ru,are described and *** of MRT to the analytical determination of precious metals is *** use of MRT in recovering precious metals from end-of-life(EOL) products is discussed.

关键词： selective metal separations molecular recognition technology metal recovery from waste electronics palladium platinum rhodium ruthenium gold analytical determinations