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Abdominal Wall Hernias in Adults: Comparative Study of Anatomo-Clinical, Therapeutic and Progressive Aspects between Two hospitals in the South of Togo

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Surgical Science 2025年第1期16卷 7-14页

作者： Sogan Ananivi Amavi Kossigan Adodossi Alassani Fousséni Tamegnon Dossouvi Ekoue-bla Premier Tchangai Boyodi Adabra Komlan Department of general Surgery Anho Hospital Anho Togo Human Anatomy Laboratory Faculty of Health Sciences University of Lom Lom Togo Department of general Surgery Teaching Hospital (Sylvanus Olympio) of Lom Lom Togo Department of Visceral Surgery Regional Hospital Center Lom-Commune Lom Togo Department of general Surgery Dapaong Regional Hospital Center Dapaong Togo Department of Visceral Surgery Teaching hospital (Sylvanus Olympio) of Lom Lom Togo

Objective: We aim to analyze the surgical nursery of abdominal wall hernias in adults between two poorly fitted medical environments, the Regional hospital Center of Tsévié (RHC-T) and the Prefectural hospital Center of Kpalimé (PHC-K) in Togo. Methodology: It was a retrospective, descriptive and comparative study carried out over five years (2018-2022) focusing on abdominal wall hernias in adults. Information was gathered from the patients’clinical notes and registers on the frequency of hernias, the anatomo-clinical forms of hernias, the type of anesthesia, the hernia repair technique and the postoperative evolution. Results: Of the 1022 and 1026 operations performed, 312 and 412 were hernial repairs, representing 30.5% and 41.2% of operations at RHC-T and PHC-K respectively (p = 0.001). The inguinal hernia was the most often found in 83.7% (n = 261) at RHC-T versus 76.6% (n = 324) at PHC-K. Herniorrhaphy was the most frequently used repair method, in 93.6% (n = 292) of patients at RHC-T and in 91.3% (n = 376) at PHC-K (p = 0.11). Postoperative complications were noted in 5.1% of cases (n = 16) at RHC-T versus 3.5% of cases (n = 15) at PHC-K (p = 0.307). These complications included scrotal hematomas, surgical areas infections, and orchitis. We recorded 1.3% (n = 4) and 0.8% (n = 3) deaths at RHC-T and PHC-K respectively (p = 0.496). Conclusion: There is homogeneity in the treatment of hernia in these two hospitals in Togo.

关键词： Hernia Comparative Study South Togo

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Mapping the landscape of gastric signet ring cell carcinoma:Overcoming hurdles and charting new paths for advancement

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World Journal of Clinical Oncology 2025年第2期16卷 94-109页

作者： Shu-Yuan Wang Jing-Hang Wang Run-Kai Chen Zhen Yuan Hao Cui Bo Wei Jian-Xin Cui School of Medicine Nankai UniversityTianjin 300071China Department of general Surgery The First Medical CenterChinese PLA General HospitalBeijing 100853China

BACKGROUND In recent years,the global prevalence of gastric cancer(GC)has witnessed a progressive decrease,accompanied by a step-growth in the incidence of gastric signet ring cell carcinoma(GSRCC).As precision medicine concepts progress,GSRCC,a distinct sub-type of GC,has drawn considerable attention from ***,there still persist some controversies regarding the associated research *** To summarize the current obstacles and potential future directions for research on *** To begin with,all literature related to GSRCC published from January 1,2004 to December 31,2023 was subjected to bibliometric analysis in this ***,this paper analyzed the research data using CiteSpace,GraphPad Prism v8.0.2,and VOSviewer,which was obtained from the Web of Science Core Collection *** analysis results were visually *** This study provided a comprehensive overview of the statistical characteristics of the 995 English articles related to GSRCC,including cited references,authors,journals,countries,institutions,and *** popular keywords and clusters contain"prognosis","survival","expression","histology",and"chemotherapy".CONCLUSION The prognosis,precise definition and classification,as well as chemoresistance of GSRCC,continue to be crucial areas of ongoing research,whose directions are closely tied to advancements in molecular biology research on GSRCC.

