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Identification of CD13,CD107a,and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-de-pendent upregulation

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Cell Research 2005年第5期15卷 325-335页

作者： Florian HENNERSDORF,Stefan FLORIAN,Andreas JAKOB,Katharina BAUMGRTNER,Karoline SONNECK,Alfred NORDHEIM,Tilo BIEDERMANN,Peter VALENT,Hans-Jrg BüHRING University Clinic of Tübingen Department of Internal Medicine II division of Hematology and Immunology Tübingen Germany Medical University Clinic of Vienna Department of Internal Medicine I division of Hematology and Hemostaseology Vienna Austria University of Tübingen Proteome Center Tübingen Germany University Clinic of Tübingen Department of Internal Medicine II division of Hematology and Immunology Tübingen Germany Medical University Clinic of Vienna Department of Internal Medicine I division of Hematology and Hemostaseology Vienna Austria University of Tübingen Proteome Center Tübingen Germany University Clinic of Tübingen Department of dermatology Tübingen Germany Medical University Clinic of Vienna Department of Internal Medicine I division of Hematology and Hemostaseology Vienna Austria University Clinic of Tübingen Department of Internal Medicine II division of Hematology and Immunology Tübingen Germany

Using two-colour flow cytometry >200 antibodies submitted to the 8th International Workshop of Human Leukocyte Differentiation Antigens (HLDA8) have been analyzed for their reactivity with resting and activated CD203c+ basophils. Four antibodies either non-reactive or weakly reactive with resting basophils exhibited an increased reactivity with basophils activated by anti-IgE-mediated cross-linking of the high affinity IgE receptor (FcεRI). These include antibod- ies against CD164 (WS-80160, clone N6B6 and WS-80162, clone 67D2), as well as two reagents with previously unknown specificities that were identified as CD13 (WS-80274, clone A8) and CD107a (WS-80280, clone E63-880). The activation patterns followed either the “CD203c-like” or “CD63-like” activation profile. The CD203c profile is characterized by a rapid and significant upregulation (of CD13, CD164, and CD203c), reaching maximum levels after 5- 15 min of stimulation. The phosphoinositide-3-kinase (PI3K)-specific inhibitor wortmannin inhibited the upregulation of these markers whereas 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced a rapid and FcεRI-independent upregulation within 1-2 min. In the CD63 profile, maximum upregulation (of CD63 and CD107a) was detected only after 20-40 min, and upregulation by TPA reached maximum levels after 60 min. In summary, our data identify CD13, CD107a, and CD164 as novel basophil-activation antigens. Based on time kinetics of upregulation, we hypothesize that molecules of the “CD203c group” and the “CD63 group” are linked to two different mechanisms of basophil activation.

关键词： CD203c CD164 CD63 CD107a basophil activation basophil marker.

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Biology of chronic graft-vs-host disease:Immune mechanisms and progress in biomarker discovery

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World Journal of Transplantation 2016年第4期6卷 608-619页

作者： Richard B Presland Department of Oral Health Sciences School of Dentistry University of Washington division of dermatology Department of Medicine University of Washington

Chronic graft-vs-host disease(c GVHD) is the leading cause of long-term morbidity and mortality following allogeneic hematopoietic stem cell transplantation. It presents as a chronic inflammatory and sclerotic autoimmune-like condition that most frequently affects the skin, oral mucosa, liver, eyes and gastrointestinal tract. Both clinical and animal studies have shown that multiple T cell subsets including Th1, Th2, Th17, T follicular helper cells and regulatory T-cells play some role in cG VHD development and progression; B cells also play an important role in the disease including the production of antibodies to HY and nuclear antigens that can cause serious tissue damage. An array of cytokines and chemokines produced by different types of immune cells also mediate tissue inflammation and damage of cG VHD target tissues such as the skin and oral cavity. Many of these same immune regulators have been studied as candidate cG VHD biomarkers. Recent studies suggest that some of these biomarkers may be useful for determining disease prognosis and planning long-term clinical followup of cG VHD patients.

