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Unveiling the silent crisis:global burden of suicide‑related deaths among children aged 10–14 years

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World Journal of Pediatrics 2024年第4期20卷 371-391页

作者： Irmina Maria Michalek Pawel Koczkodaj Marzena Michalek Florentino Luciano Caetano dos Santos Department of Cancer Epidemiology and Primary Prevention Maria Sklodowska-Curie National Research Institute of Oncologyul.Wawelska 15 BWarsawPoland private Psychiatric practice-Marzena Michalek MDSiedlcePoland Harvard Business School Harvard UniversityBostonMAUSA

Background The rise in suicides among children aged 10–14 years demands urgent attention *** study aims to assess the global burden of suicide-related deaths in this age group from 1990 to 2019,considering factors such as sex,geography,and sociodemographics,to inform prevention strategies and *** The data from Global Burden of Disease 2019,encompassing 204 countries and territories,were analyzed to investigate deaths and years of life lost(YLLs)due to suicide among children aged 10–14 *** analyses,including mortality rates,YLLs,and the sociodemographic index(SDI),were conducted using standardized *** In 2019,a total of 8327[95%uncertainty interval(UI)=7073–9685]children aged 10–14 years died globally due to suicide,with a mortality rate of 1.30(95%UI=1.10–1.51)per 100,*** rates varied across countries/territories ranging between 0.05(95%UI=0.02–0.10)in South Africa and 7.49(95%UI=5.13–10.57)in *** contribution of suicide-related deaths to all-cause mortality ranged from 0.07%(95%UI=0.04%–0.15%)in South Africa to 33.02%(95%UI=24.36%–41.53%)in ***,there were approximately 636,196(95%UI=540,383–740,009)YLLs due to suicide,with a rate of 99.07(95%UI=84.15–115.23)per 100,*** association between SDI and suicide-related deaths was evident,with higher contributions observed in countries with higher *** This study reveals a concerning global burden of suicide-related deaths among children aged 10–14 *** progress in reducing mortality rates,suicide remains a significant *** overall rates have declined,the percentage of deaths caused by suicide in this age group is increasing.

关键词： Early adolescent Global Burden of Disease Incidence Suicide Years of life lost

Lipedema:A common though often unrecognized condition

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Chinese Journal of Plastic and Reconstructive Surgery 2024年第3期6卷 149-153页

作者： Rafael Carvalho private practice R.Iolanda del Nero Barco101PirassunungaSao Paulo13631-064Brazil

Lipedema is a chronic disorder primarily affecting women,characterized by abnormal fat deposition in the extremities,leading to pain,mobility issues,and psychological *** fat deposits are clear-cut and spare hands and *** misdiagnosed as lymphedema,its prevalence remains uncertain due to a lack of universally accepted diagnostic criteria and difficulty in differentiating it from obesity or *** factors and hormonal influences are likely related to the pathophysiology of the disease,though the specific causes remain *** techniques may aid evaluation,but no definitive test exists,and diagnosis is made *** treatments such as lifestyle modifications and compression garments are considered first-line treatments,while surgical options such as liposuction and lipectomy are reserved for severe or refractory *** support may be recommended,given lipedema’s impact on quality of life and *** review aims to present the current understanding of this condition,including challenges in diagnosis,current guideline recommendations for clinical care,and associated comorbid conditions.

关键词： Lipedema Obesity Lymphedema Liposuction Lipectomy

Clinical-DNA Correlates of Anxiety in Patients with Ehlers-Danlos Syndrome

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Open Journal of Psychiatry 2024年第4期14卷 319-333页

作者： Golder N. Wilson Vijay S. Tonk Department of Pediatrics Texas Tech University Health Sciences Center Lubbock TX USA Kinder Genome Genetics private practice Dallas TX USA Medical Genetics and the Cytogenomic Laboratory Department of Pediatrics Texas Tech University Health Sciences Center Lubbock TX USA

