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Significance of neutralizing antibodies in COVID-19 therapy:progress and prospect

Journal of Chinese Pharmaceutical Sciences 2021年第2期30卷 87-106页

作者： Zeqi Zhou Xiangbin Wang Xiqing Zhang Yuan Zhang Yankai Fu Zhixian Wang Yan Su He Wang Meng Xiao Changxiao Liu dynamiker sub-center of beijing key laboratoiy for mechanisms research and precision diagnosis of invasive fungal disease Tianjin 300467China Tianjin Enterprise key Laboratory for precision diagnosis Technology of invasive fungal diseases Tianjin 300467China beijing Antai Zhiyuan Technology Co. Ltd.Beijing 102206China Clinical Laboratory Peking Union HospitalChinese Academy of Medical SciencesBeijing 100730China beijing key Laboratory beijing for Mechanism Study and precision diagnosis of invasive fungal diseases(bz0447) Beijing 100730China State key Laboratory of Drug Delivery Technology and Pharmacokinetics Tianjin Institute of Pharmaceutical ResearchTianjin 300462China

SARS-CoV-2 infection is a serious threat to human life and health all over the world,and COVID-19 is a global epidemic caused by SARS-CoV-2 ***-CoV-2 is highly infectious,strange and ***,the treatment of COVID-19 must be urgent and ***,vaccines and currently used drugs generally do not have the above-mentioned *** convalescent plasma of COVID-19 has shown a clinical application value in the emergency treatment of critical patients,it shows great *** human recombinant multivalent neutralizing nano-antibodies may meet the deficiency of COVID-19 *** engineering technologies have been used to develop specific neutralizing antibody(nAB)drugs for the treatment of COVID-19 *** of the candidate nAB drugs have been entered the clinical trials and can be used for the therapy of COVID-19 *** the present review,we studied and analyzed n ABs for the treatment of COVID-19 and the progress and prospect from the following five aspects:1)The biological and clinical characteristics of SARS-CoV-2 infection;2)The feasibility of plasma therapy for convalescents with COVID-19;3)The technical routes of developing n Ab drugs;4)The current status of developing global COVID-19 antibodies;5)The difficulties and clinical use.

关键词： SARS-CoV-2 Neutralizing antibody(nAB) COVID-19

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