关键词： Gastric cancer Signet ring cell carcinoma Bibliometric analysis CiteSpace VOSviewer

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Clinical effect and prognosis of laparoscopic surgery on colon cancer complicated with intestinal obstruction patients

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World Journal of Gastrointestinal Surgery 2025年第3期17卷 249-258页

作者： Pei-Hua Wu Zheng-Quan Ta Department of general Surgery Baoji High-tech HospitalBaoji 721000Shaanxi ProvinceChina

BACKGROUND Colon cancer is one of the most common malignancies of the digestive tract,often complicated by intestinal obstruction,which can significantly impact patient *** traditional laparotomy is the standard treatment,it is associated with large wounds,slower recovery,and higher complication *** surgery,a minimally invasive approach,may offer better outcomes for these *** To evaluate the clinical effects and prognosis of laparoscopic surgery in patients with colon cancer complicated by intestinal obstruction compared to traditional *** A retrospective analysis was conducted on 100 patients diagnosed with colon cancer and intestinal obstruction who underwent surgical treatment between January 2020 and December *** were divided into two groups:The control group(CG),treated with traditional laparotomy,and the observation group(OG),treated with laparoscopic *** effects,surgical indicators,postoperative pain,inflammatory response,complication rates,quality of life,and prognosis were assessed and compared between the two *** The OG showed superior clinical outcomes compared to the CG(Phospital stays(Pdrainage volume,1-year tumor recurrence or metastasis rates,or 1-and 3-year survival rates(P>0.05).CONCLUSION The OG showed superior cl

关键词： Colon cancer Intestinal obstruction Laparoscopic surgery Complication

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Diagnostic value of upper gastrointestinal imaging for duodenal webbing in adults:A case report

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World Journal of Clinical Cases 2025年第12期13卷 64-69页

作者： Kang-Quan Chen Wen-Qian Jiang Xiao-Rong Li Department of Radiology General Hospital of Southern Theater CommandGuangzhou 510010Guangdong ProvinceChina

BACKGROUND Duodenal web is a rare congenital malformation,exceedingly uncommon in adults,and often misdiagnosed due to the subtle imaging *** SUMMARY By analyzing the clinical diagnosis process and various imaging findings of a patient from our institution,this case report emphasizes the necessity of upper gastrointestinal series in diagnosing duodenal webs,outlines its typical radiographic features,and provides a literature review on the etiology,clinical presentation,and management of this *** This case report emphasizes the necessity of upper gastrointestinal series in diagnosing duodenal webs.

关键词： Duodenal web Upper gastrointestinal imaging technology Misdiagnosis Medical imaging Case report

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Chyle leak following root of mesentery dissection in pancreaticoduodenectomy with inferior infracolic superior mesenteric artery first approach

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World Journal of Clinical Cases 2025年第8期13卷 8-14页

作者： Prabir Maharjan Sujan Regmee Spandan D Adhikari Rabin Pahari Roshan Ghimire Dhiresh K Maharjan Suman K Shrestha Prabin B Thapa Department of Gastrointestinal and general Surgery Kathmandu Medical College and Teaching HospitalKathmandu 44600Nepal

BACKGROUND The root of mesentery dissection is one of the critical maneuvers,especially in borderline resectable pancreatic head ***-abdominal chyle leak(CL)including chylous ascites may ensue in up to 10%of patients after pancreatic *** recognized superior mesenteric artery(SMA)first approaches are invariably *** mesenteric dissection through the inferior infracolic approach has been discussed in this study emphasizing its post-operative impact on CL which is the cornerstone of this *** To assess incidence,risk factors,clinical impact of CL following root of mesentery dissection,and the different treatment *** This is a retrospective study incorporating the patients who underwent dissection of the root of mesentery with inferior infracolic SMA first approach pancreat-oduodenectomy for the ventral body and uncinate mass of pancreas in the Department of Gastrointestinal and general Surgery of Kathmandu Medical College and Teaching hospital from January 1,2021 to February 28,***-erative findings and postoperative outcomes were *** In three years,ten patients underwent root of mesentery dissection with inferior infracolic SMA first approach *** mean age was 67.6 years with a male-to-female ratio of 4:*** was seen in four *** virtue of CL,Clavien-Dindo grade Ⅱ or higher morbidity was observed in four *** patients had a hospital stay of more than 20 days with the former having a delayed gastric emptying and the latter with long-term total parenteral nutrition *** mean operative time was 330 *** resection was achieved in 100%of the *** mean duration of the intensive care unit and hospital stay were 2.55±1.45 days and 15.7±5.32 days,*** Root of mesentery dissection with lymphadenectomy and vascular resection correlated with occurrence of *** complete curative resection,these were managed with tota

