检索结果-南通市图书馆

Reconfigurable nonlinear photonic activation function for photonic neural network based on non-volatile opto-resistive RAM switch

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2022年第10期11卷 2512-2522页

作者： Zefeng Xu Baoshan Tang Xiangyu Zhang Jin Feng Leong Jieming Pan Sonu Hooda Evgeny Zamburg Aaron Voon-Yew Thean Integrative Sciences and Engineering Programme NUS Graduate SchoolNational University of SingaporeSingaporeSingapore Department of Electrical and Computer Engineering National University of Singapore4 Engineering Drive 3Singapore 117583Singapore

Photonic neural network has been sought as an alternative solution to surpass the efficiency and speed bottlenecks of electronic neural *** that the integrated Mach-Zehnder Interferometer(MZI)mesh can perform vector-matrix multiplication in photonic neural network,a programmable in-situ nonlinear activation function has not been proposed to date,suppressing further advancement of photonic neural ***,we demonstrate an efficient in-situ nonlinear accelerator comprising a unique solution-processed two-dimensional(2D)MoS2 Opto-Resistive RAM Switch(ORS),which exhibits tunable nonlinear resistance switching that allow us to introduce nonlinearity to the photonic neuron which overcomes the linear voltage-power relationship of typical photonic *** reconfigurable scheme enables implementation of a wide variety of nonlinear ***,we confirm its feasibility and capability for MNIST handwritten digit recognition,achieving a high accuracy of 91.6%.Our accelerator constitutes a major step towards the realization of in-situ photonic neural network and pave the way for the integration of photonic integrated circuits(PIC).

关键词： network neural nonlinear

The chest X ray in pulmonary embolism: Westermark sign, Hampton's Hump and Palla's sign. What's the difference?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Acute Disease 2018年第3期7卷 99-102页

作者： Tan Si Hong Shawn Lim Xin Yan Fatimah Lateef dukes-nus graduate medical school and Yong Loo Lin school of Medicine National University of Singapore DirectorSinghealth Duke NUS Institute of Medical SimulationSingapore Department of Emergency Medicine Singapore General Hospital Singapore

Pulmonary embolism (PE), with the incidence of about 60 per 100000 annually, can be a life-threatening disease if it is not treated promptly. It has been estimated that some 10% of PE patients die within the first hour of the event. Untreated PE has a mortality of about 30%. PE is a condition that is treatable if suspected and diagnosed early. The chest radiograph is still the first investigation that is ordered in patients presenting with cardiorespiratory symptoms or symptoms suggestive of PE. The CXR is also helpful in identifying or excluding other conditions or diagnoses. Thus, knowing and understanding some of the more specific CXR signs can be useful. We suggest that physicians to be aware of and utilize CXR findings such as Palla's sign, Westermark sign and Hamptons hump to help with the diagnosis of PE and to exclude other conditions that can mimic venous thrombo-embolism. Even if these signs are not common, their presence, even in an unsuspected patient without a high pretest probability of PE, should prompt further investigations such as a D-dimer test, lung scintigraphy or computed tomography pulmonary angiography as required.

关键词： Pulmonary embolism Palla's sign Hamptom's Hump Westermark sign

Study on the action mechanism of Wuling Powder on treating osteoporosis based on network pharmacology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2021年第1期19卷 28-35页

作者： ZHOU Hao-Nan LI Hao-Yu XU Wen-Hua WEI Yan-Yi YU Rui-Xin WANG Wei CHEN Yuan-Ming graduate school Guangxi University of Chinese MedicineNanning 530000China graduate school Guangxi Medical UniversityNanning 530000China Department of Orthopedics the Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000China

Osteoporosis is a health problem to cause global concern.A lot of methods have been used to prevent and treat osteoporosis,but there is still a lack of effective treatment for osteoporosis owing to limited understanding of its ***,the aim of this present study is to explore the underlying mechanism of Wuling Powder,a traditional Chinese medicine on treating *** this study,we firstly screened and identified the common targets between Wuling Powder and osteoporosis through the related databases,and then explored the relationships among these targets,Wuling Powder and osteoporosis by using Gene Ontology(GO),Kyoto Encyclopedia of Genes and Genomes(KEGG)and network ***,the molecular docking was performed by using systemsDock to evaluate the potential binding relationships between the active components of Wuling Powder and their related *** results showed that in total of 14 common targets including CREBBP,ADAM17,GOT1,GAPDH,USP8,ERBB2,EEF1 A1,MTOR,RAC1,ETS1,DDX58,GCK,EGF and S100 A8 were ***,ERBB2,MTOR and HIF-1 were the potential therapeutic targets for osteoporosis,and they were also the related targets for predicting active components in Wuling *** together,we concluded that Wuling Powder might be used to treat osteoporosis through above these targets.

