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Chronic epididymitis and Grade III varicocele and their associations with semen characteristics in men consulting for couple infertility

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Asian Journal of Andrology 2018年第4期20卷 360-365页

作者： Alejandro Oliva Luc Multigner Center for Interdisciplinary Studies National University of Rosario Rosario 2000 Argentina University of Rennes Inserm EHESP Irset (Institut de recherche en sante environnement et travail) UMR_S 1085 Rennes F-35000 France

Chronic epididymitis and varicocele are frequently observed genital disorders in men consulting for couple infertility, but their impact on semen characteristics at the time of infertility consultation is still a matter of debate. We investigated 652 male partners of couples who had their first infertility consultation between 1999 and 2015 in Argentina. Men with chronic epididymitis （n = 253）, Grade III varicocele （n = 106）, and both conditions （n = 125） were compared with a control group （n = 168） composed of men without these disorders or any other recognized causes of male infertility. We showed that men who presented isolated chronic epididymitis were more likely to have high percentages of low sperm motility and abnormal sperm morphology as well as a high number of white blood cells. Men with isolated Grade III varicocele had low sperm production and motility and an increased percentage of abnormal sperm morphology. Finally, men who simultaneously presented chronic epididymitis with Grade III varicocele had a low sperm motility and increased percentage of abnormal sperm morphology as well as a high number of white blood cells. Physical examination of the genital organs may identify common disorders, potentially involved as causal factors of patient＇s infertility. These disorders are associated with specific seminal profiles that should help in identifying the best treatment from the available therapeutic options, effectiveness, safety, and allowing as much as possible natural conception.

关键词： couple subfertility epididymitis male factor infertility semen quality varicocele

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Liver transplantation for perihilar cholangiocarcinoma is not a provocative idea

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Hepatobiliary Surgery and Nutrition 2023年第2期12卷 232-234页

作者： Alexandre Chebaro Heithem Jeddou Service de Chirurgie Hépatobiliaire et Digestive CHU RennesUniv RennesRennesFrance Inserm EHESPIrset(Institut de recherche en santéenvironnement et travail)-UMR_S 1085Univ RennesRennesFrance

This is a multicenter benchmarking study on liver transplantation(LT)for perihilar cholangiocarcinoma(PHC)after neoadjuvant chemoradiotherapy(1).The study comprises of 134 patients from 2014 to 2018 among whom the majority had underlying primary sclerosing cholangitis(PSC).Dropout rate was available from 4 out of 17 centers and was 28%,primarily for oncological reasons(tumor progression and lymph node invasion).All patients followed neo-adjuvant chemoradiotherapy according to the Mayo(88%)or Mayo-like *** grafts originated from brain-dead donors in 61.3%of cases and from living donors in 29.7%of cases.

关键词： Liver invasion patients

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EPIDEM: A Technology-Enabled COVID-19 Elimination Strategy

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E-Health Telecommunication Systems and Networks 2020年第4期9卷 60-69页

作者： Goetz Robert Uwe Grosche Sanam Shah Anna Katrina Javier Bolivar I-Optic Computing Wollongong Australia Ecole des Hautes Etudes en Sante Publique (ehesp) Paris France Independent Researcher Quezon City Philippines

Background: The novel Coronavirus disease 2019 (COVID-19) has rapidly evolved into a global emergency with far-reaching consequences. Multiple models predict mounting morbidity and mortality in the absence of appropriate interventions. Screening of sub-clinical cases through technological tools has the potential to eliminate virus containment in the population. Objective: Our aim was to develop an effective application that detected early COVID-19 infections and resulted in four-dimensional (4-D) data visualization systems to develop safe networks whilst respecting user privacy. Methods: We proposed an algorithm for a novel form of contact tracing and screening that can detect infection before manifestation of clinical symptoms and signs. We developed a simulation model that demonstrated impact on the pandemic through percent change in the “trigger point”. Results: A “trigger point” based on personal risk assessment generated a visual report to the community network. The following outcomes were rendered in the app: live surveillance of metadata, hotspot mapping, targeted live health messaging to a large population, an infection control passport technology, and personal hotspot avoidance warnings. Our model suggested that higher adoption of such strategies can potentially eliminate viral carriage in the population. Conclusions: Our proposed technology-enabled screening, detection, and elimination strategy presents a novel approach to eliminate the viral containment. This app could be applied to the COVID-19 pandemic as well as other outbreaks and epidemics in the future to control the unprecedented disease spread.

