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A Eulerian population balance/Monte Carlo approach for simulating laminar aluminum dust flames

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Particuology 2024年第5期88卷 323-343页

作者： Fabian Sewerin Jannis Finke Emmy Noether Group for Dispersed Multiphase Flows Chair of Mechanical Process EngineeringOtto-von-Guericke-Universität MagdeburgUniversitätsplatz 239106 MagdeburgGermany

Recently,metal powders have been conceptualized as carbon-free recyclable energy carriers that may form a cornerstone of a sustainable energy *** combustion of metal dusts in oxidizing atmospheres is exothermal and yields oxide particles that could,potentially,be retrieved and,subsequently,recharged by conversion to pure metals using green primary energy *** a step towards a predictive tool for designing metal dust combustors,we present a fully Eulerian modelling approach for laminar particle-laden reactive flows that is,conceptually,based on a population balance description of the dispersed particles and relies on a stochastic Eulerian solution *** the population balance equation(PBE)is formulated for the number-weighted distribution of characteristic properties among all particles near a spatial location,it is kinetically informed by the rates at which mass,momentum and heat are exchanged between the carrier gas and the particulate phase on the single particle *** the scope of the Eulerian Monte Carlo solution scheme,the property distribution is discretely represented in terms of the total number density and a finite number of property samples and the computational work is channelled towards the Eulerian estimation of mean particle *** the case of reactive aluminum particles,we combine a kinetic description of the gas-particle heat and mass transfer with a transport-limited continuum formulation to obtain rate expressions that are valid across the entire particle size range from the free molecular through the continuum *** velocity,the particle properties include only the particle mass,temperature and oxide mass *** set of thermochemical degrees of freedom is retained also as phase transitions due to melting occur,drawing on a smooth blend of the solid and liquid thermodynamic and material *** particle-level formulation encompasses aluminum evaporation,surface oxidation,scavenging of oxi

关键词： Metal dust combustion Aluminum Population balance Eulerian Monte Carlo

Photogrammetry and deep learning for energy production prediction and building-integrated photovoltaics decarbonization

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Building Simulation 2024年第2期17卷 189-205页

作者： Ilyass Abouelaziz Youssef Jouane CESI LINEACT 7 bis Av.Robert Schuman51100ReimsFrance CESI LINEACT Parc Club des Tanneries 2 all Foulons67380StrasbourgFrance

Building-Integrated photovoltaics(BIPV)have emerged as a promising sustainable energy solution,relying on accurate energy production predictions and effective decarbonization strategies for efficient *** paper presents a novel approach that combines photogrammetry and deep learning techniques to address the problem of BIPV *** method is called BIM-AITIZATION referring to the integration of BIM data,AI techniques,and automation *** integrates photogrammetric data into practical BIM *** addition,it enhances the precision and reliability of PV energy prediction by using artificial intelligence *** primary aim of this approach is to offer advanced,data-driven energy forecasts and BIPV decarbonization while fully automating the underlying *** achieve this,the first step is to capture point cloud data of the building through photogrammetric *** data undergoes preprocessing to identify and remove unwanted points,followed by plan segmentation to extract the plan *** that,a meteorological dataset is assembled,incorporating various attributes that influence energy production,including solar irradiance parameters as well as BIM ***,machine and deep learning techniques are used for accurate photovoltaic energy predictions and the automation of the entire *** experiments are conducted,including multiple tests aimed at assessing the performance of diverse machine learning *** objective is to identify the most suitable model for our specific ***,a comparative analysis is undertaken,comparing the performance of the proposed model against that of various established BIPV software *** outcomes reveal that the proposed approach surpasses existing software solutions in both accuracy and *** extend its applicability,the approach is evaluated using a building case study,demonstrating its ability to generalize effectively to new bui

关键词： building-integrated photovoltaic(BIPV) deep learning building information modeling photogrammetric building decarbonization

Current considerations on intraductal papillary neoplasms of the bile duct and pancreatic duct

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World Journal of Gastroenterology 2024年第10期30卷 1461-1465页

作者： Efstathios T Pavlidis Ioannis N Galanis Theodoros E Pavlidis 2^(nd) Propedeutic Department of Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Pancreatobiliary intraductal papillary neoplasms(IPNs)represent precursors of pancreatic cancer or bile duct cholangiocarcinoma that can be detected and *** advances in diagnostic methods,identifying these premalignant lesions is still challenging for treatment *** imaging,biomarkers and molecular tests for genomic alterations can be used for diagnosis and *** intervention in combination with new chemotherapeutic agents is considered the optimal treatment for malignant *** balance between the risk of malignancy and any risk of resection guides management policy;therefore,treatment should be individualized based on a meticulous preoperative assessment of high-risk *** of the bile duct is more aggressive;thus,early diagnosis and surgery are *** conservative management of low-risk pancreatic branch-duct lesions is safe and effective.

