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Spontaneous Ureteropelvic Junction Rupture Caused by a Small Distal Ureteral Calculus

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Chinese Medical Journal 2015年第22期128卷 3118-3119页

作者： Chi Heon Jeon Jun Ho Kang Jin Hong Min Jung Soo Park Department of Emergency medicine College of Medicine Chungbuk National University Cheongju Chungbuk 361-763 Korea

To the Editor： Spontaneous ureteral rupture is rare, and urolithiasis is the most common cause. The underlying mechanism may be the pressure around the ureteral wall due to stone impaction or a tear during the stone passage. Smaller distal stones exert higher intraureteral pressures than do larger proximal stones because of the greater length of obstructed ureter and the smaller diameter of the distal ureter.

关键词： Spontaneous urolithiasis intraureteral

A review of combined phacoemulsification and endoscopic cyclophotocoagulation:efficacy and safety

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International Journal of Ophthalmology(English edition) 2018年第8期11卷 1396-1402页

作者： Wen Sun Chen-Ying Yu Jian-Ping Tong Department of Ophthalmology the First Affiliated HospitalCollege of MedicineZhejiang University

As cataract occurs frequently in patients with glaucoma, combining phacoemulsification and endoscopic cyclophotocoagulation has been gaining attention recently due to its minimally invasive nature. A variety of studies had evaluated the efficacy and safety of this procedure and had shown extremely promising results. This review article has shown here that combined phacoemulsification and endoscopic cyclophotocoagulation procedure could effectively reduce intraocular pressure in medically uncontrolled glaucoma patients while avoiding serious complications associated with traditional cyclophotocoagulation procedure and adverse effects related to filtering surgery such as trabeculectomy.

关键词： endoscopic cyclophotocoagulation phacoemulsification glaucoma

Recent advances in diverse nanosystems for nitric oxide delivery in cancer therapy

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Acta Pharmaceutica Sinica B 2023年第4期13卷 1498-1521页

作者： Dan Gao Sajid Asghar Rongfeng Hu Su Chen Ruixin Niu Jia Liu Zhipeng Chen Yanyu Xiao State Key Laboratory of Natural medicines China Pharmaceutical UniversityNanjing 210009China Faculty of Pharmaceutical Sciences Government College University FaisalabadFaisalabad 38000Pakistan Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application Hefei 230012China Jiangyin Hospital Affiliated to Nanjing University of Chinese medicine Jiangyin 214499China Department of Pharmacy Nanjing University of Chinese MedicineNanjing 210023China

Gas therapy has been proven to be a promising and advantageous treatment option for *** have shown that nitric oxide(NO)is one of the smallest structurally significant gas molecules with great potential to suppress ***,there is controversy and concern about its use as it exhibits the opposite physiological effects based on its levels in the ***,the anti-cancer mechanism of NO is the key to cancer treatment,and rationally designed NO delivery systems are crucial to the success of NO biomedical *** review summarizes the endogenous production of NO,its physiological mechanisms of action,the application of NO in cancer treatment,and nano-delivery systems for delivering NO ***,it briefly reviews challenges in delivering NO from different nanoparticles and the issues associated with its combination treatment *** advantages and challenges of various NO delivery platforms are recapitulated for possible transformation into clinical applications.

关键词： Nitric oxide Nitric oxide donor Nitric oxide-based delivery system Anti-cancer Binding mechanisms Synergistic treatment strategy Inorganic platforms Organic platforms

Effects of melatonin implantation on cashmere yield,fibre characteristics,duration of cashmere growth as well as growth and reproductive performance of Inner Mongolian cashmere goats

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Journal of Animal Science and Biotechnology 2015年第4期6卷 463-468页

作者： Chunhui Duan Jianhai Xu Changmian Sun Zhihai Jia Wei Zhang State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural University college of Veterinary medicine China Agricultural University

