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Modularized viromimetic polymer nanoparticle vaccines(VPNVaxs) to elicit durable and effective humoral immune responses

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National Science Review 2024年第3期11卷 200-214页

作者： Zichao Huang Xinyu Zhuang Liping Liu Jiayu Zhao Sheng Ma Xinghui Si Zhenyi Zhu Fan Wu Ningyi Jin Mingyao Tian Wantong Song Xuesi Chen Key laboratory of Polymer ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Sciences School of Applied Chemistry and engineering University of Science and Technology of China Changchun Veterinary Research Institute Chinese Academy of Agricultural Sciences Jilin Biomedical Polymers engineering laboratory State Key laboratory of Polymer physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences

Virus-like particle(VLP) vaccines had shown great potential during the COVID-19 pandemic, and was thought to be the next generation of antiviral vaccine technology due to viromimetic structures. However,the time-consuming and complicated processes in establishing a current recombinant-protein–based VLP vaccine has limited its quick launch to the out-bursting pandemic. To simplify and optimize VLP vaccine design, we herein report a kind of viromimetic polymer nanoparticle vaccine(VPNVax), with subunit receptor-binding domain(RBD) proteins conjugated to the surface of polyethylene glycol-b-polylactic acid(PeG-b-PLA) nanoparticles for vaccination against SARS-CoV-2. The preparation of VPNVax based on synthetic polymer particle and chemical post-conjugation makes it possible to rapidly replace the antigens and construct matched vaccines at the emergence of different viruses. Using this modular preparation system, we identified that VPNVax with surface protein coverage of 20%–25% had the best immunostimulatory activity, which could keep high levels of specific antibody titers over 5 months and induce virus neutralizing activity when combined with an aluminum adjuvant. Moreover, the polymer nano-vectors could be armed with more immune-adjuvant functions by loading immunostimulant agents or chemical chirality design. This VPNVax platform provides a novel kind of rapidly producing and efficient vaccine against different variants of SARS-CoV-2 as well as other viral pandemics.

关键词： vaccine polymer nanomaterials SARS-CoV-2

Modulating selective interaction of NiOOH with Mg ions for high-performance aqueous batteries

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eScience 2024年第5期4卷 160-169页

作者： Bing He Ying Ling Zhixun Wang Wenbin Gong Zhe Wang Yanting Liu Tianzhu Zhou Ting Xiong Shuai Wang Yonggang Wang Qingwen Li Qichong Zhang Lei Wei School of electrical and electronic engineering Nanyang Technological University50 Nanyang Avenue 639798Singapore Key laboratory of Multifunctional nanomaterials and Smart Systems Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China Department of Chemistry Fudan UniversityShanghai 200438China School of physics and energy Xuzhou University of TechnologyXuzhou 221018China

Aqueous Mg-ion batteries(AMIBs)featuring advantages of good safety,low cost,and high specific energy have been recognized as a promising energy-storage ***,the performance of AMIBs is consistently limited by sluggish diffusion kinetics and structural degradation of cathode materials arising from the strong electrostatic interactions between high-charge-density Mg2+and host ***,layered-structured NiOOH,as traditional cathodes for alkaline batteries,is initially demonstrated to realize proton-assisted Mg-(de)intercalation chemistry with a high discharge platform(0.57V)in neutral aqueous *** from the unique core/shell structure,the resulting NiOOH/CNT cathodes achieve a high capacity of 122.5 mAh g−1 and long cycle *** theoretical calculations reveal that the binding energy of hydrated Mg2+is higher than that of Mg2+with NiOOH,resulting in that Mg2+is easily intercalated/de-intercalated into/from *** from the freestanding design,the assembled fiber-shaped“rocking-chair”NaTi2(PO4)3//NiOOH AMIB shows a high energy density and satisfactory mechanical flexibility,which could be woven into a commercial fabric and power for fiber-shaped photoelectric sensors.