关键词： Biliary tree diseases Pancreatic cystic neoplasms Biliary tract neoplasms Extrahepatic cholangiocarcinoma Pancreatic adenocarcinoma

"Five steps four quadrants" modularized en bloc dissection technique for accessing hepatic hilum lymph nodes in laparoscopic pancreaticoduodenectomy

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 503-510页

作者： Xiao-Si Hu Yong Wang Hong-Tao Pan Chao Zhu Shi-Lei Chen Hui-Chun Liu Qing Pang Hao Jin Department of Hepatopancreatobiliary Surgery Anhui No.2 Provincial People’s HospitalHefei 230041Anhui ProvinceChina

BACKGROUND Although en bloc dissection of hepatic hilum lymph nodes has many advantages in radical tumor treatment,the feasibility and safety of this approach for laparo-scopic pancreaticoduodenectomy(LPD)require further clinical evaluation and *** To explore the application value of the"five steps four quadrants"modularized en bloc dissection technique for accessing hepatic hilum lymph nodes in LPD *** A total of 52 patients who underwent LPD via the"five steps four quadrants"modularized en bloc dissection technique for hepatic hilum lymph nodes from April 2021 to July 2023 in our department were analyzed *** patients'body mass index(BMI),preoperative laboratory indices,intraoperative variables and postoperative complications were *** relationships between preoperative data and intraoperative lymph node dissection time and blood loss were also *** Among the 52 patients,36 were males and 16 were females,and the average age was 62.2±11.0 *** were 26 patients with pancreatic head cancer,16 patients with periampullary cancer,and 10 patients with distal bile duct *** BMI was 22.3±3.3 kg/m²,and the median total bilirubin(TBIL)concentration was 57.7(16.0-155.7)µmol/*** patients successfully underwent the"five steps four quadrants"modularized en bloc dissection technique without lymph node clearance-related complications such as postoperative bleeding or lymphatic *** analysis revealed significant associations between preoperative BMI(r=0.3581,P=0.0091),TBIL level(r=0.2988,P=0.0341),prothrombin time(r=0.3018,P=0.0297)and lymph node dissection ***,dissection time was significantly correlated with intraoperative blood loss(r=0.7744,Ped analysis demonstrated that patients with a preoperative BMI≥21.9 kg/m²and a TIBL concentration≥57.7μmol/L had significantly longer lymph node dissection times(both P<0.05).CONCLUSION The"five steps four quadrants

关键词： Five steps four quadrants Hepatic hilum lymph node Modularized en bloc clearance Laparoscopic pancreaticoduodenectomy

Characterizing occurrence of emerging organic contaminants in Dinaric karst catchment of Jadro andZrnovnica springs,Croatia

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Emerging Contaminants 2024年第3期10卷 158-169页

作者： Ana Selak Jasmina Lukac Reberski Ivana Boljat Josip Terzic HGI-CGS-Croatian Geological Survey Department of Hydrogeology and Engineering GeologySachsova 210000ZagrebCroatia