关键词： Chronic graft-vs-host disease Biomarker Al ogeneic hematopoietic stem cell transplantation Cytokine

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Acne Vulgaris in Jeddah Medical Students: Prevalence, Severity, Self-Report, and Treatment Practices

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Journal of Cosmetics, Dermatological Sciences and Applications 2017年第1期7卷 67-76页

作者： Shadi Zari Asraa Turkistani Department of dermatology Faculty of Medicine University of Jeddah Jeddah Saudi Arabia division of dermatology Faculty of Medicine McGill University Montreal Canada Faculty of Medicine King Abdulaziz University Jeddah Saudi Arabia

Acne is a common skin disorder of teenagers and continues into adulthood. Research has been limited regarding acne prevalence, perception and health care utilization in Saudi Arabia. The objective of this study was to assess acne prevalence in final year female medical students in Jeddah, Saudi Arabia using the global acne grading system (GAGS) compared with student’s self-report of their acne. This is a cross-sectional study conducted among 151 students during 2016, in which students were interviewed subjectively and examined objectively by a trained physician. This study showed that acne was reported subjectively by 83.4% of female students compared to 98% of students assessed objectively by the global acne grading system. 14.6% of students claimed having no acne while it was objectively present, which was statistically significant (Χ2 = 15.4, P 2 months in 39.1% of students. Acne was present in 41.1% of the students parents compared to 83.4% in their siblings. A total of 41.7% of student had trunk acne. 60.9% of students had scarring and 72.8% of them had pigmentation. Moderate to severe acne students had higher siblings acne history of 95.2% (Χ2 = 5.85, P 2 = 4.05, P 2 = 4.87, P < 0.05) which was statistically significant. Our study confirms that acne is very common in female medical students in Jeddah, Saudi Arabia with a prevalence rate of 98%. Knowledge regarding acne treatment was inadequate demonstrating the need for educational and awareness programs about early treatment that will prevent suffering from acne scarring or pigmentation.

关键词： Acne Acne Vulgaris Acne Prevalence Acne Treatment Acne Self-Report

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肿胀性红斑狼疮

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世界核心医学期刊文摘（皮肤病学分册） 2005年第4期1卷 33-34页

作者： Choonhakarn C. Poonsriaram A. Chaivoramukul J. 刘超 division of dermatology Department of Medicine Khon Kaen University Khon Kaen 40002 Thailand Dr.

Background. Lupus erythematosus tumidus (LET) is a rare form of chronic cutaneous lupus erythematosus that characteristically presents as a succulent, erythematous plaques on sun-exposed areas. The histopathological change that primarily distinguishes LET from other variants of cutaneous lupus erythematosus is the lack of alterations of the dermo-epidermal junction and epidermis. Our purpose was to describe 15 cases of LET from Thailand. Methods. The records of 15 patients diagnosedwithLETatSrinagarindHospitalMedicalSchoolbetween 1995 and 2002 were reviewed on the following aspects: clinical manifestation, laboratory investigation, direct immunofluorescence study, phototesting, histopathological findings, clinical course, and treatment. Results. All 15 patients consisted of 10 females and five males. The mean age at onset was 38.8 years. The lesions more commonly affect the face and trunk. One patient had concomitant discoid lupus erythematosus and two developed systemic involvement 4 and 6 months after LET. Direct immunofluorescence studies all showed negative results. Positive phototest reactions were detected in five of 10 tested patients: four with ultraviolet A and B and one with ultraviolet A only. Most patients responded well to chloroquine phosphate and the remainder successfully improved with methotrexate, topical and systemic corticosteroids. Conclusion. Our data demonstrate the features of LET that are repeatable and characteristic. Lupus erythematosus tumidus in this study was more common in women, and photosensitivity reactions of the patients were seen less frequently compared with those in the earlier report of Kuhn et al. Furthermore, two of 15 patients exhibited systemic involvement in the course of their disease.

关键词：直接免疫荧光氨甲蝶呤红色斑块光敏反应发病年龄肥厚性组织病理学临床病程磷酸氯喹皮质类固醇

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Vanishing bile duct and Stevens-Johnson syndrome associated with ciprofloxacin treated with tacrolimus

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World Journal of Gastroenterology 2008年第29期14卷 4697-4700页

作者： Gokhan Okan Serpil Yaylaci Onder Peker Sabahattin Kaymakoglu Murat Saruc dermatology Department Acibadem Bakirkoy HospitalIstanbul 34140 Turkey mergency Department Acibadem Bakirkoy HospitalIstanbul 34140 Turkey Pathology Department Acibadem HospitalBakirkoy 34140 Turkey division of Gastroenterohepatology Istanbul University Istanbul Medical FacultyIstanbul 34140 Turkey Gastroenterohepatology Department Acibadem Bakirkoy HospitalIstanbul 34140 Turkey

Stevens-Johnson syndrome (SJS) is a serious and potentially life-threatening disease. Vanishing bile duct syndrome (VBDS) is a rare cause of progressive cholestasis. Both syndromes are mostly related with drugs. We report a case of a patient with ciprofloxacin-induced SJS and acute onset of VBDS, and reviewed the related literature. It is the fi rst case of ciprofloxacin-induced VBDS successfully treated with tacrolimus. This case reminds physicians of the importance of drug reactions, their severity, techniques for diagnosis and methods of management.

