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Selective laser trabeculoplasty in pseudophakic and phakic eyes:a prospective study

International Journal of Ophthalmology(English edition) 2017年第4期10卷 593-598页

作者： Myrjam De Keyser Maya De Belder Veva De Groot Department of Medicine University of Antwerp Universiteitsplein Antwerp B-2610 Belgium Department of Experimental Psychology Faculty of Psychology and Education Ghent University Henri DunantlaanGhent B-9000 Belgium Department of Ophthalmology Antwerp University HospitalWilrijkstraat Edegem B-2650 Belgium

AIM：To compare the efficacy of selective laser trabeculoplasty（SLT） in replacing medical therapy in pseudophakic and phakic ***：Subgroup of a prospective randomized clinical trial including patients with primary open angle glaucoma or ocular hypertension controlled with *** 38 pseudophakic eyes were matched with 38 phakic *** was offered as a way to decrease medication while maintaining the same low eye *** was performed over 360°,at 3ns,spotsize 400 μm,100 *** [intraocular pressure（IOP）,number of medications needed] were measured at 1h,1wk,1,3,6 and 12 *** independent-samples t-test was performed to compare baseline characteristics of the phakic and the pseudophakic group and differences in evolution of mean IOP and number of used ***-squared analysis was performed to investigate proportions of fast,slow and ***：The mean IOP measurement was 13.00± 2.88 mm Hg in the phakic group（38 eyes） and 13.51±3.06 mm Hg in the pseudophakic group（38 eyes）（P〉0.05）.This changed little after SLT and IOP lowering effect was comparable between the two *** aim however was to lower the amount of medication *** the phakic group medication lowered from 1.29±0.62 at baseline,to 0.15±0.46 after 12mo;a reduction of 88.37%.In the pseudophakic group,used medication changed from 1.71±1.04,to 0.41±0.61;a 76.02% *** differences were not statistically significant at any time point（P〉0.05）.IOP lowering occurred slightly faster in thepseudophakic group（50% of patients after one week） than in the phakic group（68% of patients after more than 4wk）.The difference was not significant（P〉0.05）.CONCLUSION：IOP lowering effect of SLT is comparable between phakic and pseudophakic eyes.

关键词： mechanism of trabeculoplasty selective laser trabeculoplasty pseudophakes versus phakic eyes open angle glaucoma pressure lowering after lens extraction

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Where does selective laser trabeculoplasty stand now? A review

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Eye and Vision 2016年第1期3卷 75-83页

作者： Myrjam De Keyser Maya De Belder Simon De Belder Veva De Groot Department of Medicine University of AntwerpUniversiteitsplein 1B-2610 AntwerpBelgium Medipolis Boomsesteenweg 223B-2610 AntwerpBelgium Faculty of Psychology and Education Department of Experimental PsychologyGhent UniversityHenri Dunantlaan 2B-9000 GhentBelgium Department of Ophthalmology University Hospital AntwerpWilrijkstraat 10B-2650 EdegemBelgium

Background:Chronic treatment of glaucoma can present a challenge in patients who lack the means and/or the discipline to use daily glaucoma *** wondered if selective laser trabeculoplasty(SLT)could be a useful ***:Inclusion criteria:controlled trials comparing efficacy of SLT in adult patients with any form of open angle glaucoma or ocular hypertension and case reports on side effects of *** recent meta-analyses identified eight randomized clinical trials(RCTs)comparing the effect of SLT with medication(prostaglandin analogs)and with argon laser trabeculoplasty(ALT).We took these eight RCTs as reference base and calculated their success rates where they were not *** articles were added to elaborate on technique and side ***:Mean intraocular pressure(IOP)reduction after SLT was 3.8–8.0 mmHg after 6 months to 1 *** success rate of SLT at 6 months to 1 year is 55–82%.Higher IOP before laser predicts a higher IOP-lowering *** terms of mean IOP reduction,reduction in number of medications and treatment success,the effect of SLT was found to show no clinically relevant difference from that of contemporary medication(prostaglandin analogs)and from ***:The evidence indicates that SLT is an efficacious primary or adjunctive therapy for treating glaucoma.

