检索结果-南通市图书馆

Functionality of a next generation biosynthetic bacterial 6-phytase in enhancing phosphorus availability to weaned piglets fed a corn-soybean meal-based diet without added inorganic phosphate

引用

Animal nutrition 2020年第1期6卷 24-30页

作者： Yueming Dersjant-Li Boris Villca Vincent Sewalt Arno de Kreij Leon Marchal Deepak E.Velayudhan Robin *** Trine Christensen Rie Mejldal Igor Nikolaev Sina Pricelius Hye-Sook Kim Svend Haaning Jens F.Sorensen Rosil Lizardo dupont nutrition and biosciences Archimedesweg302333CN Leidenthe Netherlands Institut de Recerca I Tecnologia Agroalimentaries Centre Mas de BoverCtra.Reus-El Morell km.3.8E-43120Constantly Spain dupont nutrition&biosciences 925 Page Mill RoadPalo AltoCA 94304USA dupont nutrition&biosciences 21 Biopolis RoadNucleosSouth Tower138567Singapore dupont nutrition and biosciences Edwin Rahrs Vej 38DK-8220BrabrandDenmark

The utility of a next generation biosynthetic bacterial 6-phytase(PhyG)in restoring bone ash,bone phosphorus(P)content and performance in piglets depleted in P was evaluated.A total of 9 treatments were tested as *** 1,a negative control(NC)diet;treatments 2,3,4,NC supplemented with 250,500 or 1,000 FTU/kg of PhyG;treatments 5,6,NC supplemented with 500 or 1,000 FTU/kg of a commercial Buttiauxella sp phytase(PhyB);treatments 7,8,9,NC supplemented with monocalcium phosphate(MCP)to provide 0.7,1.4 and 1.8 g/kg digestible P,equating to a digestible P content of 1.8,2.5 and 2.9 g/*** latter constituting the positive control(PC)diet with adequate P and calcium(Ca).The NC was formulated without inorganic P(1.1 g digestible P/kg)and reduced in Ca(5.0 g/kg).Additional limestone was added to treatments 7 to 9 to maintain Ca-to-P ratio between 1.2 and 1.3.A total of 162 crossed Pietrain x(Large White×Landrace)21-d-old piglets(50%males and 50%females)were fed adaptation diets until 42 d old and then assigned to pens with 2 pigs/pen and 9 pens/treatment in a completely randomized block *** were fed mash diets based on corn and soybean meal ad libitum for 28 *** the end of the study,one piglet perpen was euthanized and the right feet collected for determination of bone strength,bone ash and mineral *** with the PC,the NC group had reduced average daily gain(ADG)and increased feed conversion ratio(FCR)during all growth phases and overall,and at d 28(70 d old)NC pigs had bones with reduced ash,Ca and P content(P500 FTU/kg,both PhyG and PhyB maintained ADG and FCR equivalent to *** regression analysis was done to compare the measured response parameters to increasing digestible P from *** on this analysis it was shown that PhyG and PhyB at 1,000 FTU/kg could replace 1,83 and 1.66 g/kg dige

关键词： Biosynthetic bacterial 6-phytase Bone ash Efficacy Growth performance Pigs

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Productive performance of commercial growing and finishing pigs supplemented with a Buttiauxella phytase as a total replacement of inorganic phosphate

引用

Animal nutrition 2018年第4期4卷 351-357页

作者： Yueming Dersjant-Li Peter Plumstead Ajay Awati Janet Remus Danisco Animal nutrition DuPont Industrial Biosciences Marlborough SN8 1XN United Kingdom Department of Animal and Wildlife Sciences Faculty of Agricultural and Natural Sciences University of Pretoria Hatfield Pretoria 0028 South Africa Danisco Animal nutrition DuPont Industrial Biosciences St. Louis MO 63167 USA

The objective of this study was to test if a novel phytase from Buttiauxella sp. can replace all added inorganic phosphate in a diet with reduced Ca and metabolizable energy(ME) fed to commercial pigs from12 kg body weight(BW) until slaughter, whilst maintaining performance and carcass quality *** dietary treatments were tested in a completely randomized design with 9 replicate pens, each containing 31 mixed sex Newsham Choice pigs. Diets included a positive control(PC) based on corn,soybean meal, wheat middling and bakery meal, meeting all nutrient requirement of pigs; a negative control(NC) excluded inorganic phosphate and with reduced Ca(-0.13%) and ME(-0.15 MJ/kg); and NC supplemented with Buttiauxella phytase at 500 or 1,000 FTU/kg feed. Diets were fed ad libitum in mash form in 5 phases: starter(12 to 25 kg BW), grower 1(25 to 50 kg BW) and 2(50 to 75 kg BW), and finisher1(75 to 100 kg BW) and 2(100 kg BW to slaughter). The NC group showed lower(P < 0.05) average daily feed intake(ADFI) and average daily gain(ADG) in starter and grower phases, lower gain to feed ratio(G:F)in starter and grower 1 compared with PC. Pigs receiving the high dose of phytase of 1,000 FTU/kg had improved performance vs. the 500 FTU/kg phytase treatment in starter and grower 1 phase compared with the PC in grower 1 phase. Increasing phytase dose resulted in a linear increase in ADG(12 to120 kg BW) and G:F(50 to 75 kg BW). A comparison of treatment groups over the full production period from 12 kg BW until slaughter showed that both 500 and 1,000 FTU/kg phytase treatments were able to maintain growth performance and carcass characteristics compared with PC. The application of Buttiauxella phytase could therefore be used as an effective strategy to replace all inorganic phosphate in diets of pigs fed corn, soybean meal, wheat middling and bakery meal based diets from 12 kg BW. An economic analysis showed greater return from both phytase treatments vs. the PC and favored the