关键词： Stevens-Johnson syndrome Vanishing bileduct syndrome Ciprofloxacin Tacrolimus

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Gut microbiota and nutrient interactions with skin in psoriasis:A comprehensive review of animal and human studies

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World Journal of Clinical Cases 2020年第6期8卷 1002-1012页

作者： Giovanni Damiani Nicola Luigi Bragazzi Thomas S McCormick Paolo Daniele Maria Pigatto Sebastiano Leone Alessia Pacifico Danica Tiodorovic Sveva Di Franco Aniello Alfieri Marco Fiore Department of dermatology Case Western Reserve UniversityClevelandOH 44106United States Clinical dermatology IRCCS Istituto Ortopedico GaleazziMilan 20122Italy Department of Biomedical Surgical and Dental SciencesUniversity of MilanMilan 20122Italy Postgraduate School of Public Health Department of Health SciencesUniversity of GenoaGenoa 16132Italy Department of Medicine Division of Infectious diseases“San Giuseppe Moscati”HospitalAvellino 83100Italy San Gallicano Dermatological Institute IRCCSRome 00144Italy dermatology Clinic Medical FacultyNis UniversityNis 18000Serbia Department of Women Child and General and Specialized SurgeryUniversity of Campania"Luigi Vanvitelli"Naples 80138Italy

The intestinal tract(i.e.,the gut),is where the body’s nutrients are absorbed,and is simultaneously inhabited by numerous *** increasing body of literature suggests a crucial role for the gut microbiome in modulating systemic inflammatory *** is a chronic systemic inflammatory disease and its pathogenesis is related to the interaction between genetic susceptibility,immune response and environmental *** omics era has allowed physicians to assess different aspects of psoriasis pathogenesis such as the microbiome,infectome,and ***,diet appears to play an important role in modulating disease activity,perhaps by influencing gut *** these observations,we aimed to summarize the current knowledge regarding skin-microbiome-gut-nutrients and psoriasis.

关键词： Gut Microbiota Nutrients Endotypes Exposome Psoriasis

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Expression of toxin-related human mono-ADP-ribosyltransferase 3 in human testes

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Asian Journal of Andrology 2006年第3期8卷 281-287,386页

作者： MaikFriedrich AndreasGrahnert Uwe Paasch Andrea Tannapfel Friedrich Koch-Nolte Sunna Hauschildt Institute division of Andrology Department of Dermatology Institute of Pathology University of LeipzigD-04103 LeipzigGermany Institute of Immunology University HospitalD-20246 HamburgGermany

Aim:To investigate wether the corresponding protein of mono-ADP-ribosyltransferase 3(ART3)mRNA is ex- pressed in human testes and,if so,whether the expression is cell ***:ART3 mRNA was deter- mined in human testes and sperm by reverse transcription-polymerase chain reaction(RT-PCR).The glycosyl- phosphatidylinositol linkage of ART3 was shown by treating ART3-transfected HEK-293-T cells with phospholipase *** activated cell sorter(FACS)-analyses were used to detect ART3 on mature spermatozoa and immuno- histological studies to detect the protein in ***:ART3 protein was shown to be present in *** was found on spermatocytes *** was absent from spermatogonia,spermatids and *** absence of ART3 from spermatozoa was confirmed by ***3 protein was detected neither within a seminoma nor on Leydig ***:Here we show for the first time that ART3 protein is expressed in testes in particular on spermatocytes,indicating that ART3 exerts a specific function only required at a particular stage of spermatogenesis.

关键词： mono-ADP-ribosyltransferase 3 testes human spermatocyte spermatogenesis

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Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses

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Cellular & Molecular Immunology 2018年第11期15卷 953-962页

作者： Tomonori Yaguchi Asuka Kobayashi Takashi Inozume Kenji Morii Haruna Nagumo Hiroshi Nishio Takashi Iwata Yuyo Ka Ikumi Katano Ryoji Ito Mamoru Ito Yutaka Kawakami division of Cellular Signaling Institute for Advanced Medical ResearchKeio University School of MedicineTokyo 160-8582Japan Department of dermatology Yamanashi University School of MedicineYamanashi 409-3898Japan Department of Obstetrics and Gynecology Keio University School of MedicineTokyo 160-8582Japan Central Institute for Experimental Animals Kanagawa 210-0821Japan

