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Optogenetic neuroregeneration

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Neural Regeneration Research 2022年第7期17卷 1468-1470页

作者： Harald Janovjak Sonja Kleinlogel embl Australia Australian Regenerative Medicine InstituteFaculty of MedicineNursing and Health SciencesMonash UniversityClayton/MelbourneAustralia Institute of Physiology University of BernBernSwitzerland

Optogenetics is a powerful technology that employs light and genetics to manipulate physiology and behavior with unprecedented *** high acuity of light stimulation permits fine control both in space(e.g.,to target just one tissue in an animal)and in time(e.g.,to interfere with a specific disease stage),whilst genetic targeting restricts manipulation to a functionally-relevant cell population(Figure 1A).

关键词： stimulation manipulation Figure

Improvement of polyploidy induction in Eriocheir sinensis

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Acta Oceanologica Sinica 2004年第4期23卷 725-732页

作者： CUIZhaoxia XIANGJianhai ZHOULinghua CAINaner SONGLinsheng embl InstituteofOceanologyChineseAcademyofSciencesQingdao266071China

An incubating temperature of 15 C is used to induce triploidy in Eriocheir sinensis through inhibition of the releaseof polar body II, and that of 18 C to induce tetraploidy through inhibition of the first cleavage. Flow cytometry isused to identify the ploidy in different developmental stages. For induction of triploidy in fertilized eggs in vitro, thehighest induction rate observed in blastula by cytochalasin B, 6-DMAP and KCl is 49.1%, 51.7% and 77.5%,respectively. In the KCl treatment of pregnant crabs with the fertilized eggs, the highest triploid induction rateobserved in the zoea is 85.3%. For induction of tetraploidy, the highest induction rate observed in the blastula bycytochaslasin B, 6-DMAP and KCl is 50.3%, 54.9% and 79.8% respectively. In the KCl treatment of pregnant crabswith the fertilized eggs, the highest induction rate in zoea is 27.3%. Through this study such difficulty as in vitroculture is overcome. Triploid zoea Eriocheir sinensis has been developed for the first time. The induction rate oftetraploid zoea has also been greatly improved.

关键词： Eriocheir sinensis triploid tetraploid zoea

Broader pattern of tandem repeats in the mitochondrial control region of Perciformes

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Chinese Journal of Oceanology and Limnology 2010年第4期28卷 785-794页

作者：崔朝霞刘媛朱嘉濠 embl Institute of OceanologyChinese Academy of Sciences Graduate University of the Chinese Academy of Sciences Department of Biology Chinese University of Hong Kong

Perciformes,the largest order of vertebrates with 20 suborders,is the most diverse fish order that dominates vertebrate ocean *** complete mitochondrial control region(CR) of Trichiurus japonicus(Trichiuridae,Scombroidei) and Pampus sp.(Stromateidae,Stromateoidei) were amplified and *** with data from GenBank,the tandem repeats in the mitochondrial CR from 48 species,which covered nine suborders of Perciformes,are reported in this *** tandem repeats tend to be long in the suborder Percoidei and *** identical repeats in 21 species of Cichlidae suggest a common origin and have existed before species *** crocea shows tandem repeats instead of the typical structure of the central conserved sequence blocks,which was first reported in Perciformes and *** might have resulted from interruption of the polymerase activity during the H-strand *** four broader patterns presented here for the tandem repeats,including those in both the 5' and 3' ends,only in the either 5' or 3' end,and in the central conserved domain of the control region,will be useful for understanding the evolution of species.

关键词：串联重复序列线粒体控制区鲈形目线粒体DNA控制区 GenBank 脊椎动物物种分化典型结构

Neurotrophins and their receptors in satellite glial cells following nerve injury

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Neural Regeneration Research 2014年第23期9卷 2038-2039页

作者： Christian Bjerggaard Vaegter Danish Research Institute of Translational Neuroscience DANDRITE Nordic EMBL Partnership and The Lundbeck Foundation Research Center MIND Department of Biomedicine Aarhus University

Peripheral neuropathy is a condition where damage resulting from mechanical or pathological mechanisms is inflicted on nerves within the peripheral nervous system （PNS）. Physical injury is the most common cause and may result in nerves being partially or completely severed, crushed, compressed or stretched. Other causes include metabolic or endocrine disorders, with e.g.,

关键词： cell NGF SGC Neurotrophins and their receptors in satellite glial cells following nerve injury

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好消息的传递者

科学新闻 2022年第2期 59-60页

作者： Romaric Bouveret 倪伟波新南威尔士大学embl

“夏天快到了，我和伴侣设法种出了这种散发着美妙香味的玫瑰。”在每周与研究中心的成员分享好消息的电子邮件中，附着一张美丽的橘黄色花朵照片。一年前，像这样的话语可能会被认为是无关紧要的，与重要的科学工作无关。但在2020年的...