Introduction: Anxiety disorders have a lifetime prevalence of 34% with a similar level of heritability (31%) yet lack objective markers that could differentiate patients with underlying conditions. Up to 60%-70% of patients with Ehlers-Danlos syndrome have anxiety that meets criteria of generalized anxiety disorder, their clinical-DNA findings worth examining as biomarkers for patients with generalized anxiety. Method: Of the 1899 patients diagnosed with Ehlers-Danlos syndrome, 1261 were systematically evaluated for 80 history and 40 physical findings and separated into 826 who reported anxiety and 435 who did not. The most consistently reported or management-directing 60 of these clinical findings were, along with variations in genes relevant to these disorders, examined for association with anxiety. Results: Among the 30 anxiety- associated findings judged most predictive of Ehlers-Danlos syndrome in patients with anxiety were expected ones of adrenergic stimulation (difficulty concentrating-87% frequency and 1.26 anxiety/no anxiety ratio;chronic fatigue-84%, 1.17;sleep issues 69%, 1.52 that are criteria for generalized anxiety disorder) or of cholinergic suppression (e.g., frequent nausea 64%, 1.26). Less associated but more discriminating for underlying disease were those reflective of neuromuscular impact (e.g., chronic daily headaches 76%, 1.12);hypermobility (e.g., awareness of flexibility 72%, 1.03), or skin changes (e.g., elasticity around jaw 71%, 1.06). Anxiety-associated DNA variants included 54 of 88 in collagen type I/V/VII/IX genes, 14 of 16 in sodium channel SCN9A/10A/ 11A genes, 59 of 85 in POLG/MT-DNA genes, and 21 of 28 in profilaggrin- FLG genes that respectively impacted tissue laxity, sensory neural, autonomic-mitochondrial, and autonomic-inflammatory functions. Conclusion: Analysis of pathogenetic mechanisms in Ehlers-Danlos syndrome selected some 50 clinical-DNA findings useful for its diagnosis in those with generalized anxiety disorders.

关键词： Anxiety Generalized Anxiety Disorder Ehlers-Danlos Syndrome Long COVID19 Joint Hypermobility Dysautonomia DNA Testing Whole Exome Sequencing DNA Variant Qualification

A review of whole-medical systems and holistic care approach for type 2 diabetes and associated metabolic syndrome

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Journal of Integrative Medicine 2024年第3期22卷 199-209页

作者： Loveness Makoni Idah T.Manduna Alaisa L.Mbiriri Department of Health Sciences Faculty of Health and Environmental Health SciencesCentral University of TechnologyFree State20 President Brand StreetPrivate bag X20539Bloemfontein 9300South Africa Centre for Applied Food Sustainability and Biotechnology(CAFSaB) Faculty of Health and Environmental Health SciencesCentral University of TechnologyFree State20 President Brand StreetPrivate bag X20539Bloemfontein 9300South Africa Adventist Development and Relief Agency(AdrA) 5 Cecil RoadGreendaleHarare 0000Zimbabwe

Whole-person care and holistic care approach has been proposed for complementary and integrative health care for type 2 diabetes ***,some doubts still exist on the feasibility of replicating processes followed in clinical trials and observational studies in real-world *** narrative literature review summarized and assessed existing clinical evidence(clinical trials,observational studies,and case reports)describing holistic and integrated care approach in adult and adolescent individuals with type 2 diabetes mellitus in clinical *** goal was to highlight existing evidence for implementation and outcomes of whole-medical systems and holistic integrated care approach for type 2 diabetes mellitus.A nonsystematic literature search was performed on Google Scholar,PubMed,Web of Science,ProQuest and ScienceDirect to identify clinical evidence from different parts of the world,evaluating the use of whole-medical systems and/or holistic care interventions in clinical practice for management of type 2 diabetes *** keywords were used in the *** were analyzed using content analysis and simple descriptive statistics(percentages).Most of the studies(64%)were mainly conducted in Eastern countries(India,China and Israel)while 36%of the studies were conducted in the Western countries(USA,Netherlands,Canada and Mexico).Lifestyle medicine and integrated naturopathy were shown to be the commonly used whole-medical systems for type 2 diabetes mellitus *** improvements in type 2 diabetes parameters,medication use,other symptoms,and overall feeling of wellness were observed in all *** review study revealed limited utilization and/or documentation of whole-medical systems or holistic care treatments for type 2 diabetes mellitus in regions of the world other than eastern *** medicine,naturopathy,yoga,Ayurveda and traditional Chinese medicine were shown to be effective for type 2 diabetes mellitu