Immunodeficient mice engrafted with human peripheral blood cells are promising tools for in vivo analysis of human patient individual immune ***,when human peripheral blood mononuclear cells(PBMCs)are transferred into NOG(NOD/Shi-scid,IL-2rg null)mice,severe graft versus host disease(GVHD)hinders long term detailed *** of human PBMCs into newly developed murine MHC class I-and class II-deficient NOG(NOG-dKO;NOG-Iab,B2m-double-knockout)mice showed sufficient engraftment of human immune cells with little sign of *** with influenza vaccine resulted in an increase in influenza-specific human IgG Ab,indicating induction of antigen-specific B cells in the NOG-dKO *** with human dendritic cells pulsed with HLA-A2 restricted cytomegalovirus peptide induced specific cytotoxic T cells,indicating the induction of antigen-specific T cells in the NOG-dKO *** cell therapies(ACTs)using melanoma antigen recognized by T cells(MART-1)-specific TCR-transduced activated T cells showed strong tumor growth inhibition in NOG-dKO mice without any sign of GVHD accompanied by preferential expansion of the transferred MART-1-specific T *** using cultured human melanoma infiltrating T cells also showed anti-tumor effects against autologous melanoma cells in NOG-dKO mice,in which changes in human cancer phenotypes by immune intervention,such as increased CD271 expression,could be ***,NOG-dKO mice are useful tools for more detailed analysis of both the induction and effector phases of T-cell and B-cell responses for a longer period than regular NOG mice.

关键词： adoptive cell therapy humanized mouse vaccine

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光动力疗法治疗酒渣鼻

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世界核心医学期刊文摘（皮肤病学分册） 2005年第11期1卷 45-45页

作者： Nybaek H. Jemec G.B.E. 焦婷 dr.division of dermatology Department of Medicine Roskilde Hospital DK-4000 Roskilde Denmark

Background: Rosacea is a common disease, with an estimated prevalence of 5-10%. Established systemic and topical treatment is often effective but requires continuous medication. Aim: We report the outcome of photodynamic therapy (PDT) in 4 patients with rosacea. Methods: Prior treatment consisted of standard treatment with tetracycline and metronidazole. The treatment was however either ineffective or the patients were dissatisfied with the need for continuous treatment. The patients all received standard treatment with PDT. Results: The treated skin cleared in 3 of the 4 patients. Treatment with light alone did not appear to have any effect. In one of the patients there has been no relapse during a 9-month follow-up. In 2 patients, remissions lasted 3 months, during which time no additional or supplementary treatment was used. Conclusion: Our observation suggests that PDT may play a role in the future treatment of selected cases of rosacea.

关键词：光动力疗法皮损消退局部疗法持续用药

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The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis

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Cellular & Molecular Immunology 2017年第3期14卷 276-284页

作者： Takashi Tomiyama Guo-Xiang Yang Ming Zhao Weici Zhang Hajime Tanaka Jing Wang Patrick SC Leung Kazuiclli Okazaki Xiao-Song He Qianjin Lu Ross L Coppel Christopher L Bowlus M Eric Gershwin division of Rheumatology Allergy and Clinical Immunology University of California at Davis Davis CA 95616 USA Third Department of Internal Medicine Division of Gastroenterology and Hepatology Kansai Medical University Osaka 573-1191 Japan Hunan Key Laboratory of Medical Epigenomics Department of Dermatology The Second Xiangya Hospital Central South University Changsha Hunan 410011 People's Republic of China Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical Sciences Nagoya 467-8601 Japan Department of Microbiology Monash University Melbourne Australia division of Gastroenterology and Hepatology University of California at Davis School of Medicine. Sacramento. CA 95817. USA

Exosomes are nanoparticles of endocytic origin, secreted by a myriad of cell populations that are attracting increased attention by virtue of their ability to modulate cell-to-cell communications. They are also attracting attention in a variety of immunological issues, including autoimmunity and, in particular, their ability to regulate cytokine and chemokine activation. Primary biliary cirrhosis （PBC） is considered a model autoimmune disease, which has a highly focused cytotoxic response against biliary epithelial cells. We have isolated exosomes from plasma from 29 patients with PBC and 30 healthy controls （HCs）, and studied the effect of these exosomes on co-stimulatory molecule expression and cytokine production in mononuclear cell populations using an ex vivo system. We also identified the microRNA （miRNA） populations in PBC compared to HC exosomes. We report herein that although exosomes do not change cytokine production, they do significantly alter co-stimulatory molecule expression on antigen-presenting populations. Further, we demonstrated that CD86 up-regulated expression on CD14＋ monocytes, whereas CD40 up-regulated on CD11c＋ dendritic cells by exosomes from patients with PBC. In addition, there were differences of miRNA expression of circulating exosomes in patients with PBC. These data have significant importance based on observations that co-stimulatory molecules play a differential role in the regulation of T-cell activation. Our observation indicated that aberrant exosomes from PBC selectively induce expression of co-stimulatory molecules in different subset of antigen-presenting cells. These alterations may involve in pathogenesis of autoimmune liver disease.

关键词： autoimmunity exosome microRNA primary biliary cirrhosis

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