关键词： Coronavirus Disease 2019 COVID-19 Pandemic Outbreak Contact Tracing Technology Application

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The sperm-interacting proteome in the bovine isthmus and ampulla during the periovulatory period

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Journal of Animal Science and Biotechnology 2023年第3期14卷 980-1000页

作者： Coline Mahe Regis Lavigne Emmanuelle Com Charles Pineau Aleksandra Maria Zlotkowska Guillaume Tsikis Pascal Mermillod Jennifer Schoen Marie Saint-Dizier CNRS IFCEINRAEUniversite de ToursPRC37380 NouzillyFrance Univ Rennes InsermEHESPIrset(Institut de Recherche en SanteEnvironnement Et Travail)-UMR-S 1085F‑35000 RennesFrance Univ Rennes CNRSInsermBiosit UAR 3480 US_S 018Protim Core Facility35000 RennesFrance Institute of Reproductive Biology Leibniz Institute for Farm Animal BiologyFBNDummerstorfGermany Present Address:Department of Reproduction Biology Leibniz Institute for Zoo and Wildlife Research(IZW)BerlinGermany

Background Spermatozoa interact with oviduct secretions before fertilization in vivo but the molecular players of this dialog and underlying dynamics remain largely *** objectives were to identify an exhaustive list of sperm-interacting proteins(SIPs)in the bovine oviduct fluid and to evaluate the impact of the oviduct anatomical region(isthmus ***)and time relative to ovulation(pre-ovulatory ***-ovulatory)on SIPs number and *** Pools of oviduct fluid(OF)from the pre-ovulatory ampulla,pre-ovulatory isthmus,post-ovulatory ampulla,and post-ovulatory isthmus in the side of ovulation were collected from the ***-thawed bull sperm were incubated with OF or phosphate-buffered saline(control)for 60 min at 38.5℃.After protein extraction and digestion,sperm and OF samples were analyzed by nanoLC-MS/MS and label-free protein *** A quantitative comparison between proteins identified in sperm and OF samples(2333 and 2471 proteins,respectively)allowed for the identification of 245 *** highest number(187)were found in the pre-ovulatory isthmus,i.e.,time and place of the sperm *** total,41 SIPs(17%)were differentially abundant between stages in a given region or between regions at a given stage and 76 SIPs(31%)were identified in only one region×stage *** analysis of SIPs predicted roles in cell response to stress,regulation of cell motility,fertilization,and early embryo *** This study provides a comprehensive list of SIPs in the bovine oviduct and evidences dynamic spatiotemporal changes in sperm-oviduct interactions around ovulation ***,these data provide protein candidates to improve sperm conservation and in vitro fertilization media.

关键词： Ampulla Fallopian tube Interactome Isthmus Oviduct Ovulation Post-ovulatory Pre-ovulatory Proteomics Spermatozoa

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SesIndexCreatoR:An R Package for Socioeconomic Indices Computation and Visualization

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Open Journal of Statistics 2015年第4期5卷 291-302页

作者： Benoit Lalloue Severine Deguen Jean-Marie Monnez Cindy Padilla Wahida Kihal Denis Zmirou-Navier Nolwenn Le Meur Institut Gustave Roussy ParisFrance ehesp Rennes Sorbonne Paris CiteRennesFrance Inserm UMR IRSETInstitut de recherche sur la sante l’environnement et le travail-1085RennesFrance Lorraine University CNRSINRIA UMR 7502Institut Elie CartanLorraineFrance Lorraine University Medical SchoolLorraineFrance

In order to study social inequalities, indices can be used to summarize the multiple dimensions of the socioeconomic status. As a part of the Equit’Area Project, a public health program focused on social and environmental health inequalities;a statistical procedure to create (neighborhood) socioeconomic indices was developed. This procedure uses successive principal components analyses to select variables and create the index. In order to simplify the application of the procedure for non-specialists, the R package SesIndexCreatoR was created. It allows the creation of the index with all the possible options of the procedure, the classification of the resulting index in categories using several classical methods, the visualization of the results, and the generation of automatic reports.

关键词： Socioeconomic Status Multidimensional Index Principal Component Analysis Hierarchical Classification R

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Pregnancy Air Exposure: An R Package for Estimation of Exposure to Air Pollution during Critical Windows of Pregnancy

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Open Journal of Statistics 2017年第3期7卷 422-433页

作者： Séverine Deguen Laure Nicollet Morgane Gilles Arlette Danzon Olivier Blanchard Géraldine Le Nir Denis Zmirou-Navier Wahida Kihal-Talantikite ehesp School of Public Health Rennes France Maternal and Infant Preventive Institute (PMI) Paris France Air Quality Monitoring Associations (AASQA) Airparif Paris France INSERM U1085 IRSET (Research Institute in Environmental and Occupational Health) Rennes France Lorraine University Medical School Nancy France University of Strasbourg CNRS LIVE UMR 7362 Strasbourg France

Today, it is well known that ambient air pollution exposures may be related with different health outcomes including adverse birth outcomes (for instance, low birth weight and preterm birth). Then, researchers must estimate exposure to air pollution during different critical windows of exposure across pregnancy. In the literature, the most commonly examined critical windows of exposure are the first, second, and third trimesters of pregnancy, although the entire pregnancy is also studied. In this context, we developed an automatic procedure which estimates individual exposures by trimester. We illustrate usage of the Pregnancy Air Exposure package for all births within the city of Paris in 2011. Nitrogen dioxide data from monitoring stations and data modeled at the census block level were available from the air quality monitoring networks of Ile de France Region. Nitrogen dioxide, NO2, has been chosen as an indicator of traffic-generated pollution. Newborn health data are available from the first birth certificate registered by the Maternal and Child Care department of Paris;more specifically, we used the date of birth and the gestational age to individually determine the beginning and the end of each trimester. The Pregnancy Air Exposure R package was created to simplify application of the procedure for non-specialists, and is freely available from the Equit’Area project website: (***/documents/package_Exposure). The package contains two functions as well as the help files needed to run the procedure and yields air pollution exposure estimates by pregnancy trimester. The two functions can be used successively or independently according to the available input data.