“夏天快到了，我和伴侣设法种出了这种散发着美妙香味的玫瑰。”在每周与研究中心的成员分享好消息的电子邮件中，附着一张美丽的橘黄色花朵照片。一年前，像这样的话语可能会被认为是无关紧要的，与重要的科学工作无关。但在2020年的困难中，情况远非如此。它让我脸上露出了笑容，希望我的同事也能如此。它有助于建立人际关系，它提醒我们，即使在2020年，好事还是发生了。

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3D SURFACE STRUCTURE DETERMINATION BY X-RAY DIFFRACTION

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3D SURFACE STRUCTURE DETERMINATION BY X-RAY DIFFRACTION

Crystal polymorphism as a key to structure determination of E. coli Hfq riboregulator

Sixteenth Congress of the International Union of Crystallography

作者： R.G.van Silfhout embl c/o DESYHamburgGermany

＜正＞For many years X-ray diffraction has been a standard technique to determine the atomic structure of bulk *** application to the study of surfaces is more recent and became possible with the availability of synchrotron radiation *** object of most experimental surface X-ray diffraction work performed so far was to figure out the in-plane（2D） structure of surfaces using a

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Crystal polymorphism as a key to structure determination of ...

Database Commons:A Catalog of Worldwide Biological Databases

10～(th) International Conference on the Crystallization of Biological Macromlecules

作者： Sauter C. Basquin J. Suck D. UPR 9002-IBMC-CNRS 15 rue DescartesF-67084 StrasbourgFrance embl Meyerhofstrasse 1D-69117 HeidelbergGermany embl Meyerhofstrasse 1D-69117 HeidelbergGermany

＜正＞ In the course of structural studies, the availability of several crystal forms can be a decisive advantage when looking for heavy atom derivatives or for molecular replacement solutions. Nowadays, miniaturisation of crystallization methods allows extensive screening in order to identify growth conditions of crystal polymorphs.

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Genomics, Proteomics & Bioinformatics 2023年第5期21卷 1054-1058页

作者： Lina Ma Dong Zou Lin Liu Huma Shireen Amir AAbbasi Alex Bateman Jingfa Xiao Wenming Zhao Yiming Bao Zhang Zhang National Genomics Data Center Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China National Center for Bioinformatics Programme of Comparative and Evolutionary GenomicsFaculty of Biological SciencesQuaid-i-Azam UniversityIslamabad 45320Pakistan European Molecular Biology Laboratory European Bioinformatics Institute(EMBL-EBI)HinxtonCambridge CB101SDUnited Kingdom

Biological databases serve as a global fundamental infrastructure for the worldwide scientific community,which dramatically aid the transformation of big data into knowledge discovery and drive significant innovations in a wide range of research *** the rapid data production,biological databases continue to increase in size and *** build a catalog of worldwide biological databases,we curate a total of 5825 biological databases from 8931 publications,which are geographically distributed in 72 countries/regions and developed by 1975 institutions(as of September 20,2022).We further devise a z-index,a novel index to characterize the scientific impact of a database,and rank all these biological databases as well as their hosting institutions and countries in terms of citation and ***,we present a series of statistics and trends of worldwide biological databases,yielding a global perspective to better understand their status and impact for life and health *** up-to-date catalog of worldwide biological databases,as well as their curated meta-information and derived statistics,is publicly available at Database Commons(https://***/databasecommons/).

关键词： Biological database Catalog Database Commons Citation z-index

Defects and asymmetries in the visual pathway of non-human primates with natural strabismus and amblyopia

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Zoological Research 2023年第1期44卷 153-168页

作者： Feng Liu Zhong-Hao Wang Wanjing Huang Ying Xu Xuan Sang Ruifeng Liu Zhou-Yue Li Ya-Lan Bi Lei Tang Jing-Yi Peng Jia-Ru Wei Zhi-Chao Miao Jian-Hua Yan Sheng Liu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-Sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhouGuangdong 510060China Guangdong-Hongkong-Macao Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong 510632China European Molecular Biology Laboratory European Bioinformatics Institute(EMBL-EBI)Wellcome Genome CampusCambridge CB101SDUK Translational Research Institute of Brain and Brain-Like Intelligence and Department of Anesthesiology Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200081China Guangdong Province Key Laboratory of Brain Function and Disease GuangzhouGuangdong 510080China

Strabismus and amblyopia are common ophthalmologic developmental diseases caused by abnormal visual experiences. However, the underlying pathogenesis and visual defects are still not fully understood. Most studies have used experimental interference to establish diseaseassociated animal models, while ignoring the natural pathophysiological mechanisms. This study was designed to investigate whether natural strabismus and amblyopia are associated with abnormal neurological defects. We screened one natural strabismic monkey(Macaca fascicularis) and one natural amblyopic monkey from hundreds of monkeys, and retrospectively analyzed one human strabismus case. Neuroimaging, behavioral,neurophysiological, neurostructural, and genovariation features were systematically evaluated using magnetic resonance imaging(MRI), behavioral tasks, flash visual evoked potentials(FVEP),electroretinogram(ERG), optical coherence tomography(OCT), and whole-genome sequencing(WGS), respectively. Results showed that the strabismic patient and natural strabismic and amblyopic monkeys exhibited similar abnormal asymmetries in brain structure, i.e., ipsilateral impaired right hemisphere. Visual behavior, visual function, retinal structure, and fundus of the monkeys were impaired. Aberrant asymmetry in binocular visual function and structure between the strabismic and amblyopic monkeys was closely related, with greater impairment of the left visual *** similar known mutant genes for strabismus and amblyopia were also identified. In conclusion,natural strabismus and amblyopia are accompanied by abnormal asymmetries of the visual system,especially visual neurophysiological and neurostructural defects. Our results suggest that future therapeutic and mechanistic studies should consider defects and asymmetries throughout the entire visual system.

关键词： Non-human primates Natural disease models Strabismic patients Strabismus Amblyopia