关键词： Chyle leak Chylous ascites Clavien-Dindo Pancreatoduodenectomy Root of mesentery dissection Superior mesenteric artery first approach Total parenteral nutrition Uncinate mass Vascular resection Ventral body mass

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New chapter in reform and development of organ donation and transplantation in China: Embracing past, grounding in national conditions, upholding steadfast belief, and looking forward to future

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Hepatobiliary & Pancreatic Diseases International 2025年第1期24卷 6-13页

作者： Hong-Tao Zhao Shu-Sen Zheng Jia Fan Jia-Hong Dong Zhong-Hua Chen Wu-Jun Xue Qi-Fa Ye Hai-Bo Wang Jing-Yu Chen Zhe Zheng Feng Huo Xiao-Shun He Miao Pu Jie Zhao Jie-Fu Huang China Organ Transplantation Development Foundation Beijing 100010China China National Human Organ Donation and Transplantation Committee Beijing 100010China The First Affiliated hospital Zhejiang University School of MedicineHangzhou 310003China Zhongshan hospital Fudan UniversityShanghai 200032China Beijing Tsinghua Changgung hospital Affiliated to Tsinghua University Beijing 102218China Tongji hospital Tongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430014China The First Affiliated hospital of Xi’an Jiaotong University Xi’an 710061China Zhongnan hospital of Wuhan University Wuhan 430000China Wuxi People’s hospital Wuxi 214023China Fuwai hospital Chinese Academy of Medical SciencesBeijing 100037China general hospital of Southern Theater Command of PLA Guangzhou 510120China The First Affiliated hospital of Sun Yat-sen University Guangzhou 510080China

The reform stems from honesty and determination. Since 2005, organ donation and transplantation in China has undergone thorough reform, which complies with legislation requirements and ethical principles established by the World Health Organization(WHO). Reform in China has demonstrated the unwavering confidence and utmost determination of the Chinese government and the Chinese transplantation community. The year 2015 marked a historic turning point when voluntary donations from Chinese citizens became the sole legitimate source for organ transplantation. Since 2015, China has gradually established and refined the “Chinese Mode” and “China System” for organ donation and transplantation, fulfilling its political pledge of reform, and has garnered international recognition, and fostered a social culture which promotes organ donation. This article reviewed the history of reform on organ donation and transplantation in China, presented a new pattern of establishment of organ donation system in the new era of the country, and the direction of advances in the future.

关键词： Reform Legislation Organ donation Organ transplantation Chinese mode High quality development

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Short-term efficacy of early percutaneous cholecystostomy for pancreatitis and factors associated with recurrence and mortality

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World Journal of Gastroenterology 2025年第6期31卷 20-33页

作者： Xin Yan Feng Xie Xiao-Dan Zhao Liang Li Jia-Xian Meng Department of Nuclear Medicine The People’s Hospital of Liaoning ProvinceShenyang 110016Liaoning ProvinceChina Department of Interventional Medicine Jin Qiu Hospital of Liaoning ProvinceShenyang 110016Liaoning ProvinceChina Department of general Surgery The People’s Hospital of Liaoning ProvinceShenyang 110016Liaoning ProvinceChina Department of Science and Education The People’s Hospital of Liaoning ProvinceShenyang 110016Liaoning ProvinceChina