关键词： Buttiauxella phytase Carcass Pigs Phosphorus Productive performance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

引用

Neural Regeneration Research 2025年第3期20卷 873-886页

作者： Ying Wang Xiang Zhang Henrik Biverstål Nicolas GBazan Shuai Tan Nailin Li Makiko Ohshima Marianne Schultzberg Xiaofei Li Department of Neurobiology Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Department of Neurology Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden Department of biosciences and nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excellence Louisiana State UniversityNew OrleansLAUSA Department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte–derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microglia showed that the monocyte-derived microglia resembled Alzheimer's disease–like neuroinflammation in human brain microglia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-regulating inflammatory pathway related gene expression induced by amyloid-β42 in monocyte-derived microglia, protection of maresin 1 against the effects of amyloid-β42 is mediated by a re-balancing of inflammatory transcriptional networks in which modulation of gene transcription in the nuclear factor-kappa B pathway plays a major part. We pinpointed molecular targets that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targets by maresin 1. In conclusion, monocyte-derived microglia represent a relevant in vitro microglial model for studies on Alzheimer's disease-like inflammation and drug response for individual patients. Maresin 1 ameliorates amyloid-β42–induced changes in several genes of importance in Alzheimer's disease, highlighting its potential as a therapeutic target for Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β maresin microglia monocyte neuroinflammation resolution RNA-sequencing specialized pro-resolving lipid mediator

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Correcting for non-compliance when determining colonic transit time with radio-opaque markers

引用

World Journal of Gastroenterology 2017年第4期23卷 740-742页

作者： Alvin Ibarra Kaisa Olli Arthur C Ouwehand dupont nutrition and Health 02460 KantvikFinland

The use of radio-opaque markers and abdominal X-ray is the standard method for determining colonic transit time(CTT). However, when there are deviations in the intake of these markers by participants in clinical trials it is desirable to improve observations by introducingcorrections, where possible. To date, there is no standard procedure to adjust for such deviations. This report proposes a series of alternatives based on possible scenarios for deviations from the intended intake of radio-opaque markers. The proposed method to correct for missed or delayed consumption of radioopaque markers can help to increase the accuracy of the CTT measurements in clinical trials.

关键词： Colonic transit time Gastroenterology Gut transit time Radio-opaque marker X-ray

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Limited cross-variant neutralization after primary Omicron infection:consideration for a variant-containing booster

引用

Signal Transduction and Targeted Therapy 2022年第9期7卷 3174-3176页

作者： Harold Marcotte Lennart Hammarstrom Qiang Pan-Hammarstrom Department of biosciences and nutrition Karolinska Institutet14157 HuddingeSweden

In a recent study published in Nature,Suryawanshi et *** that primary Omicron infection only elicits a mild humoral immune response and limited cross-variant neutralization in non-vaccinated individuals.1On the other hand,vaccinated individuals developed high neutralizing antibody titers against all variants of concern(VOCs)following breakthrough Omicron ***,Omicron infection can enhance existing immunity induced by vaccination but may not prevent reinfection by other VOCs in non-vaccinated individuals.

关键词： breakthrough immunity Omi

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Influence of a probiotic mixture on antibiotic induced microbiota disturbances

引用

World Journal of Gastroenterology 2014年第33期20卷 11878-11885页

作者： Sofia Forssten Malkanthi Evans Dale Wilson Arthur C Ouwehand Active nutrition DuPont Nutrition & Health 02460 Kantvik Finland KGK Synergize London ONN6A 5R8 Canada

AIM: To study the effect of probiotic consumption on the faecal microbiota during and after antibiotic exposure.

关键词： Probiotic Antibiotic treatment Amoxicillin/ clavulanate Microbiota Beta-lactamases Lactobacillus acidophilus Bifidobacterium lactis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Novel and disruptive biological strategies for resolving gut health challenges in monogastric food animal production

引用

Animal nutrition 2015年第3期1卷 138-143页

作者： Ming Z.Fan Tania Archbold Center for nutrition Modeling Department of Animal Biosciences University of Guelph