关键词： Glaucoma Selective laser trabeculoplasty Review Open angle glaucoma Glaucoma treatment Ocular hypertension

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Toxin variation among salamander populations:discussing potential causes and future directions

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Integrative Zoology 2021年第3期16卷 336-353页

作者： Gilles DE MEESTER EminaŠUNJE Els PRINSEN Erik VERBRUGGEN Raoul VANDAMME Department of Biology Functional Morphology GroupUniversity of AntwerpWilrijkBelgium Department of Biology Faculty of Natural SciencesUniversity of SarajevoSarajevoBosnia-Hercegovina Herpetological Association in Bosnia and Herzegovina:BHHU:ATRA SarajevoBosnia-Hercegovina Department of Biology ImpressUniversity of AntwerpWilrijkBelgium Department of Biology Plant and EcosystemsUniversity of AntwerpWilrijkBelgium

Amphibians produce defensive chemicals which provide protection against both predators and *** species,populations can differ considerably in the composition and amount of these chemical *** intraspecific variation in toxins and linking it to environmental variables may help us to identify the selective drivers of toxin evolution,such as predation pressure and infection ***,there has been a renewed interest in the unique toxins produced by salamanders from the genus Salamandra:the *** this attention,intraspecific variation has largely been ignored within *** aim of this study was to investigate whether geographic variation in profiles of samandarines exists,by sampling 4 populations of Salamandra atra over its range in the Dinaric *** addition,we preliminary explored whether potential variation could be explained by predation(counting the number of snake species)and infection risk(cultivation and genomic analyses of collected soil samples).Salamanders from the 4 populations differed in toxin composition and in the size of their poison glands,although not in overall toxin *** predation nor infection risk could explain this variation,as populations barely differed in these *** over a much broader geographic range,using better estimators for predation and infection risk,will contribute to an improved understanding of how environment may shape variation in chemical ***,as the 4 populations of *** did differ in their toxin profiles,we propose that this species provides an interesting opportunity for further ecological and evolutionary studies on amphibian toxins.

关键词： amphibian toxins geographic variation poison glands Salamandra atra samandarines

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Fatigue in children and adolescents with inflammatory bowel disease

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World Journal of Gastroenterology 2019年第5期25卷 632-643页

作者： Els Van de Vijver Ann Van Gils Laura Beckers Yannick Van Driessche Nicolette Dorien Moes Patrick Ferry van Rheenen Department of Paediatric Gastroenterology Hepatology and Nutrition Antwerp University Hospital Department of Anesthesiology Antwerp University Hospital Family Medicine Department of Paediatric Gastroenterology Hepatology and Nutrition University Medical Center Groningen

AIM To identify factors other than active disease and anemia that contribute to fatigue in pediatric inflammatory bowel disease(IBD).METHODS We performed an electronic search in Medline and EMBASE from their inception to May 2017 using the search term "fatigue" or the related keywords "physical impairment" and "inflammatory bowel disease" with the filter "child"(age 0-18 years). Cross-sectional and case-control studies were included. We restricted our search to studies published in English. We used the PRISMA checklist and flow diagram. Duplicate articles were manually deleted in End Note. To identify further relevant studies, we checked the reference lists of the selected *** We identified 149 papers, of which 19 were retrieved for full text review. Eleven studies were subsequently excluded because fatigue was not evaluated as an outcome measure. Eight papers focused on the desired topic and were discussed in the final analysis. A lack of uniformity of outcome measures made the pooling of data impossible. In all but one study, questionnaires were used to evaluate fatigue. In the remaining study, an accelerometer was used to measure daily activities, sleeping time and their relationships with fatigue in a more quantifiable manner. Adolescents with IBD are significantly more fatigued than healthy controls. In addition to active disease, increased anxiety or depression and disturbed family relationships were frequently reported predictors of fatigue. Quantitative measurement of physical activity in patients with Crohn's disease showed a reduction in the number of steps per day, and patients with ulcerative colitis had a shorter duration of physical activity during the *** Fatigue in pediatric IBD is related to a combination of biological, functional and behavioral factors, which should all be taken into account when managing fatigue.