关键词： NiOOHAqueous electrolyte Mg-intercalation chemistry Rocking-chair Mg-ion batteries Fiber electronics

Fullerene-derived boron-doped defective nanocarbon for highly selective H_(2)O_(2) electrosynthesis

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Nano Research 2024年第3期17卷 1217-1224页

作者： Wangqiang Shen Chang Zhang Muneerah Alomar Zhiling Du Zepeng Yang Junjie Wang Guangqing Xu Jian Zhang Jun Lv Xing Lu School of Materials Science and engineering Hefei University of TechnologyHefei 230009China School of energy and environmental Hebei University of EngineeringHandan 056038China School of Materials Science and engineering Huazhong University of Science and TechnologyWuhan 430074China Department of physics College of SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia

electrochemical production of hydrogen peroxide(H_(2)O_(2))via the two-electron(2e-)pathway of oxygen reduction reaction(ORR)supplies an auspicious alternative to the current industrial anthraquinone ***,it still lacks efficient electrocatalysts to achieve high ORR activity together with 2e-selectivity ***,a boron-doped defective nanocarbon(B-DC)electrocatalyst is synthesized by using fullerene frameworks as the precursor and boric oxide as the boron *** obtained B-DC materials have a hierarchical porous structure,befitting boron dopants,and abundant topological pentagon defects,exhibiting a high ORR onset potential of 0.78 V and a dominated 2e-selectivity(over 95%).Remarkably,when B-DC electrocatalyst is employed in a real device,it achieves a high H_(2)O_(2) yield rate(247 mg·L^(-1)·h^(-1)),quantitative Faraday efficiency(~100%),and ultrafast organic pollutant degradation *** theoretical calculation reveals that the synergistic effect of topological pentagon defects and the incorporation of boron dopants promote the activation of the O_(2) molecule and facilitates the desorption of oxygen *** finding will be very helpful for the comprehension of the synergistic effect of topological defects and heteroatom dopants for boosting the electrocatalytic performance of nanocarbon toward H_(2)O_(2) production.

关键词： fullerene electrochemical hydrogen peroxide production oxygen reduction reaction carbon nanomaterials

Structural effects induced by dialysis-based purification of carbon nanomaterials

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Nano Materials Science 2024年第4期6卷 475-483页

作者： A.D.Veloso A.M.Ferraria A.M.Botelho do Rego A.S.Viana A.J.S.Fernandes A.J.Fielding R.A.Videira M.C.Oliveira CQ-VR and Chemistry Department University of Trás-os-Montes e Alto Douro BSIRG iBB-Institute for Bioengineering and BiosciencesDepartment of Chemical Engineeringand Associate Laboratory i4HB-Institute for Health and BioeconomyInstituto Superior TécnicoUniversidade de Lisboa Centro de Química estrutural Institute of Molecular SciencesDepartamento de Química e BioquímicaFaculdade de CiênciasUniversidade de Lisboa I3N and physics Department University of AveiroCampus de Santiago Faculty of Science Pharmacy and Biomolecular SchoolLiverpool John Moores University ReQUIMTe/LAQV Laborat orio de FarmacognosiaDepartamento de QuímicaFaculdade de Farm aciaUniversidade do Porto

Dialysis plays a crucial role in the purification of nanomaterials but its impact on the structural properties of carbon nanomaterials was never ***,a carbon-based nanomaterial generated electrochemically in potassium phosphate buffer,was characterized before and after dialysis against pure *** is shown that dialysis affects the size of the carbon domains,structural organization,surface functionalization,oxidation degree of carbon,and grade of ***,dialysis drives the nanomaterial organization from discrete roundish carbon domains,with sizes ranging from 70 to 160 nm,towards linear stacking structures of small nanoparticles （el,alcohol and ether （epoxide） surface groups evolve into more oxidized carbon groups （e.g.,ketone and ester groups）.Investigation of the as-prepared nanomaterial by electron paramagnetic resonance （ePR） revealed a resonance signal consistent with carbon-oxygen centred ***,this study brings to light the selective affinity of the carbon nanomaterial under study to capture Na+ions,a property greatly enhanced by the dialysis process,and its high ability to trap oxygen,particularly before *** findings open new perspectives for the application of carbon-based nanomaterials and raise awareness of the importance of structural changes that can occur during the purification of carbon-based nanomaterials.