Use of feed antibiotics as growth promoters for control of pathogens associated with monogastric food animal morbidity and mortality has contributed to the development of antimicrobial resistance, which has now become a threat to public health on a global scale. Presently, a number of alternative feed additives have been developed and are divided into two major categories, including 1) the ones that are supposed to directly and indirectly control pathogenic bacterial proliferation; and 2) the other ones that are intended to up-regulate host gut mucosal trophic growth, whole body growth performance and active immunity. A thorough review of literature reports reveal that efficacy responses of current alternative feed additives in replacing feed antibiotics to improve performances and gut health are generally inconsistent dependent upon experimental conditions. Current alternative feed additives typically have no direct detoxification effects on endotoxin lipopolysaccharides(LPS) and this is likely the major reason that their effects are limited. It is now understood that pathogenic bacteria mediate their negative effects largely through LPS interactions with toll-like receptor 4, causing immune responses and infectious diseases. Therefore, disruptive biological strategies and a novel and new generation of feed additives need to be developed to replace feed antibiotic growth promoters and to directly and effectively detoxify the endotoxin LPS and improve gut health and performance in monogastric food animals.

关键词： Antibiotic Antimicrobial resistance Endotoxin Lipopolysaccharide

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Some latest achievements in immunology research

引用

Chinese Science Bulletin 2011年第35期56卷 3890-3893页

作者： LIU Wei Department of biosciences and nutrition Karolinska Institute NO VUM 14183 Huddinge Sweden

Immunology has become as an attractive discipline of biomedical science in the 21st century,integrated with the rapid development of molecular biology,cell biology,structural biology,genetics and other branches in life sciences.A special issue of Sci China Life Sci was published in February 2010 to highlight recent progresses in *** review articles focusing on various specific topics were contributed by leading scientists who work in respective fields of *** progresses of immunology research in China are also described.

关键词：免疫学分子生物学医学科学生命科学细胞生物学结构生物学免疫工作吸引力

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Potential of molecular chaperones for treating Alzheimer’s disease

引用

Neural Regeneration Research 2024年第11期19卷 2343-2344页

作者： Gefei Chen Jan Johansson Department of biosciences and nutrition Karolinska InstitutetHuddingeSweden Department of Cell and Molecular Biology Uppsala UniversityUppsalaSweden

Alzheimer’s disease(AD)is the most prevalent form of dementia,i.e.,progressive memory loss and profound cognitive dysfunction,resulting in a considerable societal *** the neuropathological level,the brains of AD patients exhibit amyloid-β(Aβ)plaques,neurofibrillary tangles,and neuroinflammation(Sala Frigerio and De Strooper,2016).

关键词： Alzheimer inflammation Aβ

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mycotoxin binder improves growth rate in piglets associated with reduction of toll-like receptor-4 and increase of tight junction protein gene expression in gut mucosa

引用

Journal of Animal Science and Biotechnology 2018年第2期9卷 351-360页

作者： Linghong Jin Wei Wang Jeroen Degroote Noémie Van Noten Honglin Yan Maryam Majdeddin Mario Van Poucke Luc Peelman Anne Goderis Kurt Van De Mierop Ronny Mombaerts Stefaan De Smet Joris Michiels Department of Applied biosciences Ghent University Laboratory for Animal nutrition and Animal Product Quality Department of Animal Production Ghent University Department of nutrition Genetics and EthologyFaculty of Veterinary Medicine Ghent University Nutrex

Background: Deoxynivalenol(DON) is a mycotoxin produced by Fusarium species in the field, commonly found in cereal grains, which negatively affects performances and health of animals. Mycotoxin binders are supposed to reduce the toxicity of ***: The effect of a mycotoxin binder(containing acid-activated bentonite, clinoptilolite, yeast cell walls and organic acids) on growth performance and gut health was studied. Hundred and twenty weaning piglets were allocated to 4 treatments, with 5 pens of 6 piglets each, arranged in a 2 × 2 factorial design: control diet; control diet with 1 kg/t binder; control diet with DON; and control diet with DON and 1 kg/t binder. From d0–14,the diet of DON-challenged groups was artificially contaminated with a mixture of DON(2.6 mg/kg), 3-acetyldeoxynivalenol(0.1 mg/kg) and 15-acetyl-deoxynivalenol(0.3 mg/kg), after which the total contamination level was reduced to 1 mg/kg, until d37. On d14, one pig from each pen was euthanized and distal small intestinal mucosa samples were collected for the assessment of intestinal permeability, and gene expression of tight junction proteins, toll-like receptor 4, inflammatory cytokines and intestinal alkaline ***: After 37 d, there were no differences in growth performance between control and DON-challenged groups(P > 0.05). Nevertheless, groups that received diets with binder had a significantly higher average daily gain(ADG) and average daily feed intake(ADFI) for the first 14 d as well as for the whole period, compared to groups without binder(P ≤ 0.05). Groups with binder in the diet also exhibited lower expression of toll-like receptor 4 in distal small intestinal mucosa at d14, compared to groups without binder(P ≤ 0.05). Interestingly, comparing the two DON treatments, piglets fed DON and binder had significantly higher ADFI and ADG compared to those with only DON for the first 14-d(P ≤ 0.05). Addition of binder to DON contaminated diets, also down-regulated th

关键词： Binder Deoxynivalenol Gut barrier Gut health Mycotoxin Pigs

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：