Background： Exogenous melatonin could induce cashmere growth. However, induced growth of cashmere fleece by melatonin implants cannot be combined with the typical growth, resulting in earlier shedding followed by another cycle of cashmere growth. To address this issue, we examine the effects on the cashmere yield, fibre characteristics, and the growth and reproductive performance of cashmere goats of planned administration of melatonin. Methods： Eighteen half-sib, female goats were assigned to two treatments （n = 9） including a control and a treatment where melatonin （2 mg/kg BW） was implanted at the end of April and end of June. Cashmere growth and shedding were observed for approximately ] year following implantation. Fibre samples were collected monthly to determine cumulative cashmere length. Initiation and cessation dates for cashmere growth as well as the rate of cashmere growth were calculated. Cashmere yield, weight gain of dam, kidding date, litter size, and birth weight were also recorded. Results： Melatonin implantation increased cashmere yield by 34.5 % （control 553.7 g vs. melatonin 745.0 g; P〈 0.01）, cashmere length by 21.3 % （control 95.2 mm vs. melatonin 115.4 mm; P 〈 0.01）, and decreased fibre diameter by 4.4 % （control 14.6 pm vs. melatonin 14.0 IJm; P 〈 0.03）. In melatonin-treated goats, the average initiation date was earlier than in control goats （May 18, 2013 vs. July 2, 20]3; P〈 0.01） but there was a similar cessation date （March 22, 2014 vs. March 27, 2014）. Consequently, the duration of cashmere growth was longer in melatonin-treated goats than in control goats （307 vs.270 days; P 〈 0.01）. The final BW, average daily gain, kidding date, litter size, and birth weight were not influenced by melatonin implantation. Conclusions： These data indicate that melatonin implantation （2 mg/kg BW） on two occasions （late April and June） increased cashmere yield by combining the induced growth of cashmere fleece with the typical growth and decreased the fi

关键词： Cashmere goat Cashmere yield Fibre characteristics Growth performance Melatonin,Reproductive performance

Racial and gender-based disparities and trends in common psychiatric conditions in liver cirrhosis hospitalizations:A ten-year United States study

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World Journal of Hepatology 2023年第2期15卷 289-302页

作者： Pratik Patel Hassam Ali Faisal Inayat Rahul Pamarthy Alexa Giammarino Fariha Ilyas Lucia Angela Smith-Martinez Sanjaya K Satapathy Department of Gastroenterology Mather Hospital and Hofstra University Zucker School of MedicinePort JeffersonNY 11777United States Department of Internal medicine East Carolina University Brody School of MedicineGreenvilleNC 27834United States Department of Internal medicine Allama Iqbal Medical CollegeLahore 54550PunjabPakistan Department of Internal medicine North Shore University Hospital and Hofstra University Zucker School of MedicinePort JeffersonNY 11777United States Department of Psychiatry East Carolina University Brody School of MedicineGreenvilleNC 27834United States Department of Hepatology North Shore University Hospital and Hofstra University Zucker School of MedicineManhassetNY 11030United States

BACKGROUND Chronic liver disease is associated with various neuropsychiatric *** are currently no large studies assessing and comparing the prevalence of psy-chiatric illnesses based on patient profiles and the etiology of *** To examine the trends of hospitalizations among psychiatric conditions in *** We used the National Inpatient Sample database 2016-2019 for the primary diagnosis of liver *** outcomes included the prevalence,trends,and associations of psychiatric diagnoses in these ***-square for categorical variables and the Wilcoxon rank test for continuous variables were *** The prevalence of generalized anxiety disorder(GAD)in liver cirrhosis hospitalizations increased from 0.17%in 2009 to 0.92%in 2019(P<0.001).The prevalence of depression increased from 7%in 2009 to 12%in 2019(P<0.001).Attention deficit hyperactivity disorder(ADHD)prevalence increased from 0.06%to 0.24%.The prevalence of schizophrenia increased from 0.59%to 0.87%(P<0.001).Schizoaffective disorder prevalence increased from 0.10%to 0.35%(P<0.001).Posttraumatic stress disorder(PTSD)prevalence displayed increasing trends from 0.36%in 2009 to 0.93%in 2019(P<0.001).The prevalence of suicidal ideation increased from 0.23%to 0.56%in *** related to alcoholic liver disease[adjusted odds ratios(aOR)1.18,95%CI 1.08-1.29,P<0.001]and non-alcoholic fatty liver disease(NAFLD)(aOR 1.14,95%CI 1.01-1.28,P=0.025)was associated with depression more than other ***-and NAFLD-associated cirrhosis had a stronger link to psychiatric *** had a higher association with GAD(aOR 2.56,95%CI 2.14-3.06,P<0.001),depression(aOR 1.78,95%CI 1.71-1.84,P<0.001),bipolar disorder(aOR 1.64,95%CI 1.52-1.77,P<0.001]and chronic fatigue(aOR 2.31,95%CI 1.31-4.07,P<0.001)when compared to ***,Hispanics,and Asian/Native Americans had a significantly lower association with GAD,depression,bipolar disorder,PTSD,and ADHD wh