关键词： Nanocarbon Surface functionalization NMR XPS Hydrophilic carbon Paramagnetic

SWIR FluorescenceImaging In Vivo Monitoring and evaluating Implanted M2 Macrophages in Skeletal Muscle Regeneration

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engineering 2024年第2期33卷 283-294页

作者： Mo Chen Yuzhou Chen Sijia Feng Shixian Dong Luyi Sun Huizhu Li Fuchun Chen Nguyen Thi Kim Thanh Yunxia Li Shiyi Chen You Wang Jun Chen Sports Medicine Institute of Fudan University Department of Sports MedicineHuashan HospitalFudan UniversityShanghai 200040China Department of Bone and Joint Surgery Department of OrthopedicsRenji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200127China Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Key laboratory of Infrared System Detection&Imaging Technology Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China Biophysics Group Department of Physics and AstronomyUniversity College LondonLondon WC1E 6BTUK Healthcare Biomagnetic and nanomaterials Laboratories University College LondonLondon W1S 4BSUK

Skeletal muscle has a robust regeneration ability that is impaired by severe injury,disease,and *** in a decline in skeletal muscle ***,improving skeletal muscle regeneration is a key challenge in treating skeletal muscle-related *** to their significant role in tissue regeneration,implantation of M2 macrophages(M2MФ)has great potential for improving skeletal muscle ***,we present a short-wave infrared(SWIR)fluorescence imaging technique to obtain more in vivo information for an in-depth evaluation of the skeletal muscle regeneration effect after M2MФ*** fluorescence imaging was employed to track implanted M2MФin the injured skeletal muscle of mouse *** is found that the implanted M2MФaccumulated at the injury site for two ***,SWIR fluorescence imaging of blood vessels showed that M2MФimplantation could improve the relative perfusion ratio on day 5(1.09±0.09 vs 0.85±0.05;p=0.01)and day 9(1.38±0.16 vs 0.95±0.03;p=0.01)post-injury,as well as augment the degree of skeletal muscle regencration on day 13 ***,multiple linear regression analyses determined that post-injury time and relative perfusion ratio could be used as predictive indicators to evaluate skeletal muscle *** results provide more in vivo details about M2MФin skeletal muscle regeneration and confirm that M2MФcould promote angiogenesis and improve the degree of skeletal muscle repair,which will guide the research and development of M2MФimplantation to improve skeletal muscle regeneration.

关键词： In vivo Short-wave infrared Skeletal muscle Macrophage Regeneration

enhanced biocompatibility of ZnS:Mn quantum dots encapsulated with Aloe vera extract for therapeutic applications

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Chinese physics B 2016年第8期25卷 412-416页

作者： Anilkumar M Bindu K R Sneha Saj A Anila e I Cell Culture laboratory Department of Botany UC College Optoelectronic and nanomaterials' Research laboratory Department of Physics UC College Department of physics SSV College

Toxicity of nanoparticles remains to be a major issue in their application to the biomedical field. Aloe vera（AV） is one of the most widely exploited medicinal plants that have a multitude of amazing properties in the field of *** extract of Aloe vera can be used as a novel stabilising agent for quantum dots to reduce toxicity. We report the synthesis, structural characterization, antibacterial activity and cytotoxicity studies of ZnS：Mn quantum dots synthesized by the colloidal precipitation method, using methanol extract of Aloe vera（AVMe） as the capping agent. The ZnS：Mn quantum dots capped with AVMe exhibit superior performances in biocompatibility and antibacterial activity compared with ZnS：Mn quantum dots without encapsulation.