The occurrence of emerging organic contaminants(EOCs)was investigated in vulnerable Dinaric karst catchment of Jadro andZrnovnica springs in Croatia,under varying flow conditions and across three different water resource types(groundwater,springs,and surface water).The maximal EOCs concentration in both springs were observed following autumn recharge events,while during peak discharge no detection above the limits of detection(LOD)was recorded due to dilution *** to springs,groundwater from deep borehole exhibited highest total EOCs concentration under low flow conditions,underscoring the considerable karst aquifer vulnerability and its oligotrophic *** peak EOCs concentration in karstic Cetina River coincided with the river's lowest *** highest mass flux of 1013 g/day was determined for very mobile pharmaceutical metformin detected in *** presence of potentially persistent to very persistent compounds,like DEET and 1H-benzotriazole,which exhibited highest detection frequencies across all sampling sites,was observed in association with varying hydrological *** regarding the occurrence of identified EOCs include surface contamination infiltrating directly through ponors and highly karstified areas,potential persistence in the epikarst and aquifer matrix,and site-specific contamination sources for compounds such as 1H-benzotriazole,gabapentin,and ketoprofen found in *** evaluate the risk of inadvertent human exposure to EOCs across various age groups,we utilized measured spring concentrations and calculated drinking water equivalent levels(DWEL),which ranged from 1.4 mg/L for cotinine to 503 mg/L for sucralose,both detected in Jadro *** EOCs concentrations in ng/L are unlikely to pose a significant risk to healthy population,long-term exposure to EOCs mixture remains *** scarcity of research on EOCs in karst environments on both global and national levels,our study enhances comp

关键词： Karst groundwater Emerging organic contaminants Pharmaceuticals Human exposure DEET 1H-benzotriazole

“Hepatic hilum area priority,liver posterior first”:An optimized strategy in laparoscopic resection for type Ⅲ-Ⅳ hilar cholangiocarcinoma

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2167-2174页

作者： Xiao-Si Hu Yong Wang Hong-Tao Pan Chao Zhu Shi-Lei Chen Shuai Zhou Hui-Chun Liu Qing Pang Hao Jin Department of Hepatopancreatobiliary Surgery Anhui No.2 Provincial People's HospitalHefei 230041Anhui ProvinceChina

BACKGROUND In recent years,pure laparoscopic radical surgery for Bismuth-Corlette type Ⅲ and Ⅳ hilar cholangiocarcinoma(HCCA)has been preliminarily explored and applied,but the surgical strategy and safety are still worthy of further improvement and *** To summarize and share the application experience of the emerging strategy of“hepatic hilum area dissection priority,liver posterior separation first”in pure laparoscopic radical resection for patients with HCCA of Bismuth-Corlette types Ⅲ and *** The clinical data and surgical videos of 6 patients with HCCA of Bismuth-Corlette types Ⅲ and Ⅳ who underwent pure laparoscopic radical resection in our department from December 2021 to December 2023 were retrospectively *** Among the 6 patients,4 were males and 2 were *** average age was 62.2±11.0 years,and the median body mass index was 20.7(19.2-24.1)kg/m^(2).The preoperative median total bilirubin was 57.7(16.0-155.7)μmol/*** patient had Bismuth-Corlette type Ⅲa,4 patients had Bismuth-Corlette type Ⅲb,and 1 patient had Bismuth-Corlette type Ⅳ.All patients successfully underwent pure laparoscopic radical resection following the strategy of“hepatic hilum area dissection priority,liver posterior separation first”.The operation time was 358.3±85.0 minutes,and the intraoperative blood loss volume was 195.0±108.4 *** of the patients received blood transfusions during the perioperative *** median length of stay was 8.3(7.0-10.0)*** bile leakage occurred in 2 patients,and all patients were discharged without serious surgery-related *** The emerging strategy of“hepatic hilum area dissection priority,liver posterior separation first”is safe and feasible in pure laparoscopic radical surgery for patients with HCCA of Bismuth-Corlette types Ⅲ and Ⅳ.This strategy is helpful for promoting the modularization and process of pure laparoscopic radical surgery for complicated HCCA,shortens the learning curve,and

关键词： Hilar cholangiocarcinoma Bismuth-Corlette typesⅢandⅣ Laparoscopy Radical resection Strategy

Review of Inductance Identification Methods Considering Inverter Nonlinearity for PMSM

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Chinese Journal of Electrical Engineering 2024年第2期10卷 1-15页

作者： Qiwei Wang Jiqing Xue Gaolin Wang Yihua Hu Dianguo Xu School of Electrical Engineering and Automation Harbin Institute of TechnologyHarbin 150000China Department of Engineering King’s College LondonLondon WC2R 2LSUK

Permanent magnet synchronous motors(PMSMs)are widely used in high-power-density and flexible control ***,the inductance changes significantly in real-time machine operations because of magnetic saturation and coupling ***,the identification of inductance is crucial for PMSM *** inductance identification methods are primarily based on the voltage source inverter(VSI),making inverter nonlinearity one of the main error sources in inductance *** improve the accuracy of inductance identification,it is necessary to compensate for the inverter nonlinearity *** this study,an overview of the PMSM inductance identification and the related inverter nonlinearity self-learning methods are presented.

