检索结果-南通市图书馆

Long-term outcomes following drug-eluting stent implantation in unprotected left main bifurcation lesions

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2007年第7期120卷 545-551页

作者： GE Lei John Cosgrave Ioannis Iakovou QIAN Ju-ying Pierfrancesco Agostoni Giuseppe M. Sangiorgi Flavio Airoldi Iassen Michev Alaide Chieffo Nicola Corvaja Antonio Colombo GE Jun-bo Department of Cardiology Zhongshan Hospital Fudan University Shanghai Institute of Cardiovascular Diseases Shanghai 200032 China emo centro cuore columbus and San Raffaele Hospital Milan Italy

Background The safety and efficacy of drug-eluting stents （DES） implantation in unprotected left main （LM） bifurcation lesions has yet to be determined. The aim of the present report was to evaluate the long-term outcome following implantation of DES in unprotected LM bifurcation lesions.Methods We identified 70 consecutive patients treated with DES in unprotected LM bifurcation lesions from April 2003 to January 2005. Of them, 42 patients were treated with sirolimus-eluting stent （SES） and 28 patients were treated with paclitaxel-eluting stent （PES）. Results Stents to the left anterior descending and to the circumflex were implanted in 62 patients. During 1-year follow-up, 3 （4.3%） patients died of cardiac causes. One of them had myocardial infarction and adjudicated as possibly due to stent thrombosis. Angiographic follow-up was available in 80% of patients. The per lesion restenosis rate was 13.4% in the entire cohort, of which 10.7% occurred in lesions treated with SES and 16.1% in those treated with PES （P=0.58）. All restenosis was focal and occurred in the lesions treated with a stent with stent size to post-procedural reference vessel diameter ratio 〈1.0 （17.6% vs 0, P=0.04）. The per patient target lesion revascularization rate at 1 year was 17.1%. One year survival free from major adverse cardiac events was 77.1%. Conclusions Treatment of LM bifurcation lesions using DES is a safe and feasible way with a low one-year mortality. The need for revascularization in 17% of patients demands for improvement.

关键词： stents revascularization restenosis thrombosis

在线全文

学校读者我要写书评

暂无评论

西罗莫司洗脱支架置入后的晚期再狭窄

世界核心医学期刊文摘（心脏病学分册） 2007年第11期3卷 27-28页

作者： Cosgrave J. Corbett S.J. Melzi G. 奚群英 emo centro cuore columbus Milan Italy

虽然西罗莫司洗脱支架置入的一些随机试验结果令人鼓舞,但其远期结果仍受到关注。为明确西罗莫司洗脱支架置入1年之后(晚期)发生的支架内再狭窄是否是实际存在的临床问题,作者分析了2003年3月前所有在本机构置入西罗莫司洗脱支架的相关... 详细信息

虽然西罗莫司洗脱支架置入的一些随机试验结果令人鼓舞,但其远期结果仍受到关注。为明确西罗莫司洗脱支架置入1年之后(晚期)发生的支架内再狭窄是否是实际存在的临床问题,作者分析了2003年3月前所有在本机构置入西罗莫司洗脱支架的相关资料。在此研究阶段中,共433例患者的928处病变接受了治疗。

关键词：西罗莫司洗脱支架再狭窄置入

成功置入药物洗脱支架后血栓形成的发生率、预测因素和预后

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（心脏病学分册） 2005年第10期1卷 25-26页

作者： Iakovou I. Schmidt T. Bonizzoni E. A. Colombo 任付先 emo centro cuore columbus 48 Via M Buonarroti 20145 Milan Italy

Traditionally, stent thrombosis has been regarded as a complication of percutaneous coronary interventions during the first 30 postprocedural days. However, delayed endothelialization associated with the implantation of drug-eluting stents may extend the risk of thrombosis beyond 30 days. Data are limited regarding the risks and the impact of this phenomenon outside clinical trials. Abstract: To evaluate the incidence, predictors, and clinical outcome of stent thrombosis after implantation of sirolimus-eluting and paclitaxel-eluting stents in routine clinical practice. Design, Setting, and Patients: Prospective observational cohort study conducted at 1 academic hospital and 2 community hospitals in Germany and Italy. A total of 2229 consecutive patients underwent successful implantation of sirolimus-eluting(1062 patients, 1996 lesions, 2272 stents) or paclitaxel-eluting(1167 patients, 1801 lesions, 2223 stents) stents between April 2002 and January 2004. Interventions: Implantation of a drug-eluting stent(sirolimus or paclitaxel). All patients were pretreated with ticlopidine or clopidogrel and aspirin. Aspirin was continued indefinitely and clopidogrel or ticlopidine for at least 3 months after sirolimus-eluting and for at least 6 months after paclitaxeleluting stent implantation. Main Outcome Measures: Subacute thrombosis(from procedure end through 30 days), late thrombosis( >30 days), and cumulative stent thrombosis. Results: At 9- month follow-up, 29 patients(1.3% ) had stent thrombosis(9[0.8% ] with sirolimus and 20[1.7% ] with paclitaxel; P=.09). Fourteen patients had subacute thrombosis(0.6% ) and 15 patients had late thrombosis(0.7% ). Among these 29 patients, 13 died(case fatality rate, 45% ). Independent predictors of stent thrombosis were premature antiplatelet therapy discontinuation(hazard ratio[HR], 89.78; 95% CI, 29.90- 269.60; P< .001), renal failure(HR, 6.49; 95% CI, 2.60- 16.15; P< .001), bifurcation lesions(HR, 6.42; 95% CI, 2.93- 14.07; P< .001),