关键词： Adolescents Children Fatigue Inflammatory bowel disease Physical impairment Sleep

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Short-term effects of vacuum massage on epidermal and dermal thickness and density in burn scars: an experimental study

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Burns & Trauma 2016年第3期4卷 216-224页

作者： Jill Meirte Peter Moortgat Mieke Anthonissen Koen Maertens Cynthia Lafaire Lieve De Cuyper Guy Hubens Ulrike Van Daele OSCARE Organisation for BurnsScar After-care and ResearchVan Roiestraat 182170 AntwerpBelgium Rehabilitation Sciences and Physiotherapy University of AntwerpUniversiteitsplein 12610 AntwerpBelgium OSCARE Organisation for BurnsScar After-care and ResearchVan Roiestraat 182170 AntwerpBelgium OSCARE Organisation for BurnsScar After-care and ResearchVan Roiestraat 182170 AntwerpBelgium KU Leuven Faculty of Kinesiology and Rehabilitation SciencesLeuvenBelgium OSCARE Organisation for BurnsScar After-care and ResearchVan Roiestraat 182170 AntwerpBelgium Department of Clinical and Lifespan Psychology Vrije Universiteit BrusselBrusselsBelgium OSCARE Organisation for BurnsScar After-care and ResearchVan Roiestraat 182170 AntwerpBelgium ZNA Stuivenberg Burn CenterAntwerpBelgium Department of antwerp Surgical Training Anatomy and Research Centre University of AntwerpAntwerpBelgium Rehabilitation Sciences and Physiotherapy University of AntwerpUniversiteitsplein 12610 AntwerpBelgium

Background:Vacuum massage is a non-invasive mechanical massage technique invented to treat burns and *** date,no effects of vacuum massage on thickness and density of human scar tissue have been *** process in which external stimuli are converted into biochemical responses in the cell is known as *** the skin endothelial cells,fibroblasts and myofibroblasts embedded in the extracellular matrix(ECM)sense mechanical stimuli(created by vacuum massage)and may promote intracellular processes leading to matrix *** mechanotransduction could be a plausible working mechanism for vacuum massage as an anti-scarring therapy,this study aims to investigate the short-term effects of vacuum massage on thickness and density of epidermis and dermis in burn scars in order to find proof of ECM ***:A one group experimental study was *** with burn scars on upper extremities,lower extremities,and trunk were recruited for participation in this *** DUB?cutis 22 MHz ultrasound scanner was used to assess thickness and density of the epidermal and dermal skin *** baseline measurements,vacuum massage was performed according to a pre-defined *** were carried out at 5 min,30 min,1 h,and 2 h ***:Thirteen scar sites from 9 different patients were *** 8 out of the 13 scar sites,a disruption of the epidermis was noticed after the vacuum *** minutes after the intervention,epidermal density decreased statistically significantly(p=.022)and dermal thickness increased(p=.018).Both changes lasted for more than 1 h,but after 2 h,the changes were no longer statistically *** density decreased significantly(p=.048)immediately after the intervention,and this decrease was still present after 2 h(p=.011).Conclusions:Preliminary results show that the disruption of the epidermis may indicate that vacuum massage could be able to actually breach the s

关键词： Burn Scars Vacuum massage Dermal thickness Dermal density

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Mind-body control:a new perspective on motor neuron function

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Signal Transduction and Targeted Therapy 2024年第9期9卷 3557-3559页

作者： Maria-Luise Petrovic-Erfurth Albena Jordanova Molecular Neurogenomics Group VIB Center for Molecular NeurologyVIB2610 AntwerpBelgium Molecular Neurogenomics Group Department of Biomedical SciencesUniversity of Antwerp2610 AntwerpBelgium Molecular Medicine Center Department of Medical Chemistry and BiochemistryMedical University-Sofia1431 SofiaBulgaria