BACKGROUND Percutaneous cholecystostomy(PC)can be used as a bridging therapy for moderately severe acute biliary pancreatitis(MSABP).Currently,there are only a limited number of reports of MSABP using *** To assess the short-term outcomes of early PC in MSABP and factors associated with recurrence and death in *** Patients who received conservative treatment or PC for acute biliary pancreatitis(ABP)in Liaoning Provincial People’s hospital from January 2017 to July 2022 were collected.A total of 54 patients with MSABP who received early-stage PC and 29 patients who received conservative *** short-term efficacy of PC was *** on whether there is a recurrence,compare the characteristics of the pre-PC and explore the factors of ***-PC features were compared and predictors were discussed,depending on the *** After 3 days of PC treatment,patients experienced a reduction in inflammatory markers compared to the conservative *** PC,patients were divided into non-recurrence(n=37)and recurrence(n=10)groups,and the results showed that age was an independent correlation affecting ABP recurrence[odds ratio(OR)=0.937,95%confidence interval(CI):0.878-0.999;P=0.0470.7).When the Youden index maximum was 0.565,the cut-off value was 5.5,the sensitivity was 71.4%,and the specificity was 85.1%.CONCLUSION PC is an important method in the early years(<72 hours)of *** is a protective factor against recurrence of *** pre-PC CCI is significantly associated with mortality.

关键词： Acute biliary pancreatitis Percutaneous cholecystostomy The revised Atlanta classification Charleson Comorbidity Index Yoden index

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Antithetical impacts of deleterious LRP1B mutations in non-squamous and squamous NSCLCs on predicting benefits from immune checkpoint inhibitor alone or with chemotherapy over chemotherapy alone: retrospective analyses of the POPLAR/ OAK and CHOICE-01 trials

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Science China(Life Sciences) 2025年第1期68卷 249-262页

作者： Jinliang Wang Wenyong Zhou Yu Xu Jianchun Duan Qiaoxia Zhou Guoqiang Wang Leo Li Chunwei Xu Wenxian Wang Shangli Cai Zhijie Wang Jie Wang Department of Oncology The Fifth Medical Center of Chinese PLA General HospitalBeijing 100091China Department of Thoracic Surgery Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200025China Burning Rock Biotech Guangzhou 510300China CAMS Key Laboratoryof Translational Research on LungCancer State Key Laboratoryof Molecular OncologyDepartmentof Medical OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Institute of Basic Medicine and Cancer(IBMC) Chinese Academy of SciencesHangzhou 310000China Department of Clinical Trial The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Hangzhou 310022China

In non-small cell lung cancers,the non-squamous and squamous subtypes(nsqNSCLC and sqNSCLC)exhibit disparities in pathophysiology,tumor immunology,and potential genomic correlates affecting responses to immune checkpoint inhibitor(ICI)-based *** our inhouse training cohort(n=85),the presence of the LRP1B deleterious mutation(LRP1B-del)was associated with longer and shorter progression-free survival(PFS)on ICIs alone in nsqNSCLCs and sqNSCLCs,respectively(Pinteraction=0.008).These results were validated using a larger public ICI cohort(n=208,Pinteraction<0.001).Multiplex immunofluorescence staining revealed an association between LRP1B-del and increased and decreased numbers of tumor-infiltrating CD8+T cells in nsqNSCLCs(P=0.040)and sqNSCLCs(P=0.014),*** the POPLAR/OAK cohort,nsqNSCLCs with LRP1B-del demonstrated improved PFS benefits from atezolizumab over docetaxel(hazard ratio(HR)=0.70,P=0.046),whereas this benefit was negligible in those without LRP1B-del(HR=1.05,P=0.64).Conversely,sqNSCLCs without LRP1Bdel benefited more from atezolizumab(HR=0.60,P=0.002)than those with LRP1B-del(HR=1.30,P=0.31).Consistent results were observed in the in-house CHOICE-01 cohort,in which nsqNSCLCs with LRP1B-del and sqNSCLCs without LRP1B-del benefited more from toripalimab plus chemotherapy than from chemotherapy alone(Pinteraction=0.008).This multi-cohort study delineates the antithetical impacts of LRP1Bdel in nsqNSCLCs and sqNSCLCs on predicting the benefits from ICI alone or with chemotherapy over chemotherapy *** findings highlight the distinct clinical utility of LRP1B-del in guiding treatment choices for nsqNSCLCs and sqNSCLCs,emphasizing the necessity for a detailed analysis based on pathological subtypes when investigating biomarkers for cancer therapeutics.