关键词： Wuling Powder Osteoporosis Network Pharmacology

Think muscle;Think rhabdomyolysis

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Acute Disease 2018年第5期7卷 213-216页

作者： Fatimah Lateef Arunima Gupta Department of Emergency Medicine Singapore General HospitalSingapore Singhealth duke nus Institute of medical Simulation Singapore dukes-nus graduate medical school and Yong Loo Lin school of Medicine National University of SingaporeSingapore

Rhabdomyolysis is the breakdown of striated muscle cells resulting in leakage of cell matter into the extra-cellular *** can present with myalgia,muscle weakness and *** of passing of dark tea-coloured urine have also been *** creatinine kinase is diagnostic of *** serum myoglobin levels and presence of myoglobin in the urine (myoglobinuria) help to support the *** actiology for rhabdomyolysis can be both traumatic and *** the case of trauma,individuals with crush injuries trapped in cars or under collapsed buildings,struggling against restraints,immobilized and in the same position for hours due to injuries,comatosed states or positioning during prolonged surgeries and those with high voltage electrical injuries are at increased risk of ***-traumatic causes of rhabdomyolysis include hyperthermia,metabolic myopathies,drugs and toxins ingestions,clectrolyte abnormalities and *** mechanism of rhabdomyolysis is often *** the case of trauma,direct injury to cell membranes as well as hypoxia from direct compression leading to adenosine triphosphate depletion leads to breakdown of striated muscle cells..The lysed cells release myoglobin,creatine kinase,urate and phosphate into the *** heme protein-induced toxicity on nephrons can result in acute kidney *** report a case of traumatic rhabdomyolysis and share the latest in the literature on the understanding of the subject as well as that of *** which it is often associated with.

关键词： Rhabdomyolysis Myoglobinuria Acute kidney injury

Diversion colitis and pouchitis: A mini-review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2018年第16期24卷 1734-1747页

作者： Kentaro Tominaga Kenya Kamimura Kazuya Takahashi Junji Yokoyama Satoshi Yamagiwa Shuji Terai Division of Gastroenterology and Hepatology Graduate School of Medical and Dental Sciences Niigata University

Diversion colitis is characterized by inflammation of the mucosa in the defunctioned segment of the colon after colostomy or ileostomy. Similar to diversion colitis, diversion pouchitis is an inflammatory disorder occurring in the ileal pouch, resulting from the exclusion of the fecal stream and a subsequent lack of nutrients from luminal bacteria. Although the vast majority of patients with surgically-diverted gastrointestinal tracts remain asymptomatic, it has been reported that diversion colitis and pouchitis might occur in almost all patients with diversion. Surgical closure of the stoma, with reestablishment of gut continuity, is the only curative intervention available for patients with diversion disease. Pharmacologic treatments using short-chain fatty acids, mesalamine, or corticosteroids are reportedly effective for those who are not candidates for surgical reestablishment; however, there are no established assessment criteria for determining the severity of diversion colitis, and no management strategies to date. Therefore, in this mini-review, we summarize and review various recently-reported treatments for diversion disease. We are hopeful that the information summarized here will assist physicians who treat patients with diversion colitis and pouchitis, leading to better case management.

关键词： Diversion colitis Diversion pouchitis Ileitis Inflammatory bowel disease

Considerations of elderly factors to manage the complication of liver cirrhosis in elderly patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2019年第15期25卷 1817-1827页

作者： Kenya Kamimura Akira Sakamaki Hiroteru Kamimura Toru Setsu Takeshi Yokoo Masaaki Takamura Shuji Terai Division of Gastroenterology and Hepatology Graduate School of Medical and Dental Sciences Niigata University

The aging of the organ function causes sensitivity to the disease progression and need careful consideration for the medical treatment. With the increase of aging population, the opportunity to provide medical treatment for people in very old age is rapidly increasing therefore, the understanding of the various physiological changes of cellular function, size and function of organs are essential for the decision of therapeutic options. Among the various chronic conditions seen in elderly people, we have focused on liver cirrhosis, since despite specific therapeutic options for many of liver diseases including direct acting antivirals for hepatitis C virus, nucleoside analogs for hepatitis B, and corticosteroids for autoimmune hepatitis, there is currently no standard therapy to treat liver cirrhosis, which is the final stage of these liver diseases. Therefore,management of the various symptoms of liver cirrhosis is essential, and agingrelated parameters must be considered in the decision making for therapeutic strategies and dosage of the available medicine. In this mini-review, we have summarized the therapeutic options to manage various symptoms of liver cirrhosis, carefully considering the physiological changes of various organs associated with aging.