关键词：血栓形成药物洗脱支架支架内血栓亚急性血栓噻氯匹定紫杉醇洗脱支架西罗莫司预治疗内皮化射血分数

药物洗脱支架置入后再狭窄的类型:对西罗莫司和紫杉醇洗脱支架同期比较分析的认识

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（心脏病学分册） 2007年第3期3卷 49-50页

作者： Corbett S.J. Cosgrave J. Melzi G. A. Colombo 刘少伟 emo centro cuore columbus 48 Via M. Buonarroti 20145 Milan Italy

目的:评价在未经选择的可比性病变部位置入西罗莫司洗脱支架(SES)和紫杉醇洗脱支架(PES)后的再狭窄类型。方法和结果:对2003年3月至2005年3月间在本机构置入SES或PES后发生的所有再狭窄事件进行鉴定。

关键词：西罗莫司紫杉醇洗脱支架再狭窄局灶型可比性狭窄部位近端增生型弥散型多变量分析

Role of nutraceuticals during the transition period of dairy cows: a review

在线全文

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2021年第1期12卷 64-81页

作者： Vincenzo Lopreiato Matteo Mezzetti Luca Cattaneo Giulia Ferronato Andrea Minuti Erminio Trevisi Department of Animal Sciences Food and NutritionFaculty of AgricultureFood and Environmental ScienceUniversitàCattolica del Sacro Cuore29122 PiacenzaItaly PRONUTRIGEN-centro di Ricerca Nutrigenomica e Proteomica UniversitàCattolica del Sacro CuorePiacenzaItaly

The transition period of dairy cattle is characterized by a number of metabolic, endocrine, physiologic, and immune adaptations, including the occurrence of negative energy balance, hypocalcemia, liver dysfunction, overt systemic inflammatory response, and oxidative stress status. The degree and length of time during which these systems remain out of balance could render cows more susceptible to disease, poor reproductive outcomes, and less efficient for milk production and quality. Studies on both monogastrics and ruminants have reported the health benefits of nutraceuticals(e.g. probiotics, prebiotics, dietary lipids, functional peptides, phytoextracts) beyond nutritional value, interacting at different levels of the animal's physiology. From a physiological standpoint, it seems unrealistic to disregard any systemic inflammatory processes. However, an alternate approach is to modulate the inflammatory process per se and to resolve the systemic response as quickly as *** this aim, a growing body of literature underscores the efficacy of nutraceuticals(active compounds) during the critical phase of the transition period. Supplementation of essential fatty acids throughout a 2-month period(i.e. a month before and a month after calving) successfully attenuates the inflammatory status with a quicker resolution of phenomenon. In this context, the inflammatory and immune response scenario has been recognized to be targeted by the beneficial effect of methyl donors, such as methionine and choline, directly and indirectly modulating such response with the increase of antioxidants GSH and taurine. Indirectly by the establishment of a healthy gastrointestinal tract, yeast and yeast-based products showed to modulate the immune response, mitigating negative effects associated with parturition stress and consequent *** use of phytoproducts has garnered high interest because of their wide range of actions on multiple tissue targets encompassing a series of anti

关键词： Dairy cow Essential fatty acid Immunometabolism Methyl donor Nutraceuticals Nutrition Peripartum Phytoproduct Yeast culture

Cell fusion in the liver, revisited

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2018年第2期10卷 213-221页

作者： Michela Lizier Alessandra Castelli Cristina Montagna Franco Lucchini Paolo Vezzoni Francesca Faggioli Istituto di Ricerca Genetica e Biomedica CNR Human Genome Laboratory Humanitas Clinical and Research Center IRCCS Department of Genetics and Pathology Genetics Albert Einstein College of Medicine centro Ricerche Biotecnologiche Università Cattolica del Sacro Cuore

There is wide agreement that cell fusion is a physiological process in cells in mammalian bone, muscle and placenta. In other organs, such as the cerebellum, cell fusion is controversial. The liver contains a considerable number of polyploid cells: They are commonly believed to originate by genome endoreplication, although the contribution of cell fusion to polyploidization has not been excluded. Here, we address the topic of cell fusion in the liver from a historical point of view. We discuss experimental evidence clearly supporting the hypothesis that cell fusion occurs in the liver, specifically when bone marrow cells were injected into mice and shown to rescue genetic hepatic degenerative defects. Those experiments-carried out in the latter half of the last century-were initially interpreted to show "transdifferentiation", but are now believed to demonstrate fusion between donor macrophages and host hepatocytes, raising the possibility that physiologically polyploid cells, such as hepatocytes, could originate, at least partially, through homotypic cell fusion. In support of the homotypic cell fusion hypothesis, we present new data generated using a chimera-based model, a much simpler model than those previously used. Cell fusion as a road to polyploidization in the liver has not been extensively investigated, and its contribution to a variety of conditions, such as viral infections, carcinogenesis and aging, remains unclear.