关键词： Inductance identification inverter nonlinearity self-learning permanent magnet synchronous motor

Rethinking neurodegenerative diseases:neurometabolic concept linking lipid oxidation to diseases in the central nervous system

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Neural Regeneration Research 2024年第7期19卷 1437-1445页

作者： Steinunn Sara Helgudóttir Anne Skøttrup Mørkholt Jacek Lichota Preben Bruun-Nyzell Mads Christian Andersen Nanna Marie Juhl Kristensen Amanda Krøger Johansen Mikela Reinholdt Zinn Hulda Maria Jensdóttir John Dirk Vestergaard Nieland 2N Pharma ApS NOVI Science ParkAalborgDenmark Molecular Pharmacology Group Department of Health Science and TechnologyAalborg UniversityAalborgDenmark

Currently,there is a lack of effective medicines capable of halting or reve rsing the progression of neurodegenerative disorde rs,including amyotrophic lateral sclerosis,Parkinson s disease,multiple sclerosis,or Alzheimer s *** the unmet medical need,it is necessary to reevaluate the existing para digms of how to to rget these *** considering neurodegenerative diseases from a systemic neurometabolic perspective,it becomes possible to explain the shared pathological *** innovative approach presented in this paper draws upon exte nsive research conducted by the authors and researchers *** this review,we highlight the importance of metabolic mitochondrial dysfunction in the context of neurodegenerative *** provide an overview of the risk factors associated with developing neurodegenerative disorders,including genetic,epigenetic,and environmental fa ***,we examine pathological mechanisms implicated in these diseases such as oxidative stress,accumulation of misfolded proteins,inflammation,demyelination,death of neurons,insulin resistance,dysbiosis,and neurotransmitter ***,we outline a proposal for the restoration of mitochondrial metabolism,a crucial aspect that may hold the key to facilitating curative therapeutic interventions for neurodegenerative disorders in forthcoming advancements.

关键词： brain disease carnitine palmitoyl transferase 1 epigenetics metabolism gut microbiome mitochondrial dysfunction neurodegeneration oxidative stress

Studies on the temporal,structural,and interacting features of the clubroot resistance gene Rcr1 using CRISPR/Cas9-based systems

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Horticultural Plant Journal 2024年第4期10卷 1035-1048页

作者： Hao Hu Fengqun Yu Agriculture and Agri-Food Canada Saskatoon Research and Development Centre107 Science PlaceSaskatoonSKS7N OX2Canada

Clubroot disease is a severe threat to Brassica crops globally,particularly in western *** resistance,achieved through pyramiding clubroot resistance(CR)genes with different modes of action,is the most important strategy for managing the ***,studies on the CR gene functions are quite *** this study,we have conducted investigations into the temporal,structural,and interacting features of a newly cloned CR gene,Rcr1,using CRISPR/Cas9 *** temporal functionality,we developed a novel CRISPR/Cas9-based binary vector,pHHIGR-Hsp18.2,to deliver Rcr1 into a susceptible canola line(DH12075)and observed that early expression of Rcr1 is critical for conferring *** structural functionality,several independent mutations in specific domains of Rcr1 resulted in loss-offunction,highlighting their importance for CR *** the study of the interacting features of Rcr1,a cysteine protease gene and its homologous allele in canola were successfully disrupted via CRISPR/Cas9 as an interacting component with Rcr1 protein,resulting in the conversion from clubroot resistant to susceptible in plants carrying intact *** results indicated an indispensable role of these two cysteine proteases in Rcr1-mediated resistance *** study,the first of its kind,provides valuable insights into the functionality of ***,the new vector p HHIGR-Hsp18.2 demonstrated an inducible feature on the removal of add-on traits,which should be useful for functional genomics and other similar research in brassica crops.

关键词： Clubroot resistance Brassica crops Canola Rcr1 CRISPR/Cas9 system Gene knock-out Timing control Non-synonymous mutation Protein-protein interaction