关键词： Complementary and alternative medicine Holistic care Integrative medicine Type 2 diabetes mellitus Team-based intervention

Key rheological properties of hyaluronic acid fillers:from tissue integration to product degradation

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Plastic and Aesthetic Research 2018年第5期5卷 1-8页

作者： Samuel Gavard Molliard Jérémie Bon Bétemps Basste Hadjab david Topchian Patrick Micheels Denis Salomon Research and Development Department Kylane Laboratoires S.A.Plan-les-Ouates 1228Switzerland dr.david&associates private practice Armadale VIC 3143Australia dr.Patrick Micheels private practice Genève 1206Switzerland Clinique Internationale de Dermatologie Genève S.A.private practice Genève 1201Switzerland

Aim: Over the last 15 years, hyaluronic acid (HA) fillers have become the most popular injectable biomaterial for soft tissue correction. With the increasing number of available HA fillers and the multiplication of facial treatments all over the world, there has been a need from physicians to better understand the HA fillers science. There is especially a growing interest in the science-based evaluation of rheological characteristics which represents an essential tool to guide physicians in the selection of the most appropriate HA fillers, administration techniques and depths of injection for their clinical applications. Methods: Four key rheological parameters (viscosity η, elasticity G', normal force FN and elasticity E') are measured and discussed on five HA fillers. Results: These four key rheological parameters are demonstrated to play a pivotal role, in combination with the cohesivity, for better predicting the clinical behavior of HA fillers at different stages of their lifetime. Conclusion: This article discusses the importance of four key rheological parameters during the main steps of the clinical HA fillers' lifetime, from the product injection to the loss of clinical effects. A better knowledge of these HA fillers' rheological parameters can help the physicians to optimize their aesthetic outcomes, safety and patient satisfaction.

关键词： Hyaluronic acid fillers rheological properties product lifetime tissue integration clinical effects

Clinical variants of pityriasis rosea

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World Journal of Clinical Cases 2017年第6期5卷 203-211页

作者： Francisco Urbina Anupam Das Emilio Sudy Dermatologists in private practice Dermatology KPC Medical College and Hospital

Pityriasis rosea(PR) is a common erythemato-squamous dermatosis which almost always, is easily diagnosed. Mostly the disease presents in its classical form. However, clinical dermatology is all about variations and PR is not an exception. Variants of the disease in some cases may be troublesome to diagnose and confuse clinicians. Prompt diagnosis and treatment of the condition becomes necessary to avoid unnecessary investigations. We hereby review and illustrate atypical presentations of the disease, including diverse forms of location and morphology of the lesions, the course of the eruption, and its differential diagnoses.

关键词： Pityriasis Pityriasis rosea Pityriasis rosea of Gibert Herald patch Papulo-squamous dermatosis

Botulinum toxin augmentation as a sequential procedure for residual esotropia in traumatic sixth nerve palsy

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International Journal of Ophthalmology(English edition) 2018年第12期11卷 2027-2028页

作者： Hande Taylan Sekeroglu Kadriye Erkan Turan Ali Sefik Sanac Ophthalmology Hacettepe University Faculty of Medicine Ophthalmology Private Practice

Dear Editor, We want to describe the surgical outcome of a patient with residual esotropia due to sixth nerve palsy with re-resection of the lateral rectus combined with botulinum toxin injection to previously recesse... 详细信息

关键词： In Botulinum toxin augmentation as a sequential procedure for residual esotropia in traumatic sixth nerve palsy Figure