关键词： Air Pollution Exposure Pregnant Women Critical Window of Exposure R Software

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Screening for Precancerous Cervical Lesions in Women of Reproductive Age in the Kara Region of Togo in 2022

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Open Journal of Epidemiology 2023年第4期13卷 293-305页

作者： Gatibe Yendu-Suglpak Gnatou Zézé Onivogui Latame Komla Adoli Fifonsi Adjidossi Gbeasor-Komlanvi Arnold Junior Sadio Yao Rodion Konu Martin Kouame Tchankoni Wendpouiré Ida Carine Zida-Compaore Amegnona Agbonon Didier Koumavi Ekouevi Department of Public Health University of Lomé Faculty of Health Sciences Lomé Togo African Centre for Research in Epidemiology and Public Health (CARESP) Lomé Togo Institute of Public Health and Development University of Bordeaux Bordeaux France French School of Public Health (ehesp) University of Rennes Rennes France Laboratory of Pharmacology and Physiology University of Lomé Lomé Togo Center for Training and Research in Public Health University of Lomé Lomé Togo

Introduction: Worldwide, cervical cancer is the 4th most common cancer in women and is a public health problem. The objective of this study was to estimate the prevalence of precancerous cervical lesions and to describe its associated factors among women of reproductive age in the Kara region of Togo. Methods: A cross-sectional study was conducted from March 6 to 14, 2022 in 11 health centers in Kara. Data were collected using a standardized questionnaire and screening for precancerous cervical lesions was performed by visual inspection of the cervix, after application of 5% acetic acid and Lugol’s. Logistic regression analysis was performed to describe factors associated with precancerous lesions. Results: A total of 728 women with a median age of 36, interquartile range [31 - 41] were enrolled. The prevalence of precancerous cervical lesions was 3.9%, 95% confidence interval (95% CI: [2.6 - 5.4]. Factors associated with the presence of precancerous lesions were age at first sexual intercourse ≥ 18 years (adjusted odds ratio (aOR = 3.67;95% CI [1.17 - 18.4]) and being a sex worker (aOR = 8.14;95% CI [1.96 - 27.1]). HIV infection was not associated with the presence of precancerous lesions. Conclusion: The results of this study underscore the importance of intensifying cervical cancer screening efforts in resource-limited countries for better management. These efforts should prioritize vulnerable populations such as female sex workers.

关键词： Precancerous Lesions Cervix Visual Inspection Togo

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Emergence of Toscana virus in the mediterranean area

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World Journal of Virology 2012年第5期1卷 135-141页

作者： Remi N Charrel Laurence Bichaud Xavier de Lamballerie Aix Marseille University IRD French Institute of Research for DevelopmentEHESP French School of Public HealthUMR_D 190 "Emergence des Pathologies Virales"13005 MarseilleFrance IHU Mediterranee Infection APHM Public Hospitals of Marseille13005 MarseilleFrance

Toscana virus(TOSV) is an arthropod-borne virus, identified in 1971, from Phlebotomus perniciosus and Phlebotomus perfiliewi in central Italy. TOSV belongs to the Phlebovirus genus within the Bunyaviridae family. As other bunyaviruses, the genome of TOSV consists of 3 segments(S for small, M for Medium, and L for Large) respectively encoding non structural and capsid proteins, envelope structural proteins, and the viral RNA-dependant RNA-polymerase. It is transmitted by sand flies. Therefore its distribution is dictated by that of the arthropod vectors, and virus circulation peaks during summertime when sandfly populations are active. Here, we reviewed the epidemiology of TOSV in the old world. First evidence of its pathogenicity for humans, specifically its propensity to cause central nervous system(CNS) infections such as meningitis and encephalitis, was reported in central Italy. After 2000, it was recognized that TOSV had a much larger geographic distribution than initially believed, and was present in most of the Western European countries located on the northern border of the Mediterranean Sea(Portugal, Spain, France, Greece, Croatia) as well as eastern countries such as Cyprus and Turkey. In the countries where TOSV is present, it is among the three most prevalent viruses in meningitis during the warm seasons, together with enteroviruses and herpesviruses. Up to now, epidemiological data concerning Northern Africa and other countries located south of the Mediterranean are scarce. TOSV must be considered an emerging pathogen. Despite the important role played by TOSV in CNS infections, it remains a neglected agent and is rarely considered by physicians in diagnostic algorithms of CNS infections and febrile illness during the warm season, probably because of the lack of information.

关键词： Toscana virus Phlebovirus Emergence Europe Meningitis Fever Sandfly Phlebotomus Zoonosis Arthropod-borne

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