A recent study published in Nature1 used an optogeneticallyactivated behavioral paradigm in fruit flies to demonstrate that individual motor neurons command their target muscles in a biased manner to execute body movements,based on the mechanosensory feedback preceding the *** finding contradicts the current postulate that activation of a specific motor neuron would always result in a pre-determined fixed muscle response,adding important new perspectives in the fields of neurobiology,biomechanics,and *** a dancing ballerina executes her turns,she typically controls her head position and fixes her gaze on a single orientation *** spotting technique helps her to maintain balance and to prevent dizziness during her complex *** how is this mind-body control achieved from a neurobiological point of view?

关键词： execute individual maintain

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Development of a risk score to guide targeted hepatitis C testing among human immunodeficiency virus patients in Cambodia

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World Journal of Hepatology 2021年第9期13卷 1167-1180页

作者： Anja De Weggheleire Jozefien Buyze Sokkab An Sopheak Thai Johan van Griensven Sven Francque Lutgarde Lynen Department of Clinical Sciences Institute of Tropical Medicine AntwerpAntwerp 2000Belgium Infectious Diseases Department Sihanouk Hospital Center of HopePhnom Penh 12101Cambodia Department of Gastroenterology Hepatology Antwerp University HospitalAntwerp 2000Belgium Laboratory of Experimental Medicine and Paediatrics University of AntwerpAntwerp 2000Belgium

BACKGROUND The World Health Organization recommends testing all human immunodeficiency virus(HIV)patients for hepatitis C virus(HCV).In resource-constrained contexts with low-to-intermediate HCV prevalence among HIV patients,as in Cambodia,targeted testing is,in the short-term,potentially more feasible and *** To develop a clinical prediction score(CPS)to risk-stratify HIV patients for HCV coinfection(HCV RNA detected),and derive a decision rule to guide prioritization of HCV testing in settings where‘testing all’is not feasible or unaffordable in the short *** We used data of a cross-sectional HCV diagnostic study in the HIV cohort of Sihanouk Hospital Center of Hope in Phnom *** populations were very rare in this *** development relied on the Spiegelhalter and Knill-Jones *** with an adjusted likelihood ratio≥1.5 or≤0.67 were retained,transformed to natural logarithms,and rounded to integers as score *** performance was evaluated by the area-under-the-ROC curve(AUROC)with 95% confidence intervals(CI),and diagnostic accuracy at the different *** the decision rule,HCV coinfection probability≥1% was agreed as *** Among the 3045 enrolled HIV patients,106 had an HCV *** the 11 candidate predictors(from history-taking,laboratory testing),seven had an adjusted likelihood ratio≥1.5 or≤0.67:≥50 years(+1 point),diabetes mellitus(+1),partner/household member with liver disease(+1),generalized pruritus(+1),platelets<200×10^(9)/L(+1),aspartate transaminase(AST)<30 IU/L(-1),AST-to-platelet ratio index(APRI)≥0.45(+1),and APRI<0.45(-1).The AUROC was 0.84(95%CI:0.80-0.89),indicating good discrimination of HCV/HIV coinfection and HIV *** CPS result≥0 best fits the test-threshold(negative predictive value:99.2%,95%CI:98.8-99.6).Applying this threshold,30%(n=926)would be *** coinfections(15%)would have been missed,none with advanced *** The CPS pe

关键词： Hepatitis C virus Hepatitis C/human immunodeficiency virus coinfection Clinical prediction rule Targeted screening Cambodia Development prediction model

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Could wastewater analysis be a useful tool for China?——A review

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Journal of Environmental Sciences 2015年第1期27卷 70-79页

作者： Jianfa Gao Jake O'Brien Foon Yin Lai Alexander L.N.van Nuijs Jun He Jochen F.Mueller Jingsha Xu Phong K.Thai Faculty of Science and Engineering University of Nottingham Ningbo China National Research Centre for Environmental Toxicology The University of Queensland Toxicological Center University of Antwerp