Distribution and dynamics of niche and interspecific association of dominant phytoplankton species in the Feiyun River basin,Zhejiang,China

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Journal of Oceanology and Limnology 2024年第4期42卷 1157-1172页

作者： Shengnan ZHU Zengchuan DONG Guobin FU Shujun WU Jinyu MENG Weilin LIU Yupeng LIU Xun CUI Yuejiao ZHOU College of Hydrology and Water Resources Hohai UniversityNanjing 210098China CSIRO Environment Private Bag 5Wembley WA 6913Australia Department of Agricultural and Biological Engineering Indian River Research and Education CenterUniversity of FloridaFort Pierce 34945USA Jiangxi Provincial Key Laboratory of Hydrology-Water Resources and Water Environment Nanchang Institute of TechnologyNanchang 330099China

To investigate the dominant species and interspecific association in the phytoplankton community of the Feiyun River basin in Zhejiang Province,East China,the main stream and the Shanxi Zhaoshandu Reservoir in the downstream were chosen as the study area,for which 22 sampling sites were *** was conducted in September 2021,January,May,and July *** species were identified from both quantitative samples and in-vivo *** was quantified by direct *** show that there were 98 species belonging to 6 phyla and 78 *** addition,to clarify the niches of the dominant phytoplankton species and their interspecific association,the dominance index was calculated,and a comprehensive analysis was conducted including niche width,niche overlap value,ecological response rate,overall association,chi-square test,and the *** phytoplankton community exhibited characteristics of a Cyanobacteria-Chlorophyta-Diatom type community,showing higher diversity in spring and lower diversity in *** 11 dominants phytoplankton species from 3 phyla,both frequency and dominance degree varied seasonally,of which Microcystis *** the dominant species in Spring,Autumn,and *** niche widths of the dominant species ranged from 0.234 to 0.933,and were categorized into three *** niche overlap values of the 11 dominant species ranged from 0.359 to 0.959,exhibiting significant seasonal differences-highest in winter followed by autumn,spring,and summer in *** overall correlation among dominant species in all four seasons revealed a non-significant negative association,resulting in an unstable community structure.A significant portion(84.2%)of species pairs displayed positive associations,suggesting a successional pattern where Diatoms dominated while other dominant species shared resources and *** this pattern,stability measurements indicated that the dominant species community remained unstable.T

关键词： phytoplankton dominant species niche interspecific association Feiyun River basin

Regulation of the intestinal immune system by flavonoids and its utility in chronic inflammatory bowel disease

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World Journal of Gastroenterology 2018年第8期24卷 877-881页

作者： Harald Peter Hoensch Benno Weigmann private practice Gastroenterology Marien hospital Department of Medicine 1 University Medical Center

Flavonoids are phytochemicals which can regulate the activity of the intestinal immune system. In patients with chronic inflammatory bowel disease(IBD) there is an overexpression and imbalance of the components of the inflammatory immune reactions which are chronically activated. Suppression of inflammation can be achieved by anti-inflammatory drugs which are used in clinical medicine but these can cause serious side effects. Flavonoids can have natural immunosuppressive properties and inhibit the activation of immune cells and its effectors(chemokines, TNF-, cytokines). Phytochemicals such as flavonoids bind to the nuclear Ah(aryl hydrocarbon)-receptor thereby stimulating protective enzyme activities. As shown by clinical evidence in patients and by experimental work some flavonoids(apigenin, epigallocatechin gallate) were effective in the inhibition of inflammation. Instead of or additionally to anti-inflammatory drugs flavonoids can be used in IBD patients to treat the over-reactive immunologic system. This is accomplished by upregulation of the Ah-receptor. Flavonoids interact with toll-like receptors expressing on the surface of immune cells, then they were internalized to the cytosol and transferred into the nucleus, where they were attached to the Ah-receptor. The Ah-receptor binds to the Ah-R nuclear translocator and via Ah response element beneficial protective enzymes and cytokines are induced, leading to upregulation of the anti-inflammatory system.

关键词： Flavonoids Inflammatory bowel disease Ah-receptor