关键词： Liver cirrhosis Elderly patients Quality of life Aging

Autonomic nervous system network and liver regeneration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2018年第15期24卷 1616-1621页

作者： Kenya Kamimura Ryosuke Inoue Takuro Nagoya Norihiro Sakai Ryo Goto Masayoshi Ko Yusuke Niwa Shuji Terai Division of Gastroenterology and Hepatology Graduate School of Medical and Dental Sciences Niigata University

To date, various signal transducers, cytokines, growth factors, and hormones have been reported to play an important role in homeostasis of various organs. Various cells and organs are involved in the hepatic regeneration process, which proceeds as a result of the coordination of many factors. While these factors are well known to be involved in the liver regeneration after the liver injury, however, as the details of such mechanisms have not been sufficiently elucidated, the practical applicability of hepatic regeneration based on the action of these and cytokines growth factors is still unclear. In terms of the involvement of the autonomic nervous system in hepatic regeneration, cell proliferation resulting from direct signal transduction to the liver has also been reported and recent studies focusing on the inter-organ communication via neural network opened a novel aspect of this field for therapeutic applicability. Therefore, the appropriate understanding of the relationship between autonomic neural network and liver regeneration through various organs including brain, afferent nerve, efferent nerve, etc. is essential. This mini-review explains the principle of neural system involved in the inter-organ communication and its contribution on the liver regeneration upon the liver injury reviewing recent progress in this field.

关键词： Autonomic nerve Neural network Liver regeneration Hormone

Lateral olfactory tract usher substance(LOTUS) protein,an endogenous Nogo receptor antagonist,converts a non-permissive to permissive brain environment for axonal regrowth

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第7期13卷 1193-1194页

作者： Tomoko Hirokawa Kohtaro Takei Molecular medical Bioscience Laboratory Yokohama City University Graduate School of Medical Life Science

It is well known that primates,including humans,hardly recover motor function after spinal cord injury（SCI）when compared with non-primate mammals such as *** limited functional recovery is in part due to a non-permi... 详细信息

关键词： MAG Lateral olfactory tract usher substance protein,an endogenous Nogo receptor antagonist,converts a non-permissive to permissive brain environment for axonal regrowth LOTUS SCI CNS

Spontaneous regression of hepatocellular carcinoma: A mini-review

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第21期23卷 3797-3804页

作者： Akira Sakamaki Kenya Kamimura Satoshi Abe Atsunori Tsuchiya Masaaki Takamura Hirokazu Kawai Satoshi Yamagiwa Shuji Terai Division of Gastroenterology and Hepatology Graduate School of Medical and Dental Sciences Niigata University

Spontaneous tumor regression is an extremely rare phenomenon in the oncology field. However, there are several case reports resulted in the regression of hepatocellular carcinoma(HCC) and the accumulation of clinical information and analyses of the mechanism can contribute to the development of a novel therapy. For this purpose, we have carefully reviewed 23 cases of spontaneously regressed HCC published in recent 5 years and our case. The information regarding the tumor size, tumor marker, treatments, etc., have been summarized. The mechanism of spontaneous regression has been discussed to date and presumed to be due to many factors, including hypoxia and immunological reactions. In this careful review of the 24 cases based on the clinical information, hypoxia, systemic inflammation, and both upon spontaneous regression were seen in 3, 8, and 4 cases, respectively amo ng t he 15 c as e s f or w hic h t he inf o r mat io n regarding the proposed mechanisms are available. Recent development of immunotherapeutic approaches in oncology shows promising results, therefore, accumulation of additional cases and analysis of mechanisms underlying the spontaneous regression of HCC are essential and could lead to the development of a new generation of immunotherapies including antibodies directed against immune reactions.

关键词： Spontaneous regression Hepatocellular carcinoma Immunological reaction Immunotherapy Hypoxia