Analysing wastewater samples is an innovative approach that overcomes many limitations of traditional surveys to identify and measure a range of chemicals that were consumed by or exposed to people living in a sewer catchment area. First conceptualised in 2001, much progress has been made to make wastewater analysis（WWA） a reliable and robust tool for measuring chemical consumption and/or exposure. At the moment, the most popular application of WWA, sometimes referred as sewage epidemiology, is to monitor the consumption of illicit drugs in communities around the globe, including China. The approach has been largely adopted by law enforcement agencies as a device to monitor the temporal and geographical patterns of drug consumption. In the future, the methodology can be extended to other chemicals including biomarkers of population health（e.g. environmental or oxidative stress biomarkers, lifestyle indicators or medications that are taken by different demographic groups） and pollutants that people are exposed to（e.g. polycyclic aromatic hydrocarbons,perfluorinated chemicals, and toxic pesticides）. The extension of WWA to a huge range of chemicals may give rise to a field called sewage chemical-information mining（SCIM） with unexplored potentials. China has many densely populated cities with thousands of sewage treatment plants which are favourable for applying WWA/SCIM in order to help relevant authorities gather information about illicit drug consumption and population health status. However, there are some prerequisites and uncertainties of the methodology that should be addressed for SCIM to reach its full potential in China.

关键词： Drug consumption Wastewater analysis Biomarkers Population health

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Delayed recognition:recent developments and a proposal to study this phenomenon as a fuzzy concept

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Journal of Data and Information Science 2018年第3期3卷 1-13页

作者： Ronald Rousseau university of antwerp Faculty of Social SciencesB-2020 AntwerpBelgium d KU LeuvenFacultair Onderzoekscentrum ECOOM

Purpose:New developments in the study of delayed recognition are ***/methodology/approach:Based on these new developments a method is proposed to characterize delayed recognition as a fuzzy ***:A benchmark value of 0.333 corresponding with linear growth is ***,a case is discovered in which an expert found delayed recognition several years before citation analysis could discover this *** limitations:As all citation studies also this one is database *** implications:Delayed recognition is turned into a fuzzy ***/value:The article presents a new way of studying delayed recognition.

关键词： Delayed recognition Sleeping beauty Hibernators Fuzzy membership function

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Investigation on Degradation Path of SF_(6)in Packed-bed Plasma:Effect of Plasma-generated Radicals

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1231-1241页

作者： Zhaolun Cui Chang Zhou Amin Jafarzadeh Xiaoxing Zhang Peng Gao Licheng Li Yanpeng Hao School of Electric Power Engineering South China University of TechnologyGuangzhou 510630China School of Electrical and Electronic Engineering Hubei University of TechnologyWuhan 430068China Research group PLASMANT Department of ChemistryUniversity of AntwerpUniversiteitsplein 1BE-2610 Wilrijk-AntwerpBelgium CSEE

SF_(6)degradation mechanism in non-thermal plasma(NTP)systems is not fully understood due to the formation of a complex physico-chemical reaction network,especially when reactive gases and packing materials are *** this work,we conduct a combined experimental and theoretical study to unravel the SF_(6)degradation path in a-Al_(2)O_(3)packed plasma in the presence of H_(2)O or O_(2).Our experimental results show that both H_(2)O and O_(2)have a synergetic effect with-Al_(2)O_(3)packing on promoting SF_(6)degradation,leading to higher stable gas yields than typical spark or corona discharges.H_(2)O or O_(2)addition promotes SO_(2)or SO_(2)F_(2)selectivity,*** functional theory(DFT)calculations reveal that SO_(2)generation corresponding with the highest activation barrier is the most critical step toward SF_(6)*** like H and O generated from H_(2)O or O_(2)discharge can significantly promote the degradation process via Eley-Rideal mechanism,affecting key reactions of stable product generation,advancing degradation *** results of this work could provide insights on further understanding SF_(6)degradation mechanism especially in packed-bed plasma systems.

关键词： Degradation mechanism packed-bed plasma radicals SF_(6)

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