关键词： quantum dot transmission electron microscopy biocompatibility

Thermal Conductivity of Twisted Bilayer Graphene

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Thermal Conductivity of Twisted Bilayer Graphene

enhanced performance of a solar cell based on a layer-by-layer self-assembled luminescence down-shifting layer of core–shell quantum dots

第二届海峡两岸功能材料科技与产业峰会（2015）

作者： Hao Ying Hongyang Li Xiangping Chen Denis L.Nika Alexandr I.Cocemasov Weiwei Cai Alexander A.Balandin Shanshan Chen Department of physics Laboratory of Nanoscale Condense Matter Physics and State Key Laboratory of Physical Chemistry of Solid SurfacesXiamen University Nano-Device laboratory Department of Electrical Engineering and Materials Science and Engineering ProgramUniversity of California – Riverside e.pokatilov laboratory of physics and engineering of nanomaterials Department of Physics and EngineeringMoldova State University

We have investigated experimentally the thermal conductivity of suspended twisted bilayer *** measurements were performed using the optothermal Raman *** was found that the thermal conductivity of the twisted bilayer graphene is lower than that of monolayer graphene and the reference Bernal stacked bilayer graphene in the entire examined temperature range(00 K–700 K).This finding indicates that

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Chinese physics B 2018年第12期27卷 461-465页

作者： Ni Liu Shu-Xin Li Ying-Chun Ye Yan-Li Yao College of Aeronautical engineering Binzhou UniversityBinzhou 256603China Anhui Key laboratory of nanomaterials and Technology and Key laboratory of Materials physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China

In this paper, core–shell quantum dots(QDs) with two polar surface functional groups(ZnSe/ZnS–COOH QDs and ZnSe/ZnS–NH_2 QDs) are synthesized in an aqueous phase. Photoluminescence(PL) and absorption spectra clearly indicate luminescence down-shifting(LDS) properties. On the basis of QDs, surface functional group multilayer LDS films(MLDSs) are fabricated through an electrostatic layer-by-layer(LBL) self-assembly method. The PL intensity increases linearly with the number of bilayers, showing a regular and uniform film growth. When the M-LDS is placed on the surface of a Si-based solar cell as an optical conversion layer for the first time, the external quantum efficiency(eQe) and shortcircuit current density(Jsc) notably increases for the LDS process. The eQe response improves in a wavelength region extending from the UV region to the blue region, and its maximum increase reaches more than 15% between 350 nm and 460 nm.

关键词： two-surface functional group LBL self-assembly LDS

exploring biomedical applications with silver and copper nanotechnology

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cMat 2024年第2期1卷 1-8页

作者： Xue-Qian Li Shao-Lei Xie Hui-Dong Xie Meng-Qi Shen Zhen-Hui Ma Hu Liu Key laboratory of Green and High-end Utilization of Salt Lake Resources Qinghai Institute of Salt LakesChinese Academy of SciencesXiningChina School of Chemistry and Chemical engineering Xi'an University of Architecture and TechnologyXi'anChina Lenfest Center for Sustainable energy Columbia UniversityNew YorkUSA Department of physics Beijing Technology and Business UniversityBeijingChina

The overuse and misuse of antibiotics has accelerated the emergence of bacterial resistance,making the treatment of common infections increasingly difficult and *** has led to a rise in infection rates,worsened patient outcomes,and heightened mortality *** response,researchers have been exploring new antimicrobial strategies,with metal nanomaterials of controllable shape and size gaining significant attention for their unique antibacterial *** these,silver(Ag)and copper(Cu)nanomaterials(NMs)stand out for their wide applications in biomedical materials due to their effective antimicrobial mecha-nisms when used as *** and Cu NMs,exemplifying metal biomaterials,showcase broad-spectrum antibacterial capabilities,durable antimicrobial effects,low toxicity,and reduced likelihood of developing drug ***,they are known to promote angiogenesis,making them exceptionally suitable for biomaterial *** review underscores the significance of Ag and Cu NMs in the biomedical sector,detailing their applications and the promising role they play as medical *** aim is to encourage further exploration and utilization of Ag and Cu NMs in biomaterials and industrial production sectors.

关键词： Ag nanomaterials biomaterial cell-biological activity Cu nanomaterials metal nanomaterials