关键词： Cell fusion Hepatocytes TdTomato Lineage tracing Chimeras Extracellular vesicles

西罗莫司洗脱支架和紫杉醇洗脱支架对多支冠状动脉病变支架置入的糖尿病患者预后的影响

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（心脏病学分册） 2006年第12期2卷 21-页

作者： Stankovic G. Cosgrave J. Chieffo A. A. Colombo 王亭忠 emo centro cuore columbus Milan Italy Dr.

Randomized trials have shown that implantation of sirolimus-eluting stents(SESs) and paclitaxel-eluting stents(PESs) reduce the incidence of major adverse cardiac events(MACEs) compared with bare metal stents. We compared the impact of SESs and PESs on clinical outcome in medically treated diabetic patients with multivessel stents. In this study, the in-hospital and 9-month clinical outcomes of 260 consecutive diabetic patients who underwent implantation of SESs(147 patients) or PESs(113 patients) were compared. MACEs were defined as death, nonfatal myocardial infarction, and clinically driven target vessel revascularization. The baseline demographic and angiographic characteristics were well matched. An average of 3.0±1.3 versus 2.8±1.2 lesions were treated in the SES and PES groups, respectively(p=0.34), with a mean stented length per patient of 73±43 versus 61±36 mm(p=0.08). No significant difference was observed between the SES and PES groups for in-hospital(6.1%vs 3.5%, p=0.34) or 9-month MACE(24.5%vs 19.5%, p=0.34) rates or for subacute(1.4%vs 0.9%, p=0.72) or late(0.7%vs 0.9%, p=0.85)stent thrombosis. Insulin-requiring diabetic patients treated with SESs and PESs also had similar demographic and angiographic characteristics and rates of in-hospital(4.7%vs 7.7%, p=0.57) and 9-month(28.0%vs 38.4%, p=0.44) MACEs. Insulin-dependent diabetes was the only independent predictor of MACEs(odds ratio 2.68, 95%confidence interval 1.46 to 4.89, p=0.001). In conclusion, our results demonstrated a relatively high incidence of MACEs in a diabetic population with multivessel disease, despite treatment with drug-eluting stents. In addition, we could not find any clear advantage of 1 type of stent versus the other.

关键词：冠状动脉病变紫杉醇洗脱支架西罗莫司洗脱支架糖尿病患者支架置入

紫杉醇洗脱支架置入后应用阿司匹林辅以噻氯匹啶与氯吡格雷的比较:TRUE(Taxus紫杉醇洗脱支架实际应用评价)研究结果

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（心脏病学分册） 2006年第8期2卷 57-57页

作者： Biondi-Zoccai G.G.L. Agostoni P. Sangiorgi G.M. A. Colombo 郭俊 emo centro cuore columbus Via Buonarroti 48 20145 Milan Italy

Thienopyridines and aspirin are beneficial in patients undergoing bare-metal stent implantation, and aspirin and clopidogrel treatment have also been proved effective after drug-eluting stent(DES) implantation. However, despite the common substitution of clopidogrel with ticlopidine because of cost or patient intolerance, there are no data on the comparison of ticlopidine vs. clopidogrel after DES implantation. We hereby compare ticlopidine vs. clopidogrel after paclitaxel-eluting stent implantation in subjects enrolled in the prospective multicenter Taxus in Real-life Usage Evaluation(TRUE) Study. Across the 505 analyzed patients(112 treated with ticlopidine and 393 with clopidogrel), similar rates of early and mid-term(7 months) adverse thrombotic events were found with either antiplatelet regimen, with the notable exception of 2 cases of late stent thrombosis in patients who had prematurely withdrawn ticlopidine treatment just 3 months after the procedure. These findings thus support the overall safety and effectiveness of ticlopidine after DES implantation, and also confirm the increased risk of late thrombosis when premature withdrawal of thienopyridines occurs.

关键词：药物洗脱支架噻氯匹啶氯吡格雷阿司匹林紫杉醇噻吩并吡啶金属支架置入有效治疗

雷帕霉素药物洗脱支架在冠状动脉分叉病变中的应用:一年随访结果

在线全文

学校读者我要写书评

暂无评论

雷帕霉素药物洗脱支架在冠状动脉分叉病变中的应用:一年随访结果