关键词： non-squamous NSCLC squamous NSCLC LRP1B deleterious mutations predictive biomarker immune checkpoint inhibitor

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Subretinal fibrosis secondary to neovascular age-related macular degeneration:mechanisms and potential therapeutic targets

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Neural Regeneration Research 2025年第2期20卷 378-393页

作者： Jingxiang Zhang Xia Sheng Quanju Ding Yujun Wang Jiwei Zhao Jingfa Zhang Department of Ophthalmology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Urology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of MedicineShanghaiChina National Clinical Research Center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghaiChina

Subretinal fibrosis is the end-stage sequelae of neovascular age-related macular *** causes local damage to photoreceptors,retinal pigment epithelium,and choroidal vessels,which leads to permanent central vision loss of patients with neovascular age-related macular *** pathogenesis of subretinal fibrosis is complex,and the underlying mechanisms are largely ***,there are no effective treatment options.A thorough understanding of the pathogenesis of subretinal fibrosis and its related mechanisms is important to elucidate its complications and explore potential *** current article reviews several aspects of subretinal fibrosis,including the current understanding on the relationship between neovascular age-related macular degeneration and subretinal fibrosis;multimodal imaging techniques for subretinal fibrosis;animal models for studying subretinal fibrosis;cellular and non-cellular constituents of subretinal fibrosis;pathophysiological mechanisms involved in subretinal fibrosis,such as aging,infiltration of macrophages,different sources of mesenchymal transition to myofibroblast,and activation of complement system and immune cells;and several key molecules and signaling pathways participating in the pathogenesis of subretinal fibrosis,such as vascular endothelial growth factor,connective tissue growth factor,fibroblast growth factor 2,platelet-derived growth factor and platelet-derived growth factor receptor-β,transforming growth factor-βsignaling pathway,Wnt signaling pathway,and the axis of heat shock protein 70-Toll-like receptors 2/*** review will improve the understanding of the pathogenesis of subretinal fibrosis,allow the discovery of molecular targets,and explore potential treatments for the management of subretinal fibrosis.

关键词： choroidal neovascularization epithelial-mesenchymal transition mesenchymal transition myofibroblast neovascular age-related macular degeneration submacular fibrosis subretinal fibrosis therapeutic targets transforming growth factor-β vascular endothelial growth factor

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Alterations of interhemispheric functional connectivity in patients with hypertensive retinopathy using voxelmirrored homotopic connectivity:a resting state fMRI study

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 297-307页

作者： Xue-Lin Wang Yu Chen Jin-Yu Hu Hong Wei Qian Ling Liang-Qi He Cheng Chen Yi-Xin Wang Yan-Mei Zeng Xiao-Yu Wang Qian-Min Ge Xu Chen Yi Shao Department of Ophthalmology the First Affiliated Hospital of Jiangxi Medical CollegeShangrao Center HospitalEye Hospital of Shangrao CityShangrao 334000Jiangxi ProvinceChina Department of Traditional Chinese Medicine the Second Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110000Liaoning ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina School of Optometry and Vision Science Cardiff UniversityCardiffCF244HQWalesUK Ophthalmology Centre of Maastricht University Maastricht 6200MSLimburg Provinciethe Netherlands Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Eye DiseasesShanghai 200080China

AIM:To analyze whether alterations of voxel mirror homology connectivity(VMHC)values,as determined by resting-state functional magnetic resonance imaging(rsfMRI),occur in cerebral regions of patients with hypertensive retinopathy(HR)and to determine the relationship between VMHC values and clinical characteristics in patients with ***:Twenty-one patients with HR and 21 agematched healthy controls(HCs)were assessed by rsfMRI *** functional connectivity between the hemispheres of the cerebrum was assessed by measuring VMHC,with the ability of VMHC to distinguish between the HR and HC groups assessed using receiver operating characteristic(ROC)curve *** in the demographic and clinical characteristics of the HR and HC groups were analyzed by independent sample *** relationship between average VMHC in several brain areas of HR patients and clinical features was determined using Pearson correlation ***:Mean VMHC values of the bilateral cuneus gyrus(BA19),bilateral middle orbitofrontal gyrus(BA47),bilateral middle temporal gyrus(BA39)and bilateral superior medial frontal gyrus(BA9)were lower in the HR than in the HC ***:VMHC values can predict the development of early HR,prevent the transformation of hypertensive microangiopathy,and provide useful information explaining the changes in neural mechanism associated with HR.

关键词： hypertensive retinopathy voxel-mirrored homotopic connectivity neuroimaging functional MRI resting state

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