关键词： Liver cirrhosis hospitalizations Psychiatric conditions Racial and gender disparities

Rupture of carotid artery pseudoaneurysm in the modern era of definitive chemoradiation for head and neck cancer:Two case reports

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World Journal of Clinical Cases 2020年第20期8卷 4858-4865页

作者： Myungsoo Kim Ji Hyung Hong Sang Kyu Park Sook Jung Kim Jung Hwi Lee JH Byun Yoon Ho Ko Department of Radiation Oncology Incheon St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaIncheon 403720South Korea Department of Internal medicine Incheon St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaIncheon 21431South Korea Department of Neurosurgery Gangnam Severance HospitalYonsei University College of MedicineSeoul 06273South Korea Department of Internal medicine Incheon St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 03312South Korea Department of Radiology Incheon St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 03312South Korea Department of Internal medicine Eun-pyeoung St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 03312South Korea

BACKGROUND Carotid blowout syndrome(CBS)is a rupture of the carotid artery and is mainly caused by radiation and resection of head and neck cancers or direct tumor invasion of the carotid artery *** is a life-threatening clinical *** is no established and effective mode of management of ***,there is no established preceding sign or symptom;therefore,preventive efforts are not clinically *** SUMMARY We described two cases of CBS that occurred in patients with head and neck cancer after definitive chemoradiotherapy(CRT)using three-dimensional conformal intensity-modulated radiation *** men aged 61 and 56 years with locally advanced head and neck cancer were treated with definitive *** completing CRT,both of them achieved complete ***,they had persistent severe pain in the oropharyngeal mucosal region and the irradiated neck despite the use of opioid analgesics and rehabilitation for relief of contracted ***,continuous follow-up imaging studies showed no evidence of cancer *** to twelve months after completing CRT,the patients visited the emergency room complaining about massive oronasal *** showed rupture of carotid artery pseudoaneurysms on the irradiated *** attempting to secure hemostasis with carotid arterial stent insertion and coil embolization,both patients died because of repeated bleeding from the *** In patients with persistent pain in irradiated sites,clinicians should be suspicious of progressing or impending CBS,even in the three-dimensional conformal intensity-modulated radiation therapy era.

关键词： Carotid blow-out syndrome Carotid pseudoaneurysm Head and neck neoplasms Radiation injuries Severe pain Case report

Recent advances in targeting the“undruggable”proteins:from drugdiscover to clinical trials

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Signal Transduction and Targeted Therapy 2023年第10期8卷 4477-4547页

作者： Xin Xie Tingting Yu Xiang Li Nan Zhang Leonard J.Foster Cheng Peng Wei Huang Gu He State Key Laboratory of Southwestern Chinese medicine Resources College of Medical Technology and School of PharmacyChengdu University of Traditional Chinese Medicine611137 ChengduChina Michael Smith Laboratories University of British ColumbiaVancouverBC V6T 1Z4Canada Department of Dermatology and State Key Laboratory of Biotherapy West China HospitalSichuan University610041 ChengduChina

Undruggable proteins are a class of proteins that are often characterized by large,complex structures or functions that are diffcult to interfere with using conventional drug design *** such undruggable targets has been considered also a great opportunity for treatment of human diseases and has attracted substantial efforts in the field of ***,in this review,we focus on the recent development of drug discovery targeting"undruggable"proteins and their application in *** make this review well organized,we discuss the design strategies targeting the undruggable proteins,including covalent regulation,allosteric inhibition,protein-protein/DNA interaction inhibition,targeted proteins regulation,nucleic acid-based approach,immunotherapy and others.

关键词： drug diseases clinical

Eff ects of continuous renal replacement therapy on infl ammation-related anemia, iron metabolism and prognosis in sepsis patients with acute kidney injury

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World Journal of Emergency medicine 2023年第3期14卷 186-192页

作者： Meng-meng An Chen-xi Liu Ping Gong Intensive Care Unit the Affi liated Dalian Friendship Hospital of Dalian Medical UniversityDalian 116100China Department of Emergency medicine the First Affi liated Hospital of Dalian Medical UniversityDalian 116011China Department of Emergency medicine Shenzhen People's Hospital(the Second Clinical Medical College of Jinan Universitythe First Affi liated Hospital of Southern University of Science and Technology)Shenzhen 518020China

BACKGROUND:This study aims to evaluate the eff ect of continuous renal replacement therapy(CRRT)on inflammation-related anemia,iron metabolism,and the prognosis in sepsis patients with acute kidney injury(AKI).METHODS:Sepsis patients with AKI were prospectively enrolled and randomized into the CRRT and control *** clinical and laboratory data on days 1,3 and 7 after intensive care unit(ICU)admission were *** serum interleukin(IL)-6,hepcidin,erythropoietin,ferritin,and soluble transferrin receptor(sTfR)were determined by enzyme-linked immunosorbent *** Sequential Organ Failure Assessment(SOFA)score and 28-day mortality were *** were analyzed using Pearson’s Chi-square test or Fisher’s exact test(categorical variables),and Mann-Whitney U-test or t-test(continuous variables).RESULTS:The hemoglobin and serum erythropoietin levels did not signifi cantly diff er between the CRRT and control groups though gradually decreased within the first week of ICU *** days 3 and 7,the serum IL-6,hepcidin,ferritin,and red blood cell distribution width significantly decreased in the CRRT group compared to the control group(all P<0.05).On day 7,the serum iron was significantly elevated in the CRRT group compared to the control group(P<0.05).However,the serum sTfR did not signifi cantly diff er between the groups over *** addition,the SOFA scores were signifi cantly lower in the CRRT group compared to the control group on day *** 28-day mortality did not signifi cantly diff er between the control and CRRT groups(38.0%vs.28.2%,P=0.332).CONCLUSION:CRRT might have beneficial effects on the improvement in inflammationrelated iron metabolism and disease severity during the fi rst week of ICU admission but not anemia and 28-day mortality in sepsis patients with AKI.

关键词： Sepsis Continuous renal replacement therapy Acute kidney injury Anemia Iron metabolism

SRO1 regulates heavy metal mercury stress response in Arabidopsis thaliana

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Chinese Science Bulletin 2014年第20期59卷 3134-3141页

作者： Xiaoli Zhang Xiaoliang Zhao Baozhu Li Jinchan Xia Yuchen Miao State Key Laboratory of Cotton Biology Laboratory of Plant Stress Biology Department of Biology Henan University School of Basic medicine Henan College of Traditional Chinese Medicine

Heavy metals in the environment are harmful limiting factors for the normal growth and development of ***,we isolated and identified an Arabidopsis thaliana T-DNA insertion mutant,named sro1-1,which showed a hyper-sensitive response to *** SRO1protein contains a WWE domain that mediates proteinprotein *** HgCl2treatment,when compared with the wild-type plants,the growth of sro1-1 was repressed dramatically and the number of true leaves was reduced and *** electrolyte leakage rates showed that cell membrane integrity in sro1-1 was damaged more severely than in the wild ***(3,5-diaminobenzidine)staining and confocal microscopy showed that Hg2?stress induced more hydrogen peroxide accumulation in sro1-1 than in the wild *** qRT-PCR results indicated that the expression of some abiotic stress-induced genes,such as L-ascorbate peroxidase(APX1),was reduced under oxidative or Hg2?*** plants containing a GFP::SRO1 fusion protein showed that SRO1was localized in the nucleus of the ***1 was shown to be expressed in various tissues,and was most highly expressed in the vigorous *** results suggest thatSRO1 may play an important role in the stress response of *** to heavy metals.

关键词：应激反应氯化汞重金属拟南芥抗坏血酸过氧化物酶定量RT-PCR 转基因植物 T-DNA插入